Factors that cause false-negative results in oncotic cytology exams: an integrative review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/19079 |
Resumo: | Cervical cancer (CCU) is considered a serious public health problem in the world, being the third malignancy with the highest mortality rate among Brazilian women. The Pap smear test, known as the Papanicolaou test, is a valuable strategy for the early diagnosis of CC, since it is a method with high precision and low cost. The research aims to review the literature regarding possible factors that can lead to false-negative results in the Pap smear. An integrative review was carried out in the online databases: Latin American and Caribbean Literature on Health Sciences (LILACS); Medical Literature Analysis and Retrieval System Online (MEDILINE) and Scientific Electronic Library Online (SciELO). 15 articles were selected and published between the years 2015 to 2020, in English and Portuguese. The main factors responsible for false results – negative refers to errors that occurred in the pre-analytical, analytical and post-analytical phases, the execution of the collection with an inadequate sample, is a phase that impacts the analysis of the smear when the professional misinterprets the tests, usually due to an inadequate color and improper preparation of the slides or even by practice and insufficient training. The quality of the Pap smear depends on the quality control of cytopathological tests, as this is based on measures to detect, correct and reduce errors caused in the phases: pre-analytical; analytical and post-analytical, thus avoiding false-negative results.In addition, the continuous training of professionals working in the health area directly reflects on the good quality and reliability of exams in general, with emphasis here on the Pap smear. |
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Factors that cause false-negative results in oncotic cytology exams: an integrative reviewFactores que causan resultados falso-negativos en exámenes de citología oncótica: una revisión integrativaFatores que provocam resultados falso-negativos nos exames de citologia oncótica: uma revisão integrativaTeste de PapanicolaouNeoplasias do colo do úteroControle de qualidadeControle analítico de qualidade.Prueba de PapanicolaouNeoplasias cervicalesControl de calidadControl de calidad analíticoPap smear testCervical neoplasmsQuality controlAnalytical quality control.Cervical cancer (CCU) is considered a serious public health problem in the world, being the third malignancy with the highest mortality rate among Brazilian women. The Pap smear test, known as the Papanicolaou test, is a valuable strategy for the early diagnosis of CC, since it is a method with high precision and low cost. The research aims to review the literature regarding possible factors that can lead to false-negative results in the Pap smear. An integrative review was carried out in the online databases: Latin American and Caribbean Literature on Health Sciences (LILACS); Medical Literature Analysis and Retrieval System Online (MEDILINE) and Scientific Electronic Library Online (SciELO). 15 articles were selected and published between the years 2015 to 2020, in English and Portuguese. The main factors responsible for false results – negative refers to errors that occurred in the pre-analytical, analytical and post-analytical phases, the execution of the collection with an inadequate sample, is a phase that impacts the analysis of the smear when the professional misinterprets the tests, usually due to an inadequate color and improper preparation of the slides or even by practice and insufficient training. The quality of the Pap smear depends on the quality control of cytopathological tests, as this is based on measures to detect, correct and reduce errors caused in the phases: pre-analytical; analytical and post-analytical, thus avoiding false-negative results.In addition, the continuous training of professionals working in the health area directly reflects on the good quality and reliability of exams in general, with emphasis here on the Pap smear.El cáncer de cuello uterino (UCC) es considerado un grave problema de salud pública en el mundo, siendo la tercera neoplasia con mayor tasa de mortalidad entre las mujeres brasileñas. La prueba de Papanicolaou, conocida como prueba de Papanicolaou, es una estrategia valiosa para el diagnóstico precoz de CC, ya que es un método de alta precisión y bajo costo. La investigación