Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18516 |
Resumo: | Introduction: The Acquired Immunodeficiency Syndrome (AIDS), an infectious disease, where the main characteristic is the suppression of immunity by T CD4 lymphocytes. Objective: To analyze the percentage of myocytes and collagen fiber density from autopsied fragments of skeletal striated musculature from elderly and non-elderly patients with and without AIDS. Methodology: Retrospective, observational, analytical and quantitative study carried out from 78 divided into four groups, elderly and non-elderly with and without AIDS, aged between 44 and 63 years. Results: For histomorphometric analysis of the percentage of myocytes using Hematoxylin and eosin methods and for collagen fibers and Picrosirius under polarized light, both were performed under ordinary light microscopy. Results: There was a statistically defined decrease in nuclei in the non-elderly groups with and without AIDS and elderly with AIDS compared to the elderly groups without AIDS (p˂0,001). Collagen fibers in the non-elderly and non-deaf AIDS groups were higher when compared to the elderly groups with and without AIDS (p=0,001). The correlation between nucleus and cytoplasm was negative and low in the four groups (p <0,0001), between collagen fibers and nucleus, non-elderly people without AIDS (p<0,0012) and non-elderly people with AIDS (p<0,0368) was negative and decreased, between cytoplasm and collagen fibers the non-elderly group with AIDS (p<0,0353) and non-elderly without AIDS (p<0,0012) was negative and decreased. Conclusion: Aging and AIDS influence the loss of muscle mass and contribute to the reduction of collagen fibers. |
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Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDSAnálisis histomorfométrico del músculo pectoral mayor de pacientes ancianos y no ancianos sometidos a autopsia con y sin SIDAAnálise histomorfométrica do músculo peitoral maior de idosos e não idosos autopsiados com e sem AIDSCélulas muscularesAncianosSíndrome de inmunodeficiencia adquirida.Muscle cellsElderlyAcquired immunodeficiency syndrome.Células muscularesIdososSíndrome da imunodeficiência adquirida.Introduction: The Acquired Immunodeficiency Syndrome (AIDS), an infectious disease, where the main characteristic is the suppression of immunity by T CD4 lymphocytes. Objective: To analyze the percentage of myocytes and collagen fiber density from autopsied fragments of skeletal striated musculature from elderly and non-elderly patients with and without AIDS. Methodology: Retrospective, observational, analytical and quantitative study carried out from 78 divided into four groups, elderly and non-elderly with and without AIDS, aged between 44 and 63 years. Results: For histomorphometric analysis of the percentage of myocytes using Hematoxylin and eosin methods and for collagen fibers and Picrosirius under polarized light, both were performed under ordinary light microscopy. Results: There was a statistically defined decrease in nuclei in the non-elderly groups with and without AIDS and elderly with AIDS compared to the elderly groups without AIDS (p˂0,001). Collagen fibers in the non-elderly and non-deaf AIDS groups were higher when compared to the elderly groups with and without AIDS (p=0,001). The correlation between nucleus and cytoplasm was negative and low in the four groups (p <0,0001), between collagen fibers and nucleus, non-elderly people without AIDS (p<0,0012) and non-elderly people with AIDS (p<0,0368) was negative and decreased, between cytoplasm and collagen fibers the non-elderly group with AIDS (p<0,0353) and non-elderly without AIDS (p<0,0012) was negative and decreased. Conclusion: Aging and AIDS influence the loss of muscle mass and contribute to the reduction of collagen fibers.Introducción: El Síndrome de Inmunodeficiencia Adquirida (SIDA), una enfermedad infecciosa, cuya característica principal es la supresión de la inmunidad por parte de los linfocitos T CD4. Objetivo: Analizar el porcentaje de miocitos y densidad de fibra de colágeno de fragmentos autopsiados de musculatura estriada esquelética de pacientes