The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/22642 |
Resumo: | Currently, one of the greatest challenges for adhesive dentistry is to maintain the integrity of the hybrid layer in restorations. It is known that the complicating factor is related to the action of matrix metalloproteinase (MMP), which degrade unprotected collagen filaments. It is understood that chlorhexidine (CHX) behaves in an inhibitory manner on this enzyme, changing its structure and chelating the metal ions essential for its activation, which would break this degradation sequence. One of the aims of this study was to describe, based on the literature, the influence of the use of CHX prior to the application of the adhesive system on the conservation of the hybrid layer and, consequently, on the improvement of composite resin bonding. Another purpose is to verify, among the adhesive systems, if any elucidates better results after the application of CHX and to understand if, in the long term, this inhibition is maintained. This research was carried out as an integrative literature review, and is purely basic in nature. To this end, a search was conducted in the "PubMed-NCBI" database with the search terms: ((chlorhexidine) and (matrix metalloproteinase inhibitors)) or (mmp) and (adhesives) considering publications from the last 10 years. Given the data collected it is clear that this is still a subject that requires further and longer scientific evidence due to the heterogeneity of results between authors. However, no study has shown that the use of inhibitors is detrimental to the longevity of the restoration. |
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The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative reviewUso de la clorhexidina como inhibidor de la metaloproteinasa de la matriz para aumentar la longevidad de las restauraciones de resina compuesta: una revisión integradoraUso da clorexidina como inibidora de matriz de metaloproteinase na perspectiva do aumento da longevidade de restaurações em resina composta: uma revisão integrativaMetalloproteinase matrixChlorhexidineHybrid layerAdhesionComposite resin.Matriz de metaloproteinaseClorexidinaCamada híbridaAdesãoResina composta.Matriz de metaloproteinasaClorhexidinaCapa híbridaAdhesiónResina compuesta.Currently, one of the greatest challenges for adhesive dentistry is to maintain the integrity of the hybrid layer in restorations. It is known that the complicating factor is related to the action of matrix metalloproteinase (MMP), which degrade unprotected collagen filaments. It is understood that chlorhexidine (CHX) behaves in an inhibitory manner on this enzyme, changing its structure and chelating the metal ions essential for its activation, which would break this degradation sequence. One of the aims of this study was to describe, based on the literature, the influence of the use of CHX prior to the application of the adhesive system on the conservation of the hybrid layer and, consequently, on the improvement of composite resin bonding. Another purpose is to verify, among the adhesive systems, if any elucidates better results after the application of CHX and to understand if, in the long term, this inhibition is maintained. This research was carried out as an integrative literature review, and is purely basic in nature. To this end, a search was conducted in the "PubMed-NCBI" database with the search terms: ((chlorhexidine) and (matrix metalloproteinase inhibitors)) or (mmp) and (adhesives) considering publications from the last 10 years. Given the data collected it is clear that this is still a subject that requires further and longer scientific evidence due to the heterogeneity of results between authors. However, no study has shown that the use of inhibitors is detrimental to the longevity of the restoration.Actualmente, uno de los mayores retos de la odontología adhesiva es mantener la integridad de la capa híbrida en las restauraciones. Se sabe que el factor de complicación está relacionado con la acción de las metaloproteinasas de la matriz (MMP), que degradan los filamentos de colágeno desprotegidos. Se entiende que la clorhexidina (CHX) se comporta de manera inhibitoria sobre esta enzima, cambiando su estructura y quelando los iones metálicos esenciales para su activación, lo que rompería esta secuencia de degradación. Uno de los objetivos de este trabajo ha sido describir, basándose en la literatura, la influencia del uso de CHX antes de la aplicación del sistema adhesivo para la conservación de la capa híbrida y la consiguiente mejora de la adhesión de las resinas compuestas. Otro propósito es verificar, entre los sistemas adhesivos, si alguno dilucida mejores resultados tras la aplicación de CHX y entender si, a largo plazo, esta inhibición se mantiene. Esta investigación se realizó en forma de revisión bibliográfica integradora, con carácter puramente básico. Para ello, se realizó una búsqueda en la base de datos "PubMed-NCBI" con los siguientes términos de búsqueda: ((clorhexidina) y (inhibidores de la metaloproteinasa de la matriz)) o (mmp) y (adhesivos) considerando las publicaciones de los últimos 10 años. A la vista de los datos recogidos, es evidente que se trata de un tema que requiere más pruebas científicas y más largas debido a la heterogeneidad de los resultados entre los autores. Sin embargo, ningún estudio demostró que el uso del inhibidor fuera perjudicial para la longevidad de la restauración.Atualmente, um dos grandes desafios para a odontologia adesiva é manter conservada a integridade da camada híbrida em restaurações. É sabido que o fator dificultador está relacionado à ação das matrizes de metaloproteinase (MMP), que degradam os filamentos colágenos desprotegidos. É compreendido que a clorexidina (CHX) se comporta de forma inibitória sobre essa enzima, alterando sua estrutura e quelando os íons metálicos essenciais para sua ativação, o que quebraria essa sequência de degradação. Um dos objetivos deste trabalho foi descrever, com base na literatura, a influência do uso da CHX prévia a aplicação do sistema adesivo perante a conservação da camada hibrida e consequentemente melhora da adesão das resinas compostas. Outro