Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/22903 |
Resumo: | Lung cancer has the highest incidence and the highest mortality rate in the world. Precision medicine has significantly improved therapeutic options, increasing survival rates. However, a significant number of patients are not eligible for targeted therapies. Thus, molecular characterization and definition of gene signatures based on pathway enrichment can be essential for clinical management and understanding of the therapeutic plan. The objective is to define molecular signatures, enriched pathways and biomarkers of non-small cell lung cancer (NSCLC), outlining a molecular panel of gene expression. The bibliographic study performed was a quick review, with searches in the Latin American and Caribbean Literature in Health Sciences (LILACS) and Scientific Electronic Library Online (SciELO) electronic databases, using the descriptors "lung cancer", “molecular signatures”, “enrichment of pathways” and “neoplastic biomarkers”. Therefore, it was possible to identify differentially expressed genes and their inscription in possible signaling pathways, which can be important therapeutic targets. |
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Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkersPerspectivas en el tratamiento del cáncer de pulmón: análisis de vías de señalización y biomarcadoresPerspectivas no tratamento do câncer de pulmão: análise das vias de sinalização e biomarcadoresCáncer de pulmón de células no pequenasMarcadores tumoralesTerapia biológica.Non-small cell lung cancerTumor markersBiological therapy.Câncer de pulmão de não pequenas célulasMarcadores tumoraisTerapia biológica. Lung cancer has the highest incidence and the highest mortality rate in the world. Precision medicine has significantly improved therapeutic options, increasing survival rates. However, a significant number of patients are not eligible for targeted therapies. Thus, molecular characterization and definition of gene signatures based on pathway enrichment can be essential for clinical management and understanding of the therapeutic plan. The objective is to define molecular signatures, enriched pathways and biomarkers of non-small cell lung cancer (NSCLC), outlining a molecular panel of gene expression. The bibliographic study performed was a quick review, with searches in the Latin American and Caribbean Literature in Health Sciences (LILACS) and Scientific Electronic Library Online (SciELO) electronic databases, using the descriptors "lung cancer", “molecular signatures”, “enrichment of pathways” and “neoplastic biomarkers”. Therefore, it was possible to identify differentially expressed genes and their inscription in possible signaling pathways, which can be important therapeutic targets.El cáncer de pulmón tiene la mayor incidencia y la mayor tasa de mortalidad del mundo. La medicina de precisión ha mejorado significativamente las opciones terapéuticas, aumentando las tasas de supervivencia. Sin embargo, un número significativo de pacientes no son elegibles para terapias dirigidas. Por lo tanto, la caracterización molecular y la definición de firmas genéticas basadas en el enriquecimiento de la vía pueden ser esenciales para el manejo clínico y la comprensión del plan terapéutico. El objetivo es definir firmas moleculares, rutas enriquecidas y biomarcadores del cáncer de pulmón de células no pequeñas (CPCNP), delineando un panel molecular de expresión génica. El estudio bibliográfico realizado fue de revisión rápida, con búsquedas en las bases de datos electrónicas de Literatura Latinoamericana y Caribeña en Ciencias de la Salud (LILACS) y Scientific Electronic Library Online (SciELO), utilizando los descriptores "cáncer de pulmón", "firmas moleculares", "enriquecimiento de vías” y “biomarcadores neoplásicos”. Entonces fue posible identificar genes expresados diferencialmente y su inscripción en posibles vías de señalización, que pueden ser importantes dianas terapéuticas.O câncer de pulmão tem a incidência mais alta e a maior taxa de mortalidade em todo o mundo. A medicina de precisão melhorou significativamente as opções terapêuticas, aumentando as taxas de sobrevivência. No entanto, um número significativo de pacientes não é elegível para terapias direcionadas. Assim, a caracterização molecular e a definição de assinaturas gênicas baseadas no enriquecimento de vias podem ser essenciais para o manejo clínico e a compreensão do plano terapêutico. Objetiva-se definir assinaturas moleculares, vias enriquecidas e biomarcadores do câncer de pulmão de não pequenas células (CPNPC), delineando um painel molecular de expressão gênica. O estudo bibliográfico realizado foi do tipo revisão rápida, com buscas nas bases de dados eletrônicas Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Scientific Electronic Library Online (SciELO), utilizando-se os descritores “câncer de pulmão”, “biomarcadores”, “enriquecimento de vias” e “biomarcadores neoplásicos”. Logo, foi possível identificar genes diferencialmente