Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/45115 |
Resumo: | The excessive consumption of alcohol poses a significant public health concern due to its detrimental effects on individual well-being, particularly on the gastrointestinal (GI) tract. Chronic ethanol ingestion leads to morphological and functional alterations in the GI tract, affecting epithelial cells and resident microbial flora, thus impairing intestinal absorption. This study aimed to assess the impact of chronic ethanol consumption on small intestinal histological morphology. Animals were divided into control (water), 5% ethanol, and 20% ethanol groups, with 10 animals in each. Over 80 days, ethanol consumption was monitored ad libitum. Histopathological and histomorphometric analyses of the small intestine were conducted. Results revealed similar daily liquid consumption among the groups. However, alcoholic groups exhibited increased mononuclear cells, eosinophils, and villus degeneration compared to the control group. Ethanol-treated animals also displayed reduced villi extension, indicating structural damage to the intestine. Chronic ethanol consumption induced a chronic inflammatory pattern and deterioration of intestinal structures. In conclusion, regardless of alcohol content, chronic ethanol consumption adversely affects the gastrointestinal tract. This study underscores the importance of understanding the pathological effects of alcohol on the GI system and emphasizes the need for interventions to mitigate its impact on public health. |
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Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcoholHistopathological and histomorphometric analysis of the small intestine in wistar rats subjected to daily alcohol intakeAnálise histopatológica e histomorfométrica do intestino delgado de ratos wistar submetidos à ingestão diária de álcoolEtanolAlcoholismoIntestino delgadoAbsorciónNutrición.EtanolAlcoolismoIntestino delgadoAbsorçãoNutrição.EthanolAlcoholismSmall intestineAbsorptionNutrition.The excessive consumption of alcohol poses a significant public health concern due to its detrimental effects on individual well-being, particularly on the gastrointestinal (GI) tract. Chronic ethanol ingestion leads to morphological and functional alterations in the GI tract, affecting epithelial cells and resident microbial flora, thus impairing intestinal absorption. This study aimed to assess the impact of chronic ethanol consumption on small intestinal histological morphology. Animals were divided into control (water), 5% ethanol, and 20% ethanol groups, with 10 animals in each. Over 80 days, ethanol consumption was monitored ad libitum. Histopathological and histomorphometric analyses of the small intestine were conducted. Results revealed similar daily liquid consumption among the groups. However, alcoholic groups exhibited increased mononuclear cells, eosinophils, and villus degeneration compared to the control group. Ethanol-treated animals also displayed reduced villi extension, indicating structural damage to the intestine. Chronic ethanol consumption induced a chronic inflammatory pattern and deterioration of intestinal structures. In conclusion, regardless of alcohol content, chronic ethanol consumption adversely affects the gastrointestinal tract. This study underscores the importance of understanding the pathological effects of alcohol on the GI system and emphasizes the need for interventions to mitigate its impact on public health.El consumo excesivo de alcohol representa una preocupación significativa para la salud pública debido a sus efectos perjudiciales en el bienestar individual, especialmente en el tracto gastrointestinal (GI). La ingesta crónica de etanol resulta en alteraciones morfológicas y funcionales en el tracto GI, afectando las células epiteliales y la flora microbiana residente, lo que dificulta la absorción intestinal. Este estudio tuvo como objetivo evaluar el impacto del consumo crónico de etanol en la morfología histológica del intestino delgado. Los animales se dividieron en grupos de control (agua), 5% de etanol y 20% de etanol, con 10 animales en cada grupo. A lo largo de 80 días, se monitorizó la ingesta de etanol ad libitum. Se realizaron análisis histopatológicos e histomorfométricos del intestino delgado. Los resultados revelaron un consumo diario de líquidos similar entre los grupos. Sin embargo, los grupos alcohólicos mostraron un aumento de células mononucleares, eosinófilos y degeneración vilosa en comparación con el grupo de control. Los animales tratados con etanol también mostraron una reducción en la extensión de las vellosidades, lo que indica daños estructurales en el intestino. El consumo crónico de etanol indujo un patrón inflamatorio crónico y deterioro de las estructuras intestinales. En conclusión, independientemente del contenido alcohólico, el consumo crónico de etanol afecta negativamente al tracto gastrointestinal. Este estudio destaca la importancia de comprender los efectos patológicos del alcohol en el sistema GI y enfatiza la necesidad de intervenciones para mitigar su impacto en la salud pública.O consumo excessivo de álcool representa uma preocupação significativa para a saúde pública devido aos seus efeitos prejudiciais no bem-estar individual, especialmente no trato gastrointestinal (GI). A ingestão crônica de etanol resulta em alterações morfológicas e funcionais no trato GI, afetando células epiteliais e a flora microbiana residente, prejudicando assim a absorção intestinal. Este estudo teve como objetivo avaliar o impacto do consumo crônico de etanol na morfologia histológica do intestino delgado. Os animais foram divididos em grupos de controle (água), 5% de etanol e 20% de etanol, com 10 animais em cada grupo. Ao longo de 80 dias, o consumo de etanol foi monitorado ad libitum. Análises histopatológicas e histomorfométricas do intestino