Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/35378 |
Resumo: | Polar extracts of Tapirira guianensis Aubl. were prepared for evaluation of biological activities. Identification and quantification of phenolic compounds, antioxidant activity, inhibition of acetylcholinesterase enzyme and antifungal potential were performed in all extracts. High contents of total phenols were detected in the ethanolic and aqueous extracts of the leaves (237.10±5.39 mg EAG/g and 346.46±5.67 mg EAG) respectively. The same extracts had a free radical scavenging potential by both DPPH and ABTS+ methods. Ethanolic extract of the leaves with IC50= 15.06±0.02 µg/mL and 16.49±0.01µg/mL) and aqueous extracts (11.54±0.01 µg/mL and 15.14±0.02 µg/mL respectively. In the study by high-performance liquid chromatography the phenolic substances were recorded: gallic acid, rutin, ellagic acid, quercetin and apigenin in the leaves and gallic acid and quercetin in the stem bark. Ethanolic and aqueous extracts of the leaves and stem bark showed high potency of inhibiting the enzyme acetylcholinesterase, with IC50 values = 13.94±0.02 µg/mL, 13.69±0.08 µg/mL and 14.79±0.20 µg/mL respectively. The aqueous extract of the leaves showed anti-Candida action against all four strains of the microorganism. The in silico studies evidenced that all the ligands analyzed presented interaction with the SAP5 protein highlighting the ellagic acid, the rutin and the quercetin. With these results, the activities previously reported for the species T. guianensis are confirmed, highlighting the polar extracts, mainly aqueous as a source of antioxidant, acetylcholinesterase inhibitor and antifungal substances. |
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Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extractsEvaluación del perfil fenólico y el potencial antioxidante, anticolinesterásico y anti-candida in vitro e in silico de extractos de Tapirira guianensis Aubl.Avaliação do perfil fenólico e do potencial antioxidante, anticolinesterase e anti-candida in vitro e in silico de extratos de Tapirira guianensis Aubl.Tapirira guianensisAntioxidantAcetilcolinesteraseAnti-Candida.Tapirira guianensisAntioxidanteAcetilcolinesteraseAnti-Candida.Tapirira guianensisAntioxidanteAcetilcolinesterasaAnti-Candida.Polar extracts of Tapirira guianensis Aubl. were prepared for evaluation of biological activities. Identification and quantification of phenolic compounds, antioxidant activity, inhibition of acetylcholinesterase enzyme and antifungal potential were performed in all extracts. High contents of total phenols were detected in the ethanolic and aqueous extracts of the leaves (237.10±5.39 mg EAG/g and 346.46±5.67 mg EAG) respectively. The same extracts had a free radical scavenging potential by both DPPH and ABTS+ methods. Ethanolic extract of the leaves with IC50= 15.06±0.02 µg/mL and 16.49±0.01µg/mL) and aqueous extracts (11.54±0.01 µg/mL and 15.14±0.02 µg/mL respectively. In the study by high-performance liquid chromatography the phenolic substances were recorded: gallic acid, rutin, ellagic acid, quercetin and apigenin in the leaves and gallic acid and quercetin in the stem bark. Ethanolic and aqueous extracts of the leaves and stem bark showed high potency of inhibiting the enzyme acetylcholinesterase, with IC50 values = 13.94±0.02 µg/mL, 13.69±0.08 µg/mL and 14.79±0.20 µg/mL respectively. The aqueous extract of the leaves showed anti-Candida action against all four strains of the microorganism. The in silico studies evidenced that all the ligands analyzed presented interaction with the SAP5 protein highlighting the ellagic acid, the rutin and the quercetin. With these results, the activities previously reported for the species T. guianensis are confirmed, highlighting the polar extracts, mainly aqueous as a source of antioxidant, acetylcholinesterase inhibitor and antifungal substances.Se prepararon extractos polares de Tapirira guianensis Aubl. para evaluar las actividades biológicas. En todos los extractos se realizó la identificación y cuantificación de los compuestos fenólicos, la actividad antioxidante, la inhibición de la enzima acetilcolinesterasa y el potencial antifúngico. Se detectaron altos contenidos de fenoles totales en los extractos etanólico y acuoso de las hojas (237,10±5,39 mg EAG/g y 346,46±5,67 mg EAG) respectivamente. Los