Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/27153 |
Resumo: | A balanced diet is essential in obesity control. Fruits stand out for the presence of various bioactive compounds, which represent promising tools in the prevention and treatment of various pathologies. In obesity, fruits phytochemicals present are related to different important mechanisms of action, such as antioxidant and anti-inflammatory activity. This narrative review aims to understand the main physiological alterations of obesity and the effects of bioactive compounds in fruits on them, identifying the best-known substances and their likely mechanisms of action on the main biomarkers. The research was carried out in the Google Scholar, Scielo, Pubmed and Science Direct databases, considering reviews published since 2015 and experimental studies since 2010. Inflammatory cytokines and adipokines are considered primary biomarkers of obesity, and are currently also considered the insulin resistance, lower glucose tolerance, oxidative stress, gut microbiota, nutrients and microRNAs. Three groups of fruits stood out for their effects: Citrus fruits, berries and tropical fruits, sources mainly of flavonoids, anthocyanins and carotenoids. Experimental results indicate that fruits and their compounds can help in the prevention and treatment of obesity through the regulation of inflammatory cytokines and adipokines involved in the mechanisms of this disease, as well as antioxidant properties and modulation of lipogenesis. More clinical studies are needed to understand the biochemical mechanisms involved, in order to favor not only the production of specific supplements but also the best clinical dietary prescription. |
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Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative reviewMecanismos de la obesidad e importancia de los compuestos bioactivos de la fruta en su regulación – una revisión narrativaMecanismos da obesidade e importância dos compostos bioativos de frutas em sua regulação – uma revisão narrativaBiomarcadoresFitoquímicosFrutasCompuestos bioactivos.ObesityBiomarkersPhytochemicalsFruitsBioactive compounds.ObesidadeBiomarcadoresFitoquímicosFrutasCompostos bioativos.A balanced diet is essential in obesity control. Fruits stand out for the presence of various bioactive compounds, which represent promising tools in the prevention and treatment of various pathologies. In obesity, fruits phytochemicals present are related to different important mechanisms of action, such as antioxidant and anti-inflammatory activity. This narrative review aims to understand the main physiological alterations of obesity and the effects of bioactive compounds in fruits on them, identifying the best-known substances and their likely mechanisms of action on the main biomarkers. The research was carried out in the Google Scholar, Scielo, Pubmed and Science Direct databases, considering reviews published since 2015 and experimental studies since 2010. Inflammatory cytokines and adipokines are considered primary biomarkers of obesity, and are currently also considered the insulin resistance, lower glucose tolerance, oxidative stress, gut microbiota, nutrients and microRNAs. Three groups of fruits stood out for their effects: Citrus fruits, berries and tropical fruits, sources mainly of flavonoids, anthocyanins and carotenoids. Experimental results indicate that fruits and their compounds can help in the prevention and treatment of obesity through the regulation of inflammatory cytokines and adipokines involved in the mechanisms of this disease, as well as antioxidant properties and modulation of lipogenesis. More clinical studies are needed to understand the biochemical mechanisms involved, in order to favor not only the production of specific supplements but also the best clinical dietary prescription.Una dieta equilibrada es fundamental para controlar la obesidad. Las frutas se destacan por la presencia de diversos compuestos bioactivos, que representan herramientas prometedoras en la prevención y tratamiento de diversas patologías. En la obesidad, los fitoquímicos presentes en las frutas están relacionados con diferentes mecanismos de acción importantes, como la actividad antioxidante y antiinflamatoria. Esta revisión narrativa pretende comprender las principales alteraciones fisiológicas de la obesidad y los efectos de los compuestos bioactivos de las frutas sobre las mismas, identificando las sustancias más conocidas y sus probables mecanismos de acción sobre los principales biomarcadores. La investigación se realizó en las bases de datos Google Scholar, Scielo, Pubmed y Science Direct, considerando revisiones publicadas a partir de 2015 y estudios experimentales a partir de 2010. Las citocinas y adipocinas inflamatorias se consideran biomarcadores primarios de la obesidad, y actualmente también se consideran la resistencia a la insulina, menor tolerancia a la glucosa, estrés oxidativo, microbiota intestinal, nutrientes y microARN. Tres grupos de frutas se destacaron por sus efectos: cítricos, “berries” y frutas tropicales, fuentes principalmente de flavonoides, antocianinas y carotenoides. Los resultados experimentales indican que las frutas y sus compuestos pueden ayudar en la prevención y tratamiento de la obesidad a través de la regulación de citoquinas y adipoquinas inflamatorias involucradas en los mecanismos de esta enfermedad, así como propiedades antioxidantes y modulación de la lipogénesis. Se necesitan más estudios clínicos para comprender los mecanismos bioquímicos involucrados, a fin de favorecer no solo la producción de suplementos específicos sino también la mejor prescripción dietética clínica.Uma dieta equilibrada é essencial no controle da obesidade. As frutas destacam-se pela presença de variados compostos bioativos, que representam ferramentas promissoras na prevenção e tratamento de diversas patologias. Na obesidade, fitoquímicos presentes nas frutas são relacionados a diferentes mecanismos de ação importantes, como atividade antioxidante e anti-inflamatória. Esta revisão narrativa visa entender as principais alterações fisiológicas da obesidade e os efeitos dos compostos bioativos de frutas sobre elas, identificando as substâncias mais conhecidas e seus prováveis mecanismos de ação sobre os principais biomarcadores. A pesquisa foi realizada nas bases de dados Google Acadêmico, Scielo, Pubmed