Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells

Detalhes bibliográficos
Autor(a) principal: Fernandes, Luciana Cristina Borges
Data de Publicação: 2021
Outros Autores: Gomes Junior , Salvador Viana, Costa, Ianara Mendonça da, Idalina Neta, Francisca, Oliveira, Rodrigo Freire, Oliveira, Lucídio Clebeson de, Azevedo, Eduardo Pereira de, Oliveira, Francisco Fábio Mesquita, Albuquerque, Cynthia Cavalcanti de, Silva, Francisco Felipe Maia da, Batista, Jael Soares, Cavalcanti, José Rodolfo Lopes de Paiva, Freitas, Carlos Iberê Alves, Guzen, Fausto Pierdoná
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14591
Resumo: Spinal cord injury is a devastating condition that leads to significant disabilities. The treatment for this problem is a challenge in neuroscience, and it is necessary to combine different strategies to obtain functional recovery outcomes. There are many herbal natural products, such as Croton blanchetianus Baill (CB) essential oil, a Brazilian semi-arid bush with neuroprotective substances tested in regeneration processes and synaptic plasticity. Thus, this study analyzed the cellular plasticity of spinal cord neurons and glial cells in the presence of sciatic nerve-conditioned medium (SNCM) before the addition of CB essential oil. Cell morphology was assessed over 96 hours, and immunocytochemistry analyses were conducted for GFAP, GAP-43 and NeuN. Photomicrographs were made by scanning electron microscopy (SEM). Morphological analysis showed evident trophic development in the groups that received CB essential oil (P>0.000), immunoreactivity for GFAP, GAP-43 and NeuN and the plasticity of these cells were confirmed by SEM. This pioneer study about the plasticity of spinal cord neurons and glial cells opens new possibilities and techniques with essential oils for cell therapy in the presence of SNCM, which promoted neuroprotective action.
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spelling Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cellsEl medio acondicionado del el nervio ciático con la adición de aceite esencial de Croton blanchetianus Baill promueve la plasticidad morfológica en las células cultivadas de la médula espinal Meio condicionado de nervo ciático com a adição de óleo essencial de Croton blanchetianus Baill promove plasticidade morfológica em cultura de células de medula espinalEssential oilSciatic nerveTrophismNeuroprotection.Aceite essencialNervio ciáticoTrofismoNeuroprotección.Óleo essencialNervo ciáticoTrofismoNeuroproteção.Spinal cord injury is a devastating condition that leads to significant disabilities. The treatment for this problem is a challenge in neuroscience, and it is necessary to combine different strategies to obtain functional recovery outcomes. There are many herbal natural products, such as Croton blanchetianus Baill (CB) essential oil, a Brazilian semi-arid bush with neuroprotective substances tested in regeneration processes and synaptic plasticity. Thus, this study analyzed the cellular plasticity of spinal cord neurons and glial cells in the presence of sciatic nerve-conditioned medium (SNCM) before the addition of CB essential oil. Cell morphology was assessed over 96 hours, and immunocytochemistry analyses were conducted for GFAP, GAP-43 and NeuN. Photomicrographs were made by scanning electron microscopy (SEM). Morphological analysis showed evident trophic development in the groups that received CB essential oil (P>0.000), immunoreactivity for GFAP, GAP-43 and NeuN and the plasticity of these cells were confirmed by SEM. This pioneer study about the plasticity of spinal cord neurons and glial cells opens new possibilities and techniques with essential oils for cell therapy in the presence of SNCM, which promoted neuroprotective action.La lesión de la médula espinal es una condición devastadora que conduce a discapacidades importantes. El tratamiento de este problema es un desafío para la neurociencia, y es necesario combinar diferentes estrategias para obtener resultados de recuperación funcional. Hay muchos productos herbales naturales, como el aceite esencial de Croton blanchetianus Baill (CB), un arbusto del semiárido brasileño con sustancias neuroprotectoras probadas en procesos de regeneración y plasticidad sináptica. Por lo