ancianos y no ancianos con y sin SIDA. Metodología: Estudio retrospectivo, observacional, analítico y cuantitativo realizado a 78 divididos en cuatro grupos, ancianos y no ancianos con y sin sida, con edades comprendidas entre 44 y 63 años. Resultados: Para el análisis histomorfométrico del porcentaje de miocitos mediante métodos de hematoxilina y eosina y para fibras de colágeno y Picrosirius bajo luz polarizada, ambos se realizaron bajo microscopía óptica ordinaria. Resultados: Hubo una disminución estadísticamente definida en los núcleos en los grupos de no ancianos con y sin SIDA y ancianos con SIDA en comparación con los grupos de ancianos sin SIDA (p˂0,001). Las fibras de colágeno en los grupos de SIDA no ancianos y no sordos fueron más altas en comparación con los grupos de ancianos con y sin SIDA (p=0,001). La correlación entre núcleo y citoplasma fue negativa y baja en los cuatro grupos (p<0,0001), entre fibras de colágeno y núcleo, personas no ancianas sin SIDA (p<0,0012) y personas no ancianas con SIDA (p<0,0368) fue negativo y disminuido, entre el citoplasma y las fibras de colágeno el grupo de no ancianos con SIDA (p<0,0353) y no ancianos sin SIDA (p<0,0012) fue negativo y disminuyó. Conclusión: Inferimos que el envejecimiento y el SIDA influyen en la pérdida de masa muscular y contribuyen a la reducción de las fibras de colágeno.Introdução: A Síndrome da Imunodeficiência Adquirida (AIDS), uma doença infectocontagiosa, onde a principal característica é a supressão da imunidade pelos Linfócitos T CD4. Objetivo: Analisar a porcentagem dos miócitos e a densidade das fibras colágenas de fragmentos autopsiados da musculatura estriada esquelética de pacientes idosos e não idosos com e sem AIDS. Metodologia: Estudo, retrospectivo, observacional, analítico e quantitativo realizado a partir de 78 amostras divididas em quatro grupos, idosos e não idosos com e sem AIDS, com idade entre 44 e 63 anos. Resultados: Para as análises histomorfométricas da porcentagem dos miócitos utilizamos métodos de Hematoxilina e eosina e para as fibras colágenas o Picrosirius sob luz polarizada, ambos foram realizados em microscopia de luz comum. Resultados: Houve uma diminuição estatisticamente significativa de núcleos nos grupos não idosos com e sem AIDS e idosos com AIDS em comparação aos grupos idosos sem AIDS (p˂0,001). As fibras colágenas nos grupos não idosos com e sem AIDS apresentaram maior quando comparados aos grupos idosos com e sem AIDS (p=0,001). A correlação entre núcleo e citoplasma foi negativa e significativa nos quatro grupos (p<0,0001), entre fibras colágenas e núcleo, não idosos sem AIDS (p<0,0012) e não idosos com AIDS (p<0,0368) foi negativa e significativa, entre citoplasma e fibras colágenas o grupo não idoso com AIDS (p<0,0353) e não idosos sem AIDS (p<0,0012) foi negativa e significativa. Conclusão: Inferimos que o envelhecimento e a AIDS influencia na perda de massa muscular e contribui na diminuição das fibras colágenas.Research, Society and Development2021-08-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1851610.33448/rsd-v10i10.18516Research, Society and Development; Vol. 10 No. 10; e151101018516Research, Society and Development; Vol. 10 Núm. 10; e151101018516Research, Society and Development; v. 10 n. 10; e1511010185162525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18516/18489Copyright (c) 2021 Vandair Gonçalves Pereira ; Lourrayne Andressa Rocha; Flávio José Pereira de Almeida Ferreira ; Vicente de Paula Antunes Teixeira; Aline Cristina Souza da Silva ; Rodrigo César Rosa; Ana Paula Espindulahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPereira , Vandair Gonçalves Rocha, Lourrayne Andressa Ferreira , Flávio José Pereira de Almeida Teixeira, Vicente de Paula Antunes Silva , Aline Cristina Souza da Rosa, Rodrigo César Espindula, Ana Paula2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18516Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:38.476685Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS Análisis histomorfométrico del músculo pectoral mayor de pacientes ancianos y no ancianos sometidos a autopsia con y sin SIDA Análise histomorfométrica do músculo peitoral maior de idosos e não idosos autopsiados com e sem AIDS |
