Penile cancer and factors associated with metastases in inguinal lymph nodes

Detalhes bibliográficos
Autor(a) principal: Santos, Kelly Monteiro dos
Data de Publicação: 2021
Outros Autores: Barros, Felipe Dubourcq de, Araujo-Mariz, Carolline de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/12854
Resumo: Purpose: Penile cancer has a high incidence in some developing countries and metastasis in lymph   nodes in the inguinal chain is a major challenge in the treatment of this neoplasia. The aim of this study was to identify the prevalence of metastasis in inguinal lymph nodes and their associated factors in patients with penile cancer.Methods: A retrospective analysis was made of all consultations by adult males with regard to penile lesions at our institution. Metastasis in inguinal lymph nodes was the event of interest and was defined based on the presence of squamous cell carcinoma in inguinal lymph nodes which had been confirmed by anatomopathological examination. We performed bivariate logistic regression analysis and the magnitude of the associations was expressed by the Odds Ratio as an estimate of the relative risk with a 90% confidence interval.Results: A prevalence of 24% of metastases was found among the 179 analyzed cases of squamous cell carcinoma of the penis. The presence of palpable lymph nodes in the inguinal region at the time of diagnosis (p = 0.008) and abuse of alcohol (p = 0.07) were independent associated factors for the disease becoming more aggressive.Conclusions: Patients diagnosed with penile squamous cell carcinoma, who present palpable lymph nodes in the inguinal region during the clinical examination and those who drink alcohol, should be an early target for interventions in the uro-oncology services.
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spelling Penile cancer and factors associated with metastases in inguinal lymph nodesCáncer de pene y factores asociados a metástasis en ganglios linfáticos inguinalesCâncer de pênis e fatores associados a metástases em linfonodos inguinaisPenile neoplasmsSquamous cell carcinomaLymphatic metastasisPrevalence. Neoplasias del peneCarcinoma de células escamosasMetástasis linfáticaPrevalencia.Câncer de PênisMetástase linfáticaCarcinoma de células escamosasPrevalência.Purpose: Penile cancer has a high incidence in some developing countries and metastasis in lymph   nodes in the inguinal chain is a major challenge in the treatment of this neoplasia. The aim of this study was to identify the prevalence of metastasis in inguinal lymph nodes and their associated factors in patients with penile cancer.Methods: A retrospective analysis was made of all consultations by adult males with regard to penile lesions at our institution. Metastasis in inguinal lymph nodes was the event of interest and was defined based on the presence of squamous cell carcinoma in inguinal lymph nodes which had been confirmed by anatomopathological examination. We performed bivariate logistic regression analysis and the magnitude of the associations was expressed by the Odds Ratio as an estimate of the relative risk with a 90% confidence interval.Results: A prevalence of 24% of metastases was found among the 179 analyzed cases of squamous cell carcinoma of the penis. The presence of palpable lymph nodes in the inguinal region at the time of diagnosis (p = 0.008) and abuse of alcohol (p = 0.07) were independent associated factors for the disease becoming more aggressive.Conclusions: Patients diagnosed with penile squamous cell carcinoma, who present palpable lymph nodes in the inguinal region during the clinical examination and those who drink alcohol, should be an early target for interventions in the uro-oncology services.Objetivo: El cáncer de pene tiene una alta incidencia en algunos países en desarrollo y la metástasis en los ganglios linfáticos de la cadena inguinal es un desafío importante en el tratamiento de esta neoplasia. El objetivo de este estudio fue identificar la prevalencia de metástasis en los ganglios linfáticos inguinales y sus factores asociados en pacientes con cáncer de pene.Métodos: Se realizó un análisis retrospectivo de todas las consultas de varones adultos por lesiones peneanas en nuestra institución. La metástasis en los ganglios linfáticos inguinales fue el evento de interés y se definió en función de la presencia de carcinoma de células escamosas en los ganglios linfáticos inguinales que se había confirmado mediante examen anatomopatológico. Realizamos análisis de regresión logística bivariante y la magnitud de las asociaciones se expresó mediante el Odds Ratio como una estimación del riesgo relativo con un intervalo de confianza del 90%. Resultados: Se encontró una prevalencia del 24% de metástasis entre los 179 casos analizados de carcinoma epidermoide de pene. La presencia de ganglios linfáticos palpables en la región inguinal en el momento del diagnóstico (p = 0,008) y el abuso de alcohol (p = 0,07) fueron factores asociados independientes para que la enfermedad se volviera más agresiva.Conclusiones: Los pacientes diagnosticados de carcinoma epidermoide de pene, que presenten ganglios linfáticos palpables en la región inguinal durante el examen clínico y los que consumen alcohol, deben ser un objetivo temprano para las intervenciones en los servicios de urooncología.Objetivo: O câncer de pênis tem alta incidência em alguns países em desenvolvimento e a metástase em linfonodos da cadeia inguinal é um grande desafio no tratamento dessa neoplasia. O objetivo deste estudo foi identificar a prevalência de metástases em linfonodos inguinais e seus fatores associados em pacientes com câncer de pênis.Métodos: Conduzimos uma análise retrospectiva de todas as consultas de lesões penianas realizadas por homens adultos em nossa instituição. Metástase em linfonodos inguinais constituiu o evento de interesse e foi definida a partir