Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/36720 |
Resumo: | Butia catarinensis Noblick & Lorenzi, popularly known as “beach butiá”, is a species extensively used in the food area, but little explored regarding its toxicological safety and pharmacological potential. Therefore, the aim of this study was to evaluate whether the fixed oil of B. catarinensis (OFBc) promotes hemolysis in vitro and if it can increase the resistance of human erythrocytes to hemolysis (anti-hemolytic activity), and also to investigate whether it has antibacterial properties. The hemolytic, antihemolytic and antibacterial activities were described for the first time, respectively. For the study, human erythrocytes from healthy volunteers were isolated and incubated with different concentrations of the oil and Triton X-100 or 0, 24% NaCl as hemolysis inducers. OFBc showed low dose-dependent cytotoxicity to human erythrocytes. None of the concentrations exhibited cytoprotective effect nor inhibitory activity against the bacteria tested. In conclusion, the cytotoxicity screening performed in this study using the in vitro hemolysis assay suggests that the fixed oil of B. catarinensis may be pharmacologically safe for use in humans. |
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Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains Efectos del aceite fijo de Butia catarinensis Noblick & Lorenzi sobre la membrana de eritrocitos y cepas bacterianas Efeitos do óleo fixo de Butia catarinensis Noblick & Lorenzi sobre a membrana eritrocitária e cepas bacterianasArecaceaeHemolysisOsmotic FragilityTherapeutics.ArecaceaeHemólisisFragilidad OsmóticaTerapéutica.ArecaceaeHemóliseFragilidade OsmóticaTerapêutica.Butia catarinensis Noblick & Lorenzi, popularly known as “beach butiá”, is a species extensively used in the food area, but little explored regarding its toxicological safety and pharmacological potential. Therefore, the aim of this study was to evaluate whether the fixed oil of B. catarinensis (OFBc) promotes hemolysis in vitro and if it can increase the resistance of human erythrocytes to hemolysis (anti-hemolytic activity), and also to investigate whether it has antibacterial properties. The hemolytic, antihemolytic and antibacterial activities were described for the first time, respectively. For the study, human erythrocytes from healthy volunteers were isolated and incubated with different concentrations of the oil and Triton X-100 or 0, 24% NaCl as hemolysis inducers. OFBc showed low dose-dependent cytotoxicity to human erythrocytes. None of the concentrations exhibited cytoprotective effect nor inhibitory activity against the bacteria tested. In conclusion, the cytotoxicity screening performed in this study using the in vitro hemolysis assay suggests that the fixed oil of B. catarinensis may be pharmacologically safe for use in humans.Butia catarinensis Noblick & Lorenzi, conocida popularmente como butiá-da-praia, es una especie ampliamente utilizada en el sector alimentario, pero poco explorada en cuanto a su seguridad toxicológica y potencial farmacológico. Por lo tanto, el objetivo de este estudio fue evaluar si el aceite fijo de B. catarinensis (OFBc) promueve la hemólisis in vitro y puede aumentar la resistencia de los eritrocitos humanos a la hemólisis (actividad antihemolítica), además de investigar si tiene propiedades antibacterianas. Las actividades hemolítica, anti-hemolítica y antibacteriana se describieron por primera vez, respectivamente. Para el estudio, se aislaron eritrocitos humanos de voluntarios sanos y se incubaron con diferentes concentraciones del aceite y Triton X-100 o NaCl al 0, 24 % como inductores de hemólisis. OFBc mostró una citotoxicidad dependiente de la dosis baja para los glóbulos rojos humanos. Ninguna de las concentraciones exhibió efecto citoprotector o actividad inhibitoria contra las bacterias ensayadas. En conclusión, la detección de citotoxicidad realizada en este estudio a través del ensayo de hemólisis in vitro sugiere que el aceite fijado de B. catarinensis puede ser farmacológicamente seguro para su uso en humanos.Butia catarinensis Noblick & Lorenzi, popularmente conhecida como butiá-da-praia, é uma espécie extensivamente utilizada na área alimentícia, mas pouco explorada quanto a sua segurança toxicológica e potencial farmacológico. Logo, o objetivo deste estudo foi avaliar se o óleo de fixo de B. catarinensis (OFBc) promove hemólise in vitro e pode aumentar a resistência dos eritrócitos humanos à hemólise (atividade anti-hemolítica), além de investigar se possui propriedades antibacterianas. As atividades hemolítica, anti-hemolítica e antibacteriana foram descritas pela primeira vez, respectivamente. Para o estudo, eritrócitos humanos de voluntários saudáveis foram isolados e incubados com diferentes concentrações do óleo e Triton X-100 ou NaCl 0, 24% como indutores de hemólise. O OFBc mostrou baixa citotoxicidade dose-dependente para hemácias humanas. Nenhuma das concentrações exibiu efeito citoprotetor e nem atividade inibitória frente as bactérias testadas. Em conclusão, a triagem de citotoxicidade realizada neste estudo através do ensaio de hemólise in vitro, sugere que o óleo fixo de B. catarinensis pode ser seguro farmacologicamente