Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/17442 |
Resumo: | Diabetes Mellitus (DM) is a serious public health problem that lacks new therapeutic alternatives, among which, phytotherapy stands out. This study aimed to evaluate the activity of hydroethanolic extract of leaves and flour from Guabiju fruits (Myrcianthes pungens) on the laboratory parameters of diabetic animals. The flour of the Guabiju fruits incorporated into the daily diet in the form of pelleted feed or the extract of the Guabiju leaves administered by gavage (oral dose of 300 mg/kg/day), were administered in an experimental model of Wistar rats with type 1 DM induced by alloxane, for 45 and 90 days, respectively. The anti-hyperglycemic effect and other biochemical parameters were evaluated, such as triglycerides, total cholesterol, and liver (AST) and renal (creatinine) function marker enzymes. The outcome of both treatments did not result in a marked decrease in fasting glycemia, improvement of the lipid profile or renal function when compared to untreated diabetic rats. However, treatment with Guabiju leaf extract prevented the increase in liver injury, and the results of the hepatic function showed significant beneficial changes in animals treated with Guabiju leaf extract, with decreased levels of AST. The AST value for non-diabetic rats was 72.12 ± 10.52 mg/dl, for diabetic rats it was 111.0 ± 16.84 mg/dl and for treated diabetic rats it was 82.66 ± 5.50 mg/dl (p < 0.05). This action in preventing typical complications of DM, such as liver damage, in a low dose, demonstrates that this plant can present a possible therapeutic activity, which must be refined with further tests and clinical trials that prove its effectiveness and safety. |
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Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic ratsEfectos del extracto hidroalcohólico de las hojas y harina de los frutos de Guabiju (Myrcianthes pungens) sobre parámetros de laboratorio de ratas diabéticasEfeitos do extrato hidroalcoólico das folhas e da farinha dos frutos de Guabiju (Myrcianthes pungens) sobre parâmetros laboratoriais de ratos diabéticosDiabetes mellitusMyrcianthes pungensMedicinal plantsCreatinineLipid profileAST.Diabetes mellitusMyrcianthes pungensPlantas medicinalesCreatininaPerfil lipídicoAST.Diabetes mellitusMyrcianthes pungensPlantas medicinaisCreatininaPerfil lipídicoAST.Diabetes Mellitus (DM) is a serious public health problem that lacks new therapeutic alternatives, among which, phytotherapy stands out. This study aimed to evaluate the activity of hydroethanolic extract of leaves and flour from Guabiju fruits (Myrcianthes pungens) on the laboratory parameters of diabetic animals. The flour of the Guabiju fruits incorporated into the daily diet in the form of pelleted feed or the extract of the Guabiju leaves administered by gavage (oral dose of 300 mg/kg/day), were administered in an experimental model of Wistar rats with type 1 DM induced by alloxane, for 45 and 90 days, respectively. The anti-hyperglycemic effect and other biochemical parameters were evaluated, such as triglycerides, total cholesterol, and liver (AST) and renal (creatinine) function marker enzymes. The outcome of both treatments did not result in a marked decrease in fasting glycemia, improvement of the lipid profile or renal function when compared to untreated diabetic rats. However, treatment with Guabiju leaf extract prevented the increase in liver injury, and the results of the hepatic function showed significant beneficial changes in animals treated with Guabiju leaf extract, with decreased levels of AST. The AST value for non-diabetic rats was 72.12 ± 10.52 mg/dl, for diabetic rats it was 111.0 ± 16.84 mg/dl and for treated diabetic rats it was 82.66 ± 5.50 mg/dl (p < 0.05). This action in preventing typical complications of DM, such as liver damage, in a low dose, demonstrates that this plant can present a possible therapeutic activity, which must be refined with further tests and clinical trials that prove its effectiveness and safety.La Diabetes Mellitus (DM) es un grave problema de salud pública que carece de nuevas alternativas terapéuticas, entre las que destaca la fitoterapia. Este estudio tuvo como objetivo evaluar la acción del extracto hidroetanólico de las hojas y harina de los frutos de Guabiju (Myrcianthes pungens) sobre los parámetros de laboratorio de animales diabéticos. Se administró harina de fruta de guabiju incorporada a la dieta diaria en forma de pienso granulado o el extracto de hojas de guabiju administrado por sonda (dosis oral de 300 mg/kg/día) en un modelo experimental de