Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review

Detalhes bibliográficos
Autor(a) principal: Almeida, Paloma de Jesus
Data de Publicação: 2022
Outros Autores: Mera Lopez, Manuel Humberto, Araújo, Suzana Guimarães de, Lopes, Karla Braz, Borin, Maria de Fátima
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/38060
Resumo: Vitiligo is characterized by skin discoloration in different body regions, and its prevalence in the world population can reach 1%. Its cause is still undefined but possibly related to biochemical, environmental, immunological, and genetic events. In addition, individuals with vitiligo present electrolyte disturbances in the melanocytes, and it has been one of the targets of studies for treating this pathology. This systematic review aimed to gather and evaluate in vivo studies that described the mechanism of action of antioxidants in vitiligo. PubMed, Web of Science, Embase, Science Direct, LILACS, Open Grey and Google Scholar were used as research sources. The search included all articles up to October 16, 2021, with no start date restrictions. The search yielded 390 articles, and 7 of these were selected according to the inclusion criteria. The compounds studied in the articles selected for this review were curcumin, Cold Atmospheric Plasma, butin, galangin, 2',3,4,4'-tetrahydrochalcone and its derivatives, 6-benzylaminopurine, piperine, chrysin, kaempferol, scopoletin, vitamin D3, caffeic acid, and luteolin. The results showed that the main mechanisms of action of antioxidants in the treatment of vitiligo are the increase in tyrosinase activity by increasing the synthesis of TYR and TRP-1, the positive regulation of the number of epidermal cells, the redox balance, activation and regulation of MITF, and malondialdehyde and cholinesterase/acetylcholinesterase content. Thus, these pathways can be considered targets for evaluating different antioxidant compounds to act in treating vitiligo.
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spelling Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review Mecanismos de los antioxidantes en el tratamiento del vitíligo in vivo: una revisión sistemáticaMecanismos de antioxidantes no tratamento do vitiligo in vivo: uma revisão sistemáticaVitiligoAntioxidantsMolecular mechanisms of pharmacological actionBiological assaySystematic review.VitíligoAntioxidantesMecanismos moleculares de acción farmacológicaBioensayoRevisión sistemática.VitiligoAntioxidantesMecanismos moleculares de ação farmacológicaBioensaioRevisão sistemática.Vitiligo is characterized by skin discoloration in different body regions, and its prevalence in the world population can reach 1%. Its cause is still undefined but possibly related to biochemical, environmental, immunological, and genetic events. In addition, individuals with vitiligo present electrolyte disturbances in the melanocytes, and it has been one of the targets of studies for treating this pathology. This systematic review aimed to gather and evaluate in vivo studies that described the mechanism of action of antioxidants in vitiligo. PubMed, Web of Science, Embase, Science Direct, LILACS, Open Grey and Google Scholar were used as research sources. The search included all articles up to October 16, 2021, with no start date restrictions. The search yielded 390 articles, and 7 of these were selected according to the inclusion criteria. The compounds studied in the articles selected for this review were curcumin, Cold Atmospheric Plasma, butin, galangin, 2',3,4,4'-tetrahydrochalcone and its derivatives, 6-benzylaminopurine, piperine, chrysin, kaempferol, scopoletin, vitamin D3, caffeic acid, and luteolin. The results showed that the main mechanisms of action of antioxidants in the treatment of vitiligo are the increase in tyrosinase activity by increasing the synthesis of TYR and TRP-1, the positive regulation of the number of epidermal cells, the redox balance, activation and regulation of MITF, and malondialdehyde and cholinesterase/acetylcholinesterase content. Thus, these pathways can be considered targets for evaluating different antioxidant compounds to act in treating vitiligo.El vitíligo se caracteriza por la decoloración de la piel en diferentes regiones del cuerpo, y su prevalencia en la población mundial puede llegar al 1%. Su causa aún no está todo aclarada, pero posiblemente esté relacionada con eventos bioquímicos, ambientales, inmunológicos y