Pathophysiology of leprosy: immunological response related to clinical forms

Detalhes bibliográficos
Autor(a) principal: Yonemoto, Ana Cláudia Ferreira
Data de Publicação: 2022
Outros Autores: Choptian Júnior, Mario Ciro, Mattara, Victor Augusto de Oliveira, Abreu, Marilda Aparecida Milanez Morgado de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/32058
Resumo: The aim of this study is to elucidate the physiopathology of leprosy and relate it to its clinical forms through an narrative review. The search for articles was carried out in the LILACS, PUBMED, SCIELO, MEDLINE and VHL databases, and the following descriptors were used: Leprosy, Mycobacterium leprae, physiopathology and leprosy reaction. The search was restricted to studies published from 2013 until the year 2021, and articles related to the theme were selected. Leprosy presents a complex pathophysiology, correlated with different immune patterns, involving dendritic cells, pattern recognition receptors (PRRs), macrophages and natural killer (NK) cells, which will release interleukins that will determine the type of immune response of the host, among which we address Th1, Th2, Th17, T regulators (Treg), Th9, Th22 and others. When the cellular immune pattern is activated with a predominance of the Th1 pattern, the patient tends to progress to the benign pole (tuberculoid leprosy), if the specific cellular response is mild or absent to the antigens of the same agent, with a prevalence of the Th2 pattern and humoral response, the individual tends to the malignant pole (lepromatous leprosy) of the disease, as well as to the development of type 1 and type 2 leprosy reactions.
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spelling Pathophysiology of leprosy: immunological response related to clinical formsFisiopatología del hanseníasis: respuesta inmunológica relacionada con formas clínicasFisiopatologia da hanseníase: resposta imunológica relacionada às formas clínicasHanseníasisMycobacterium lepraeFisiopatologíaReacción de la lepra. LeprosyMycobacterium lepraePhysiopathologyLeprosy Reaction.HanseníaseMycobacterium lepraeFisiopatologiaReação Hansênica.The aim of this study is to elucidate the physiopathology of leprosy and relate it to its clinical forms through an narrative review. The search for articles was carried out in the LILACS, PUBMED, SCIELO, MEDLINE and VHL databases, and the following descriptors were used: Leprosy, Mycobacterium leprae, physiopathology and leprosy reaction. The search was restricted to studies published from 2013 until the year 2021, and articles related to the theme were selected. Leprosy presents a complex pathophysiology, correlated with different immune patterns, involving dendritic cells, pattern recognition receptors (PRRs), macrophages and natural killer (NK) cells, which will release interleukins that will determine the type of immune response of the host, among which we address Th1, Th2, Th17, T regulators (Treg), Th9, Th22 and others. When the cellular immune pattern is activated with a predominance of the Th1 pattern, the patient tends to progress to the benign pole (tuberculoid leprosy), if the specific cellular response is mild or absent to the antigens of the same agent, with a prevalence of the Th2 pattern and humoral response, the individual tends to the malignant pole (lepromatous leprosy) of the disease, as well as to the development of type 1 and type 2 leprosy reactions.El objetivo del presente estudio es dilucidar la fisiopatología de la lepra y relacionarla con sus formas clínicas por medio de una revisión narrativa. La búsqueda de artículos se se realizó en las bases de datos LILACS, PUBMED, SCIELO, MEDLINE y BVS, y se utilizaron los descriptores: Lepra, Mycobacterium leprae, fisiopatología y reacción de la lepra. La investigación se restringió a estudios publicados desde 2013 hasta el año de 2021, en que se seleccionaron artículos relacionados al tema.  La lepra presenta una fisiopatología compleja, correlacionada con diferentes patrones inmunes, involucrando células dendríticas, receptores de reconocimiento de patrones (PRRs), macrófagos y células asesinas naturales (NK), las cuales liberarán interleucinas que determinarán el tipo de respuesta inmune del huésped, entre las cuales nos dirigimos a los reguladores Th1, Th2, Th17, T (Treg), Th9, Th22 y otros. Cuando el patrón inmune celular se activa con predominio del patrón Th1, el paciente tiende a progresar al polo benigno (lepra tuberculoide), si la respuesta celular específica es leve o ausente a los antígenos del mismo agente, con predominio del Patrón Th2 y respuesta humoral, el individuo tiende al polo maligno (lepra lepromatosa) de la enfermedad, así como al desarrollo de reacciones leprosas tipo 1 y tipo 2.O objetivo do presente estudo é elucidar a fisiopatologia da hanseníase e relacioná-la com as suas formas clínicas por meio de uma revisão narrativa. A busca dos artigos foi realizada nas bases de dados LILACS, PUBMED, SCIELO, MEDLINE e BVS, e foram utilizados os descritores: hanseníase, Mycobacterium leprae, fisiopatologia e reação hansênica. A pesquisa foi restrita aos estudos publicados a partir de 2013 até o ano de 2021, e os artigos pertinentes ao tema foram selecionados. A hanseníase apresenta fisiopatologia complexa, correlacionada a diferentes padrões imunes, envolvendo células dendríticas, receptores de reconhecimento padrão (PRRs), macrófagos e células natural killers (NK), os quais liberarão interleucinas