ratas Wistar con DM tipo 1 inducida por aloxano, durante 45 y 90 días, respectivamente. Se evaluó el efecto antihiperglucémico y otros parámetros bioquímicos, como triglicéridos, colesterol total y enzimas marcadores de función hepática (AST) y renal (creatinina). El resultado de ambos tratamientos no culminó en una disminución marcada de la glucosa en ayunas, una mejora en el perfil de lípidos o la función renal en comparación con las ratas diabéticas no tratadas. Sin embargo, el tratamiento con extracto de hoja de Guabiju evitó el aumento de los marcadores de daño hepático, y los resultados de la prueba de función hepática mostraron cambios beneficiosos significativos en los animales tratados con extracto de hoja de Guabiju, con niveles reducidos de AST. El valor de AST para ratas no diabéticas fue 72,12 ± 10,52 mg/dl, para ratas diabéticas fue 111,0 ± 16,84 mg/dl y para ratas diabéticas tratadas fue 82,66 ± 5,50 mg/dl (p < 0,05). Esta acción en la prevención de complicaciones típicas de la DM, como el daño hepático, en dosis bajas, demuestra que esta planta puede presentar una posible actividad terapéutica, la cual debe refinarse con más pruebas y ensayos clínicos que demuestren una acción eficaz y segura.O Diabetes Mellitus (DM) é um sério problema de saúde pública que carece de novas alternativas terapêuticas, dentre estas, destaca-se a fitoterapia. Esse estudo teve como objetivo avaliar a ação do extrato hidroetanólico das folhas e da farinha dos frutos de Guabiju (Myrcianthes pungens) sobre os parâmetros laboratoriais de animais diabéticos. A farinha dos frutos de Guabiju incorporada na alimentação diária em forma de ração peletizada ou o extrato das folhas de Guabiju administrado por gavagem (dose oral de 300 mg/kg/dia), foram administrados em um modelo experimental de ratos Wistar com DM tipo 1 induzido por aloxano, durante 45 e 90 dias, respectivamente. Avaliou-se o efeito anti-hiperglicemiante e outros parâmetros bioquímicos, como triglicérides, colesterol total e enzimas marcadoras de função hepática (AST) e renal (creatinina). O desfecho de ambos os tratamentos não culminou em marcante diminuição da glicemia de jejum, melhora do perfil lipídico ou função renal quando comparado aos ratos diabéticos não tratados. No entanto, o tratamento com o extrato das folhas de Guabiju preveniu o aumento de marcadores de lesão hepática, sendo que os resultados da prova de função hepática mostraram alterações benéficas significativas nos animais tratados com o extrato das folhas de Guabiju, com redução dos níveis de AST. O valor de AST para os ratos não diabéticos foi 72,12 ± 10,52 mg/dl, para os ratos diabéticos foi 111,0 ± 16,84 mg/dl e para os ratos diabéticos tratados foi 82,66 ± 5,50 mg/dl (p < 0,05). Esta ação em prevenir típicas complicações do DM, como os danos hepáticos, em uma baixa dose, demonstra que esta planta pode apresentar uma possível atividade terapêutica, que deve ser refinada com mais testes e ensaios clínicos que comprovem uma eficácia da ação e segurança.Research, Society and Development2021-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1744210.33448/rsd-v10i8.17442Research, Society and Development; Vol. 10 No. 8; e39910817442Research, Society and Development; Vol. 10 Núm. 8; e39910817442Research, Society and Development; v. 10 n. 8; e399108174422525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/17442/16816Copyright (c) 2021 Amanda Batista da Silva Lemos ; Amanda Ribeiro da Fonseca ; Ana Elisa Silveira de Souza; Luiza Bim Vivan; Laryssa Aparecida Oliveira Lomonaco; Sara Tais Dias; Bruno Cesar Correa Salles; Cláudio Daniel Cerdeira; Maria Tereza Bernardes Pascoal; Rafaela Bergmann Strada de Oliveira ; Gérsika Bitencourt Santos Barroshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLemos , Amanda Batista da Silva Fonseca , Amanda Ribeiro da Souza, Ana Elisa Silveira de Vivan, Luiza Bim Lomonaco, Laryssa Aparecida Oliveira Dias, Sara Tais Salles, Bruno Cesar Correa Cerdeira, Cláudio DanielPascoal, Maria Tereza Bernardes Oliveira , Rafaela Bergmann Strada de Barros, Gérsika Bitencourt Santos 2021-08-21T18:46:59Zoai:ojs.pkp.sfu.ca:article/17442Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:46.752556Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats Efectos del extracto hidroalcohólico de las hojas y harina de los frutos de Guabiju (Myrcianthes pungens) sobre parámetros de laboratorio de ratas diabéticas Efeitos do extrato hidroalcoólico das folhas e da farinha dos frutos de Guabiju (Myrcianthes pungens) sobre parâmetros laboratoriais de ratos diabéticos |
title |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats |
