Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/9708 |
Resumo: | Introduction: Tuberculosis is an infectious disease that has Mycobacterium tuberculosis (M. tuberculosis) as its main etiological agent, which is configured as a worldwide public health problem. Errors in the individual's immune response to the pathogen can trigger susceptibility to the infectious agent, thus, studies with SNPs in the NRAMP1 / SLC11A1 gene, have been widely carried out in investigations of susceptibility to infectious diseases, especially tuberculosis. Objective: The objective was to relate the simple nucleotide polymorphisms in the 5´Promotor, D543N, INT4 and 3´UTR variants of the NRAMP1 / SLC11A1 gene in the individual's susceptibility to M. tuberculosis through a meta-analysis. Methodology: This work was carried out following the methodological guidelines of a Systematic Review according to the PRISMA protocol, from which searches were carried out on the main Medline electronic databases via Pubmed, Science Direct and Lilacs. The studies were selected according to the eligibility criteria, with a total of 39 scientific articles chosen for data collection, without language or year restriction. Results and Discussion: The results of this study showed a possible association between the SNPs of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. The subgroup analysis suggested that of the 5 ethnicities and / or continents analyzed (Africa, South America, North America, Caucasian and Asians), only Caucasians did not obtain statistically significant results of any variant at a higher risk of susceptibility to tuberculosis. Conclusion: The present study showed a possible association between polymorphisms in the SNPs variant 5´Promotor, INT4, D543N and 3´UTR of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. |
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Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosisPolimorfismos de nucleótidos simples en el gen NRAMP1 / SLC11A1 para el riesgo de susceptibilidad a la tuberculosisPolimorfismos de nucleotídeo simples no gene NRAMP1 / SLC11A1 ao risco de suscetibilidade para a tuberculoseSNPGeneMycobacterium tuberculosis.SNPGeneTuberculosis micobacteriana.SNPGENEMycobacterium tuberculosis.Introduction: Tuberculosis is an infectious disease that has Mycobacterium tuberculosis (M. tuberculosis) as its main etiological agent, which is configured as a worldwide public health problem. Errors in the individual's immune response to the pathogen can trigger susceptibility to the infectious agent, thus, studies with SNPs in the NRAMP1 / SLC11A1 gene, have been widely carried out in investigations of susceptibility to infectious diseases, especially tuberculosis. Objective: The objective was to relate the simple nucleotide polymorphisms in the 5´Promotor, D543N, INT4 and 3´UTR variants of the NRAMP1 / SLC11A1 gene in the individual's susceptibility to M. tuberculosis through a meta-analysis. Methodology: This work was carried out following the methodological guidelines of a Systematic Review according to the PRISMA protocol, from which searches were carried out on the main Medline electronic databases via Pubmed, Science Direct and Lilacs. The studies were selected according to the eligibility criteria, with a total of 39 scientific articles chosen for data collection, without language or year restriction. Results and Discussion: The results of this study showed a possible association between the SNPs of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. The subgroup analysis suggested that of the 5 ethnicities and / or continents analyzed (Africa, South America, North America, Caucasian and Asians), only Caucasians did not obtain statistically significant results of any variant at a higher risk of susceptibility to tuberculosis. Conclusion: The present study showed a possible association between polymorphisms in the SNPs variant 5´Promotor, INT4, D543N and 3´UTR of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis.Introducción: La tuberculosis es una enfermedad infecciosa que tiene como principal agente etiológico a Mycobacterium tuberculosis (M. tuberculosis), lo que se configura como un problema de salud pública mundial. Los errores en la respuesta inmune del individuo al patógeno pueden desencadenar la susceptibilidad al agente infeccioso, por lo que los estudios con SNP en el gen NRAMP1 / SLC11A1 se han llevado a cabo ampliamente en investigaciones