tanto, este estudio analizó la plasticidad celular de las neuronas de la médula espinal y las células gliales en presencia de medio del nervio ciático acondicionado (SNCM) antes de la adición del aceite esencial CB. Se evaluó la morfología celular durante 96 horas y se realizaron análisis de inmunocitoquímica para GFAP, GAP-43 y NeuN. Las fotomicrografías se realizaron mediante microscopía electrónica de barrido (SEM). El análisis morfológico mostró un evidente desarrollo trófico en los grupos que recibieron aceite esencial CB (P> 0,000), inmunorreactividad para GFAP, GAP-43 y NeuN y la plasticidad de estas células fue confirmada por SEM. Este estudio pionero sobre la plasticidad de las neuronas en la médula espinal y las células gliales abre nuevas posibilidades y técnicas con aceites esenciales para terapia celular en presencia de SNCM, que promovió la acción neuroprotectora.A lesão da medula espinhal é uma condição devastadora que leva a deficiências significativas. O tratamento desse problema é um desafio da neurociência, sendo necessário combinar diferentes estratégias para obter resultados de recuperação funcional. Muitos são os produtos naturais à base de plantas, como o óleo essencial de Croton blanchetianus Baill (CB), um arbusto do semiárido brasileiro com substâncias neuroprotetoras testadas em processos de regeneração e plasticidade sináptica. Assim, este estudo analisou a plasticidade celular dos neurônios da medula espinhal e células da glia na presença de meio condicionado de nervo ciático (SNCM) antes da adição do óleo essencial de CB. A morfologia celular foi avaliada ao longo de 96 horas e as análises de imunocitoquímica foram conduzidas para GFAP, GAP-43 e NeuN. As fotomicrografias foram feitas por microscopia eletrônica de varredura (SEM). A análise morfológica mostrou evidente desenvolvimento trófico nos grupos que receberam óleo essencial de CB (P> 0,000), imunorreatividade para GFAP, GAP-43 e NeuN e a plasticidade dessas células foi confirmada por SEM. Esse estudo pioneiro sobre a plasticidade dos neurônios da medula espinhal e das células gliais abre novas possibilidades e técnicas com óleos essenciais para terapia celular na presença de SNCM, que promoveu ação neuroprotetora.Research, Society and Development2021-04-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1459110.33448/rsd-v10i5.14591Research, Society and Development; Vol. 10 No. 5; e5410514591Research, Society and Development; Vol. 10 Núm. 5; e5410514591Research, Society and Development; v. 10 n. 5; e54105145912525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/14591/13124Copyright (c) 2021 Luciana Cristina Borges Fernandes; Salvador Viana Gomes Junior ; Ianara Mendonça da Costa; Francisca Idalina Neta; Rodrigo Freire Oliveira; Lucídio Clebeson de Oliveira; Eduardo Pereira de Azevedo; Francisco Fábio Mesquita Oliveira; Cynthia Cavalcanti de Albuquerque; Francisco Felipe Maia da Silva; Jael Soares Batista; José Rodolfo Lopes de Paiva Cavalcanti; Carlos Iberê Alves Freitas; Fausto Pierdoná Guzenhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFernandes, Luciana Cristina Borges Gomes Junior , Salvador Viana Costa, Ianara Mendonça daIdalina Neta, FranciscaOliveira, Rodrigo FreireOliveira, Lucídio Clebeson deAzevedo, Eduardo Pereira deOliveira, Francisco Fábio MesquitaAlbuquerque, Cynthia Cavalcanti deSilva, Francisco Felipe Maia daBatista, Jael SoaresCavalcanti, José Rodolfo Lopes de PaivaFreitas, Carlos Iberê AlvesGuzen, Fausto Pierdoná2021-05-17T18:20:49Zoai:ojs.pkp.sfu.ca:article/14591Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:40.379669Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
El medio acondicionado del el nervio ciático con la adición de aceite esencial de Croton blanchetianus Baill promueve la plasticidad morfológica en las células cultivadas de la médula espinal
Meio condicionado de nervo ciático com a adição de óleo essencial de Croton blanchetianus Baill promove plasticidade morfológica em cultura de células de medula espinal
title Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
spellingShingle Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
Fernandes, Luciana Cristina Borges
Essential oil
Sciatic nerve
Trophism
Neuroprotection.
Aceite essencial
Nervio ciático
Trofismo
Neuroprotección.