genéticos. Además, las personas con vitíligo presentan alteraciones electrolíticas en sus melanocitos, y este ha sido uno de los objetivos de estudios para el tratamiento de esta patología. Esta revisión sistemática tuvo como objetivo recopilar y evaluar estudios in vivo que describieran el mecanismo de acción de los antioxidantes en el vitíligo. Se utilizaron como fuentes de investigación las bases de datos PubMed, Web of Science, Embase, Science Direct, LILACS, Open Grey y Google Scholar. La búsqueda incluyó todos los artículos hasta el 16 de octubre de 2021. La búsqueda resultó en 390 artículos, y 7 de estos fueron seleccionados de acuerdo con los criterios de inclusión. Los compuestos estudiados en los artículos seleccionados fueron curcumina, plasma atmosférico frío, butina, galangina, 2',3,4,4'-tetrahidrocalcona y sus derivados, 6-bencilaminopurina, piperina, crisina, kaempferol, escopoletina, vitamina D3, ácido cafeico y luteolina. Los resultados mostraron que los principales mecanismos de acción de los antioxidantes en el tratamiento del vitíligo son el aumento de la actividad tirosinasa al incrementar la síntesis de TYR y TRP-1, regulación positiva del número de células epidérmicas, balance redox, activación y regulación. de MITF, y contenido de malondialdehído y colinesterasa/acetilcolinesterasa. Estas vías pueden considerarse dianas para la evaluación de diferentes compuestos antioxidantes para actuar en el tratamiento del vitíligo.O vitiligo é caracterizado pela descoloração da pele em diferentes regiões do corpo, e sua prevalência na população mundial pode chegar a 1%. Sua causa ainda não está totalmente elucidada, mas possivelmente está relacionada a eventos bioquímicos, ambientais, imunológicos e genéticos. Além disso, indivíduos com vitiligo apresentam distúrbios eletrolíticos em seus melanócitos, e este tem sido um dos alvos de estudos para tratamento desta patologia. Esta revisão sistemática teve como objetivo reunir e avaliar estudos in vivo que descreveram o mecanismo de ação de antioxidantes no vitiligo. As bases de dados PubMed, Web of Science, Embase, Science Direct, LILACS, Open Grey e Google Scholar foram utilizadas como fonte de pesquisa. A busca incluiu todos os artigos até 16 de outubro de 2021, sem restrições de data de início. A pesquisa resultou em 390 artigos, e 7 desses foram selecionados de acordo com os critérios de inclusão. Os compostos estudados nos artigos selecionados foram curcumina, Cold Atmospheric Plasma, butina, galangina, 2',3,4,4'-tetrahidrochalcona e seus derivados, 6-benzilaminopurina, piperina, crisina, kaempferol, escopoletina, vitamina D3, ácido cafeico e luteolina. Os resultados demonstraram que os principais mecanismos de ação dos antioxidantes no tratamento do vitiligo são o aumento da atividade da tirosinase pelo aumento da síntese de TYR e TRP-1, a regulação positiva do número de células epidérmicas, o balanço redox, ativação e regulação do MITF, e conteúdo de malondialdeído e colinesterase/acetilcolinesterase. Assim, essas vias podem ser consideradas alvos para avaliação de diferentes compostos antioxidantes para atuar no tratamento do vitiligo.Research, Society and Development2022-12-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3806010.33448/rsd-v11i16.38060Research, Society and Development; Vol. 11 No. 16; e277111638060Research, Society and Development; Vol. 11 Núm. 16; e277111638060Research, Society and Development; v. 11 n. 16; e2771116380602525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/38060/31644Copyright (c) 2022 Paloma de Jesus Almeida; Manuel Humberto Mera Lopez; Suzana Guimarães de Araújo; Karla Braz Lopes; Maria de Fátima Borinhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAlmeida, Paloma de JesusMera Lopez, Manuel Humberto Araújo, Suzana Guimarães deLopes, Karla BrazBorin, Maria de Fátima2022-12-18T18:26:42Zoai:ojs.pkp.sfu.ca:article/38060Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:57.990350Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
Mecanismos de los antioxidantes en el tratamiento del vitíligo in vivo: una revisión sistemática
Mecanismos de antioxidantes no tratamento do vitiligo in vivo: uma revisão sistemática
title Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
spellingShingle Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
Almeida, Paloma de Jesus
Vitiligo
Antioxidants
Molecular mechanisms of pharmacological action
Biological assay
Systematic review.