delgado foram realizadas. Os resultados revelaram consumo diário de líquidos semelhante entre os grupos. No entanto, os grupos alcoólicos apresentaram aumento de células mononucleares, eosinófilos e degeneração vilosa em comparação com o grupo de controle. Os animais tratados com etanol também exibiram redução na extensão das vilosidades, indicando danos estruturais ao intestino. O consumo crônico de etanol induziu um padrão inflamatório crônico e deterioração das estruturas intestinais. Em conclusão, independentemente do teor alcoólico, o consumo crônico de etanol afeta negativamente o trato gastrointestinal. Este estudo destaca a importância de compreender os efeitos patológicos do álcool no sistema GI e enfatiza a necessidade de intervenções para mitigar seu impacto na saúde pública.Research, Society and Development2024-03-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4511510.33448/rsd-v13i2.45115Research, Society and Development; Vol. 13 No. 2; e13513245115Research, Society and Development; Vol. 13 Núm. 2; e13513245115Research, Society and Development; v. 13 n. 2; e135132451152525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/45115/36027Copyright (c) 2024 Thaís Santa Cruz Moraes; Sara Semaan Silveira; Thiago Jardim de Oliveira; Adriana Rodrigues dos Anjos Mendonça; Paulo Roberto Maia; Fiorita Gonzales Lopes Mundim; Rodrigo Machado Pereirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMoraes, Thaís Santa CruzSilveira, Sara SemaanOliveira, Thiago Jardim de Mendonça, Adriana Rodrigues dos AnjosMaia, Paulo RobertoMundim, Fiorita Gonzales LopesPereira, Rodrigo Machado2024-03-04T09:47:20Zoai:ojs.pkp.sfu.ca:article/45115Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-03-04T09:47:20Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol Histopathological and histomorphometric analysis of the small intestine in wistar rats subjected to daily alcohol intake Análise histopatológica e histomorfométrica do intestino delgado de ratos wistar submetidos à ingestão diária de álcool |
title |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol |
spellingShingle |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol Moraes, Thaís Santa Cruz Etanol Alcoholismo Intestino delgado Absorción Nutrición. Etanol Alcoolismo Intestino delgado Absorção Nutrição. Ethanol Alcoholism Small intestine Absorption Nutrition. |
title_short |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol |
title_full |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol |
title_fullStr |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol |
title_full_unstemmed |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol |
title_sort |
Análisis histopatológico e histomorfométrico del intestino delgado en ratas wistar sometidas a la ingesta diaria de alcohol |
author |
Moraes, Thaís Santa Cruz |
author_facet |
Moraes, Thaís Santa Cruz Silveira, Sara Semaan Oliveira, Thiago Jardim de Mendonça, Adriana Rodrigues dos Anjos Maia, Paulo Roberto Mundim, Fiorita Gonzales Lopes Pereira, Rodrigo Machado |
author_role |
author |
author2 |
Silveira, Sara Semaan Oliveira, Thiago Jardim de Mendonça, Adriana Rodrigues dos Anjos Maia, Paulo Roberto Mundim, Fiorita Gonzales Lopes Pereira, Rodrigo Machado |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Moraes, Thaís Santa Cruz Silveira, Sara Semaan Oliveira, Thiago Jardim de Mendonça, Adriana Rodrigues dos Anjos Maia, Paulo Roberto Mundim, Fiorita Gonzales Lopes Pereira, Rodrigo Machado |
dc.subject.por.fl_str_mv |
Etanol Alcoholismo Intestino delgado Absorción Nutrición. Etanol Alcoolismo Intestino delgado Absorção Nutrição. Ethanol Alcoholism Small intestine Absorption Nutrition. |
topic |
Etanol Alcoholismo Intestino delgado Absorción Nutrición. Etanol Alcoolismo Intestino delgado Absorção Nutrição. Ethanol Alcoholism Small intestine Absorption Nutrition. |
description |
The excessive consumption of alcohol poses a significant public health concern due to its detrimental effects on individual well-being, particularly on the gastrointestinal (GI) tract. Chronic ethanol ingestion leads to morphological and functional alterations in the GI tract, affecting epithelial cells and resident microbial flora, thus impairing intestinal absorption. This study aimed to assess the impact of chronic ethanol consumption on small intestinal histological morphology. Animals were divided into control (water), 5% ethanol, and 20% ethanol groups, with 10 animals in each. Over 80 days, ethanol consumption was monitored ad libitum. Histopathological and histomorphometric analyses of the small intestine were conducted. Results revealed similar daily liquid consumption among the groups. However, alcoholic groups exhibited increased mononuclear cells, eosinophils, and villus degeneration compared to the control group. Ethanol-treated animals also displayed reduced villi extension, indicating structural damage to the intestine. Chronic ethanol consumption induced a chronic inflammatory pattern and deterioration of intestinal structures. In conclusion, regardless of alcohol content, chronic ethanol consumption adversely affects the gastrointestinal tract. This study underscores the importance of understanding the pathological effects of alcohol on the GI system and emphasizes the need for interventions to mitigate its impact on public health. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-03-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/45115 10.33448/rsd-v13i2.45115 |
url |
https://rsdjournal.org/index.php/rsd/article/view/45115 |
identifier_str_mv |
10.33448/rsd-v13i2.45115 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/45115/36027 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 13 No. 2; e13513245115 Research, Society and Development; Vol. 13 Núm. 2; e13513245115 Research, Society and Development; v. 13 n. 2; e13513245115 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052638311743488 |