Neuroprogression and depression: a literature review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/6740 |
Resumo: | This review aims to show evidence of possible neuroprotective agents, and to identify new avenues for possible intervention, in search of neuroprotection in patients affected by depression. It is a narrative review that used PubMed, Lilacs, Scielo, Cochrane and Latindex as a database, in the period between 2015 to 2020, resulting in 1009 articles and 19 different articles using selection criteria. Neuropsychiatric disorders, including depression, often exhibit a neuroprogressive course from the prodrome to chronicity. There are a variety of agents exhibiting the ability to attenuate biological mechanisms associated with neuroprogression. Signs of evidence of clinical neuroprotection are evident when evaluating studies by different authors. The adjuvant use of multiple drug agents may present a viable path for the clinical realization of neuroprotection. Definitive prospective studies on neuroprotection with multimodal assessment are needed. |
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Neuroprogression and depression: a literature reviewNeuroprogresión y depresión: revisión de la literaturaNeuroprogressão e depressão: uma revisão de literaturaTrastorno depresivoNeuropsiquiatríaPsiquiatría biológicaEnfermedades neurodegenerativas.Depressive disorderNeuropsychiatryBiological psychiatryNeurodegenerative diseases.Transtorno depressivoNeuropsiquiatriaPsiquiatria biológicaDoenças neurodegenerativas.This review aims to show evidence of possible neuroprotective agents, and to identify new avenues for possible intervention, in search of neuroprotection in patients affected by depression. It is a narrative review that used PubMed, Lilacs, Scielo, Cochrane and Latindex as a database, in the period between 2015 to 2020, resulting in 1009 articles and 19 different articles using selection criteria. Neuropsychiatric disorders, including depression, often exhibit a neuroprogressive course from the prodrome to chronicity. There are a variety of agents exhibiting the ability to attenuate biological mechanisms associated with neuroprogression. Signs of evidence of clinical neuroprotection are evident when evaluating studies by different authors. The adjuvant use of multiple drug agents may present a viable path for the clinical realization of neuroprotection. Definitive prospective studies on neuroprotection with multimodal assessment are needed.Esta revisión tiene como objetivo mostrar evidencia de posibles agentes neuroprotectores e identificar nuevas vías para una posible intervención, en busca de neuroprotección en pacientes afectados por depresión. Se trata de una revisión narrativa que utilizó PubMed, Lilacs, Scielo, Cochrane y Latindex como base de datos, en el período de 2015 a 2020, dando como resultado 1009 artículos y utilizando 19 artículos diferentes según criterios de selección. Los trastornos neuropsiquiátricos, incluida la depresión, a menudo presentan un curso neuroprogresivo desde el pródromo hasta la cronicidad. Existe una variedad de agentes que exhiben la capacidad de atenuar los mecanismos biológicos asociados con la neuroprogresión. Los signos de evidencia de neuroprotección clínica son evidentes al evaluar estudios de diferentes autores. El uso adyuvante de múltiples fármacos puede presentar una vía viable para la realización clínica de la neuroprotección. Se necesitan estudios prospectivos definitivos sobre neuroprotección con evaluación multimodal.Esta revisão tem por objetivo mostrar evidências de possíveis agentes neuroprotetores, e identificar novas vias de possível intervenção, em busca da neuroproteção nos pacientes acometidos por depressão. Trata-se de uma revisão narrativa que utilizou a PubMed, Lilacs, Scielo, Cochrane e Latindex como base de dados, no período entre 2015 a 2020, resultando em 1009 artigos e utilizados 19 artigos distintos seguindo critérios de seleção. Transtornos neuropsiquiátricos, incluindo depressão, frequentemente exibem um curso neuroprogressivo do pródromo à cronicidade. Há uma variedade de agentes exibindo capacidade de atenuar mecanismos biológicos associados à neuroprogressão. Sinais de evidência de neuroproteção clínica são evidentes quando avaliados os estudos de diferentes autores. O uso adjuvante de múltiplos agentes