Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/29330 |
Resumo: | The objective of the present study was to evaluate the effect of selenium (Se) supplementation on oxidative stress in rat ovaries. For this purpose, 36 rats were divided into 3 groups (control group, group 1 - 48 μg of Se, and group 2 - 96 μg of Se), which underwent daily gavage with chelated selenium for 6 weeks, and then underwent total hysterectomy and subsequent total TIOL and TBARS dosage of the ovaries using spectrophotometry. As results, there was a statistically significant drop in TBARS levels between group 1 (3.07±3.19 nM) and group 2 (0.54±0.80 nM) (p=0.01). Regarding TIOL, there was no significant difference between the control group (51.05 ± 35.02 μg SH-NP. g tissue-1), group 1 (61.15 ± 33.47 μg SH-NP. g tissue-1) and group 2 (62.9 ± 18.04 μg SH-NP. g tissue-1) (p=0.883). It was concluded that selenium supplementation significantly reduced TBARS concentration in the ovary of rats and there was no statistically significant difference in ovarian TIOL levels between the groups. Therefore, selenium had an effect on some markers of oxidative stress. |
| id |
UNIFEI_b660e2af0bfdf9e0c8f93d687d782d27 |
|---|---|
| oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/29330 |
| network_acronym_str |
UNIFEI |
| network_name_str |
Research, Society and Development |
| repository_id_str |
|
| spelling |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovariesEvaluación de los efectos de la suplementación con selenio sobre el estrés oxidativo en ovarios de rataAvaliação dos efeitos da suplementação com selênio no estresse oxidativo em ovários de ratasEnsinoSelênioRatos WistarEstresse oxidativoOvário. TeachingSeleniumRats, WistarOxidative StressOvary.EnseñanzaSelenioRatas WistarEstrés OxidativoOvario.The objective of the present study was to evaluate the effect of selenium (Se) supplementation on oxidative stress in rat ovaries. For this purpose, 36 rats were divided into 3 groups (control group, group 1 - 48 μg of Se, and group 2 - 96 μg of Se), which underwent daily gavage with chelated selenium for 6 weeks, and then underwent total hysterectomy and subsequent total TIOL and TBARS dosage of the ovaries using spectrophotometry. As results, there was a statistically significant drop in TBARS levels between group 1 (3.07±3.19 nM) and group 2 (0.54±0.80 nM) (p=0.01). Regarding TIOL, there was no significant difference between the control group (51.05 ± 35.02 μg SH-NP. g tissue-1), group 1 (61.15 ± 33.47 μg SH-NP. g tissue-1) and group 2 (62.9 ± 18.04 μg SH-NP. g tissue-1) (p=0.883). It was concluded that selenium supplementation significantly reduced TBARS concentration in the ovary of rats and there was no statistically significant difference in ovarian TIOL levels between the groups. Therefore, selenium had an effect on some markers of oxidative stress.El objetivo del presente estudio fue evaluar el efecto de la suplementación con selenio (Se) sobre el estrés oxidativo en ovarios de rata. Para ello, se dividieron 36 ratas en 3 grupos (grupo de control, grupo 1 - 48 μg de Se, y grupo 2 - 96 μg de Se), que se sometieron a una gavación diaria con selenio quelado durante 6 semanas, y luego se sometieron a una histerectomía total y a la posterior dosificación total de TIOL y TBARS de los ovarios mediante espectrofotometría. Como resultados, hubo un descenso estadísticamente significativo en los niveles de TBARS entre el grupo 1 (3,07±3,19 nM) y el grupo 2 (0,54±0,80 nM) (p=0,01). En cuanto al TIOL, no hubo diferencias significativas entre el grupo de control (51,05 ± 35,02 μg SH-NP. g de tejido-1), el grupo 1 (61,15 ± 33,47 μg SH-NP. g de tejido-1) y el grupo 2 (62,9 ± 18,04 μg SH-NP. g de tejido-1) (p=0,883). Se concluyó que la suplementación con selenio redujo significativamente la concentración de TBARS en el ovario de las ratas y no hubo diferencias estadísticamente significativas en los niveles de TIOL en el ovario entre los grupos. Por lo tanto, el selenio tuvo un efecto sobre algunos marcadores de estrés oxidativo.O objetivo do presente trabalho foi avaliar o efeito da suplementação de selênio (Se) no estresse oxidativo de ovários de ratas. Para isso, 36 ratas foram divididas em 3 grupos (grupo controle, grupo 1 - 48 μg de Se, e grupo 2 - 96 μg de Se), que passaram por gavagem diária com selênio quelado durante 6 semanas, e em seguida foram submetidas a histerectomia total e subsequente dosagem total de TIOL e TBARS dos ovários utilizando espectrofotometria. Como resultados, houve queda estatisticamente significativa dos níveis de TBARS entre o grupo 1 (3,07±3,19 nM) e o grupo 2 (0,54±0,80 nM) (p=0,01). Em relação ao TIOL, não houve diferença significativa entre o grupo controle (51,05 ± 35,02 μg SH-NP. g tecido-1), o grupo 1 (61,15 ± 33,47 μg SH-NP. g tecido-1) e o grupo 2 (62,9 ± 18,04 μg SH-NP. g tecido-1) (p=0,883). Concluiu-se que a suplementação de selênio reduziu de forma significativa a concentração de TBARS no ovário de ratas e que não houve diferença estatisticamente significativa nos níveis de TIOL dos ovários entre os grupos. Portanto, o selênio exerceu efeito sobre alguns marcadores de estresse oxidativo. Research, Society and Development2022-04-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2933010.33448/rsd-v11i6.29330Research, Society and