mismos extractos tenían un potencial de barrido de radicales libres por los métodos DPPH y ABTS+. Extracto etanólico de las hojas con CI50= 15,06±0,02 µg/mL y 16,49±0,01µg/mL) y extractos acuosos (11,54±0,01 µg/mL y 15,14±0,02 µg/mL respectivamente. En el estudio por cromatografía líquida de alto rendimiento se registraron las sustancias fenólicas: ácido gálico, rutina, ácido elágico, quercetina y apigenina en las hojas y ácido gálico y quercetina en la corteza del tallo. Los extractos etanólicos y acuosos de las hojas y de la corteza del tallo mostraron una alta potencia de inhibición de la enzima acetilcolinesterasa con valores CI50 = 13,94±0,02 µg/mL, 13,69±0,08 µg/mL y 14,79±0,20 µg/mL respectivamente. El extracto acuoso de las hojas mostró una acción anti-Candida contra las cuatro cepas del microorganismo. Los estudios in silico evidenciaron que todos los ligandos analizados presentaron interacción con la proteína SAP5 destacando el ácido elágico, la rutina y la quercetina. Con estos resultados, se confirman las actividades previamente reportadas para la especie T. guianensis, destacando los extractos polares, principalmente acuosos como fuente de sustancias antioxidantes, inhibidoras de la acetilcolinesterasa y antifúngicas.Extratos polares de Tapirira guianensis Aubl. foram preparados para avaliação de atividades biológicas. Identificação e quantificação de compostos fenólicos, atividade antioxidante, inibição da enzima acetilcolinesterase e potencial antifúngico foram realizados em todos os extratos. Foram detectados teores elevados de fenóis totais nos extratos etanolicos e aquosos das folhas (237,10±5,39 mg EAG/g e 346,46±5,67 mg EAG) respectivamente. Os mesmos extratos apresentavam um potencial de extração de radicais livres tanto pelo método DPPH como pelo método ABTS+. Extrato etanólico das folhas com CI50= 15,06±0,02 µg/mL e 16,49±0,01µg/mL) e extratos aquosos (11,54±0,01 µg/mL e 15,14±0,02 µg/mL respectivamente. No estudo por cromatografia líquida de alta eficiência foram registradas as substâncias fenólicas: ácido gálico, rutina, ácido elágico, quercetina e apigenina nas folhas e ácido gálico e quercetina na casca do caule. Extratos etanólicos e aquosos das folhas e casca do caule mostraram uma elevada potência de inibição da enzima acetilcolinesterase, com valores de CI50 = 13,94±0,02 µg/mL, 13,69±0,08 µg/mL e 14,79±0,20 µg/mL respectivamente. O extrato aquoso das folhas mostrou ação anti-Candida contra as quatro cepas do microrganismo. Os estudos in silico evidenciaram que todos os ligantes analisados apresentaram interação com a proteína SAP5 destacando o ácido elágico, a rutina e a quercetina. Com estes resultados, confirmam-se as atividades anteriormente relatadas para a espécie T. guianensis, destacando-se os extratos polares, principalmente aquosos como fonte de antioxidante, inibidor da acetilcolinesterase e substâncias antifúngicas.Research, Society and Development2022-10-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3537810.33448/rsd-v11i13.35378Research, Society and Development; Vol. 11 No. 13; e317111335378Research, Society and Development; Vol. 11 Núm. 13; e317111335378Research, Society and Development; v. 11 n. 13; e3171113353782525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/35378/29758Copyright (c) 2022 Daniel Pereira de Oliveira; Selene Maia de Morais; Francisco Flávio da Silva Lopes; Daniela Ribeiro Alves; José Ribamar Garcez Neto; Raquel Oliveira dos Santos Fontenelle; Júlio Cesar Sousa Prado; Emmanuel da Silva Marinho; Márcia Machado Marinho; Lucas Lima Bezerrahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Daniel Pereira de Morais, Selene Maia de Lopes, Francisco Flávio da Silva Alves, Daniela Ribeiro Garcez Neto, José Ribamar Fontenelle, Raquel Oliveira dos Santos Prado, Júlio Cesar Sousa Marinho, Emmanuel da Silva Marinho, Márcia Machado Bezerra, Lucas Lima 2022-10-17T13:43:46Zoai:ojs.pkp.sfu.ca:article/35378Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:50:19.075160Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts Evaluación del perfil fenólico y el potencial antioxidante, anticolinesterásico y anti-candida in vitro e in silico de extractos de Tapirira guianensis Aubl. Avaliação do perfil fenólico e do potencial antioxidante, anticolinesterase e anti-candida in vitro e in silico de extratos de Tapirira guianensis Aubl. |