medicamentosos pode apresentar um caminho viável para a realização clínica de neuroproteção. Estudos prospectivos definitivos a respeito da neuroproteção com avaliação multimodal são necessários.Research, Society and Development2020-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/674010.33448/rsd-v9i9.6740Research, Society and Development; Vol. 9 No. 9; e191996740Research, Society and Development; Vol. 9 Núm. 9; e191996740Research, Society and Development; v. 9 n. 9; e1919967402525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/6740/6323Copyright (c) 2020 Matheus Gonçalves Chaves Mello, José Carlos Rosa Pires Souza, José Carlos Rosa Pires Souza, Vinicius Oliveira Andrade, Vinicius Oliveira Andradehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAndrade, Vinicius Oliveira deMello, Matheus Gonçalves ChavesSouza, José Carlos 2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/6740Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:29:45.110476Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Neuroprogression and depression: a literature review Neuroprogresión y depresión: revisión de la literatura Neuroprogressão e depressão: uma revisão de literatura |
title |
Neuroprogression and depression: a literature review |
spellingShingle |
Neuroprogression and depression: a literature review Andrade, Vinicius Oliveira de Trastorno depresivo Neuropsiquiatría Psiquiatría biológica Enfermedades neurodegenerativas. Depressive disorder Neuropsychiatry Biological psychiatry Neurodegenerative diseases. Transtorno depressivo Neuropsiquiatria Psiquiatria biológica Doenças neurodegenerativas. |
title_short |
Neuroprogression and depression: a literature review |
title_full |
Neuroprogression and depression: a literature review |
title_fullStr |
Neuroprogression and depression: a literature review |
title_full_unstemmed |
Neuroprogression and depression: a literature review |
title_sort |
Neuroprogression and depression: a literature review |
author |
Andrade, Vinicius Oliveira de |
author_facet |
Andrade, Vinicius Oliveira de Mello, Matheus Gonçalves Chaves Souza, José Carlos |
author_role |
author |
author2 |
Mello, Matheus Gonçalves Chaves Souza, José Carlos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Andrade, Vinicius Oliveira de Mello, Matheus Gonçalves Chaves Souza, José Carlos |
dc.subject.por.fl_str_mv |
Trastorno depresivo Neuropsiquiatría Psiquiatría biológica Enfermedades neurodegenerativas. Depressive disorder Neuropsychiatry Biological psychiatry Neurodegenerative diseases. Transtorno depressivo Neuropsiquiatria Psiquiatria biológica Doenças neurodegenerativas. |
topic |
Trastorno depresivo Neuropsiquiatría Psiquiatría biológica Enfermedades neurodegenerativas. Depressive disorder Neuropsychiatry Biological psychiatry Neurodegenerative diseases. Transtorno depressivo Neuropsiquiatria Psiquiatria biológica Doenças neurodegenerativas. |
description |
This review aims to show evidence of possible neuroprotective agents, and to identify new avenues for possible intervention, in search of neuroprotection in patients affected by depression. It is a narrative review that used PubMed, Lilacs, Scielo, Cochrane and Latindex as a database, in the period between 2015 to 2020, resulting in 1009 articles and 19 different articles using selection criteria. Neuropsychiatric disorders, including depression, often exhibit a neuroprogressive course from the prodrome to chronicity. There are a variety of agents exhibiting the ability to attenuate biological mechanisms associated with neuroprogression. Signs of evidence of clinical neuroprotection are evident when evaluating studies by different authors. The adjuvant use of multiple drug agents may present a viable path for the clinical realization of neuroprotection. Definitive prospective studies on neuroprotection with multimodal assessment are needed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/6740 10.33448/rsd-v9i9.6740 |
url |
https://rsdjournal.org/index.php/rsd/article/view/6740 |
identifier_str_mv |
10.33448/rsd-v9i9.6740 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/6740/6323 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 9; e191996740 Research, Society and Development; Vol. 9 Núm. 9; e191996740 Research, Society and Development; v. 9 n. 9; e191996740 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052803183542272 |