title |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS |
spellingShingle |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS Pereira , Vandair Gonçalves Células musculares Ancianos Síndrome de inmunodeficiencia adquirida. Muscle cells Elderly Acquired immunodeficiency syndrome. Células musculares Idosos Síndrome da imunodeficiência adquirida. |
title_short |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS |
title_full |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS |
title_fullStr |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS |
title_full_unstemmed |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS |
title_sort |
Histomorphometric analysis of the pectoralis major muscle of elderly and non-elderly autopsied patients with and without AIDS |
author |
Pereira , Vandair Gonçalves |
author_facet |
Pereira , Vandair Gonçalves Rocha, Lourrayne Andressa Ferreira , Flávio José Pereira de Almeida Teixeira, Vicente de Paula Antunes Silva , Aline Cristina Souza da Rosa, Rodrigo César Espindula, Ana Paula |
author_role |
author |
author2 |
Rocha, Lourrayne Andressa Ferreira , Flávio José Pereira de Almeida Teixeira, Vicente de Paula Antunes Silva , Aline Cristina Souza da Rosa, Rodrigo César Espindula, Ana Paula |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira , Vandair Gonçalves Rocha, Lourrayne Andressa Ferreira , Flávio José Pereira de Almeida Teixeira, Vicente de Paula Antunes Silva , Aline Cristina Souza da Rosa, Rodrigo César Espindula, Ana Paula |
dc.subject.por.fl_str_mv |
Células musculares Ancianos Síndrome de inmunodeficiencia adquirida. Muscle cells Elderly Acquired immunodeficiency syndrome. Células musculares Idosos Síndrome da imunodeficiência adquirida. |
topic |
Células musculares Ancianos Síndrome de inmunodeficiencia adquirida. Muscle cells Elderly Acquired immunodeficiency syndrome. Células musculares Idosos Síndrome da imunodeficiência adquirida. |
description |
Introduction: The Acquired Immunodeficiency Syndrome (AIDS), an infectious disease, where the main characteristic is the suppression of immunity by T CD4 lymphocytes. Objective: To analyze the percentage of myocytes and collagen fiber density from autopsied fragments of skeletal striated musculature from elderly and non-elderly patients with and without AIDS. Methodology: Retrospective, observational, analytical and quantitative study carried out from 78 divided into four groups, elderly and non-elderly with and without AIDS, aged between 44 and 63 years. Results: For histomorphometric analysis of the percentage of myocytes using Hematoxylin and eosin methods and for collagen fibers and Picrosirius under polarized light, both were performed under ordinary light microscopy. Results: There was a statistically defined decrease in nuclei in the non-elderly groups with and without AIDS and elderly with AIDS compared to the elderly groups without AIDS (p˂0,001). Collagen fibers in the non-elderly and non-deaf AIDS groups were higher when compared to the elderly groups with and without AIDS (p=0,001). The correlation between nucleus and cytoplasm was negative and low in the four groups (p <0,0001), between collagen fibers and nucleus, non-elderly people without AIDS (p<0,0012) and non-elderly people with AIDS (p<0,0368) was negative and decreased, between cytoplasm and collagen fibers the non-elderly group with AIDS (p<0,0353) and non-elderly without AIDS (p<0,0012) was negative and decreased. Conclusion: Aging and AIDS influence the loss of muscle mass and contribute to the reduction of collagen fibers. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18516 10.33448/rsd-v10i10.18516 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18516 |
identifier_str_mv |
10.33448/rsd-v10i10.18516 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18516/18489 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 10; e151101018516 Research, Society and Development; Vol. 10 Núm. 10; e151101018516 Research, Society and Development; v. 10 n. 10; e151101018516 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052787702366208 |