spellingShingle |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats Lemos , Amanda Batista da Silva Diabetes mellitus Myrcianthes pungens Medicinal plants Creatinine Lipid profile AST. Diabetes mellitus Myrcianthes pungens Plantas medicinales Creatinina Perfil lipídico AST. Diabetes mellitus Myrcianthes pungens Plantas medicinais Creatinina Perfil lipídico AST. |
title_short |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats |
title_full |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats |
title_fullStr |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats |
title_full_unstemmed |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats |
title_sort |
Effects of the hydroalcoholic extract from the leaves and flour of the fruits of Guabiju (Myrcianthes pungens) on laboratory parameters of diabetic rats |
author |
Lemos , Amanda Batista da Silva |
author_facet |
Lemos , Amanda Batista da Silva Fonseca , Amanda Ribeiro da Souza, Ana Elisa Silveira de Vivan, Luiza Bim Lomonaco, Laryssa Aparecida Oliveira Dias, Sara Tais Salles, Bruno Cesar Correa Cerdeira, Cláudio Daniel Pascoal, Maria Tereza Bernardes Oliveira , Rafaela Bergmann Strada de Barros, Gérsika Bitencourt Santos |
author_role |
author |
author2 |
Fonseca , Amanda Ribeiro da Souza, Ana Elisa Silveira de Vivan, Luiza Bim Lomonaco, Laryssa Aparecida Oliveira Dias, Sara Tais Salles, Bruno Cesar Correa Cerdeira, Cláudio Daniel Pascoal, Maria Tereza Bernardes Oliveira , Rafaela Bergmann Strada de Barros, Gérsika Bitencourt Santos |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lemos , Amanda Batista da Silva Fonseca , Amanda Ribeiro da Souza, Ana Elisa Silveira de Vivan, Luiza Bim Lomonaco, Laryssa Aparecida Oliveira Dias, Sara Tais Salles, Bruno Cesar Correa Cerdeira, Cláudio Daniel Pascoal, Maria Tereza Bernardes Oliveira , Rafaela Bergmann Strada de Barros, Gérsika Bitencourt Santos |
dc.subject.por.fl_str_mv |
Diabetes mellitus Myrcianthes pungens Medicinal plants Creatinine Lipid profile AST. Diabetes mellitus Myrcianthes pungens Plantas medicinales Creatinina Perfil lipídico AST. Diabetes mellitus Myrcianthes pungens Plantas medicinais Creatinina Perfil lipídico AST. |
topic |
Diabetes mellitus Myrcianthes pungens Medicinal plants Creatinine Lipid profile AST. Diabetes mellitus Myrcianthes pungens Plantas medicinales Creatinina Perfil lipídico AST. Diabetes mellitus Myrcianthes pungens Plantas medicinais Creatinina Perfil lipídico AST. |
description |
Diabetes Mellitus (DM) is a serious public health problem that lacks new therapeutic alternatives, among which, phytotherapy stands out. This study aimed to evaluate the activity of hydroethanolic extract of leaves and flour from Guabiju fruits (Myrcianthes pungens) on the laboratory parameters of diabetic animals. The flour of the Guabiju fruits incorporated into the daily diet in the form of pelleted feed or the extract of the Guabiju leaves administered by gavage (oral dose of 300 mg/kg/day), were administered in an experimental model of Wistar rats with type 1 DM induced by alloxane, for 45 and 90 days, respectively. The anti-hyperglycemic effect and other biochemical parameters were evaluated, such as triglycerides, total cholesterol, and liver (AST) and renal (creatinine) function marker enzymes. The outcome of both treatments did not result in a marked decrease in fasting glycemia, improvement of the lipid profile or renal function when compared to untreated diabetic rats. However, treatment with Guabiju leaf extract prevented the increase in liver injury, and the results of the hepatic function showed significant beneficial changes in animals treated with Guabiju leaf extract, with decreased levels of AST. The AST value for non-diabetic rats was 72.12 ± 10.52 mg/dl, for diabetic rats it was 111.0 ± 16.84 mg/dl and for treated diabetic rats it was 82.66 ± 5.50 mg/dl (p < 0.05). This action in preventing typical complications of DM, such as liver damage, in a low dose, demonstrates that this plant can present a possible therapeutic activity, which must be refined with further tests and clinical trials that prove its effectiveness and safety. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17442 10.33448/rsd-v10i8.17442 |
url |
https://rsdjournal.org/index.php/rsd/article/view/17442 |
identifier_str_mv |
10.33448/rsd-v10i8.17442 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17442/16816 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 8; e39910817442 Research, Society and Development; Vol. 10 Núm. 8; e39910817442 Research, Society and Development; v. 10 n. 8; e39910817442 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052682413801472 |