propósito é verificar, entre os sistemas adesivos, se algum elucida melhores resultados após a aplicação da CHX e entender se, em longo prazo, essa inibição se mantém. Essa pesquisa foi realizada na forma de revisão integrativa de literatura, possuindo natureza básica pura. Para tal, foi realizada uma busca pela base de dados “PubMed-NCBI” com os termos de pesquisa: ((clorexidina) and (inibidores de matriz de metaloproteinase)) or (mmp) and (adesivos) considerando publicações dos últimos 10 anos. Perante aos dados coletados fica claro que este ainda é um assunto que demanda maiores e mais longas provas científicas devido a heterogenicidade dos resultados entre autores. Entretanto, nenhum estudo demonstrou que o uso do inibidor seria prejudicial a longevidade da restauração.Research, Society and Development2021-11-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2264210.33448/rsd-v10i15.22642Research, Society and Development; Vol. 10 No. 15; e80101522642Research, Society and Development; Vol. 10 Núm. 15; e80101522642Research, Society and Development; v. 10 n. 15; e801015226422525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/22642/20082Copyright (c) 2021 Larissa Cristina Pereira Costa; Lorene Queiroz Casali Reis; Mariana Vieira Melo ; Mirelle Estéfane de Oliveira Caixeta; Priscila Capelari Orsolin; Rodrigo Soares de Andradehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCosta, Larissa Cristina PereiraReis, Lorene Queiroz CasaliMelo , Mariana VieiraCaixeta, Mirelle Estéfane de Oliveira Orsolin, Priscila Capelari Andrade, Rodrigo Soares de 2021-12-06T10:13:53Zoai:ojs.pkp.sfu.ca:article/22642Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:45.330200Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review Uso de la clorhexidina como inhibidor de la metaloproteinasa de la matriz para aumentar la longevidad de las restauraciones de resina compuesta: una revisión integradora Uso da clorexidina como inibidora de matriz de metaloproteinase na perspectiva do aumento da longevidade de restaurações em resina composta: uma revisão integrativa |
title |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review |
spellingShingle |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review Costa, Larissa Cristina Pereira Metalloproteinase matrix Chlorhexidine Hybrid layer Adhesion Composite resin. Matriz de metaloproteinase Clorexidina Camada híbrida Adesão Resina composta. Matriz de metaloproteinasa Clorhexidina Capa híbrida Adhesión Resina compuesta. |
title_short |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review |
title_full |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review |
title_fullStr |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review |
title_full_unstemmed |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review |
title_sort |
The use of chlorhexidine as a matrix metalloproteinase inhibitor to increase the longevity of composite resin restorations: an integrative review |
author |
Costa, Larissa Cristina Pereira |
author_facet |
Costa, Larissa Cristina Pereira Reis, Lorene Queiroz Casali Melo , Mariana Vieira Caixeta, Mirelle Estéfane de Oliveira Orsolin, Priscila Capelari Andrade, Rodrigo Soares de |
author_role |
author |
author2 |
Reis, Lorene Queiroz Casali Melo , Mariana Vieira Caixeta, Mirelle Estéfane de Oliveira Orsolin, Priscila Capelari Andrade, Rodrigo Soares de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Larissa Cristina Pereira Reis, Lorene Queiroz Casali Melo , Mariana Vieira Caixeta, Mirelle Estéfane de Oliveira Orsolin, Priscila Capelari Andrade, Rodrigo Soares de |
dc.subject.por.fl_str_mv |
Metalloproteinase matrix Chlorhexidine Hybrid layer Adhesion Composite resin. Matriz de metaloproteinase Clorexidina Camada híbrida Adesão Resina composta. Matriz de metaloproteinasa Clorhexidina Capa híbrida Adhesión Resina compuesta. |
topic |
Metalloproteinase matrix Chlorhexidine Hybrid layer Adhesion Composite resin. Matriz de metaloproteinase Clorexidina Camada híbrida Adesão Resina composta. Matriz de metaloproteinasa Clorhexidina Capa híbrida Adhesión Resina compuesta. |
description |
Currently, one of the greatest challenges for adhesive dentistry is to maintain the integrity of the hybrid layer in restorations. It is known that the complicating factor is related to the action of matrix metalloproteinase (MMP), which degrade unprotected collagen filaments. It is understood that chlorhexidine (CHX) behaves in an inhibitory manner on this enzyme, changing its structure and chelating the metal ions essential for its activation, which would break this degradation sequence. One of the aims of this study was to describe, based on the literature, the influence of the use of CHX prior to the application of the adhesive system on the conservation of the hybrid layer and, consequently, on the improvement of composite resin bonding. Another purpose is to verify, among the adhesive systems, if any elucidates better results after the application of CHX and to understand if, in the long term, this inhibition is maintained. This research was carried out as an integrative literature review, and is purely basic in nature. To this end, a search was conducted in the "PubMed-NCBI" database with the search terms: ((chlorhexidine) and (matrix metalloproteinase inhibitors)) or (mmp) and (adhesives) considering publications from the last 10 years. Given the data collected it is clear that this is still a subject that requires further and longer scientific evidence due to the heterogeneity of results between authors. However, no study has shown that the use of inhibitors is detrimental to the longevity of the restoration. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/22642 10.33448/rsd-v10i15.22642 |
url |
https://rsdjournal.org/index.php/rsd/article/view/22642 |
identifier_str_mv |
10.33448/rsd-v10i15.22642 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/22642/20082 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 15; e80101522642 Research, Society and Development; Vol. 10 Núm. 15; e80101522642 Research, Society and Development; v. 10 n. 15; e80101522642 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052790507307008 |