Óleo essencial
Nervo ciático
Trofismo
Neuroproteção.
title_short Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
title_full Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
title_fullStr Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
title_full_unstemmed Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
title_sort Sciatic nerve-conditioned medium with the addition of Croton blanchetianus Baill essential oil promotes morphological plasticity in spinal cord cultured cells
author Fernandes, Luciana Cristina Borges
author_facet Fernandes, Luciana Cristina Borges
Gomes Junior , Salvador Viana
Costa, Ianara Mendonça da
Idalina Neta, Francisca
Oliveira, Rodrigo Freire
Oliveira, Lucídio Clebeson de
Azevedo, Eduardo Pereira de
Oliveira, Francisco Fábio Mesquita
Albuquerque, Cynthia Cavalcanti de
Silva, Francisco Felipe Maia da
Batista, Jael Soares
Cavalcanti, José Rodolfo Lopes de Paiva
Freitas, Carlos Iberê Alves
Guzen, Fausto Pierdoná
author_role author
author2 Gomes Junior , Salvador Viana
Costa, Ianara Mendonça da
Idalina Neta, Francisca
Oliveira, Rodrigo Freire
Oliveira, Lucídio Clebeson de
Azevedo, Eduardo Pereira de
Oliveira, Francisco Fábio Mesquita
Albuquerque, Cynthia Cavalcanti de
Silva, Francisco Felipe Maia da
Batista, Jael Soares
Cavalcanti, José Rodolfo Lopes de Paiva
Freitas, Carlos Iberê Alves
Guzen, Fausto Pierdoná
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Luciana Cristina Borges
Gomes Junior , Salvador Viana
Costa, Ianara Mendonça da
Idalina Neta, Francisca
Oliveira, Rodrigo Freire
Oliveira, Lucídio Clebeson de
Azevedo, Eduardo Pereira de
Oliveira, Francisco Fábio Mesquita
Albuquerque, Cynthia Cavalcanti de
Silva, Francisco Felipe Maia da
Batista, Jael Soares
Cavalcanti, José Rodolfo Lopes de Paiva
Freitas, Carlos Iberê Alves
Guzen, Fausto Pierdoná
dc.subject.por.fl_str_mv Essential oil
Sciatic nerve
Trophism
Neuroprotection.
Aceite essencial
Nervio ciático
Trofismo
Neuroprotección.
Óleo essencial
Nervo ciático
Trofismo
Neuroproteção.
topic Essential oil
Sciatic nerve
Trophism
Neuroprotection.
Aceite essencial
Nervio ciático
Trofismo
Neuroprotección.
Óleo essencial
Nervo ciático
Trofismo
Neuroproteção.
description Spinal cord injury is a devastating condition that leads to significant disabilities. The treatment for this problem is a challenge in neuroscience, and it is necessary to combine different strategies to obtain functional recovery outcomes. There are many herbal natural products, such as Croton blanchetianus Baill (CB) essential oil, a Brazilian semi-arid bush with neuroprotective substances tested in regeneration processes and synaptic plasticity. Thus, this study analyzed the cellular plasticity of spinal cord neurons and glial cells in the presence of sciatic nerve-conditioned medium (SNCM) before the addition of CB essential oil. Cell morphology was assessed over 96 hours, and immunocytochemistry analyses were conducted for GFAP, GAP-43 and NeuN. Photomicrographs were made by scanning electron microscopy (SEM). Morphological analysis showed evident trophic development in the groups that received CB essential oil (P>0.000), immunoreactivity for GFAP, GAP-43 and NeuN and the plasticity of these cells were confirmed by SEM. This pioneer study about the plasticity of spinal cord neurons and glial cells opens new possibilities and techniques with essential oils for cell therapy in the presence of SNCM, which promoted neuroprotective action.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14591
10.33448/rsd-v10i5.14591
url https://rsdjournal.org/index.php/rsd/article/view/14591
identifier_str_mv 10.33448/rsd-v10i5.14591
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14591/13124
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 5; e5410514591
Research, Society and Development; Vol. 10 Núm. 5; e5410514591
Research, Society and Development; v. 10 n. 5; e5410514591
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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