Clinical profile, prevalence and mortality of hospitalized patients with chronic liver diseases infected with SARS-COV-2: An integrative review

• Autor(a) principal: Afonso, Thyago de Oliveira
• Data de Publicação: 2021
• Outros Autores: Freitas, Sarah Maria Soares de, Souza, Douglas Rogério Freitas de, Andrade, Gabriel Vítor Lima de, Gonçalves, José Erivaldo, Silva, Mariana Pereira Barbosa, Santos, Samuel Lopes dos, Carvalho, Simone Barroso de, Loures, Leandro Luiz da Silva, Araujo, Gustavo Baroni, Melo, Beatriz Cardoso, Gomes, Yulle Morais, Brayner, Luís Eduardo Arcoverde Nogueira, Fonseca, Natana Maranhão Noleto da, Carvalho, Maria Clara Osório Meneses, Zanovello, Mariana Magalhães Bergantini, Miranda, Ilana Marjorie Macedo Borges, Santos, Amanda Viana, Maciel, Amanda Costa, Ribeiro, Yonara Cristiane, Brito, Pâmela Ferreira
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/13143
• topic: Enfermidad hepática crónica; Infecciones por Coronavirus; Coinfección; Mortalidad.; Chronic liver disease; Coronavirus infection; Coinfection; Mortality.; Doença hepática crônica; Infecções por coronavírus; Coinfecção; Mortalidade.

Objective: To analyze scientific evidence on the clinical profile, prevalence and mortality of adult hospitalized patients with chronic liver disease (CLD) infected with SARS-COV-2. Methodology: This is a bibliographic review in the integrative literature review method, carried out in February 2021, in the databases MEDLINE / PubMed, EMBASE and LILACS, using the descriptors / MESH: "COVID-19" AND "chronic liver disease ", combined with the Boolean operator "AND”. Inclusion criteria were: original articles available in full, complete, published between 2019 and January 2021, in Portuguese, English and/or Spanish, and a suitable theme. The exclusion criteria were: incomplete, duplicate articles, unrelated to the topic, in pre-proof, theses, dissertations, monographs and manuals. Results: Seven articles were included. 1693 adult hospitalized patients infected with SARS-COV-2 were analyzed and the frequency was varied between 0.79% and 50%, compared to the hospitalized population infected with COVID-19 with and without CLD. The clinical profile of patients with CLD and COVID-19 was predominantly male, mean age: 55 years, non-alcoholic fatty liver disease as a previous CLD and hypertension as the main comorbidity. The most reported symptoms were cough (80.8%), presence of infection(73.1%), sputum(26.9%), dyspnea(25%), myalgia or fatigue(13.5%). The main laboratory and imaging changes included elevation in liver enzymes, lymphopenia, diffuse opacities and ground-glass. Mortality was more significant in immunosuppressed CLD and COVID-19 patients, ranging from 1.78% to 8.1%. Conclusion: The data propose a trend in clinical profile, prevalence and mortality, but there is a need for further cohort studies or randomized clinical trials with larger samples to confirm hypotheses.