Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/23547 |
Resumo: | Introduction: Aids is a disease characterized by a deficiency of the immune system and which, in the past, brought great social stigma and low life expectancy to its patients. Associated with the increase in life expectancy, new health issues emerged among this population related to both aging and the vulnerability of HIV, which resulted in the inherent complexity of the pharmacological management of these diseases concomitant with antiretroviral therapy and their inadvertent iatrogenic risks, thus highlighting the interaction between Ritonavir. Method: A literature review was carried out in the online databases of the Virtual Health Library (VHL), using the descriptors: "Iatrogenic Cushing's syndrome" AND “HIV” from 2011 to 2021. Results and discussion: 24 articles found, 2 were literature reviews with an approach to the relationship between HIV and iatrogenic Cushing's syndrome and 22 corresponded to case reports that had based on patients with HIV in association with chronic diseases developed by age, with emphasis on musculoskeletal, respiratory and rheumatological disorders. Due to this combination, polypharmacy was applied, with the use of corticosteroids and antiretroviral therapy with Ritonavir the convergent pharmacological factor among all cases, as well as the main clinical manifestation: Cushing's Syndrome. Conclusion: It was noted that the use of exogenous glucocorticoids, like Triamcinolone, Fluticasone and Budesonide stand out, which interact with Ritonavir, in patients taking antiretroviral therapy for HIV can induce clinical presentations of Cushing's syndrome. |
id |
UNIFEI_bcd6785761013c5f68d23494454391f2 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/23547 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavirSíndrome de Cushing iatrogénico en pacientes con VIH: análisis de la interacción farmacológica entre esteroides y ritonavirSíndrome de Cushing iatrogênica em pacientes com HIV: análise da interação farmacológica entre esteróides e ritonavirEndocrinologíaSíndrome de CushingVIH.Cushing's SyndromeEndocrinologyHIV.EndocrinologiaHIVSíndrome de Cushing.Introduction: Aids is a disease characterized by a deficiency of the immune system and which, in the past, brought great social stigma and low life expectancy to its patients. Associated with the increase in life expectancy, new health issues emerged among this population related to both aging and the vulnerability of HIV, which resulted in the inherent complexity of the pharmacological management of these diseases concomitant with antiretroviral therapy and their inadvertent iatrogenic risks, thus highlighting the interaction between Ritonavir. Method: A literature review was carried out in the online databases of the Virtual Health Library (VHL), using the descriptors: "Iatrogenic Cushing's syndrome" AND “HIV” from 2011 to 2021. Results and discussion: 24 articles found, 2 were literature reviews with an approach to the relationship between HIV and iatrogenic Cushing's syndrome and 22 corresponded to case reports that had based on patients with HIV in association with chronic diseases developed by age, with emphasis on musculoskeletal, respiratory and rheumatological disorders. Due to this combination, polypharmacy was applied, with the use of corticosteroids and antiretroviral therapy with Ritonavir the convergent pharmacological factor among all cases, as well as the main clinical manifestation: Cushing's Syndrome. Conclusion: It was noted that the use of exogenous glucocorticoids, like Triamcinolone, Fluticasone and Budesonide stand out, which interact with Ritonavir, in patients taking antiretroviral therapy for HIV can induce clinical presentations of Cushing's syndrome.Introducción: El sida es una enfermedad caracterizada por una deficiencia del sistema inmunológico y que, en el pasado, trajo un gran estigma social y una baja esperanza de vida a sus pacientes. Asociados con el aumento de la esperanza de vida, surgieron nuevos problemas de salud en esta población relacionados tanto con el envejecimiento como con la vulnerabilidad del VIH, que derivaron en la complejidad inherente del manejo farmacológico de estas enfermedades concomitantes con terapia antirretroviral y sus riesgos iatrogénicos