e Science Direct, considerando revisões publicadas a partir de 2015 e estudos experimentais a partir de 2010. As citocinas inflamatórias e adipocinas são consideradas biomarcadores primários da obesidade, sendo considerados atualmente também a resistência insulínica, a menor tolerância à glicose, estresse oxidativo, microbiota intestinal, nutrientes e microRNAs. Três grupos de frutas destacaram-se por seus efeitos: as frutas cítricas, “berries” e frutas tropicais, fontes principalmente de flavonoides, antocianinas e carotenoides. Resultados experimentais apontam que as frutas e seus compostos podem auxiliar na prevenção e tratamento da obesidade através da regulação de citocinas inflamatórias e adipocinas envolvidas nos mecanismos desta doença, bem como propriedades antioxidantes e modulação da lipogênese. Mais estudos clínicos são necessários para entender sobre os mecanismos bioquímicos envolvidos, a fim de favorecer não só a produção de suplementos específicos como também a melhor prescrição clínica dietética.Research, Society and Development2022-03-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2715310.33448/rsd-v11i4.27153Research, Society and Development; Vol. 11 No. 4; e11411427153Research, Society and Development; Vol. 11 Núm. 4; e11411427153Research, Society and Development; v. 11 n. 4; e114114271532525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/27153/23722Copyright (c) 2022 Raquel Martins Martinez ; Carolina de Oliveira Ramos Petra de Almeida; Thuane Passos Barbosa Lima ; Mariana Sarto Figueiredo ; Anderson Junger Teodorohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMartinez , Raquel Martins Almeida, Carolina de Oliveira Ramos Petra de Lima , Thuane Passos Barbosa Figueiredo , Mariana Sarto Teodoro, Anderson Junger2022-03-27T17:17:09Zoai:ojs.pkp.sfu.ca:article/27153Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:58.332879Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review Mecanismos de la obesidad e importancia de los compuestos bioactivos de la fruta en su regulación – una revisión narrativa Mecanismos da obesidade e importância dos compostos bioativos de frutas em sua regulação – uma revisão narrativa |
| title |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review |
| spellingShingle |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review Martinez , Raquel Martins Biomarcadores Fitoquímicos Frutas Compuestos bioactivos. Obesity Biomarkers Phytochemicals Fruits Bioactive compounds. Obesidade Biomarcadores Fitoquímicos Frutas Compostos bioativos. |
| title_short |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review |
| title_full |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review |
| title_fullStr |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review |
| title_full_unstemmed |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review |
| title_sort |
Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review |
| author |
Martinez , Raquel Martins |
| author_facet |
Martinez , Raquel Martins Almeida, Carolina de Oliveira Ramos Petra de Lima , Thuane Passos Barbosa Figueiredo , Mariana Sarto Teodoro, Anderson Junger |
| author_role |
author |
| author2 |
Almeida, Carolina de Oliveira Ramos Petra de Lima , Thuane Passos Barbosa Figueiredo , Mariana Sarto Teodoro, Anderson Junger |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Martinez , Raquel Martins Almeida, Carolina de Oliveira Ramos Petra de Lima , Thuane Passos Barbosa Figueiredo , Mariana Sarto Teodoro, Anderson Junger |
| dc.subject.por.fl_str_mv |
Biomarcadores Fitoquímicos Frutas Compuestos bioactivos. Obesity Biomarkers Phytochemicals Fruits Bioactive compounds. Obesidade Biomarcadores Fitoquímicos Frutas Compostos bioativos. |
| topic |
Biomarcadores Fitoquímicos Frutas Compuestos bioactivos. Obesity Biomarkers Phytochemicals Fruits Bioactive compounds. Obesidade Biomarcadores Fitoquímicos Frutas Compostos bioativos. |
| description |
A balanced diet is essential in obesity control. Fruits stand out for the presence of various bioactive compounds, which represent promising tools in the prevention and treatment of various pathologies. In obesity, fruits phytochemicals present are related to different important mechanisms of action, such as antioxidant and anti-inflammatory activity. This narrative review aims to understand the main physiological alterations of obesity and the effects of bioactive compounds in fruits on them, identifying the best-known substances and their likely mechanisms of action on the main biomarkers. The research was carried out in the Google Scholar, Scielo, Pubmed and Science Direct databases, considering reviews published since 2015 and experimental studies since 2010. Inflammatory cytokines and adipokines are considered primary biomarkers of obesity, and are currently also considered the insulin resistance, lower glucose tolerance, oxidative stress, gut microbiota, nutrients and microRNAs. Three groups of fruits stood out for their effects: Citrus fruits, berries and tropical fruits, sources mainly of flavonoids, anthocyanins and carotenoids. Experimental results indicate that fruits and their compounds can help in the prevention and treatment of obesity through the regulation of inflammatory cytokines and adipokines involved in the mechanisms of this disease, as well as antioxidant properties and modulation of lipogenesis. More clinical studies are needed to understand the biochemical mechanisms involved, in order to favor not only the production of specific supplements but also the best clinical dietary prescription. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-03-12 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/27153 10.33448/rsd-v11i4.27153 |
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https://rsdjournal.org/index.php/rsd/article/view/27153 |
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10.33448/rsd-v11i4.27153 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/27153/23722 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Research, Society and Development |
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Research, Society and Development |
| dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 4; e11411427153 Research, Society and Development; Vol. 11 Núm. 4; e11411427153 Research, Society and Development; v. 11 n. 4; e11411427153 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052811135942656 |