tiene como objetivo revisar la literatura sobre posibles factores que pueden conducir a resultados falsos negativos en la prueba de Papanicolaou. Se realizó una revisión integradora en las bases de datos en línea: Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS); Sistema de Análisis y Recuperación de Literatura Médica en Línea (MEDILINE) y Biblioteca Electrónica Científica en Línea (SciELO). Se seleccionaron y publicaron 15 artículos entre los años 2015 a 2020, en inglés y portugués. Los principales factores responsables de los resultados falsos – negativo se refiere a los errores que se produjeron en las fases preanalítica, analítica y postanalítica, la ejecución de la colección con una muestra inadecuada, es una fase que impacta en el análisis del frotis cuando el profesional malinterpreta las pruebas, generalmente debido a un color inadecuado y una preparación inadecuada de los portaobjetos o incluso por la práctica y la capacitación insuficiente. La calidad de la prueba de Papanicolaou depende del control de calidad de las pruebas citopatológicas, ya que este se basa en medidas para detectar, corregir y reducir los errores causados en las fases: preanalíticas; analíticos y post-analíticos, evitando así resultados falsos negativos. Además, la formación continua de los profesionales que trabajan en el área de la salud se refleja directamente en la buena calidad y confiabilidad de los exámenes en general, con énfasis aquí en la prueba de Papanicolaou.O câncer do colo do útero (CCU) é considerado um grave problema de saúde pública no mundo sendo a terceira malignidade de maior índice de mortalidades entre as mulheres brasileiras. O exame citopatológico, mas conhecido como exame do Papanicolaou, é uma estratégia valiosa para o diagnóstico precoce do CCU, uma vez que se trata de um método com alta precisão e baixo custo. A pesquisa tem como objetivo revisar a literatura quanto os possíveis fatores que podem levar a resultados falso-negativos no exame do Papanicolaou. Foi realizada revisão integrativa nas bases de dados on-line: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS); Medical Literature Analysis and Retrieval System Online (MEDILINE) e Scientific Electronic Library Online (SciELO). Sendo selecionadas 15 artigos com publicação entre os anos de 2015 a 2020, nos idiomas inglês e português. Os principais fatores responsáveis por ocasionar resultados falso – negativos referem-se a erros ocorridos nas fases pré-analítica, analítica e pós-analítica, a execução da coleta com uma amostra inadequada, é uma fase relevante que impacta na análise do esfregaço quando o profissional interpreta erroneamente os exames, geralmente em decorrência de uma coloração inadequada e uma confecção imprópria das lâminas ou ainda por prática e formação insuficiente do citologista. A qualidade do exame Papanicolaou depende do controle de qualidade dos exames citopatológicos, pois este se baseia em medidas para detectar, corrigir e reduzir erros ocasionados nas fases: pré-analítica; analítica e pós-analítica evitando, assim, os resultados falsos-negativos. Além disso, a capacitação contínua dos profissionais atuantes na área da saúde reflete diretamente na boa qualidade e confiabilidade dos exames em geral, tendo ênfase aqui, para o exame Papanicolaou.Research, Society and Development2021-08-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1907910.33448/rsd-v10i10.19079Research, Society and Development; Vol. 10 No. 10; e361101019079Research, Society and Development; Vol. 10 Núm. 10; e361101019079Research, Society and Development; v. 10 n. 10; e3611010190792525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/19079/16920Copyright (c) 2021 Maria Cristiane Oliveira Costa; Carla Mayla Silva de Melo; Eduarda dos Santos Lima; Jean Carlos Rodrigues da Cunha; Ana Paula Muniz Serejo; Heliana de Araújo Moraishttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCosta, Maria Cristiane OliveiraMelo, Carla Mayla Silva deLima, Eduarda dos Santos Cunha, Jean Carlos Rodrigues daSerejo, Ana Paula MunizMorais, Heliana de Araújo 2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/19079Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:03.694337Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Factors that cause false-negative results in oncotic cytology exams: an integrative review Factores que causan resultados falso-negativos en exámenes de citología oncótica: una revisión integrativa Fatores que provocam resultados falso-negativos nos exames de citologia oncótica: uma revisão integrativa |
