Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis

Detalhes bibliográficos
Autor(a) principal: Souza, Karolayne Silva
Data de Publicação: 2020
Outros Autores: Félix, Kátia Cilene da Silva, Carvas Júnior, Nelson, Pereira, Rafaell Batista, Silva, Milena Roberta Freire da, Miranda, Flávia Steffany Leite, Oliveira, Maria Betania Melo de, Santos , Graziele dos, Lima, Felicson Leonardo Oliveira, Silva, Rodrigo Reges dos Santos, Brito, Leandro Paes de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/9708
Resumo: Introduction: Tuberculosis is an infectious disease that has Mycobacterium tuberculosis (M. tuberculosis) as its main etiological agent, which is configured as a worldwide public health problem. Errors in the individual's immune response to the pathogen can trigger susceptibility to the infectious agent, thus, studies with SNPs in the NRAMP1 / SLC11A1 gene, have been widely carried out in investigations of susceptibility to infectious diseases, especially tuberculosis. Objective: The objective was to relate the simple nucleotide polymorphisms in the 5´Promotor, D543N, INT4 and 3´UTR variants of the NRAMP1 / SLC11A1 gene in the individual's susceptibility to M. tuberculosis through a meta-analysis. Methodology: This work was carried out following the methodological guidelines of a Systematic Review according to the PRISMA protocol, from which searches were carried out on the main Medline electronic databases via Pubmed, Science Direct and Lilacs. The studies were selected according to the eligibility criteria, with a total of 39 scientific articles chosen for data collection, without language or year restriction. Results and Discussion: The results of this study showed a possible association between the SNPs of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. The subgroup analysis suggested that of the 5 ethnicities and / or continents analyzed (Africa, South America, North America, Caucasian and Asians), only Caucasians did not obtain statistically significant results of any variant at a higher risk of susceptibility to tuberculosis. Conclusion: The present study showed a possible association between polymorphisms in the SNPs variant 5´Promotor, INT4, D543N and 3´UTR of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis.
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spelling Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosisPolimorfismos de nucleótidos simples en el gen NRAMP1 / SLC11A1 para el riesgo de susceptibilidad a la tuberculosisPolimorfismos de nucleotídeo simples no gene NRAMP1 / SLC11A1 ao risco de suscetibilidade para a tuberculoseSNPGeneMycobacterium tuberculosis.SNPGeneTuberculosis micobacteriana.SNPGENEMycobacterium tuberculosis.Introduction: Tuberculosis is an infectious disease that has Mycobacterium tuberculosis (M. tuberculosis) as its main etiological agent, which is configured as a worldwide public health problem. Errors in the individual's immune response to the pathogen can trigger susceptibility to the infectious agent, thus, studies with SNPs in the NRAMP1 / SLC11A1 gene, have been widely carried out in investigations of susceptibility to infectious diseases, especially tuberculosis. Objective: The objective was to relate the simple nucleotide polymorphisms in the 5´Promotor, D543N, INT4 and 3´UTR variants of the NRAMP1 / SLC11A1 gene in the individual's susceptibility to M. tuberculosis through a meta-analysis. Methodology: This work was carried out following the methodological guidelines of a Systematic Review according to the PRISMA protocol, from which searches were carried out on the main Medline electronic databases via Pubmed, Science Direct and Lilacs. The studies were selected according to the eligibility criteria, with a total of 39 scientific articles chosen for data collection, without language or year restriction. Results and Discussion: The results of this study showed a possible association between the SNPs of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. The subgroup analysis suggested that of the 5 ethnicities and / or continents analyzed (Africa, South America, North America, Caucasian and Asians), only Caucasians did not obtain statistically significant results of any variant at a higher risk of susceptibility to tuberculosis. Conclusion: The present study showed a possible association between polymorphisms in the SNPs variant 5´Promotor, INT4, D543N and 3´UTR of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis.Introducción: La tuberculosis es una enfermedad infecciosa que tiene como principal agente etiológico a Mycobacterium tuberculosis (M. tuberculosis), lo que se configura como un problema de salud pública mundial. Los errores en la respuesta inmune del individuo al patógeno pueden desencadenar la susceptibilidad al agente infeccioso, por lo que los estudios con SNP en el gen NRAMP1 / SLC11A1 se han llevado a cabo ampliamente en