The influence of vitamin D on cancer: an integrative review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/11388 |
Resumo: | Theoretical framework: cancer is a group of more than one hundred diseases, of which have intrinsic and/or extrinsic factors, modifiable and non-modifiable for its onset. Vitamin D, in turn, is a steroid hormone that has its biological actions mediated by the vitamin D receptor, consequently developing roles related to the control of cell growth, differentiation and proliferation, in which, the administration of its active metabolites or analogues can result in inhibition of angiogenesis, delegating effects antiproliferative and activation of apoptotic mechanisms. Objective: Present the influence of vitamin D action on cancers that affect the gastrointestinal tract and distinct organs. Methodology: It is an integrative review, with a qualitative approach. Based on research on BVS and PubMed databases, 19 articles were selected that were consistent with the theme and the inclusion and exclusion criteria, through the association of descriptors and keywords. Results: 84.62% and 71.43% of the studies demonstrated a positive correlation of vitamin D in the anti-carcinogenesis process of cancers that affect the gastrointestinal tract and different organs, respectively. The carcinogenesis process can be influenced by vitamin D deficiency, polymorphisms in the vitamin D receptor gene and other changes and relationships with underlying pathways. Conclusion: This study highlights the positive influence of vitamin D in the prevention of carcinogenesis that affects the gastrointestinal tract and different organs. |
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The influence of vitamin D on cancer: an integrative reviewLa influencia de la vitamina D en el cáncer: una revisión integradoraA influência da vitamina D sobre o câncer: uma revisão integrativaOncologiaNeoplasiaCalcitriolPrevenção de doenças.OncologíaNeoplasmaCalcitriolPrevención de enfermedades. OncologyNeoplasmCalcitriolPrevention of diseases. Theoretical framework: cancer is a group of more than one hundred diseases, of which have intrinsic and/or extrinsic factors, modifiable and non-modifiable for its onset. Vitamin D, in turn, is a steroid hormone that has its biological actions mediated by the vitamin D receptor, consequently developing roles related to the control of cell growth, differentiation and proliferation, in which, the administration of its active metabolites or analogues can result in inhibition of angiogenesis, delegating effects antiproliferative and activation of apoptotic mechanisms. Objective: Present the influence of vitamin D action on cancers that affect the gastrointestinal tract and distinct organs. Methodology: It is an integrative review, with a qualitative approach. Based on research on BVS and PubMed databases, 19 articles were selected that were consistent with the theme and the inclusion and exclusion criteria, through the association of descriptors and keywords. Results: 84.62% and 71.43% of the studies demonstrated a positive correlation of vitamin D in the anti-carcinogenesis process of cancers that affect the gastrointestinal tract and different organs, respectively. The carcinogenesis process can be influenced by vitamin D deficiency, polymorphisms in the vitamin D receptor gene and other changes and relationships with underlying pathways. Conclusion: This study highlights the positive influence of vitamin D in the prevention of carcinogenesis that affects the gastrointestinal tract and different organs.Marco teórico: el cáncer es un grupo de más de cien enfermedades, de las cuales tienen factores intrínsecos y/o extrínsecos, modificables y no modificables para su aparición. La vitamina D, a su vez, es una hormona esteroidea que tiene sus acciones biológicas mediadas por el receptor de vitamina D, por lo que desarrolla roles relacionados con el control del crecimiento, diferenciación y proliferación celular, en los cuales, la administración de sus metabolitos activos. o análogos pueden resultar en la inhibición de la angiogénesis, permitido efectos antiproliferativos y activación de mecanismos apoptóticos. Objetivo: esclarecer la influencia de la acción de la vitamina D sobre los cánceres que afectan al tracto gastrointestinal y diferentes órganos. Metodología: esta es una revisión integradora, con enfoque cualitativo. Mediante búsquedas en las bases de datos de BVS y PubMed, 19 artículos fueran seleccionados consistentes con el tema y los criterios de inclusión y exclusión, a través de la asociación de descriptores y palabras clave. Resultados: El 84,62% y el 71,43% de los estudios expusieron una correlación positiva de la vitamina D en el proceso anticancerígeno de cánceres que afectan el tracto gastrointestinal y diferentes órganos, respectivamente. El proceso de carcinogénesis puede verse influenciado por la deficiencia de vitamina D, los polimorfismos en el gen del receptor de vitamina D y otros cambios y relaciones con las vías subyacentes. Conclusión: En este estudio se destaca la influencia positiva de la vitamina D en la prevención de la carcinogénesis que afecta el tracto gastrointestinal y diferentes órganos.Marco teórico: o câncer é um conjunto de mais de cem doenças, das quais possuem fatores intrínsecos e/ou extrínsecos, modificáveis e não modicáveis para o seu desencadeamento. A vitamina D, por sua vez, é um hormônio esteroide que possui as suas ações biológicas mediadas pelo receptor de vitamina D, desenvolvendo, consequentemente, papéis relacionados ao controle do crescimento, diferenciação e proliferação