inadvertidos, destacando así la interacción entre ritonavir. Método: Se realizó una revisión de la literatura en las bases de datos en línea de la Biblioteca Virtual en Salud (BVS), utilizando los descriptores: "Síndrome de Cushing iatrogénico" Y "VIH" de 2011 a 2021. Resultados y discusión: 24 artículos fueron encontrados, 2 fueron revisiones de literatura con un abordaje de la relación entre VIH y síndrome de Cushing iatrogénico y 22 correspondieron a reportes de casos que se habían basado en pacientes con VIH en asociación con enfermedades crónicas desarrolladas por edad, con énfasis sobre trastornos musculoesqueléticos, respiratorios y reumatológicos. Debido a esta combinación se aplicó polifarmacia, con el uso de corticoides y terapia antirretroviral con ritonavir el factor farmacológico convergente entre todos los casos, así como la principal manifestación clínica: el síndrome de Cushing. Conclusión: Se observó que el uso de glucocorticoides exógenos, como Triamcinolona, Fluticasona y Budesonida, que interactúan con ritonavir, en pacientes que toman terapia antirretroviral para el VIH puede inducir presentaciones clínicas del síndrome de Cushing.Introdução: A Aids é uma doença que se caracteriza pela deficiência do sistema imunológico e que, no passado, trouxe para os seus portadores grande estigma social e baixa expectativa de vida. Com o aumento da expectativa de vida, surgiram novas questões de saúde dentre essa população relacionadas tanto ao envelhecimento quanto ao quadro de vulnerabilidade do HIV, o que resultou na complexidade inerente ao manejo farmacológico de doenças concomitante à terapia antirretroviral e seus riscos iatrogênicos inadvertidos, destacando-se assim a interação entre o Ritonavir. Método: Foi realizada uma revisão de literatura nas bases de dados on-line da Biblioteca Virtual em Saúde (BVS), com a utilização dos descritores: “Iatrogenic Cushing´s syndrome” AND “HIV” de 2011 a 2021. Resultados e discussão: 24 artigos foram encontrados, 2 eram revisões de literatura com abordagem sobre a relação entre o HIV e a síndrome de Cushing iatrogênica e 22 correspondiam a relatos de caso que tinham por base pacientes portadores de HIV em associação a doenças crônicas desenvolvidas pela idade, com destaque para as afecções osteomusculares, respiratórias e reumatológicas. Em função dessa combinação, a polifarmácia era aplicada, sendo o uso de corticoides e a terapia antirretroviral com o Ritonavir o fator farmacológico convergente entre todos os casos, bem como a principal manifestação clínica: A Síndrome de Cushing. Conclusão: Notou-se que o uso de glicocorticóides exógenos, como Triancinolona, Fluticasona e a Budesonida, que interagem com o Ritonavir, em pacientes que fazem uso de terapia antirretroviral do HIV pode induzir quadros clínicos da síndrome de Cushing.Research, Society and Development2021-12-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2354710.33448/rsd-v10i17.23547Research, Society and Development; Vol. 10 No. 17; e34101723547Research, Society and Development; Vol. 10 Núm. 17; e34101723547Research, Society and Development; v. 10 n. 17; e341017235472525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23547/21326Copyright (c) 2021 Ana Carolina Sardo de Oliveira Pinheiro; Beatriz Sayuri Vieira Ishigaki; Mariana Cristina Santos Andrade; Arthur Cesar Batista Rodrigues; Matheus Levy da Costa Freitas; Gabriel de Sá Sastre; Silas José Guimarães Pantoja Cardoso; Bárbara Maria Paiva Corrêa; Jhonatan Lucas Ferreira Borges; André Luiz Cardoso Cardoso; Thiago Santos Hirosehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPinheiro, Ana Carolina Sardo de Oliveira Ishigaki, Beatriz Sayuri Vieira Andrade, Mariana Cristina Santos Rodrigues, Arthur Cesar Batista Freitas, Matheus Levy da Costa Sastre, Gabriel de Sá Cardoso, Silas José Guimarães Pantoja Corrêa, Bárbara Maria Paiva Borges, Jhonatan Lucas Ferreira Cardoso, André Luiz Cardoso Hirose, Thiago Santos 2022-01-01T11:11:08Zoai:ojs.pkp.sfu.ca:article/23547Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:23.077788Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir Síndrome de Cushing iatrogénico en pacientes con VIH: análisis de la interacción farmacológica entre esteroides y ritonavir Síndrome de Cushing iatrogênica em pacientes com HIV: análise da interação farmacológica entre esteróides e ritonavir |