que determinarão o tipo de resposta imunológica do hospedeiro, dentre as quais abordamos Th1, Th2, Th17, T reguladores (Treg), Th9, Th22 e outras. Quando o padrão imune celular for ativado com predomínio do padrão Th1, o paciente tende a evoluir ao polo benigno (hanseníase tuberculoide), caso a resposta celular específica seja branda ou ausente aos antígenos do mesmo agente, com prevalência do padrão Th2 e resposta humoral, o indivíduo tende ao polo maligno (hanseníase virchowiana) da doença, bem como ao desenvolvimento de reações hansênicas tipo 1 e tipo 2.Research, Society and Development2022-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3205810.33448/rsd-v11i9.32058Research, Society and Development; Vol. 11 No. 9; e42211932058Research, Society and Development; Vol. 11 Núm. 9; e42211932058Research, Society and Development; v. 11 n. 9; e422119320582525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32058/27281Copyright (c) 2022 Ana Cláudia Ferreira Yonemoto; Mario Ciro Choptian Júnior; Victor Augusto de Oliveira Mattara; Marilda Aparecida Milanez Morgado de Abreuhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessYonemoto, Ana Cláudia Ferreira Choptian Júnior, Mario CiroMattara, Victor Augusto de Oliveira Abreu, Marilda Aparecida Milanez Morgado de 2022-07-21T12:36:16Zoai:ojs.pkp.sfu.ca:article/32058Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:10.845581Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Pathophysiology of leprosy: immunological response related to clinical forms
Fisiopatología del hanseníasis: respuesta inmunológica relacionada con formas clínicas
Fisiopatologia da hanseníase: resposta imunológica relacionada às formas clínicas
title Pathophysiology of leprosy: immunological response related to clinical forms
spellingShingle Pathophysiology of leprosy: immunological response related to clinical forms
Yonemoto, Ana Cláudia Ferreira
Hanseníasis
Mycobacterium leprae
Fisiopatología
Reacción de la lepra.
Leprosy
Mycobacterium leprae
Physiopathology
Leprosy Reaction.
Hanseníase
Mycobacterium leprae
Fisiopatologia
Reação Hansênica.
title_short Pathophysiology of leprosy: immunological response related to clinical forms
title_full Pathophysiology of leprosy: immunological response related to clinical forms
title_fullStr Pathophysiology of leprosy: immunological response related to clinical forms
title_full_unstemmed Pathophysiology of leprosy: immunological response related to clinical forms
title_sort Pathophysiology of leprosy: immunological response related to clinical forms
author Yonemoto, Ana Cláudia Ferreira
author_facet Yonemoto, Ana Cláudia Ferreira
Choptian Júnior, Mario Ciro
Mattara, Victor Augusto de Oliveira
Abreu, Marilda Aparecida Milanez Morgado de
author_role author
author2 Choptian Júnior, Mario Ciro
Mattara, Victor Augusto de Oliveira
Abreu, Marilda Aparecida Milanez Morgado de
author2_role author
author
author
dc.contributor.author.fl_str_mv Yonemoto, Ana Cláudia Ferreira
Choptian Júnior, Mario Ciro
Mattara, Victor Augusto de Oliveira
Abreu, Marilda Aparecida Milanez Morgado de
dc.subject.por.fl_str_mv Hanseníasis
Mycobacterium leprae
Fisiopatología
Reacción de la lepra.
Leprosy
Mycobacterium leprae
Physiopathology
Leprosy Reaction.
Hanseníase
Mycobacterium leprae
Fisiopatologia
Reação Hansênica.
topic Hanseníasis
Mycobacterium leprae
Fisiopatología
Reacción de la lepra.
Leprosy
Mycobacterium leprae
Physiopathology
Leprosy Reaction.
Hanseníase
Mycobacterium leprae
Fisiopatologia
Reação Hansênica.
description The aim of this study is to elucidate the physiopathology of leprosy and relate it to its clinical forms through an narrative review. The search for articles was carried out in the LILACS, PUBMED, SCIELO, MEDLINE and VHL databases, and the following descriptors were used: Leprosy, Mycobacterium leprae, physiopathology and leprosy reaction. The search was restricted to studies published from 2013 until the year 2021, and articles related to the theme were selected. Leprosy presents a complex pathophysiology, correlated with different immune patterns, involving dendritic cells, pattern recognition receptors (PRRs), macrophages and natural killer (NK) cells, which will release interleukins that will determine the type of immune response of the host, among which we address Th1, Th2, Th17, T regulators (Treg), Th9, Th22 and others. When the cellular immune pattern is activated with a predominance of the Th1 pattern, the patient tends to progress to the benign pole (tuberculoid leprosy), if the specific cellular response is mild or absent to the antigens of the same agent, with a prevalence of the Th2 pattern and humoral response, the individual tends to the malignant pole (lepromatous leprosy) of the disease, as well as to the development of type 1 and type 2 leprosy reactions.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-14
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info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/32058
10.33448/rsd-v11i9.32058
url https://rsdjournal.org/index.php/rsd/article/view/32058
identifier_str_mv 10.33448/rsd-v11i9.32058
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/32058/27281
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 9; e42211932058
Research, Society and Development; Vol. 11 Núm. 9; e42211932058
Research, Society and Development; v. 11 n. 9; e42211932058
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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