Antitumor activity of Apocynaceae species used in Amazon traditional medicine
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/9241 |
Resumo: | This study reviews the use of Apocynaceae species for cancer and tumor treatment in the Amazon. Databases and books were searched for ethnobotanical and phytochemical evaluations of the cytotoxic and anticancer activities of Apocynaceae species. The literature reports the use of several Amazonian species, such as Asclepias curassavica, Himatanthus articulates, and Macoubea sprucei, in treating tumors and cancers. Phytochemical studies on A. curassavica and H. articulatus have shown their chemical compositions to be variable, possessing cardenolides, iridoids, flavonoids, steroids, and terpenes. Most of the species have not been subjected to in vitro experiments for anticancer activity, and the evaluated species showed moderate-to-weak responses or were inactive. Other studies have shown that iridoids, flavonoids, and steroids are promising as antitumor treatments. The following action mechanisms have been attributed to iridoids: topoisomerase I-DNA complex stabilization, cellular cytoskeleton alteration, and induction of apoptosis. The activities of flavonoids have been reported to include apoptosis induction in liver tumor cells. Some authors suggest that flavonoids reduce oxidative stress cellular response which reduces mitochondrial dysfunction and cell death. In summary, Apocynaceae species appear to be promising as a source for antitumor agents; however, further studies are required to confirm their antitumor activities and to better elucidate the underlying mechanisms involved. |
id |
UNIFEI_9365ffb95e1cbb960bb7fcbf94837101 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/9241 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Antitumor activity of Apocynaceae species used in Amazon traditional medicineActividad antitumoral de especies de Apocynaceae utilizadas en la medicina tradicional amazónicaAtividade antitumoral de espécies de Apocynaceae utilizadas na medicina tradicional amazônicaApocynaceaeCâncerFiquímicaCitotoxicidade.ApocynaceaeCancerFitoquímicaCitotoxicidad.ApocynaceaeCancerPhytochemistryCytotoxicity.This study reviews the use of Apocynaceae species for cancer and tumor treatment in the Amazon. Databases and books were searched for ethnobotanical and phytochemical evaluations of the cytotoxic and anticancer activities of Apocynaceae species. The literature reports the use of several Amazonian species, such as Asclepias curassavica, Himatanthus articulates, and Macoubea sprucei, in treating tumors and cancers. Phytochemical studies on A. curassavica and H. articulatus have shown their chemical compositions to be variable, possessing cardenolides, iridoids, flavonoids, steroids, and terpenes. Most of the species have not been subjected to in vitro experiments for anticancer activity, and the evaluated species showed moderate-to-weak responses or were inactive. Other studies have shown that iridoids, flavonoids, and steroids are promising as antitumor treatments. The following action mechanisms have been attributed to iridoids: topoisomerase I-DNA complex stabilization, cellular cytoskeleton alteration, and induction of apoptosis. The activities of flavonoids have been reported to include apoptosis induction in liver tumor cells. Some authors suggest that flavonoids reduce oxidative stress cellular response which reduces mitochondrial dysfunction and cell death. In summary, Apocynaceae species appear to be promising as a source for antitumor agents; however, further studies are required to confirm their antitumor activities and to better elucidate the underlying mechanisms involved.Este estudio revisa el uso de especies de Apocynaceae para el tratamiento del cáncer y tumores en la Amazonía. Se buscaron bases de datos y libros para realizar evaluaciones etnobotánicas y fitoquímicas de las actividades citotóxicas y anticancerígenas de las especies de Apocynaceae. La literatura reporta el uso de varias especies amazónicas, como Asclepias curassavica, Himatanthus articulate y Macoubea sprucei, en el tratamiento de tumores y cánceres. Los estudios fitoquímicos sobre A. curassavica y H. articulatus han demostrado que sus composiciones químicas son variables y poseen cardenólidos, iridoides, flavonoides, esteroides y terpenos. La mayoría de las especies no se han sometido a experimentos in vitro para determinar la actividad anticancerosa, y las especies evaluadas mostraron respuestas de moderadas a débiles o estuvieron inactivas. Otros estudios han demostrado que los iridoides, flavonoides y esteroides son prometedores como tratamientos antitumorales. Se han atribuido a los iridoides los siguientes mecanismos de acción: estabilización del complejo topoisomerasa I-ADN, alteración del citoesqueleto celular e inducción de apoptosis. Se ha informado que las actividades de los flavonoides incluyen la inducción de apoptosis en células tumorales hepáticas. Algunos autores sugieren que los flavonoides reducen la respuesta celular al estrés oxidativo, lo que reduce la disfunción mitocondrial y la muerte celular. En resumen, las especies de Apocynaceae parecen prometedoras como fuente de agentes antitumorales; sin embargo, se requieren más estudios para confirmar sus actividades antitumorales y para dilucidar mejor los mecanismos subyacentes involucrados.Este estudo revisa o uso de espécies de Apocynaceae para o tratamento de câncer e tumores na Amazônia. Bancos de dados e livros foram pesquisados para avaliações etnobotânicas e fitoquímicas das atividades citotóxicas e anticâncer de espécies de Apocynaceae. A literatura relata o uso de várias espécies amazônicas, como Asclepias curassavica, Himatanthus articulatus e Macoubea sprucei, no tratamento de tumores e cânceres. Estudos fitoquímicos em A. curassavica e H. articulatus mostraram