Lipid profile and blood glucose in patients with Diabetes Mellitus treated with Cinnamon - Systematic Review and Meta-analysis with randomized clinical research

• Autor(a) principal: Silva, Antônio Guilherme Sousa
• Data de Publicação: 2021
• Outros Autores: Gonçalves, Lucas Cândido, Silva, Paulo Alex Neves da, Carneiro, Lilian Carla, Sousa, José Arthur Silva e, Ataídes, Fábio Silvestre, Passos, Xisto Sena, Silva, Antonio Márcio Teodoro Cordeiro, Maia, Yara Lúcia Marques
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/18203
• topic: Type 2 diabetes mellitus; Cinnamon; Blood glucose; Lipid profiles.; Diabetes Mellitus tipo 2; Canela; Glucosa; Perfiles lipídicos.; Diabete Mellitus tipo 2; Canela; Glicemia; Perfis lipídicos.

This study aimed to measure the efficiency of cinnamon in patients with Type 2 Diabetes Mellitus (DM2), comparing fasting plasma glucose averages and lipid profiles with a placebo group through a meta-analysis. Four databases were the source of the research to find the articles used, including: Medline / PubMed, LILACS and NCBI. 11 randomized clinical trials that evaluated cinnamon on glycemic and lipid parameters were included in this study. Meta-analysis was performed with the aid of the STATA® 16.0 software, which determined the difference in glucose means and lipid profiles compared to a placebo group. Cinnamon at concentrations of 250 mg twice a day decreased blood glucose with MD = -0.25 (95%CI = - 0.36 to -0.14; p<0.00001) and in the intervention with 2 g 3 times a day with MD = -5.60 (95%CI = -6.98 to -4.22; p<0.00001). Total cholesterol was significant with 2 g 3 times a day with MD = 0.98 (95%CI = -1.27 to -0.69), followed by LDL-cholesterol MD = 0.64 (95%CI = 0.88 to 0.40; p<0.00001), and HDL-cholesterol with 500 mg 3 times daily with MD = 0.12 (95%CI = 0.05 to 0.19). High-dose supplementation of cinnamon can reduce glucose and lipid profiles in patients with DM2. This supporting treatment can be useful when added to the diet plan of patients with DM2.