Development; Vol. 11 No. 6; e36111629330Research, Society and Development; Vol. 11 Núm. 6; e36111629330Research, Society and Development; v. 11 n. 6; e361116293302525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/29330/25295Copyright (c) 2022 Tiago Daniel Gueiber; André Amaro Mamédio dos Santos; Luiz Gustavo Lima; Matheus Von Jelita Salina; Vitor Hugo Moro Pironatto; Julia Kapp Lepinski; Guilherme Linha Secco; Jenifer Gabrielle Benitez; Camila Marinelli Martins; Ricardo Zanetti Gomeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGueiber, Tiago DanielSantos, André Amaro Mamédio dos Lima, Luiz Gustavo Salina, Matheus Von Jelita Pironatto, Vitor Hugo Moro Lepinski, Julia Kapp Secco, Guilherme Linha Benitez, Jenifer Gabrielle Martins, Camila Marinelli Gomes, Ricardo Zanetti 2022-05-13T18:04:10Zoai:ojs.pkp.sfu.ca:article/29330Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:26.876783Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries Evaluación de los efectos de la suplementación con selenio sobre el estrés oxidativo en ovarios de rata Avaliação dos efeitos da suplementação com selênio no estresse oxidativo em ovários de ratas |
| title |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries |
| spellingShingle |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries Gueiber, Tiago Daniel Ensino Selênio Ratos Wistar Estresse oxidativo Ovário. Teaching Selenium Rats, Wistar Oxidative Stress Ovary. Enseñanza Selenio Ratas Wistar Estrés Oxidativo Ovario. |
| title_short |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries |
| title_full |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries |
| title_fullStr |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries |
| title_full_unstemmed |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries |
| title_sort |
Evaluation of the effects of selenium supplementation on oxidative stress in rat ovaries |
| author |
Gueiber, Tiago Daniel |
| author_facet |
Gueiber, Tiago Daniel Santos, André Amaro Mamédio dos Lima, Luiz Gustavo Salina, Matheus Von Jelita Pironatto, Vitor Hugo Moro Lepinski, Julia Kapp Secco, Guilherme Linha Benitez, Jenifer Gabrielle Martins, Camila Marinelli Gomes, Ricardo Zanetti |
| author_role |
author |
| author2 |
Santos, André Amaro Mamédio dos Lima, Luiz Gustavo Salina, Matheus Von Jelita Pironatto, Vitor Hugo Moro Lepinski, Julia Kapp Secco, Guilherme Linha Benitez, Jenifer Gabrielle Martins, Camila Marinelli Gomes, Ricardo Zanetti |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gueiber, Tiago Daniel Santos, André Amaro Mamédio dos Lima, Luiz Gustavo Salina, Matheus Von Jelita Pironatto, Vitor Hugo Moro Lepinski, Julia Kapp Secco, Guilherme Linha Benitez, Jenifer Gabrielle Martins, Camila Marinelli Gomes, Ricardo Zanetti |
| dc.subject.por.fl_str_mv |
Ensino Selênio Ratos Wistar Estresse oxidativo Ovário. Teaching Selenium Rats, Wistar Oxidative Stress Ovary. Enseñanza Selenio Ratas Wistar Estrés Oxidativo Ovario. |
| topic |
Ensino Selênio Ratos Wistar Estresse oxidativo Ovário. Teaching Selenium Rats, Wistar Oxidative Stress Ovary. Enseñanza Selenio Ratas Wistar Estrés Oxidativo Ovario. |
| description |
The objective of the present study was to evaluate the effect of selenium (Se) supplementation on oxidative stress in rat ovaries. For this purpose, 36 rats were divided into 3 groups (control group, group 1 - 48 μg of Se, and group 2 - 96 μg of Se), which underwent daily gavage with chelated selenium for 6 weeks, and then underwent total hysterectomy and subsequent total TIOL and TBARS dosage of the ovaries using spectrophotometry. As results, there was a statistically significant drop in TBARS levels between group 1 (3.07±3.19 nM) and group 2 (0.54±0.80 nM) (p=0.01). Regarding TIOL, there was no significant difference between the control group (51.05 ± 35.02 μg SH-NP. g tissue-1), group 1 (61.15 ± 33.47 μg SH-NP. g tissue-1) and group 2 (62.9 ± 18.04 μg SH-NP. g tissue-1) (p=0.883). It was concluded that selenium supplementation significantly reduced TBARS concentration in the ovary of rats and there was no statistically significant difference in ovarian TIOL levels between the groups. Therefore, selenium had an effect on some markers of oxidative stress. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-04-30 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29330 10.33448/rsd-v11i6.29330 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/29330 |
| identifier_str_mv |
10.33448/rsd-v11i6.29330 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29330/25295 |
| dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Research, Society and Development |
| publisher.none.fl_str_mv |
Research, Society and Development |
| dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 6; e36111629330 Research, Society and Development; Vol. 11 Núm. 6; e36111629330 Research, Society and Development; v. 11 n. 6; e36111629330 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
| instname_str |
Universidade Federal de Itajubá (UNIFEI) |
| instacron_str |
UNIFEI |
| institution |
UNIFEI |
| reponame_str |
Research, Society and Development |
| collection |
Research, Society and Development |
| repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
| repository.mail.fl_str_mv |
rsd.articles@gmail.com |
| _version_ |
1797052711885078528 |