Case report: candidemia in a child with cystic fibrosis with fatal course

Detalhes bibliográficos
Autor(a) principal: Silva, Gleiciere Maia
Data de Publicação: 2023
Outros Autores: Silveira, Alice Cristiane Rangel, Lima Neto, Reginaldo Gonçalves de, Neves, Rejane Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/39762
Resumo: In the present study we report a case of candidemia in an infant with cystic fibrosis admitted to a Pediatric Intensive Care Unit (PICU) with a fatal course. Six-month-old male patient with a history of productive cough and persistent fever. He was admitted to the PICU of a public hospital in the city of Recife, PE, Brazil, with a diagnosis of dyspnea and cystic fibrosis, with a respiratory infection. Antibiotics were administered, however without success, peripheral blood and transcatheter blood cultures were requested, the isolated agents were Staphylococcus epidermidis and Pseudomonas aeruginosa, respectively. After seven days, the patient presented lesions on the genitalia and persistent fever. Blood and genital lesions were collected, the samples were identified as Candida albicans through the classical taxonomy and the VITEK 120 automated system. The antifungal sensitivity test followed the protocol by the broth microdilution method (CLSI- Clinical and Laboratory Standard Institute, 2008b). The isolates from blood samples were sensitive to amphotericin B with a Minimal Inhibitory Concentration (MIC) of 0.03 µg/mL, 0.12 µg/mL for anidulafungin and 0.25 µg/mL for voriconazole, exhibiting resistance to fluconazole with MIC of 64 µg/mL. C. albicans isolated from the genitalia lesion was sensitive to all the drugs used. The patient was administered nystatin 4 times a day and amphotericin B. The patient improved from the genital lesion and fever. However, after three days, the patient presented cardiac and respiratory deficit that led to cardiac arrest, leading to death.
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spelling Case report: candidemia in a child with cystic fibrosis with fatal course Relato de caso: candidemia en niño con fibrosis quística de curso fatalRelato de caso: candidemia em criança portadora de fibrose cística com curso fatal CandidemiaNiñoFibrosis quística.CandidemiaChildrenCystic fibrosis.CandidemiaCriançaFibrose cística.In the present study we report a case of candidemia in an infant with cystic fibrosis admitted to a Pediatric Intensive Care Unit (PICU) with a fatal course. Six-month-old male patient with a history of productive cough and persistent fever. He was admitted to the PICU of a public hospital in the city of Recife, PE, Brazil, with a diagnosis of dyspnea and cystic fibrosis, with a respiratory infection. Antibiotics were administered, however without success, peripheral blood and transcatheter blood cultures were requested, the isolated agents were Staphylococcus epidermidis and Pseudomonas aeruginosa, respectively. After seven days, the patient presented lesions on the genitalia and persistent fever. Blood and genital lesions were collected, the samples were identified as Candida albicans through the classical taxonomy and the VITEK 120 automated system. The antifungal sensitivity test followed the protocol by the broth microdilution method (CLSI- Clinical and Laboratory Standard Institute, 2008b). The isolates from blood samples were sensitive to amphotericin B with a Minimal Inhibitory Concentration (MIC) of 0.03 µg/mL, 0.12 µg/mL for anidulafungin and 0.25 µg/mL for voriconazole, exhibiting resistance to fluconazole with MIC of 64 µg/mL. C. albicans isolated from the genitalia lesion was sensitive to all the drugs used. The patient was administered nystatin 4 times a day and amphotericin B. The patient improved from the genital lesion and fever. However, after three days, the patient presented cardiac and respiratory deficit that led to cardiac arrest, leading to death.En el presente estudio reportamos un caso de candidemia en un lactante con fibrosis quística ingresado en una Unidad de Cuidados Intensivos Pediátricos (UCIP) con evolución fatal. Paciente masculino de seis meses de edad con antecedentes de tos productiva y fiebre persistente. Ingresó en la UCIP de un hospital público de la ciudad de Recife, PE, Brasil, con diagnóstico de disnea y fibrosis quística, con infección respiratoria. Se administraron antibióticos, sin embargo, sin éxito, se solicitaron hemocultivos de sangre periférica y transcatéter, los agentes aislados fueron Staphylococcus epidermidis y Pseudomonas aeruginosa, respectivamente. Después de siete días, el paciente presentó lesiones en los genitales y fiebre persistente. Se recolectó sangre y lesiones genitales, las muestras se identificaron como Candida albicans mediante la taxonomía clásica y el sistema automatizado VITEK 120. La prueba de sensibilidad antifúngica siguió el protocolo por el método de microdilución en caldo (CLSI- Clinical and Laboratory Standard Institute, 2008b). Los aislados de muestras de sangre fueron sensibles a la anfotericina B con una Concentración Mínima Inhibitoria (MIC) de 0,03 µg/mL, 0,12 µg/mL para anidulafungina y 0,25 µg/mL para voriconazol, presentando resistencia a fluconazol con MIC de 64 µg/mL. C. albicans aislado de la lesión de los genitales fue sensible a todos los fármacos utilizados. Se le administró nistatina 4 veces al día y anfotericina B. La paciente mejoró de la lesión genital y fiebre. Sin embargo, después de tres días, el paciente presentó un déficit cardíaco y respiratorio que lo llevó a un paro cardíaco que lo llevó a la muerte.No presente estudo relatamos um caso de candidemia em lactente portador de fibrose cística internado em Unidade de Terapia Intensiva Pediátrica (UTIP) com curso fatal.  