Vitíligo
Antioxidantes
Mecanismos moleculares de acción farmacológica
Bioensayo
Revisión sistemática.
Vitiligo
Antioxidantes
Mecanismos moleculares de ação farmacológica
Bioensaio
Revisão sistemática.
title_short Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
title_full Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
title_fullStr Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
title_full_unstemmed Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
title_sort Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review
author Almeida, Paloma de Jesus
author_facet Almeida, Paloma de Jesus
Mera Lopez, Manuel Humberto
Araújo, Suzana Guimarães de
Lopes, Karla Braz
Borin, Maria de Fátima
author_role author
author2 Mera Lopez, Manuel Humberto
Araújo, Suzana Guimarães de
Lopes, Karla Braz
Borin, Maria de Fátima
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Paloma de Jesus
Mera Lopez, Manuel Humberto
Araújo, Suzana Guimarães de
Lopes, Karla Braz
Borin, Maria de Fátima
dc.subject.por.fl_str_mv Vitiligo
Antioxidants
Molecular mechanisms of pharmacological action
Biological assay
Systematic review.
Vitíligo
Antioxidantes
Mecanismos moleculares de acción farmacológica
Bioensayo
Revisión sistemática.
Vitiligo
Antioxidantes
Mecanismos moleculares de ação farmacológica
Bioensaio
Revisão sistemática.
topic Vitiligo
Antioxidants
Molecular mechanisms of pharmacological action
Biological assay
Systematic review.
Vitíligo
Antioxidantes
Mecanismos moleculares de acción farmacológica
Bioensayo
Revisión sistemática.
Vitiligo
Antioxidantes
Mecanismos moleculares de ação farmacológica
Bioensaio
Revisão sistemática.
description Vitiligo is characterized by skin discoloration in different body regions, and its prevalence in the world population can reach 1%. Its cause is still undefined but possibly related to biochemical, environmental, immunological, and genetic events. In addition, individuals with vitiligo present electrolyte disturbances in the melanocytes, and it has been one of the targets of studies for treating this pathology. This systematic review aimed to gather and evaluate in vivo studies that described the mechanism of action of antioxidants in vitiligo. PubMed, Web of Science, Embase, Science Direct, LILACS, Open Grey and Google Scholar were used as research sources. The search included all articles up to October 16, 2021, with no start date restrictions. The search yielded 390 articles, and 7 of these were selected according to the inclusion criteria. The compounds studied in the articles selected for this review were curcumin, Cold Atmospheric Plasma, butin, galangin, 2',3,4,4'-tetrahydrochalcone and its derivatives, 6-benzylaminopurine, piperine, chrysin, kaempferol, scopoletin, vitamin D3, caffeic acid, and luteolin. The results showed that the main mechanisms of action of antioxidants in the treatment of vitiligo are the increase in tyrosinase activity by increasing the synthesis of TYR and TRP-1, the positive regulation of the number of epidermal cells, the redox balance, activation and regulation of MITF, and malondialdehyde and cholinesterase/acetylcholinesterase content. Thus, these pathways can be considered targets for evaluating different antioxidant compounds to act in treating vitiligo.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/38060
10.33448/rsd-v11i16.38060
url https://rsdjournal.org/index.php/rsd/article/view/38060
identifier_str_mv 10.33448/rsd-v11i16.38060
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/38060/31644
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 16; e277111638060
Research, Society and Development; Vol. 11 Núm. 16; e277111638060
Research, Society and Development; v. 11 n. 16; e277111638060
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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