Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains

Detalhes bibliográficos
Autor(a) principal: Silva, Nabuêr Francieli da
Data de Publicação: 2022
Outros Autores: Silva, Gisele Nayara Bezerra da, Santos, Elvis Bezerra, Santos, João Paulo Cristovam Leite dos, Espindola, Maria Tamires Alves, Correia, Sammara Drinny de Siqueira, Castanha, Elisângela Ramos, Silva, Márcia Vanusa da, Falcão , Rosângela Estevão Alves, Correia , Maria Tereza dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/36720
Resumo: Butia catarinensis Noblick & Lorenzi, popularly known as “beach butiá”, is a species extensively used in the food area, but little explored regarding its toxicological safety and pharmacological potential. Therefore, the aim of this study was to evaluate whether the fixed oil of B. catarinensis (OFBc) promotes hemolysis in vitro and if it can increase the resistance of human erythrocytes to hemolysis (anti-hemolytic activity), and also to investigate whether it has antibacterial properties. The hemolytic, antihemolytic and antibacterial activities were described for the first time, respectively. For the study, human erythrocytes from healthy volunteers were isolated and incubated with different concentrations of the oil and Triton X-100 or 0, 24% NaCl as hemolysis inducers. OFBc showed low dose-dependent cytotoxicity to human erythrocytes. None of the concentrations exhibited cytoprotective effect nor inhibitory activity against the bacteria tested. In conclusion, the cytotoxicity screening performed in this study using the in vitro hemolysis assay suggests that the fixed oil of B. catarinensis may be pharmacologically safe for use in humans.
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spelling Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains Efectos del aceite fijo de Butia catarinensis Noblick & Lorenzi sobre la membrana de eritrocitos y cepas bacterianas Efeitos do óleo fixo de Butia catarinensis Noblick & Lorenzi sobre a membrana eritrocitária e cepas bacterianasArecaceaeHemolysisOsmotic FragilityTherapeutics.ArecaceaeHemólisisFragilidad OsmóticaTerapéutica.ArecaceaeHemóliseFragilidade OsmóticaTerapêutica.Butia catarinensis Noblick & Lorenzi, popularly known as “beach butiá”, is a species extensively used in the food area, but little explored regarding its toxicological safety and pharmacological potential. Therefore, the aim of this study was to evaluate whether the fixed oil of B. catarinensis (OFBc) promotes hemolysis in vitro and if it can increase the resistance of human erythrocytes to hemolysis (anti-hemolytic activity), and also to investigate whether it has antibacterial properties. The hemolytic, antihemolytic and antibacterial activities were described for the first time, respectively. For the study, human erythrocytes from healthy volunteers were isolated and incubated with different concentrations of the oil and Triton X-100 or 0, 24% NaCl as hemolysis inducers. OFBc showed low dose-dependent cytotoxicity to human erythrocytes. None of the concentrations exhibited cytoprotective effect nor inhibitory activity against the bacteria tested. In conclusion, the cytotoxicity screening performed in this study using the in vitro hemolysis assay suggests that the fixed oil of B. catarinensis may be pharmacologically safe for use in humans.Butia catarinensis Noblick & Lorenzi, conocida popularmente como butiá-da-praia, es una especie ampliamente utilizada en el sector alimentario, pero poco explorada en cuanto a su seguridad toxicológica y potencial farmacológico. Por lo tanto, el objetivo de este estudio fue evaluar si el aceite fijo de B. catarinensis (OFBc) promueve la hemólisis in vitro y puede aumentar la resistencia de los eritrocitos humanos a la hemólisis (actividad antihemolítica), además de investigar si tiene propiedades antibacterianas. Las actividades hemolítica, anti-hemolítica y antibacteriana se describieron por primera vez, respectivamente. Para el estudio, se aislaron eritrocitos humanos de voluntarios sanos y se incubaron con diferentes concentraciones del aceite y Triton X-100 o NaCl al 0, 24 % como inductores de hemólisis. OFBc mostró una citotoxicidad dependiente de la dosis baja para los glóbulos rojos humanos. Ninguna de las concentraciones exhibió efecto citoprotector o actividad inhibitoria contra las bacterias ensayadas. En conclusión, la detección de citotoxicidad realizada en este estudio a través del ensayo de hemólisis in vitro sugiere que el aceite fijado de B. catarinensis puede ser farmacológicamente seguro para su uso en humanos.Butia catarinensis Noblick & Lorenzi, popularmente conhecida como butiá-da-praia, é uma espécie extensivamente utilizada na área alimentícia, mas pouco explorada quanto a sua segurança toxicológica e potencial farmacológico. Logo, o objetivo deste estudo foi avaliar se o óleo de fixo de B. catarinensis (OFBc) promove hemólise in vitro e pode aumentar a resistência dos eritrócitos humanos à hemólise (atividade anti-hemolítica), além de investigar se possui propriedades antibacterianas. As atividades hemolítica, anti-hemolítica e antibacteriana foram descritas pela primeira vez, respectivamente. Para o estudo, eritrócitos humanos de voluntários saudáveis foram isolados e incubados com diferentes concentrações do óleo e Triton X-100 ou NaCl 0, 24% como indutores de hemólise. O OFBc mostrou baixa citotoxicidade dose-dependente para hemácias humanas. Nenhuma das concentrações exibiu efeito citoprotetor e nem atividade