Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible

Detalhes bibliográficos
Autor(a) principal: Balderrama, Ísis de Fátima
Data de Publicação: 2021
Outros Autores: Ferreira, Rafael, Leão, Moira Pedroso, Marcantonio-Júnior, Elcio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/15900
Resumo: Objectives: This literature review aimed to perform a strategic search for scientific articles on the applicability of adipose tissue stem cells associated with grafts in bone regeneration surgeries in the maxilla and atrophic mandible. Methodology: A search strategy was carried out in four databases (PubMed, Embase, Web of Science and Cochrane Library) by crossing different descriptors according to the PICO strategy. Results: 206 articles were obtained, however according to the inclusion and exclusion criteria of this review, a total of 9 articles were selected for a critical and analytical analysis. The results of articles from this review showed that for obtaining mesenchymal stem cells (MSCs) from adipose tissue, it can be collected from abdominal tissue (TA) or by buccal fat pad (BB). Studies that carried out the characterization of the cells present in the adipose tissue result in expression of markers of mesenchymal cells. For transplantation in a clinical approach, surgeries for maxillary sinus grafting, bone regeneration for atrophic premaxilla and mandible, as well as condyle fracture, demonstrated good outcomes when MSCs or the stromal vascular fraction (SVF) were associated with autogenous, alloplastic, allogenic or xenogenic grafts. Conclusion: According to the limited scientific evidence, the cellular approach with SVF and CTMs derived from TA or BB prove to be safe and effective when associated with autogenous, alloplastic, allogenic or xenogenic grafts, improving the osteogenic potential in bone regeneration surgeries.
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spelling Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandibleAplicabilidad clínica de células madre mesenquimales indiferenciadas del tejido adiposo para cirurgías de regeneración ósea de maxilar y mandibula atrofica Aplicabilidade clínica das células-tronco mesenquimais indiferenciadas do tecido adiposo para cirurgias de regeneração óssea de maxila e mandíbula atrófica Regeneração ósseaEngenharia tecidualCélulas-tronco.Regeneración óseaIngeniería de tejidosCélulas madre.Bone regenerationTissue engineeringStem cells.Objectives: This literature review aimed to perform a strategic search for scientific articles on the applicability of adipose tissue stem cells associated with grafts in bone regeneration surgeries in the maxilla and atrophic mandible. Methodology: A search strategy was carried out in four databases (PubMed, Embase, Web of Science and Cochrane Library) by crossing different descriptors according to the PICO strategy. Results: 206 articles were obtained, however according to the inclusion and exclusion criteria of this review, a total of 9 articles were selected for a critical and analytical analysis. The results of articles from this review showed that for obtaining mesenchymal stem cells (MSCs) from adipose tissue, it can be collected from abdominal tissue (TA) or by buccal fat pad (BB). Studies that carried out the characterization of the cells present in the adipose tissue result in expression of markers of mesenchymal cells. For transplantation in a clinical approach, surgeries for maxillary sinus grafting, bone regeneration for atrophic premaxilla and mandible, as well as condyle fracture, demonstrated good outcomes when MSCs or the stromal vascular fraction (SVF) were associated with autogenous, alloplastic, allogenic or xenogenic grafts. Conclusion: According to the limited scientific evidence, the cellular approach with SVF and CTMs derived from TA or BB prove to be safe and effective when associated with autogenous, alloplastic, allogenic or xenogenic grafts, improving the osteogenic potential in bone regeneration surgeries.Objetivo: Esta revisión de la literatura tiene como objetivo realizar una búsqueda estratégica de artículos científicos sobre la aplicabilidad de las células madre del tejido adiposo asociadas a los injertos en cirugías de regeneración ósea en el maxilar y la mandíbula atrófica. Metodología: Se realizó una estrategia de búsqueda en cuatro bases de datos (PubMed, Embase, Web of Science y Cochrane Library) cruzando diferentes descriptores según la estrategia PICO. Resultados: 206 artículos fueron recuperados, más de acuerdo con los criterios de inclusión y exclusión de esta revisión, un total de 9 artículos fueron seleccionados para su análisis crítico y analítico. Los resultados mostraron que para obtener células madre mesenquimales (MSC) a partir del tejido adiposo, se pueden recolectar del tejido abdominal (TA) o mediante la bola de Bichat (BB). Los estudios que llevaron a cabo la caracterización de células presentes en el tejido adiposo, dan como resultado la expresión de marcadores de células mesenquimales. Para el trasplante en un abordaje clínico, las cirugías para el levantamiento del seno maxilar, la regeneración ósea en la atrófica premaxila y mandíbula, así como la fractura del cóndilo, mostraron buenos resultados cuando las CMM o la fracción estromal vascular (FVE) cuando asociada con  injerto autógenos, aloplástico, alogénicos y xenogénicos. Conclusión: De acuerdo con la limitada evidencia científica, el abordaje celular con FVE y CTMs derivados de TA o BB resulta en un seguro y efectivo método cuando se asocia a injertos autógenos, aloplástico, alogénicos y xenogénicos, favoreciendo el potencial osteogénico en cirugías de regeneración ósea.Objetivo: Esta revisão de literatura tem como objetivo realizar uma busca estratégica de artigos científicos sobre a aplicabilidade das células-tronco do tecido adiposo associado aos enxertos em cirurgias de regeneração óssea em maxila e mandíbula atrófica. Metodologia: Foi realizada uma estratégia de busca em quatro bases de