investigaciones de susceptibilidad a enfermedades infecciosas, especialmente tuberculosis. Objetivo: El objetivo fue relacionar los polimorfismos de nucleótidos simples en las variantes 5´Promotor, D543N, INT4 y 3´UTR del gen NRAMP1 / SLC11A1 en la susceptibilidad del individuo a M. tuberculosis mediante un metaanálisis. Metodología: Este trabajo se realizó siguiendo las pautas metodológicas de una Revisión Sistemática según el protocolo PRISMA, a partir de la cual se realizaron búsquedas en las principales bases de datos electrónicas de Medline a través de Pubmed, Science Direct y Lilacs. Los estudios fueron seleccionados según los criterios de elegibilidad, con un total de 39 artículos científicos elegidos para la recolección de datos, sin restricción de idioma o año. Resultados y discusión: Los resultados de este estudio mostraron una posible asociación entre los SNP del gen NRAMP1 / SLC11A1 con el riesgo de susceptibilidad a la tuberculosis. El análisis de subgrupos sugirió que de las 5 etnias y / o continentes analizados (África, Sudamérica, Norteamérica, caucásicos y asiáticos), solo los caucásicos no obtuvieron resultados estadísticamente significativos de ninguna variante con mayor riesgo de susceptibilidad a la tuberculosis. Conclusión: El presente estudio mostró una posible asociación entre polimorfismos en la variante 5´Promotor, INT4, D543N y 3´UTR de SNP del gen NRAMP1 / SLC11A1 con el riesgo de susceptibilidad a la tuberculosis.Introdução: A tuberculose é uma doença infectocontagiosa que possui como principal agente etiológico o Mycobacterium tuberculosis (M. tuberculosis), que se configura como um problema de saúde pública mundial. Erros na resposta imunológica do indivíduo ao patógeno pode desencadear a suscetibilidade ao agente infeccioso, assim, estudos com SNPs no gene NRAMP1/SLC11A1, tem sido realizado amplamente em investigações de suscetibilidade às doenças infecciosas, principalmente a tuberculose. Objetivo: O objetivo foi relacionar os polimorfismos de nucleotídeo simples nas variantes 5´Promotor, D543N, INT4 e 3´UTR do gene NRAMP1/SLC11A1 na susceptibilidade do indivíduo ao M. tuberculosis por meio de uma meta-análise. Metodologia: Este trabalho foi conduzido seguindo as diretrizes metodológicas de uma Revisão Sistemática de acordo com o protocolo PRISMA, dos quais, realizou-se buscas nas principais bases eletrônicas Medline via Pubmed, Science Direct e Lilacs. Os estudos foram selecionados seguindo os critérios de elegibilidade, sendo escolhidos uma totalidade de 39 artigos científicos para a coleta de dados, sem restrição de idioma ou ano. Resultados e Discussão: Os resultados desse trabalho evidenciaram uma possível associação entre os SNPs do gene NRAMP1/SLC11A1 ao risco de suscetibilidade à tuberculose. A análise de subgrupo sugeriu que das 5 etnias e/ou continentes analisados (África, América do Sul, América do Norte, Caucasiano e Asiáticos), apenas os caucasianos não obtiveram resultados estatisticamente significativos de nenhuma variante a um maior risco de suscetibilidade à tuberculose. Conclusão: O presente estudo, evidenciou uma possível associação entre os polimorfismos nos SNPs variantes 5´Promotor, INT4, D543N e 3´UTR do gene NRAMP1/SLC11A1 ao risco de suscetibilidade a tuberculose.Research, Society and Development2020-11-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/970810.33448/rsd-v9i11.9708Research, Society and Development; Vol. 9 No. 11; e2489119708Research, Society and Development; Vol. 9 Núm. 11; e2489119708Research, Society and Development; v. 9 n. 11; e24891197082525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/9708/9113Copyright (c) 2020 Karolayne Silva Souza; Kátia Cilene da Silva Félix; Nelson Carvas Júnior; Rafaell Batista Pereira; Milena Roberta Freire da Silva; Flávia Steffany Leite Miranda; Maria Betania Melo de Oliveira; Graziele dos Santos ; Felicson Leonardo Oliveira Lima; Rodrigo Rege dos Santos Silva; Leandro Paes de Britohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza, Karolayne Silva Félix, Kátia Cilene da Silva Carvas Júnior, Nelson Pereira, Rafaell Batista Silva, Milena Roberta Freire da Miranda, Flávia Steffany Leite Oliveira, Maria Betania Melo de Santos , Graziele dos Lima, Felicson Leonardo Oliveira Silva, Rodrigo Reges dos Santos Brito, Leandro Paes de 2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/9708Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:31:55.488607Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
Polimorfismos de nucleótidos simples en el gen NRAMP1 / SLC11A1 para el riesgo de susceptibilidad a la tuberculosis
Polimorfismos de nucleotídeo simples no gene NRAMP1 / SLC11A1 ao risco de suscetibilidade para a tuberculose
title Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
spellingShingle Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
Souza, Karolayne Silva
SNP
Gene
Mycobacterium tuberculosis.