celular, em que, a administração dos seus metabólicos ativos ou análogos podem resultar na inibição da angiogênese, delegando efeitos antiproliferativos e ativação dos mecanismos apoptóticos. Objetivo: esclarecer a influência da ação da vitamina D sobre os cânceres que acometem o trato gastrointestinal e órgãos distintos. Metodologia: trata-se de uma revisão integrativa, com abordagem qualitativa. A partir de buscas nas bases de dados BVS e PubMed, foram selecionados 19 artigos congruentes à temática e aos critérios de inclusão e exclusão, através da associação de descritores e palavras-chaves. Resultados: 84,62% e 71,43% dos estudos expuseram uma correlação positiva da vitamina D no processo anti-carcinogênese dos cânceres que acometem o trato gastrointestinal e órgãos distintos, respectivamente. O processo de carcinogênese pode ser influenciado pela deficiência de vitamina D, polimorfismos no gene receptor da vitamina D e demais alterações e relações com vias subjacentes. Conclusão: Destaca-se neste estudo a influência positiva da vitamina D na prevenção da carcinogênese que acomete o trato gastrointestinal e órgãos distintos.Research, Society and Development2021-01-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1138810.33448/rsd-v10i1.11388Research, Society and Development; Vol. 10 No. 1; e9610111388Research, Society and Development; Vol. 10 Núm. 1; e9610111388Research, Society and Development; v. 10 n. 1; e96101113882525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/11388/10296Copyright (c) 2021 Mauro Celso de Souza; Marceli Pitt Coserhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza, Mauro Celso deCoser, Marceli Pitt2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11388Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:13.877666Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
The influence of vitamin D on cancer: an integrative review La influencia de la vitamina D en el cáncer: una revisión integradora A influência da vitamina D sobre o câncer: uma revisão integrativa |
title |
The influence of vitamin D on cancer: an integrative review |
spellingShingle |
The influence of vitamin D on cancer: an integrative review Souza, Mauro Celso de Oncologia Neoplasia Calcitriol Prevenção de doenças. Oncología Neoplasma Calcitriol Prevención de enfermedades. Oncology Neoplasm Calcitriol Prevention of diseases. |
title_short |
The influence of vitamin D on cancer: an integrative review |
title_full |
The influence of vitamin D on cancer: an integrative review |
title_fullStr |
The influence of vitamin D on cancer: an integrative review |
title_full_unstemmed |
The influence of vitamin D on cancer: an integrative review |
title_sort |
The influence of vitamin D on cancer: an integrative review |
author |
Souza, Mauro Celso de |
author_facet |
Souza, Mauro Celso de Coser, Marceli Pitt |
author_role |
author |
author2 |
Coser, Marceli Pitt |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Souza, Mauro Celso de Coser, Marceli Pitt |
dc.subject.por.fl_str_mv |
Oncologia Neoplasia Calcitriol Prevenção de doenças. Oncología Neoplasma Calcitriol Prevención de enfermedades. Oncology Neoplasm Calcitriol Prevention of diseases. |
topic |
Oncologia Neoplasia Calcitriol Prevenção de doenças. Oncología Neoplasma Calcitriol Prevención de enfermedades. Oncology Neoplasm Calcitriol Prevention of diseases. |
description |
Theoretical framework: cancer is a group of more than one hundred diseases, of which have intrinsic and/or extrinsic factors, modifiable and non-modifiable for its onset. Vitamin D, in turn, is a steroid hormone that has its biological actions mediated by the vitamin D receptor, consequently developing roles related to the control of cell growth, differentiation and proliferation, in which, the administration of its active metabolites or analogues can result in inhibition of angiogenesis, delegating effects antiproliferative and activation of apoptotic mechanisms. Objective: Present the influence of vitamin D action on cancers that affect the gastrointestinal tract and distinct organs. Methodology: It is an integrative review, with a qualitative approach. Based on research on BVS and PubMed databases, 19 articles were selected that were consistent with the theme and the inclusion and exclusion criteria, through the association of descriptors and keywords. Results: 84.62% and 71.43% of the studies demonstrated a positive correlation of vitamin D in the anti-carcinogenesis process of cancers that affect the gastrointestinal tract and different organs, respectively. The carcinogenesis process can be influenced by vitamin D deficiency, polymorphisms in the vitamin D receptor gene and other changes and relationships with underlying pathways. Conclusion: This study highlights the positive influence of vitamin D in the prevention of carcinogenesis that affects the gastrointestinal tract and different organs. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11388 10.33448/rsd-v10i1.11388 |
url |
https://rsdjournal.org/index.php/rsd/article/view/11388 |
identifier_str_mv |
10.33448/rsd-v10i1.11388 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11388/10296 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Mauro Celso de Souza; Marceli Pitt Coser https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Mauro Celso de Souza; Marceli Pitt Coser https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 1; e9610111388 Research, Society and Development; Vol. 10 Núm. 1; e9610111388 Research, Society and Development; v. 10 n. 1; e9610111388 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052667333181440 |