Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/16989 |
Resumo: | Sjögren's Syndrome is an autoimmune disease, characterized by lymphocytic infiltration in the glandular epithelium, where it affects mainly the exocrine salivary and lacrimal glands. The study shows the classifications of the syndrome and the relation of autoantibodies related to its diagnosis. An integrative literature review was conducted, using articles published between the years 2010 and 2020, in Portuguese, English and Spanish languages that were published integrally in PubMed, SciELO and LILACS databases. Sicca syndrome is caused by genetic, environmental and hormonal factors. It affects mainly women with an average age of 56 years, where they have been suffering from hormonal imbalance. The autoimmune reaction is caused by the overstimulation of T cells and B cells that will stimulate hypergammaglobulinemia and the production of autoantibodies. In the long term the changes may mutate and lead to the development of non-Hodgkin lymphoma. The literature shows that the delay in diagnosis for Sjögren's Syndrome is due to the subtle symptoms that often go unnoticed or are confused with other pathologies. Anti-Ro and anti-La are the most frequent autoantibodies in patients with SS. |
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Pathophysiology of Sjögren's Syndrome and its diagnostic difficultyFisiopatología del Síndrome de Sjögren y su dificultad de diagnósticoFisiopatologia da Síndrome de Sjögren e sua dificuldade diagnósticaSíndrome de SjögrenAutoanticuerposGlándulas exócrinas.Síndrome de SjögrenAutoanticorposGlândulas exócrinas.Sjögren's SyndromeAutoantibodiesExocrine glands.Sjögren's Syndrome is an autoimmune disease, characterized by lymphocytic infiltration in the glandular epithelium, where it affects mainly the exocrine salivary and lacrimal glands. The study shows the classifications of the syndrome and the relation of autoantibodies related to its diagnosis. An integrative literature review was conducted, using articles published between the years 2010 and 2020, in Portuguese, English and Spanish languages that were published integrally in PubMed, SciELO and LILACS databases. Sicca syndrome is caused by genetic, environmental and hormonal factors. It affects mainly women with an average age of 56 years, where they have been suffering from hormonal imbalance. The autoimmune reaction is caused by the overstimulation of T cells and B cells that will stimulate hypergammaglobulinemia and the production of autoantibodies. In the long term the changes may mutate and lead to the development of non-Hodgkin lymphoma. The literature shows that the delay in diagnosis for Sjögren's Syndrome is due to the subtle symptoms that often go unnoticed or are confused with other pathologies. Anti-Ro and anti-La are the most frequent autoantibodies in patients with SS.El síndrome de Sjögren es una enfermedad autoinmune, caracterizada por la infiltración linfocítica en el epitelio glandular, donde afecta principalmente a las glándulas exocrinas salivales y lacrimales. El estudio muestra las clasificaciones del síndrome y la relación de los autoanticuerpos relacionados con su diagnóstico. Se realizó una revisión bibliográfica integradora a partir de artículos publicados entre los años 2010 y 2020, en los idiomas portugués, inglés y español que fueron publicados íntegramente en las bases de datos PubMed, SciELO y LILACS. El síndrome de la ''sicca'' está causado por factores genéticos, ambientales y hormonales. Afecta principalmente a las mujeres con una edad media de 56 años, que sufren un desequilibrio hormonal. La reacción autoinmune está causada por la sobreestimulación de las células T y B que estimularán la hipergammaglobulinemia y la producción de autoanticuerpos. A largo plazo, estas alteraciones pueden sufrir mutaciones que conduzcan al desarrollo de un linfoma no Hodgkin. La literatura muestra que el retraso en el diagnóstico del Síndrome de Sjögren se debe a los sutiles síntomas que muchas veces pasan desapercibidos o se confunden con otras patologías. El anti-Ro y el anti-La son los principales autoanticuerpos más frecuentes en pacientes con SS.A Síndrome de Sjögren é uma doença autoimune, caracterizada pela infiltração linfocitária no epitélio glandular, onde acomete principalmente as glândulas exócrinas salivares e lacrimais. O estudo mostra as classificações da síndrome e a relação dos autoanticorpos relacionados com seu diagnóstico. Foi realizada uma revisão de literatura integrativa, utilizando artigos publicados entre os anos de 2010 à 2020, nas línguas portuguesa, inglesa e espanhola que foram publicados de forma integra nos bancos de dados PubMed, SciELO e LILACS. A síndrome ‘’ Sicca’’ é causada por fatores