da presença de carcinoma escamocelular em linfonodos inguinais, confirmado por exame anatomopatológico. Foi realizada análise de regressão logística bivariada e a magnitude das associações expressa pelo Odds Ratio como estimativa do risco relativo com intervalo de confiança de 90%. Resultados: A prevalência de metástases observada entre os 179 casos de carcinoma escamocelular de pênis foi de 24%. A presença de linfonodos palpáveis na região inguinal no momento do diagnóstico (p = 0,008) e o uso abusivo de álcool (p = 0,07) foram fatores associados independentes para que a doença se tornasse mais agressiva.Conclusões: Pacientes com diagnóstico de carcinoma epidermóide de pênis, que apresentam linfonodos palpáveis na região inguinal durante o exame clínico e aqueles que fazem uso de bebidas alcoólicas, devem ser alvo precoce de intervenções nos serviços de urooncologia.Research, Society and Development2021-02-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1285410.33448/rsd-v10i2.12854Research, Society and Development; Vol. 10 No. 2; e55810212854Research, Society and Development; Vol. 10 Núm. 2; e55810212854Research, Society and Development; v. 10 n. 2; e558102128542525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/12854/11597Copyright (c) 2021 Kelly Monteiro dos Santos; Felipe Dubourcq de Barros; Carolline de Araujo-Marizhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Kelly Monteiro dosBarros, Felipe Dubourcq deAraujo-Mariz, Carolline de 2021-03-02T09:32:39Zoai:ojs.pkp.sfu.ca:article/12854Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:19.659442Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Penile cancer and factors associated with metastases in inguinal lymph nodes
Cáncer de pene y factores asociados a metástasis en ganglios linfáticos inguinales
Câncer de pênis e fatores associados a metástases em linfonodos inguinais
title Penile cancer and factors associated with metastases in inguinal lymph nodes
spellingShingle Penile cancer and factors associated with metastases in inguinal lymph nodes
Santos, Kelly Monteiro dos
Penile neoplasms
Squamous cell carcinoma
Lymphatic metastasis
Prevalence.
Neoplasias del pene
Carcinoma de células escamosas
Metástasis linfática
Prevalencia.
Câncer de Pênis
Metástase linfática
Carcinoma de células escamosas
Prevalência.
title_short Penile cancer and factors associated with metastases in inguinal lymph nodes
title_full Penile cancer and factors associated with metastases in inguinal lymph nodes
title_fullStr Penile cancer and factors associated with metastases in inguinal lymph nodes
title_full_unstemmed Penile cancer and factors associated with metastases in inguinal lymph nodes
title_sort Penile cancer and factors associated with metastases in inguinal lymph nodes
author Santos, Kelly Monteiro dos
author_facet Santos, Kelly Monteiro dos
Barros, Felipe Dubourcq de
Araujo-Mariz, Carolline de
author_role author
author2 Barros, Felipe Dubourcq de
Araujo-Mariz, Carolline de
author2_role author
author
dc.contributor.author.fl_str_mv Santos, Kelly Monteiro dos
Barros, Felipe Dubourcq de
Araujo-Mariz, Carolline de
dc.subject.por.fl_str_mv Penile neoplasms
Squamous cell carcinoma
Lymphatic metastasis
Prevalence.
Neoplasias del pene
Carcinoma de células escamosas
Metástasis linfática
Prevalencia.
Câncer de Pênis
Metástase linfática
Carcinoma de células escamosas
Prevalência.
topic Penile neoplasms
Squamous cell carcinoma
Lymphatic metastasis
Prevalence.
Neoplasias del pene
Carcinoma de células escamosas
Metástasis linfática
Prevalencia.
Câncer de Pênis
Metástase linfática
Carcinoma de células escamosas
Prevalência.
description Purpose: Penile cancer has a high incidence in some developing countries and metastasis in lymph   nodes in the inguinal chain is a major challenge in the treatment of this neoplasia. The aim of this study was to identify the prevalence of metastasis in inguinal lymph nodes and their associated factors in patients with penile cancer.Methods: A retrospective analysis was made of all consultations by adult males with regard to penile lesions at our institution. Metastasis in inguinal lymph nodes was the event of interest and was defined based on the presence of squamous cell carcinoma in inguinal lymph nodes which had been confirmed by anatomopathological examination. We performed bivariate logistic regression analysis and the magnitude of the associations was expressed by the Odds Ratio as an estimate of the relative risk with a 90% confidence interval.Results: A prevalence of 24% of metastases was found among the 179 analyzed cases of squamous cell carcinoma of the penis. The presence of palpable lymph nodes in the inguinal region at the time of diagnosis (p = 0.008) and abuse of alcohol (p = 0.07) were independent associated factors for the disease becoming more aggressive.Conclusions: Patients diagnosed with penile squamous cell carcinoma, who present palpable lymph nodes in the inguinal region during the clinical examination and those who drink alcohol, should be an early target for interventions in the uro-oncology services.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12854
10.33448/rsd-v10i2.12854
url https://rsdjournal.org/index.php/rsd/article/view/12854
identifier_str_mv 10.33448/rsd-v10i2.12854
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12854/11597
dc.rights.driver.fl_str_mv Copyright (c) 2021 Kelly Monteiro dos Santos; Felipe Dubourcq de Barros; Carolline de Araujo-Mariz
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Kelly Monteiro dos Santos; Felipe Dubourcq de Barros; Carolline de Araujo-Mariz
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 2; e55810212854
Research, Society and Development; Vol. 10 Núm. 2; e55810212854
Research, Society and Development; v. 10 n. 2; e55810212854
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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