que suas composições químicas são variáveis, possuindo cardenolideos, iridoides, flavonoides, esteroides e terpenos. A maioria das espécies não foi submetida a experimentos in vitro para atividade anticâncer, e as espécies avaliadas apresentaram respostas moderadas a fracas ou eram inativas. Outros estudos mostraram que iridoides, flavonoides e esteroides são promissores nos tratamentos antitumorais. Os seguintes mecanismos de ação foram atribuídos aos iridóides: estabilização do complexo topoisomerase I-DNA, alteração do citoesqueleto celular e indução de apoptose. Foi relatado que as atividades dos flavonoides incluem a indução de apoptose em células tumorais do fígado. Alguns autores sugerem que os flavonoides reduzem a resposta celular ao estresse oxidativo, o que reduz a disfunção mitocondrial e a morte celular. Em resumo, as espécies Apocynaceae parecem ser promissoras como fonte de agentes antitumorais; no entanto, mais estudos são necessários para confirmar suas atividades antitumorais e para melhor elucidar os mecanismos subjacentes envolvidos.Research, Society and Development2020-10-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/924110.33448/rsd-v9i10.9241Research, Society and Development; Vol. 9 No. 10; e9149109241Research, Society and Development; Vol. 9 Núm. 10; e9149109241Research, Society and Development; v. 9 n. 10; e91491092412525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/9241/8357Copyright (c) 2020 Mirian Letícia Carmo Bastos; Rosana Moura Sarmento; Marcelo de Oliveira Bahia; Jaqueline da Silva Rodrigues; Valdicley Vieira Vale; Sandro Percário; Maria Fâni Dolabelahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBastos, Mirian Letícia Carmo Sarmento, Rosana MouraBahia, Marcelo de OliveiraRodrigues, Jaqueline da Silva Vale, Valdicley VieiraPercário, SandroDolabela, Maria Fâni 2020-10-31T12:03:23Zoai:ojs.pkp.sfu.ca:article/9241Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:31:34.323716Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine Actividad antitumoral de especies de Apocynaceae utilizadas en la medicina tradicional amazónica Atividade antitumoral de espécies de Apocynaceae utilizadas na medicina tradicional amazônica |
title |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine |
spellingShingle |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine Bastos, Mirian Letícia Carmo Apocynaceae Câncer Fiquímica Citotoxicidade. Apocynaceae Cancer Fitoquímica Citotoxicidad. Apocynaceae Cancer Phytochemistry Cytotoxicity. |
title_short |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine |
title_full |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine |
title_fullStr |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine |
title_full_unstemmed |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine |
title_sort |
Antitumor activity of Apocynaceae species used in Amazon traditional medicine |
author |
Bastos, Mirian Letícia Carmo |
author_facet |
Bastos, Mirian Letícia Carmo Sarmento, Rosana Moura Bahia, Marcelo de Oliveira Rodrigues, Jaqueline da Silva Vale, Valdicley Vieira Percário, Sandro Dolabela, Maria Fâni |
author_role |
author |
author2 |
Sarmento, Rosana Moura Bahia, Marcelo de Oliveira Rodrigues, Jaqueline da Silva Vale, Valdicley Vieira Percário, Sandro Dolabela, Maria Fâni |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bastos, Mirian Letícia Carmo Sarmento, Rosana Moura Bahia, Marcelo de Oliveira Rodrigues, Jaqueline da Silva Vale, Valdicley Vieira Percário, Sandro Dolabela, Maria Fâni |
dc.subject.por.fl_str_mv |
Apocynaceae Câncer Fiquímica Citotoxicidade. Apocynaceae Cancer Fitoquímica Citotoxicidad. Apocynaceae Cancer Phytochemistry Cytotoxicity. |
topic |
Apocynaceae Câncer Fiquímica Citotoxicidade. Apocynaceae Cancer Fitoquímica Citotoxicidad. Apocynaceae Cancer Phytochemistry Cytotoxicity. |
description |
This study reviews the use of Apocynaceae species for cancer and tumor treatment in the Amazon. Databases and books were searched for ethnobotanical and phytochemical evaluations of the cytotoxic and anticancer activities of Apocynaceae species. The literature reports the use of several Amazonian species, such as Asclepias curassavica, Himatanthus articulates, and Macoubea sprucei, in treating tumors and cancers. Phytochemical studies on A. curassavica and H. articulatus have shown their chemical compositions to be variable, possessing cardenolides, iridoids, flavonoids, steroids, and terpenes. Most of the species have not been subjected to in vitro experiments for anticancer activity, and the evaluated species showed moderate-to-weak responses or were inactive. Other studies have shown that iridoids, flavonoids, and steroids are promising as antitumor treatments. The following action mechanisms have been attributed to iridoids: topoisomerase I-DNA complex stabilization, cellular cytoskeleton alteration, and induction of apoptosis. The activities of flavonoids have been reported to include apoptosis induction in liver tumor cells. Some authors suggest that flavonoids reduce oxidative stress cellular response which reduces mitochondrial dysfunction and cell death. In summary, Apocynaceae species appear to be promising as a source for antitumor agents; however, further studies are required to confirm their antitumor activities and to better elucidate the underlying mechanisms involved. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9241 10.33448/rsd-v9i10.9241 |
url |
https://rsdjournal.org/index.php/rsd/article/view/9241 |
identifier_str_mv |
10.33448/rsd-v9i10.9241 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9241/8357 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 10; e9149109241 Research, Society and Development; Vol. 9 Núm. 10; e9149109241 Research, Society and Development; v. 9 n. 10; e9149109241 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052741533564928 |