expressos e sua inscrição em possíveis vias de sinalização, que podem ser importantes alvos terapêuticos.Research, Society and Development2022-05-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2290310.33448/rsd-v11i7.22903Research, Society and Development; Vol. 11 No. 7; e5411722903Research, Society and Development; Vol. 11 Núm. 7; e5411722903Research, Society and Development; v. 11 n. 7; e54117229032525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/22903/25617Copyright (c) 2022 Ronilson Ferreira Xavier; Gabriel Henrique Cardoso Silva; Charles Henrique Estrela Gonçalves; Daianne Estrela Gonçalves; Cláudio Gonçalves Moreira; João Lucas Caldas Minervino; Jardeson Joaquim Bezerrahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessXavier, Ronilson Ferreira Silva, Gabriel Henrique Cardoso Gonçalves, Charles Henrique Estrela Gonçalves, Daianne Estrela Moreira, Cláudio Gonçalves Minervino, João Lucas Caldas Bezerra, Jardeson Joaquim 2022-06-06T15:12:05Zoai:ojs.pkp.sfu.ca:article/22903Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:56.074478Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers Perspectivas en el tratamiento del cáncer de pulmón: análisis de vías de señalización y biomarcadores Perspectivas no tratamento do câncer de pulmão: análise das vias de sinalização e biomarcadores |
| title |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers |
| spellingShingle |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers Xavier, Ronilson Ferreira Cáncer de pulmón de células no pequenas Marcadores tumorales Terapia biológica. Non-small cell lung cancer Tumor markers Biological therapy. Câncer de pulmão de não pequenas células Marcadores tumorais Terapia biológica. |
| title_short |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers |
| title_full |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers |
| title_fullStr |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers |
| title_full_unstemmed |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers |
| title_sort |
Perspectives in the treatment of lung cancer: analysis of signaling pathways and biomarkers |
| author |
Xavier, Ronilson Ferreira |
| author_facet |
Xavier, Ronilson Ferreira Silva, Gabriel Henrique Cardoso Gonçalves, Charles Henrique Estrela Gonçalves, Daianne Estrela Moreira, Cláudio Gonçalves Minervino, João Lucas Caldas Bezerra, Jardeson Joaquim |
| author_role |
author |
| author2 |
Silva, Gabriel Henrique Cardoso Gonçalves, Charles Henrique Estrela Gonçalves, Daianne Estrela Moreira, Cláudio Gonçalves Minervino, João Lucas Caldas Bezerra, Jardeson Joaquim |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Xavier, Ronilson Ferreira Silva, Gabriel Henrique Cardoso Gonçalves, Charles Henrique Estrela Gonçalves, Daianne Estrela Moreira, Cláudio Gonçalves Minervino, João Lucas Caldas Bezerra, Jardeson Joaquim |
| dc.subject.por.fl_str_mv |
Cáncer de pulmón de células no pequenas Marcadores tumorales Terapia biológica. Non-small cell lung cancer Tumor markers Biological therapy. Câncer de pulmão de não pequenas células Marcadores tumorais Terapia biológica. |
| topic |
Cáncer de pulmón de células no pequenas Marcadores tumorales Terapia biológica. Non-small cell lung cancer Tumor markers Biological therapy. Câncer de pulmão de não pequenas células Marcadores tumorais Terapia biológica. |
| description |
Lung cancer has the highest incidence and the highest mortality rate in the world. Precision medicine has significantly improved therapeutic options, increasing survival rates. However, a significant number of patients are not eligible for targeted therapies. Thus, molecular characterization and definition of gene signatures based on pathway enrichment can be essential for clinical management and understanding of the therapeutic plan. The objective is to define molecular signatures, enriched pathways and biomarkers of non-small cell lung cancer (NSCLC), outlining a molecular panel of gene expression. The bibliographic study performed was a quick review, with searches in the Latin American and Caribbean Literature in Health Sciences (LILACS) and Scientific Electronic Library Online (SciELO) electronic databases, using the descriptors "lung cancer", “molecular signatures”, “enrichment of pathways” and “neoplastic biomarkers”. Therefore, it was possible to identify differentially expressed genes and their inscription in possible signaling pathways, which can be important therapeutic targets. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-05-15 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/22903 10.33448/rsd-v11i7.22903 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/22903 |
| identifier_str_mv |
10.33448/rsd-v11i7.22903 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/22903/25617 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 11 No. 7; e5411722903 Research, Society and Development; Vol. 11 Núm. 7; e5411722903 Research, Society and Development; v. 11 n. 7; e5411722903 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052696386076672 |