Paciente com seis meses de idade, do sexo masculino com histórico de tosse produtiva e febre persistente. Foi admitido na UTIP de um hospital público da cidade do Recife, PE, Brasil, com diagnóstico de dispneia e fibrose cística, apresentando um quadro infeccioso respiratório. Foi administrado antibióticos, entretanto sem sucesso, foi solicitada hemocultura de sangue periférico e de transcateter, os agentes isolados foram Staphylococcus epidermidis e Pseudomonas aeruginosa, respectivamente. Após sete dias o paciente apresentou lesão na genitália e febre persistente. Foi realizada coleta de sangue e da lesão da genitália, as amostras foram identificas como Candida albicans através da taxonomia clássica e do sistema automatizado VITEK 120. O teste de sensibilidade a antifúngicos seguiu protocolo pelo método de microdiluição em caldo (CLSI- Clinical and Laboratory Standard Institute, 2008b). Os isolados de amostras de sangue foram sensíveis a anfotericina B com Concentração Inibitória Mínima (CIM) de 0,03 µg/mL, 0,12 µg/mL para anidulafungina e ao 0,25 µg/mL para voriconazol, exibindo resistência ao fluconazol com CIM de 64 µg/mL. C. albicans isolada da lesão da genitália foi sensível a todas as drogas utilizadas. Foi administrado ao paciente nistatina 4 vezes ao dia e anfotericina B. O paciente obteve melhora da lesão da genitália e da febre. Contudo, após três dias o paciente apresentou déficit cardíaco e respiratório que conduziu a parada cardíaca, indo ao óbito.Research, Society and Development2023-01-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3976210.33448/rsd-v12i1.39762Research, Society and Development; Vol. 12 No. 1; e29712139762Research, Society and Development; Vol. 12 Núm. 1; e29712139762Research, Society and Development; v. 12 n. 1; e297121397622525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/39762/32634Copyright (c) 2023 Gleiciere Maia Silva; Alice Cristiane Rangel Silveira; Reginaldo Gonçalves de Lima Neto; Rejane Pereira Neveshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Gleiciere Maia Silveira, Alice Cristiane Rangel Lima Neto, Reginaldo Gonçalves de Neves, Rejane Pereira 2023-01-13T10:30:42Zoai:ojs.pkp.sfu.ca:article/39762Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-01-13T10:30:42Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Case report: candidemia in a child with cystic fibrosis with fatal course
Relato de caso: candidemia en niño con fibrosis quística de curso fatal
Relato de caso: candidemia em criança portadora de fibrose cística com curso fatal
title Case report: candidemia in a child with cystic fibrosis with fatal course
spellingShingle Case report: candidemia in a child with cystic fibrosis with fatal course
Silva, Gleiciere Maia
Candidemia
Niño
Fibrosis quística.
Candidemia
Children
Cystic fibrosis.
Candidemia
Criança
Fibrose cística.
title_short Case report: candidemia in a child with cystic fibrosis with fatal course
title_full Case report: candidemia in a child with cystic fibrosis with fatal course
title_fullStr Case report: candidemia in a child with cystic fibrosis with fatal course
title_full_unstemmed Case report: candidemia in a child with cystic fibrosis with fatal course
title_sort Case report: candidemia in a child with cystic fibrosis with fatal course
author Silva, Gleiciere Maia
author_facet Silva, Gleiciere Maia
Silveira, Alice Cristiane Rangel
Lima Neto, Reginaldo Gonçalves de
Neves, Rejane Pereira
author_role author
author2 Silveira, Alice Cristiane Rangel
Lima Neto, Reginaldo Gonçalves de
Neves, Rejane Pereira
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Gleiciere Maia
Silveira, Alice Cristiane Rangel
Lima Neto, Reginaldo Gonçalves de
Neves, Rejane Pereira
dc.subject.por.fl_str_mv Candidemia
Niño
Fibrosis quística.
Candidemia
Children
Cystic fibrosis.
Candidemia
Criança
Fibrose cística.
topic Candidemia
Niño
Fibrosis quística.
Candidemia
Children
Cystic fibrosis.
Candidemia
Criança
Fibrose cística.
description In the present study we report a case of candidemia in an infant with cystic fibrosis admitted to a Pediatric Intensive Care Unit (PICU) with a fatal course. Six-month-old male patient with a history of productive cough and persistent fever. He was admitted to the PICU of a public hospital in the city of Recife, PE, Brazil, with a diagnosis of dyspnea and cystic fibrosis, with a respiratory infection. Antibiotics were administered, however without success, peripheral blood and transcatheter blood cultures were requested, the isolated agents were Staphylococcus epidermidis and Pseudomonas aeruginosa, respectively. After seven days, the patient presented lesions on the genitalia and persistent fever. Blood and genital lesions were collected, the samples were identified as Candida albicans through the classical taxonomy and the VITEK 120 automated system. The antifungal sensitivity test followed the protocol by the broth microdilution method (CLSI- Clinical and Laboratory Standard Institute, 2008b). The isolates from blood samples were sensitive to amphotericin B with a Minimal Inhibitory Concentration (MIC) of 0.03 µg/mL, 0.12 µg/mL for anidulafungin and 0.25 µg/mL for voriconazole, exhibiting resistance to fluconazole with MIC of 64 µg/mL. C. albicans isolated from the genitalia lesion was sensitive to all the drugs used. The patient was administered nystatin 4 times a day and amphotericin B. The patient improved from the genital lesion and fever. However, after three days, the patient presented cardiac and respiratory deficit that led to cardiac arrest, leading to death.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/39762
10.33448/rsd-v12i1.39762
url https://rsdjournal.org/index.php/rsd/article/view/39762
identifier_str_mv 10.33448/rsd-v12i1.39762
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/39762/32634
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 12 No. 1; e29712139762
Research, Society and Development; Vol. 12 Núm. 1; e29712139762
Research, Society and Development; v. 12 n. 1; e29712139762
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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