title |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts |
spellingShingle |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts Oliveira, Daniel Pereira de Tapirira guianensis Antioxidant Acetilcolinesterase Anti-Candida. Tapirira guianensis Antioxidante Acetilcolinesterase Anti-Candida. Tapirira guianensis Antioxidante Acetilcolinesterasa Anti-Candida. |
title_short |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts |
title_full |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts |
title_fullStr |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts |
title_full_unstemmed |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts |
title_sort |
Phenolic profile and antioxidant, anticholinesterase and anti- candida potential evaluation in vitro and in silico studies of Tapirira guianensis Aubl. extracts |
author |
Oliveira, Daniel Pereira de |
author_facet |
Oliveira, Daniel Pereira de Morais, Selene Maia de Lopes, Francisco Flávio da Silva Alves, Daniela Ribeiro Garcez Neto, José Ribamar Fontenelle, Raquel Oliveira dos Santos Prado, Júlio Cesar Sousa Marinho, Emmanuel da Silva Marinho, Márcia Machado Bezerra, Lucas Lima |
author_role |
author |
author2 |
Morais, Selene Maia de Lopes, Francisco Flávio da Silva Alves, Daniela Ribeiro Garcez Neto, José Ribamar Fontenelle, Raquel Oliveira dos Santos Prado, Júlio Cesar Sousa Marinho, Emmanuel da Silva Marinho, Márcia Machado Bezerra, Lucas Lima |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Daniel Pereira de Morais, Selene Maia de Lopes, Francisco Flávio da Silva Alves, Daniela Ribeiro Garcez Neto, José Ribamar Fontenelle, Raquel Oliveira dos Santos Prado, Júlio Cesar Sousa Marinho, Emmanuel da Silva Marinho, Márcia Machado Bezerra, Lucas Lima |
dc.subject.por.fl_str_mv |
Tapirira guianensis Antioxidant Acetilcolinesterase Anti-Candida. Tapirira guianensis Antioxidante Acetilcolinesterase Anti-Candida. Tapirira guianensis Antioxidante Acetilcolinesterasa Anti-Candida. |
topic |
Tapirira guianensis Antioxidant Acetilcolinesterase Anti-Candida. Tapirira guianensis Antioxidante Acetilcolinesterase Anti-Candida. Tapirira guianensis Antioxidante Acetilcolinesterasa Anti-Candida. |
description |
Polar extracts of Tapirira guianensis Aubl. were prepared for evaluation of biological activities. Identification and quantification of phenolic compounds, antioxidant activity, inhibition of acetylcholinesterase enzyme and antifungal potential were performed in all extracts. High contents of total phenols were detected in the ethanolic and aqueous extracts of the leaves (237.10±5.39 mg EAG/g and 346.46±5.67 mg EAG) respectively. The same extracts had a free radical scavenging potential by both DPPH and ABTS+ methods. Ethanolic extract of the leaves with IC50= 15.06±0.02 µg/mL and 16.49±0.01µg/mL) and aqueous extracts (11.54±0.01 µg/mL and 15.14±0.02 µg/mL respectively. In the study by high-performance liquid chromatography the phenolic substances were recorded: gallic acid, rutin, ellagic acid, quercetin and apigenin in the leaves and gallic acid and quercetin in the stem bark. Ethanolic and aqueous extracts of the leaves and stem bark showed high potency of inhibiting the enzyme acetylcholinesterase, with IC50 values = 13.94±0.02 µg/mL, 13.69±0.08 µg/mL and 14.79±0.20 µg/mL respectively. The aqueous extract of the leaves showed anti-Candida action against all four strains of the microorganism. The in silico studies evidenced that all the ligands analyzed presented interaction with the SAP5 protein highlighting the ellagic acid, the rutin and the quercetin. With these results, the activities previously reported for the species T. guianensis are confirmed, highlighting the polar extracts, mainly aqueous as a source of antioxidant, acetylcholinesterase inhibitor and antifungal substances. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/35378 10.33448/rsd-v11i13.35378 |
url |
https://rsdjournal.org/index.php/rsd/article/view/35378 |
identifier_str_mv |
10.33448/rsd-v11i13.35378 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/35378/29758 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 13; e317111335378 Research, Society and Development; Vol. 11 Núm. 13; e317111335378 Research, Society and Development; v. 11 n. 13; e317111335378 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052837557960704 |