genéticos, ambientais e hormonais. Acomete principalmente mulheres com idade média de 56 anos, onde vem sofrendo um desequilíbrio hormonal. A reação autoimune dar-se pela superestimulação das células T e células B que irão estimular a hipergamaglobulinemia e produção de autoanticorpos. A longo prazo as alterações podem sofrer mutações acarretando no desenvolvimento de linfoma não Hodgkin. A literatura mostra que o retardo do diagnóstico para a Síndrome de Sjögren dar-se pelos sutis sintomas que muitas vezes passam despercebidos ou são confundidos com outras patologias. O anti-Ro e o anti-La são os principais autoanticorpos mais frequentes em pacientes com SS.Research, Society and Development2021-06-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1698910.33448/rsd-v10i7.16989Research, Society and Development; Vol. 10 No. 7; e41010716989Research, Society and Development; Vol. 10 Núm. 7; e41010716989Research, Society and Development; v. 10 n. 7; e410107169892525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/16989/14950Copyright (c) 2021 Cassia Vilar de Araújo; Natália Millena Silva; Pâmella Grasielle Vital Dias de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAraújo, Cassia Vilar de Silva, Natália Millena Souza, Pâmella Grasielle Vital Dias de2021-07-18T21:07:03Zoai:ojs.pkp.sfu.ca:article/16989Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:24.008652Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty Fisiopatología del Síndrome de Sjögren y su dificultad de diagnóstico Fisiopatologia da Síndrome de Sjögren e sua dificuldade diagnóstica |
title |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty |
spellingShingle |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty Araújo, Cassia Vilar de Síndrome de Sjögren Autoanticuerpos Glándulas exócrinas. Síndrome de Sjögren Autoanticorpos Glândulas exócrinas. Sjögren's Syndrome Autoantibodies Exocrine glands. |
title_short |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty |
title_full |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty |
title_fullStr |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty |
title_full_unstemmed |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty |
title_sort |
Pathophysiology of Sjögren's Syndrome and its diagnostic difficulty |
author |
Araújo, Cassia Vilar de |
author_facet |
Araújo, Cassia Vilar de Silva, Natália Millena Souza, Pâmella Grasielle Vital Dias de |
author_role |
author |
author2 |
Silva, Natália Millena Souza, Pâmella Grasielle Vital Dias de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Araújo, Cassia Vilar de Silva, Natália Millena Souza, Pâmella Grasielle Vital Dias de |
dc.subject.por.fl_str_mv |
Síndrome de Sjögren Autoanticuerpos Glándulas exócrinas. Síndrome de Sjögren Autoanticorpos Glândulas exócrinas. Sjögren's Syndrome Autoantibodies Exocrine glands. |
topic |
Síndrome de Sjögren Autoanticuerpos Glándulas exócrinas. Síndrome de Sjögren Autoanticorpos Glândulas exócrinas. Sjögren's Syndrome Autoantibodies Exocrine glands. |
description |
Sjögren's Syndrome is an autoimmune disease, characterized by lymphocytic infiltration in the glandular epithelium, where it affects mainly the exocrine salivary and lacrimal glands. The study shows the classifications of the syndrome and the relation of autoantibodies related to its diagnosis. An integrative literature review was conducted, using articles published between the years 2010 and 2020, in Portuguese, English and Spanish languages that were published integrally in PubMed, SciELO and LILACS databases. Sicca syndrome is caused by genetic, environmental and hormonal factors. It affects mainly women with an average age of 56 years, where they have been suffering from hormonal imbalance. The autoimmune reaction is caused by the overstimulation of T cells and B cells that will stimulate hypergammaglobulinemia and the production of autoantibodies. In the long term the changes may mutate and lead to the development of non-Hodgkin lymphoma. The literature shows that the delay in diagnosis for Sjögren's Syndrome is due to the subtle symptoms that often go unnoticed or are confused with other pathologies. Anti-Ro and anti-La are the most frequent autoantibodies in patients with SS. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16989 10.33448/rsd-v10i7.16989 |
url |
https://rsdjournal.org/index.php/rsd/article/view/16989 |
identifier_str_mv |
10.33448/rsd-v10i7.16989 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16989/14950 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 7; e41010716989 Research, Society and Development; Vol. 10 Núm. 7; e41010716989 Research, Society and Development; v. 10 n. 7; e41010716989 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052751390179328 |