Pathophysiology of leprosy: immunological response related to clinical forms
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/32058 |
Resumo: | The aim of this study is to elucidate the physiopathology of leprosy and relate it to its clinical forms through an narrative review. The search for articles was carried out in the LILACS, PUBMED, SCIELO, MEDLINE and VHL databases, and the following descriptors were used: Leprosy, Mycobacterium leprae, physiopathology and leprosy reaction. The search was restricted to studies published from 2013 until the year 2021, and articles related to the theme were selected. Leprosy presents a complex pathophysiology, correlated with different immune patterns, involving dendritic cells, pattern recognition receptors (PRRs), macrophages and natural killer (NK) cells, which will release interleukins that will determine the type of immune response of the host, among which we address Th1, Th2, Th17, T regulators (Treg), Th9, Th22 and others. When the cellular immune pattern is activated with a predominance of the Th1 pattern, the patient tends to progress to the benign pole (tuberculoid leprosy), if the specific cellular response is mild or absent to the antigens of the same agent, with a prevalence of the Th2 pattern and humoral response, the individual tends to the malignant pole (lepromatous leprosy) of the disease, as well as to the development of type 1 and type 2 leprosy reactions. |
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Pathophysiology of leprosy: immunological response related to clinical formsFisiopatología del hanseníasis: respuesta inmunológica relacionada con formas clínicasFisiopatologia da hanseníase: resposta imunológica relacionada às formas clínicasHanseníasisMycobacterium lepraeFisiopatologíaReacción de la lepra. LeprosyMycobacterium lepraePhysiopathologyLeprosy Reaction.HanseníaseMycobacterium lepraeFisiopatologiaReação Hansênica.The aim of this study is to elucidate the physiopathology of leprosy and relate it to its clinical forms through an narrative review. The search for articles was carried out in the LILACS, PUBMED, SCIELO, MEDLINE and VHL databases, and the following descriptors were used: Leprosy, Mycobacterium leprae, physiopathology and leprosy reaction. The search was restricted to studies published from 2013 until the year 2021, and articles related to the theme were selected. Leprosy presents a complex pathophysiology, correlated with different immune patterns, involving dendritic cells, pattern recognition receptors (PRRs), macrophages and natural killer (NK) cells, which will release interleukins that will determine the type of immune response of the host, among which we address Th1, Th2, Th17, T regulators (Treg), Th9, Th22 and others. When the cellular immune pattern is activated with a predominance of the Th1 pattern, the patient tends to progress to the benign pole (tuberculoid leprosy), if the specific cellular response is mild or absent to the antigens of the same agent, with a prevalence of the Th2 pattern and humoral response, the individual tends to the malignant pole (lepromatous leprosy) of the disease, as well as to the development of type 1 and type 2 leprosy reactions.El objetivo del presente estudio es dilucidar la fisiopatología de la lepra y relacionarla con sus formas clínicas por medio de una revisión narrativa. La búsqueda de artículos se se realizó en las bases de datos LILACS, PUBMED, SCIELO, MEDLINE y BVS, y se utilizaron los descriptores: Lepra, Mycobacterium leprae, fisiopatología y reacción de la lepra. La investigación se restringió a estudios publicados desde 2013 hasta el año de 2021, en que se seleccionaron artículos relacionados al tema. La lepra presenta una fisiopatología compleja, correlacionada con diferentes patrones inmunes, involucrando células dendríticas, receptores de reconocimiento de patrones (PRRs), macrófagos y células asesinas naturales (NK), las cuales liberarán interleucinas que determinarán el tipo de respuesta inmune del huésped, entre las cuales nos dirigimos a los reguladores Th1, Th2, Th17, T (Treg), Th9, Th22 y otros. Cuando el patrón inmune celular se activa con predominio del patrón Th1, el paciente tiende a progresar al polo benigno (lepra tuberculoide), si la respuesta celular específica es leve o ausente a los antígenos del mismo agente, con predominio del Patrón Th2 y respuesta humoral, el individuo tiende al polo maligno (lepra lepromatosa) de la enfermedad, así como al desarrollo de reacciones leprosas tipo 1 y tipo 2.O objetivo do presente estudo é elucidar a fisiopatologia da hanseníase e relacioná-la com as suas formas clínicas por meio de uma revisão narrativa. A busca dos artigos foi realizada nas bases de dados LILACS, PUBMED, SCIELO, MEDLINE e BVS, e foram utilizados os descritores: hanseníase, Mycobacterium leprae, fisiopatologia e reação hansênica. A pesquisa foi restrita aos estudos publicados a partir de 2013 até o ano de 2021, e os artigos pertinentes ao tema foram selecionados. A hanseníase apresenta fisiopatologia complexa, correlacionada a diferentes padrões imunes, envolvendo células dendríticas, receptores de reconhecimento padrão (PRRs), macrófagos e células natural killers (NK), os quais liberarão interleucinas que determinarão o tipo de resposta imunológica do