title |
Factors that cause false-negative results in oncotic cytology exams: an integrative review |
spellingShingle |
Factors that cause false-negative results in oncotic cytology exams: an integrative review Costa, Maria Cristiane Oliveira Teste de Papanicolaou Neoplasias do colo do útero Controle de qualidade Controle analítico de qualidade. Prueba de Papanicolaou Neoplasias cervicales Control de calidad Control de calidad analítico Pap smear test Cervical neoplasms Quality control Analytical quality control. |
title_short |
Factors that cause false-negative results in oncotic cytology exams: an integrative review |
title_full |
Factors that cause false-negative results in oncotic cytology exams: an integrative review |
title_fullStr |
Factors that cause false-negative results in oncotic cytology exams: an integrative review |
title_full_unstemmed |
Factors that cause false-negative results in oncotic cytology exams: an integrative review |
title_sort |
Factors that cause false-negative results in oncotic cytology exams: an integrative review |
author |
Costa, Maria Cristiane Oliveira |
author_facet |
Costa, Maria Cristiane Oliveira Melo, Carla Mayla Silva de Lima, Eduarda dos Santos Cunha, Jean Carlos Rodrigues da Serejo, Ana Paula Muniz Morais, Heliana de Araújo |
author_role |
author |
author2 |
Melo, Carla Mayla Silva de Lima, Eduarda dos Santos Cunha, Jean Carlos Rodrigues da Serejo, Ana Paula Muniz Morais, Heliana de Araújo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Maria Cristiane Oliveira Melo, Carla Mayla Silva de Lima, Eduarda dos Santos Cunha, Jean Carlos Rodrigues da Serejo, Ana Paula Muniz Morais, Heliana de Araújo |
dc.subject.por.fl_str_mv |
Teste de Papanicolaou Neoplasias do colo do útero Controle de qualidade Controle analítico de qualidade. Prueba de Papanicolaou Neoplasias cervicales Control de calidad Control de calidad analítico Pap smear test Cervical neoplasms Quality control Analytical quality control. |
topic |
Teste de Papanicolaou Neoplasias do colo do útero Controle de qualidade Controle analítico de qualidade. Prueba de Papanicolaou Neoplasias cervicales Control de calidad Control de calidad analítico Pap smear test Cervical neoplasms Quality control Analytical quality control. |
description |
Cervical cancer (CCU) is considered a serious public health problem in the world, being the third malignancy with the highest mortality rate among Brazilian women. The Pap smear test, known as the Papanicolaou test, is a valuable strategy for the early diagnosis of CC, since it is a method with high precision and low cost. The research aims to review the literature regarding possible factors that can lead to false-negative results in the Pap smear. An integrative review was carried out in the online databases: Latin American and Caribbean Literature on Health Sciences (LILACS); Medical Literature Analysis and Retrieval System Online (MEDILINE) and Scientific Electronic Library Online (SciELO). 15 articles were selected and published between the years 2015 to 2020, in English and Portuguese. The main factors responsible for false results – negative refers to errors that occurred in the pre-analytical, analytical and post-analytical phases, the execution of the collection with an inadequate sample, is a phase that impacts the analysis of the smear when the professional misinterprets the tests, usually due to an inadequate color and improper preparation of the slides or even by practice and insufficient training. The quality of the Pap smear depends on the quality control of cytopathological tests, as this is based on measures to detect, correct and reduce errors caused in the phases: pre-analytical; analytical and post-analytical, thus avoiding false-negative results.In addition, the continuous training of professionals working in the health area directly reflects on the good quality and reliability of exams in general, with emphasis here on the Pap smear. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19079 10.33448/rsd-v10i10.19079 |
url |
https://rsdjournal.org/index.php/rsd/article/view/19079 |
identifier_str_mv |
10.33448/rsd-v10i10.19079 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19079/16920 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 10; e361101019079 Research, Society and Development; Vol. 10 Núm. 10; e361101019079 Research, Society and Development; v. 10 n. 10; e361101019079 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052753819729920 |