dados (PubMed, Embase, Web of Science e Cochrane Library) por meio do cruzamento de diferentes descritores de acordo com a estratégia PICO. Resultados: Foram recuperados 206 artigos, porém, de acordo com os critérios de inclusão e exclusão desta revisão, um total de 9 artigos foram selecionados para uma análise crítica e analítica. Os resultados dos artigos desta revisão demonstraram que para a obtenção das células-tronco mesenquimais (CTMs) do tecido adiposo, pode ser coletada através do tecido abdominal (TA) ou pela bola de Bichat (BB). Estudos que realizaram a caracterização das células presentes no tecido adiposo, resultam em expressão de marcadores de células mesenquimais. Para a transplantação em abordagem clínica, as cirurgias de levantamento de seio maxilar, regeneração óssea em pré-maxila e mandíbula atrófica, assim como fratura de côndilo, demonstraram bons resultados quando as CTMs ou com a fração vascular estromal (FVE) foram associados com enxerto autógeno, xenógeno ou aloplástico. Conclusão: Apesar da limitada evidência científica, a abordagem celular com FVE e as CTMs derivadas do TA ou BB demonstram ser seguras e eficazes quando associadas com enxerto autógeno, sintético, alógeno ou xenógeno, favorecendo o potencial osteogênico nas cirurgias de regeneração óssea.Research, Society and Development2021-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1590010.33448/rsd-v10i6.15900Research, Society and Development; Vol. 10 No. 6; e48810616023Research, Society and Development; Vol. 10 Núm. 6; e48810616023Research, Society and Development; v. 10 n. 6; e488106160232525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/15900/14326Copyright (c) 2021 Ísis de Fátima Balderrama; Rafael Ferreira; Moira Pedroso Leão; Elcio Marcantonio-Júniorhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBalderrama, Ísis de FátimaFerreira, Rafael Leão, Moira Pedroso Marcantonio-Júnior, Elcio 2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/15900Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:36.997218Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
Aplicabilidad clínica de células madre mesenquimales indiferenciadas del tejido adiposo para cirurgías de regeneración ósea de maxilar y mandibula atrofica
Aplicabilidade clínica das células-tronco mesenquimais indiferenciadas do tecido adiposo para cirurgias de regeneração óssea de maxila e mandíbula atrófica
title Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
spellingShingle Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
Balderrama, Ísis de Fátima
Regeneração óssea
Engenharia tecidual
Células-tronco.
Regeneración ósea
Ingeniería de tejidos
Células madre.
Bone regeneration
Tissue engineering
Stem cells.
title_short Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
title_full Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
title_fullStr Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
title_full_unstemmed Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
title_sort Clinical applicability of undifferentiated mesenchymal stem cells from adipose tissue for bone regeneration surgeries of the atrophic maxilla and mandible
author Balderrama, Ísis de Fátima
author_facet Balderrama, Ísis de Fátima
Ferreira, Rafael
Leão, Moira Pedroso
Marcantonio-Júnior, Elcio
author_role author
author2 Ferreira, Rafael
Leão, Moira Pedroso
Marcantonio-Júnior, Elcio
author2_role author
author
author
dc.contributor.author.fl_str_mv Balderrama, Ísis de Fátima
Ferreira, Rafael
Leão, Moira Pedroso
Marcantonio-Júnior, Elcio
dc.subject.por.fl_str_mv Regeneração óssea
Engenharia tecidual
Células-tronco.
Regeneración ósea
Ingeniería de tejidos
Células madre.
Bone regeneration
Tissue engineering
Stem cells.
topic Regeneração óssea
Engenharia tecidual
Células-tronco.
Regeneración ósea
Ingeniería de tejidos
Células madre.
Bone regeneration
Tissue engineering
Stem cells.
description Objectives: This literature review aimed to perform a strategic search for scientific articles on the applicability of adipose tissue stem cells associated with grafts in bone regeneration surgeries in the maxilla and atrophic mandible. Methodology: A search strategy was carried out in four databases (PubMed, Embase, Web of Science and Cochrane Library) by crossing different descriptors according to the PICO strategy. Results: 206 articles were obtained, however according to the inclusion and exclusion criteria of this review, a total of 9 articles were selected for a critical and analytical analysis. The results of articles from this review showed that for obtaining mesenchymal stem cells (MSCs) from adipose tissue, it can be collected from abdominal tissue (TA) or by buccal fat pad (BB). Studies that carried out the characterization of the cells present in the adipose tissue result in expression of markers of mesenchymal cells. For transplantation in a clinical approach, surgeries for maxillary sinus grafting, bone regeneration for atrophic premaxilla and mandible, as well as condyle fracture, demonstrated good outcomes when MSCs or the stromal vascular fraction (SVF) were associated with autogenous, alloplastic, allogenic or xenogenic grafts. Conclusion: According to the limited scientific evidence, the cellular approach with SVF and CTMs derived from TA or BB prove to be safe and effective when associated with autogenous, alloplastic, allogenic or xenogenic grafts, improving the osteogenic potential in bone regeneration surgeries.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15900
10.33448/rsd-v10i6.15900
url https://rsdjournal.org/index.php/rsd/article/view/15900
identifier_str_mv 10.33448/rsd-v10i6.15900
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15900/14326
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 6; e48810616023
Research, Society and Development; Vol. 10 Núm. 6; e48810616023
Research, Society and Development; v. 10 n. 6; e48810616023
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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