hospedeiro, dentre as quais abordamos Th1, Th2, Th17, T reguladores (Treg), Th9, Th22 e outras. Quando o padrão imune celular for ativado com predomínio do padrão Th1, o paciente tende a evoluir ao polo benigno (hanseníase tuberculoide), caso a resposta celular específica seja branda ou ausente aos antígenos do mesmo agente, com prevalência do padrão Th2 e resposta humoral, o indivíduo tende ao polo maligno (hanseníase virchowiana) da doença, bem como ao desenvolvimento de reações hansênicas tipo 1 e tipo 2.Research, Society and Development2022-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3205810.33448/rsd-v11i9.32058Research, Society and Development; Vol. 11 No. 9; e42211932058Research, Society and Development; Vol. 11 Núm. 9; e42211932058Research, Society and Development; v. 11 n. 9; e422119320582525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32058/27281Copyright (c) 2022 Ana Cláudia Ferreira Yonemoto; Mario Ciro Choptian Júnior; Victor Augusto de Oliveira Mattara; Marilda Aparecida Milanez Morgado de Abreuhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessYonemoto, Ana Cláudia Ferreira Choptian Júnior, Mario CiroMattara, Victor Augusto de Oliveira Abreu, Marilda Aparecida Milanez Morgado de 2022-07-21T12:36:16Zoai:ojs.pkp.sfu.ca:article/32058Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:10.845581Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Pathophysiology of leprosy: immunological response related to clinical forms Fisiopatología del hanseníasis: respuesta inmunológica relacionada con formas clínicas Fisiopatologia da hanseníase: resposta imunológica relacionada às formas clínicas |
title |
Pathophysiology of leprosy: immunological response related to clinical forms |
spellingShingle |
Pathophysiology of leprosy: immunological response related to clinical forms Yonemoto, Ana Cláudia Ferreira Hanseníasis Mycobacterium leprae Fisiopatología Reacción de la lepra. Leprosy Mycobacterium leprae Physiopathology Leprosy Reaction. Hanseníase Mycobacterium leprae Fisiopatologia Reação Hansênica. |
title_short |
Pathophysiology of leprosy: immunological response related to clinical forms |
title_full |
Pathophysiology of leprosy: immunological response related to clinical forms |
title_fullStr |
Pathophysiology of leprosy: immunological response related to clinical forms |
title_full_unstemmed |
Pathophysiology of leprosy: immunological response related to clinical forms |
title_sort |
Pathophysiology of leprosy: immunological response related to clinical forms |
author |
Yonemoto, Ana Cláudia Ferreira |
author_facet |
Yonemoto, Ana Cláudia Ferreira Choptian Júnior, Mario Ciro Mattara, Victor Augusto de Oliveira Abreu, Marilda Aparecida Milanez Morgado de |
author_role |
author |
author2 |
Choptian Júnior, Mario Ciro Mattara, Victor Augusto de Oliveira Abreu, Marilda Aparecida Milanez Morgado de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Yonemoto, Ana Cláudia Ferreira Choptian Júnior, Mario Ciro Mattara, Victor Augusto de Oliveira Abreu, Marilda Aparecida Milanez Morgado de |
dc.subject.por.fl_str_mv |
Hanseníasis Mycobacterium leprae Fisiopatología Reacción de la lepra. Leprosy Mycobacterium leprae Physiopathology Leprosy Reaction. Hanseníase Mycobacterium leprae Fisiopatologia Reação Hansênica. |
topic |
Hanseníasis Mycobacterium leprae Fisiopatología Reacción de la lepra. Leprosy Mycobacterium leprae Physiopathology Leprosy Reaction. Hanseníase Mycobacterium leprae Fisiopatologia Reação Hansênica. |
description |
The aim of this study is to elucidate the physiopathology of leprosy and relate it to its clinical forms through an narrative review. The search for articles was carried out in the LILACS, PUBMED, SCIELO, MEDLINE and VHL databases, and the following descriptors were used: Leprosy, Mycobacterium leprae, physiopathology and leprosy reaction. The search was restricted to studies published from 2013 until the year 2021, and articles related to the theme were selected. Leprosy presents a complex pathophysiology, correlated with different immune patterns, involving dendritic cells, pattern recognition receptors (PRRs), macrophages and natural killer (NK) cells, which will release interleukins that will determine the type of immune response of the host, among which we address Th1, Th2, Th17, T regulators (Treg), Th9, Th22 and others. When the cellular immune pattern is activated with a predominance of the Th1 pattern, the patient tends to progress to the benign pole (tuberculoid leprosy), if the specific cellular response is mild or absent to the antigens of the same agent, with a prevalence of the Th2 pattern and humoral response, the individual tends to the malignant pole (lepromatous leprosy) of the disease, as well as to the development of type 1 and type 2 leprosy reactions. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32058 10.33448/rsd-v11i9.32058 |
url |
https://rsdjournal.org/index.php/rsd/article/view/32058 |
identifier_str_mv |
10.33448/rsd-v11i9.32058 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32058/27281 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 9; e42211932058 Research, Society and Development; Vol. 11 Núm. 9; e42211932058 Research, Society and Development; v. 11 n. 9; e42211932058 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052768754597888 |