para uso em seres humanos. Research, Society and Development2022-11-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3672010.33448/rsd-v11i15.36720Research, Society and Development; Vol. 11 No. 15; e24111536720Research, Society and Development; Vol. 11 Núm. 15; e24111536720Research, Society and Development; v. 11 n. 15; e241115367202525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/36720/30733Copyright (c) 2022 Nabuêr Francieli da Silva; Gisele Nayara Bezerra da Silva; Elvis Bezerra Santos; João Paulo Cristovam Leite dos Santos; Maria Tamires Alves Espindola; Sammara Drinny de Siqueira Correia; Elisângela Ramos Castanha; Márcia Vanusa da Silva; Rosângela Estevão Alves Falcão ; Maria Tereza dos Santos Correia https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Nabuêr Francieli daSilva, Gisele Nayara Bezerra daSantos, Elvis Bezerra Santos, João Paulo Cristovam Leite dosEspindola, Maria Tamires Alves Correia, Sammara Drinny de Siqueira Castanha, Elisângela Ramos Silva, Márcia Vanusa daFalcão , Rosângela Estevão AlvesCorreia , Maria Tereza dos Santos 2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/36720Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:09.974684Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains Efectos del aceite fijo de Butia catarinensis Noblick & Lorenzi sobre la membrana de eritrocitos y cepas bacterianas Efeitos do óleo fixo de Butia catarinensis Noblick & Lorenzi sobre a membrana eritrocitária e cepas bacterianas |
title |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains |
spellingShingle |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains Silva, Nabuêr Francieli da Arecaceae Hemolysis Osmotic Fragility Therapeutics. Arecaceae Hemólisis Fragilidad Osmótica Terapéutica. Arecaceae Hemólise Fragilidade Osmótica Terapêutica. |
title_short |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains |
title_full |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains |
title_fullStr |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains |
title_full_unstemmed |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains |
title_sort |
Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains |
author |
Silva, Nabuêr Francieli da |
author_facet |
Silva, Nabuêr Francieli da Silva, Gisele Nayara Bezerra da Santos, Elvis Bezerra Santos, João Paulo Cristovam Leite dos Espindola, Maria Tamires Alves Correia, Sammara Drinny de Siqueira Castanha, Elisângela Ramos Silva, Márcia Vanusa da Falcão , Rosângela Estevão Alves Correia , Maria Tereza dos Santos |
author_role |
author |
author2 |
Silva, Gisele Nayara Bezerra da Santos, Elvis Bezerra Santos, João Paulo Cristovam Leite dos Espindola, Maria Tamires Alves Correia, Sammara Drinny de Siqueira Castanha, Elisângela Ramos Silva, Márcia Vanusa da Falcão , Rosângela Estevão Alves Correia , Maria Tereza dos Santos |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Nabuêr Francieli da Silva, Gisele Nayara Bezerra da Santos, Elvis Bezerra Santos, João Paulo Cristovam Leite dos Espindola, Maria Tamires Alves Correia, Sammara Drinny de Siqueira Castanha, Elisângela Ramos Silva, Márcia Vanusa da Falcão , Rosângela Estevão Alves Correia , Maria Tereza dos Santos |
dc.subject.por.fl_str_mv |
Arecaceae Hemolysis Osmotic Fragility Therapeutics. Arecaceae Hemólisis Fragilidad Osmótica Terapéutica. Arecaceae Hemólise Fragilidade Osmótica Terapêutica. |
topic |
Arecaceae Hemolysis Osmotic Fragility Therapeutics. Arecaceae Hemólisis Fragilidad Osmótica Terapéutica. Arecaceae Hemólise Fragilidade Osmótica Terapêutica. |
description |
Butia catarinensis Noblick & Lorenzi, popularly known as “beach butiá”, is a species extensively used in the food area, but little explored regarding its toxicological safety and pharmacological potential. Therefore, the aim of this study was to evaluate whether the fixed oil of B. catarinensis (OFBc) promotes hemolysis in vitro and if it can increase the resistance of human erythrocytes to hemolysis (anti-hemolytic activity), and also to investigate whether it has antibacterial properties. The hemolytic, antihemolytic and antibacterial activities were described for the first time, respectively. For the study, human erythrocytes from healthy volunteers were isolated and incubated with different concentrations of the oil and Triton X-100 or 0, 24% NaCl as hemolysis inducers. OFBc showed low dose-dependent cytotoxicity to human erythrocytes. None of the concentrations exhibited cytoprotective effect nor inhibitory activity against the bacteria tested. In conclusion, the cytotoxicity screening performed in this study using the in vitro hemolysis assay suggests that the fixed oil of B. catarinensis may be pharmacologically safe for use in humans. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/36720 10.33448/rsd-v11i15.36720 |
url |
https://rsdjournal.org/index.php/rsd/article/view/36720 |
identifier_str_mv |
10.33448/rsd-v11i15.36720 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/36720/30733 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 15; e24111536720 Research, Society and Development; Vol. 11 Núm. 15; e24111536720 Research, Society and Development; v. 11 n. 15; e24111536720 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052727845453824 |