de susceptibilidad a enfermedades infecciosas, especialmente tuberculosis. Objetivo: El objetivo fue relacionar los polimorfismos de nucleótidos simples en las variantes 5´Promotor, D543N, INT4 y 3´UTR del gen NRAMP1 / SLC11A1 en la susceptibilidad del individuo a M. tuberculosis mediante un metaanálisis. Metodología: Este trabajo se realizó siguiendo las pautas metodológicas de una Revisión Sistemática según el protocolo PRISMA, a partir de la cual se realizaron búsquedas en las principales bases de datos electrónicas de Medline a través de Pubmed, Science Direct y Lilacs. Los estudios fueron seleccionados según los criterios de elegibilidad, con un total de 39 artículos científicos elegidos para la recolección de datos, sin restricción de idioma o año. Resultados y discusión: Los resultados de este estudio mostraron una posible asociación entre los SNP del gen NRAMP1 / SLC11A1 con el riesgo de susceptibilidad a la tuberculosis. El análisis de subgrupos sugirió que de las 5 etnias y / o continentes analizados (África, Sudamérica, Norteamérica, caucásicos y asiáticos), solo los caucásicos no obtuvieron resultados estadísticamente significativos de ninguna variante con mayor riesgo de susceptibilidad a la tuberculosis. Conclusión: El presente estudio mostró una posible asociación entre polimorfismos en la variante 5´Promotor, INT4, D543N y 3´UTR de SNP del gen NRAMP1 / SLC11A1 con el riesgo de susceptibilidad a la tuberculosis.Introdução: A tuberculose é uma doença infectocontagiosa que possui como principal agente etiológico o Mycobacterium tuberculosis (M. tuberculosis), que se configura como um problema de saúde pública mundial. Erros na resposta imunológica do indivíduo ao patógeno pode desencadear a suscetibilidade ao agente infeccioso, assim, estudos com SNPs no gene NRAMP1/SLC11A1, tem sido realizado amplamente em investigações de suscetibilidade às doenças infecciosas, principalmente a tuberculose. Objetivo: O objetivo foi relacionar os polimorfismos de nucleotídeo simples nas variantes 5´Promotor, D543N, INT4 e 3´UTR do gene NRAMP1/SLC11A1 na susceptibilidade do indivíduo ao M. tuberculosis por meio de uma meta-análise. Metodologia: Este trabalho foi conduzido seguindo as diretrizes metodológicas de uma Revisão Sistemática de acordo com o protocolo PRISMA, dos quais, realizou-se buscas nas principais bases eletrônicas Medline via Pubmed, Science Direct e Lilacs. Os estudos foram selecionados seguindo os critérios de elegibilidade, sendo escolhidos uma totalidade de 39 artigos científicos para a coleta de dados, sem restrição de idioma ou ano. Resultados e Discussão: Os resultados desse trabalho evidenciaram uma possível associação entre os SNPs do gene NRAMP1/SLC11A1 ao risco de suscetibilidade à tuberculose. A análise de subgrupo sugeriu que das 5 etnias e/ou continentes analisados (África, América do Sul, América do Norte, Caucasiano e Asiáticos), apenas os caucasianos não obtiveram resultados estatisticamente significativos de nenhuma variante a um maior risco de suscetibilidade à tuberculose. Conclusão: O presente estudo, evidenciou uma possível associação entre os polimorfismos nos SNPs variantes 5´Promotor, INT4, D543N e 3´UTR do gene NRAMP1/SLC11A1 ao risco de suscetibilidade a tuberculose.Research, Society and Development2020-11-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/970810.33448/rsd-v9i11.9708Research, Society and Development; Vol. 9 No. 11; e2489119708Research, Society and Development; Vol. 9 Núm. 11; e2489119708Research, Society and Development; v. 9 n. 11; e24891197082525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/9708/9113Copyright (c) 2020 Karolayne Silva Souza; Kátia Cilene da Silva Félix; Nelson Carvas Júnior; Rafaell Batista Pereira; Milena Roberta Freire da Silva; Flávia Steffany Leite Miranda; Maria Betania Melo de Oliveira; Graziele dos Santos ; Felicson Leonardo Oliveira Lima; Rodrigo Rege dos Santos Silva; Leandro Paes de Britohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza, Karolayne Silva Félix, Kátia Cilene da Silva Carvas Júnior, Nelson Pereira, Rafaell Batista Silva, Milena Roberta Freire da Miranda, Flávia Steffany Leite Oliveira, Maria Betania Melo de Santos , Graziele dos Lima, Felicson Leonardo Oliveira Silva, Rodrigo Reges dos Santos Brito, Leandro Paes de 2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/9708Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:31:55.488607Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis Polimorfismos de nucleótidos simples en el gen NRAMP1 / SLC11A1 para el riesgo de susceptibilidad a la tuberculosis Polimorfismos de nucleotídeo simples no gene NRAMP1 / SLC11A1 ao risco de suscetibilidade para a tuberculose |