SNP
Gene
Tuberculosis micobacteriana.
SNP
GENE
Mycobacterium tuberculosis.
title_short Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
title_full Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
title_fullStr Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
title_full_unstemmed Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
title_sort Simple nucleotide polymorphisms in the NRAMP1 / SLC11A1 gene to the risk of susceptibility to tuberculosis
author Souza, Karolayne Silva
author_facet Souza, Karolayne Silva
Félix, Kátia Cilene da Silva
Carvas Júnior, Nelson
Pereira, Rafaell Batista
Silva, Milena Roberta Freire da
Miranda, Flávia Steffany Leite
Oliveira, Maria Betania Melo de
Santos , Graziele dos
Lima, Felicson Leonardo Oliveira
Silva, Rodrigo Reges dos Santos
Brito, Leandro Paes de
author_role author
author2 Félix, Kátia Cilene da Silva
Carvas Júnior, Nelson
Pereira, Rafaell Batista
Silva, Milena Roberta Freire da
Miranda, Flávia Steffany Leite
Oliveira, Maria Betania Melo de
Santos , Graziele dos
Lima, Felicson Leonardo Oliveira
Silva, Rodrigo Reges dos Santos
Brito, Leandro Paes de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Karolayne Silva
Félix, Kátia Cilene da Silva
Carvas Júnior, Nelson
Pereira, Rafaell Batista
Silva, Milena Roberta Freire da
Miranda, Flávia Steffany Leite
Oliveira, Maria Betania Melo de
Santos , Graziele dos
Lima, Felicson Leonardo Oliveira
Silva, Rodrigo Reges dos Santos
Brito, Leandro Paes de
dc.subject.por.fl_str_mv SNP
Gene
Mycobacterium tuberculosis.
SNP
Gene
Tuberculosis micobacteriana.
SNP
GENE
Mycobacterium tuberculosis.
topic SNP
Gene
Mycobacterium tuberculosis.
SNP
Gene
Tuberculosis micobacteriana.
SNP
GENE
Mycobacterium tuberculosis.
description Introduction: Tuberculosis is an infectious disease that has Mycobacterium tuberculosis (M. tuberculosis) as its main etiological agent, which is configured as a worldwide public health problem. Errors in the individual's immune response to the pathogen can trigger susceptibility to the infectious agent, thus, studies with SNPs in the NRAMP1 / SLC11A1 gene, have been widely carried out in investigations of susceptibility to infectious diseases, especially tuberculosis. Objective: The objective was to relate the simple nucleotide polymorphisms in the 5´Promotor, D543N, INT4 and 3´UTR variants of the NRAMP1 / SLC11A1 gene in the individual's susceptibility to M. tuberculosis through a meta-analysis. Methodology: This work was carried out following the methodological guidelines of a Systematic Review according to the PRISMA protocol, from which searches were carried out on the main Medline electronic databases via Pubmed, Science Direct and Lilacs. The studies were selected according to the eligibility criteria, with a total of 39 scientific articles chosen for data collection, without language or year restriction. Results and Discussion: The results of this study showed a possible association between the SNPs of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis. The subgroup analysis suggested that of the 5 ethnicities and / or continents analyzed (Africa, South America, North America, Caucasian and Asians), only Caucasians did not obtain statistically significant results of any variant at a higher risk of susceptibility to tuberculosis. Conclusion: The present study showed a possible association between polymorphisms in the SNPs variant 5´Promotor, INT4, D543N and 3´UTR of the NRAMP1 / SLC11A1 gene with the risk of susceptibility to tuberculosis.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/9708
10.33448/rsd-v9i11.9708
url https://rsdjournal.org/index.php/rsd/article/view/9708
identifier_str_mv 10.33448/rsd-v9i11.9708
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/9708/9113
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 11; e2489119708
Research, Society and Development; Vol. 9 Núm. 11; e2489119708
Research, Society and Development; v. 9 n. 11; e2489119708
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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