title |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir |
spellingShingle |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir Pinheiro, Ana Carolina Sardo de Oliveira Endocrinología Síndrome de Cushing VIH. Cushing's Syndrome Endocrinology HIV. Endocrinologia HIV Síndrome de Cushing. |
title_short |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir |
title_full |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir |
title_fullStr |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir |
title_full_unstemmed |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir |
title_sort |
Iatrogenic Cushing syndrome in HIV patients: analysis of the pharmacological interaction between steroids and ritonavir |
author |
Pinheiro, Ana Carolina Sardo de Oliveira |
author_facet |
Pinheiro, Ana Carolina Sardo de Oliveira Ishigaki, Beatriz Sayuri Vieira Andrade, Mariana Cristina Santos Rodrigues, Arthur Cesar Batista Freitas, Matheus Levy da Costa Sastre, Gabriel de Sá Cardoso, Silas José Guimarães Pantoja Corrêa, Bárbara Maria Paiva Borges, Jhonatan Lucas Ferreira Cardoso, André Luiz Cardoso Hirose, Thiago Santos |
author_role |
author |
author2 |
Ishigaki, Beatriz Sayuri Vieira Andrade, Mariana Cristina Santos Rodrigues, Arthur Cesar Batista Freitas, Matheus Levy da Costa Sastre, Gabriel de Sá Cardoso, Silas José Guimarães Pantoja Corrêa, Bárbara Maria Paiva Borges, Jhonatan Lucas Ferreira Cardoso, André Luiz Cardoso Hirose, Thiago Santos |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pinheiro, Ana Carolina Sardo de Oliveira Ishigaki, Beatriz Sayuri Vieira Andrade, Mariana Cristina Santos Rodrigues, Arthur Cesar Batista Freitas, Matheus Levy da Costa Sastre, Gabriel de Sá Cardoso, Silas José Guimarães Pantoja Corrêa, Bárbara Maria Paiva Borges, Jhonatan Lucas Ferreira Cardoso, André Luiz Cardoso Hirose, Thiago Santos |
dc.subject.por.fl_str_mv |
Endocrinología Síndrome de Cushing VIH. Cushing's Syndrome Endocrinology HIV. Endocrinologia HIV Síndrome de Cushing. |
topic |
Endocrinología Síndrome de Cushing VIH. Cushing's Syndrome Endocrinology HIV. Endocrinologia HIV Síndrome de Cushing. |
description |
Introduction: Aids is a disease characterized by a deficiency of the immune system and which, in the past, brought great social stigma and low life expectancy to its patients. Associated with the increase in life expectancy, new health issues emerged among this population related to both aging and the vulnerability of HIV, which resulted in the inherent complexity of the pharmacological management of these diseases concomitant with antiretroviral therapy and their inadvertent iatrogenic risks, thus highlighting the interaction between Ritonavir. Method: A literature review was carried out in the online databases of the Virtual Health Library (VHL), using the descriptors: "Iatrogenic Cushing's syndrome" AND “HIV” from 2011 to 2021. Results and discussion: 24 articles found, 2 were literature reviews with an approach to the relationship between HIV and iatrogenic Cushing's syndrome and 22 corresponded to case reports that had based on patients with HIV in association with chronic diseases developed by age, with emphasis on musculoskeletal, respiratory and rheumatological disorders. Due to this combination, polypharmacy was applied, with the use of corticosteroids and antiretroviral therapy with Ritonavir the convergent pharmacological factor among all cases, as well as the main clinical manifestation: Cushing's Syndrome. Conclusion: It was noted that the use of exogenous glucocorticoids, like Triamcinolone, Fluticasone and Budesonide stand out, which interact with Ritonavir, in patients taking antiretroviral therapy for HIV can induce clinical presentations of Cushing's syndrome. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/23547 10.33448/rsd-v10i17.23547 |
url |
https://rsdjournal.org/index.php/rsd/article/view/23547 |
identifier_str_mv |
10.33448/rsd-v10i17.23547 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/23547/21326 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 17; e34101723547 Research, Society and Development; Vol. 10 Núm. 17; e34101723547 Research, Society and Development; v. 10 n. 17; e34101723547 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052698094206976 |