title |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis |
spellingShingle |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis Souza, Karolayne Silva SNP Gene Mycobacterium tuberculosis. SNP Gene Tuberculosis micobacteriana. SNP GENE Mycobacterium tuberculosis. |
title_short |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis |
title_full |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis |
title_fullStr |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis |
title_full_unstemmed |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis |
title_sort |
Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis |
author |
Souza, Karolayne Silva |
author_facet |
Souza, Karolayne Silva Félix, Kátia Cilene da Silva Carvas Júnior, Nelson Pereira, Rafaell Batista Silva, Milena Roberta Freire da Miranda, Flávia Steffany Leite Oliveira, Maria Betania Melo de Santos , Graziele dos Lima, Felicson Leonardo Oliveira Silva, Rodrigo Reges dos Santos Brito, Leandro Paes de |
author_role |
author |
author2 |
Félix, Kátia Cilene da Silva Carvas Júnior, Nelson Pereira, Rafaell Batista Silva, Milena Roberta Freire da Miranda, Flávia Steffany Leite Oliveira, Maria Betania Melo de Santos , Graziele dos Lima, Felicson Leonardo Oliveira Silva, Rodrigo Reges dos Santos Brito, Leandro Paes de |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Karolayne Silva Félix, Kátia Cilene da Silva Carvas Júnior, Nelson Pereira, Rafaell Batista Silva, Milena Roberta Freire da Miranda, Flávia Steffany Leite Oliveira, Maria Betania Melo de Santos , Graziele dos Lima, Felicson Leonardo Oliveira Silva, Rodrigo Reges dos Santos Brito, Leandro Paes de |
dc.subject.por.fl_str_mv |
SNP Gene Mycobacterium tuberculosis. SNP Gene Tuberculosis micobacteriana. SNP GENE Mycobacterium tuberculosis. |
topic |
SNP Gene Mycobacterium tuberculosis. SNP Gene Tuberculosis micobacteriana. SNP GENE Mycobacterium tuberculosis. |
description |
Introduction: Tuberculosis is an infectious disease that has Mycobacterium tuberculosis (M. tuberculosis) as its main etiological agent, which is configured as a worldwide public health problem. Errors in the individual's immune response to the pathogen can trigger susceptibility to the infectious agent, thus, studies with SNPs in the NRAMP1 / SLC11A1 gene, have been widely carried out in investigations of susceptibility to infectious diseases, especially tuberculosis. Objective: The objective was to relate the simple nucleotide polymorphisms in the 5´Promotor, D543N, INT4 and 3´UTR variants of the NRAMP1 / SLC11A1 gene in the individual's susceptibility to M. tuberculosis through a meta-analysis. Methodology: This work was carried out following the methodological guidelines of a Systematic Review according to the PRISMA protocol, from which searches were carried out on the main Medline electronic databases via Pubmed, Science Direct and Lilacs. The studies were selected according to the eligibility criteria, with a total of 39 scientific articles chosen for data collection, without language or year restriction. Results and Discussion: The results of this study showed a possible association between the SNPs of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. The subgroup analysis suggested that of the 5 ethnicities and / or continents analyzed (Africa, South America, North America, Caucasian and Asians), only Caucasians did not obtain statistically significant results of any variant at a higher risk of susceptibility to tuberculosis. Conclusion: The present study showed a possible association between polymorphisms in the SNPs variant 5´Promotor, INT4, D543N and 3´UTR of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-12 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9708 10.33448/rsd-v9i11.9708 |
url |
https://rsdjournal.org/index.php/rsd/article/view/9708 |
identifier_str_mv |
10.33448/rsd-v9i11.9708 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9708/9113 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 11; e2489119708 Research, Society and Development; Vol. 9 Núm. 11; e2489119708 Research, Society and Development; v. 9 n. 11; e2489119708 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052804363190272 |