inibitória frente as bactérias testadas. Em conclusão, a triagem de citotoxicidade realizada neste estudo através do ensaio de hemólise in vitro, sugere que o óleo fixo de B. catarinensis pode ser seguro farmacologicamente para uso em seres humanos. Research, Society and Development2022-11-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3672010.33448/rsd-v11i15.36720Research, Society and Development; Vol. 11 No. 15; e24111536720Research, Society and Development; Vol. 11 Núm. 15; e24111536720Research, Society and Development; v. 11 n. 15; e241115367202525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/36720/30733Copyright (c) 2022 Nabuêr Francieli da Silva; Gisele Nayara Bezerra da Silva; Elvis Bezerra Santos; João Paulo Cristovam Leite dos Santos; Maria Tamires Alves Espindola; Sammara Drinny de Siqueira Correia; Elisângela Ramos Castanha; Márcia Vanusa da Silva; Rosângela Estevão Alves Falcão ; Maria Tereza dos Santos Correia https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Nabuêr Francieli daSilva, Gisele Nayara Bezerra daSantos, Elvis Bezerra Santos, João Paulo Cristovam Leite dosEspindola, Maria Tamires Alves Correia, Sammara Drinny de Siqueira Castanha, Elisângela Ramos Silva, Márcia Vanusa daFalcão , Rosângela Estevão AlvesCorreia , Maria Tereza dos Santos 2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/36720Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:09.974684Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
Efectos del aceite fijo de Butia catarinensis Noblick & Lorenzi sobre la membrana de eritrocitos y cepas bacterianas
Efeitos do óleo fixo de Butia catarinensis Noblick & Lorenzi sobre a membrana eritrocitária e cepas bacterianas
title Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
spellingShingle Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
Silva, Nabuêr Francieli da
Arecaceae
Hemolysis
Osmotic Fragility
Therapeutics.
Arecaceae
Hemólisis
Fragilidad Osmótica
Terapéutica.
Arecaceae
Hemólise
Fragilidade Osmótica
Terapêutica.
title_short Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
title_full Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
title_fullStr Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
title_full_unstemmed Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
title_sort Effects of the fixed oil of Butia catarinensis Noblick & Lorenzi on the erythrocyte membrane and bacterial strains
author Silva, Nabuêr Francieli da
author_facet Silva, Nabuêr Francieli da
Silva, Gisele Nayara Bezerra da
Santos, Elvis Bezerra
Santos, João Paulo Cristovam Leite dos
Espindola, Maria Tamires Alves
Correia, Sammara Drinny de Siqueira
Castanha, Elisângela Ramos
Silva, Márcia Vanusa da
Falcão , Rosângela Estevão Alves
Correia , Maria Tereza dos Santos
author_role author
author2 Silva, Gisele Nayara Bezerra da
Santos, Elvis Bezerra
Santos, João Paulo Cristovam Leite dos
Espindola, Maria Tamires Alves
Correia, Sammara Drinny de Siqueira
Castanha, Elisângela Ramos
Silva, Márcia Vanusa da
Falcão , Rosângela Estevão Alves
Correia , Maria Tereza dos Santos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Nabuêr Francieli da
Silva, Gisele Nayara Bezerra da
Santos, Elvis Bezerra
Santos, João Paulo Cristovam Leite dos
Espindola, Maria Tamires Alves
Correia, Sammara Drinny de Siqueira
Castanha, Elisângela Ramos
Silva, Márcia Vanusa da
Falcão , Rosângela Estevão Alves
Correia , Maria Tereza dos Santos
dc.subject.por.fl_str_mv Arecaceae
Hemolysis
Osmotic Fragility
Therapeutics.
Arecaceae
Hemólisis
Fragilidad Osmótica
Terapéutica.
Arecaceae
Hemólise
Fragilidade Osmótica
Terapêutica.
topic Arecaceae
Hemolysis
Osmotic Fragility
Therapeutics.
Arecaceae
Hemólisis
Fragilidad Osmótica
Terapéutica.
Arecaceae
Hemólise
Fragilidade Osmótica
Terapêutica.
description Butia catarinensis Noblick & Lorenzi, popularly known as “beach butiá”, is a species extensively used in the food area, but little explored regarding its toxicological safety and pharmacological potential. Therefore, the aim of this study was to evaluate whether the fixed oil of B. catarinensis (OFBc) promotes hemolysis in vitro and if it can increase the resistance of human erythrocytes to hemolysis (anti-hemolytic activity), and also to investigate whether it has antibacterial properties. The hemolytic, antihemolytic and antibacterial activities were described for the first time, respectively. For the study, human erythrocytes from healthy volunteers were isolated and incubated with different concentrations of the oil and Triton X-100 or 0, 24% NaCl as hemolysis inducers. OFBc showed low dose-dependent cytotoxicity to human erythrocytes. None of the concentrations exhibited cytoprotective effect nor inhibitory activity against the bacteria tested. In conclusion, the cytotoxicity screening performed in this study using the in vitro hemolysis assay suggests that the fixed oil of B. catarinensis may be pharmacologically safe for use in humans.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/36720
10.33448/rsd-v11i15.36720
url https://rsdjournal.org/index.php/rsd/article/view/36720
identifier_str_mv 10.33448/rsd-v11i15.36720
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/36720/30733
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 15; e24111536720
Research, Society and Development; Vol. 11 Núm. 15; e24111536720
Research, Society and Development; v. 11 n. 15; e24111536720
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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