Tricyclic antidepressants: An update
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/45539 |
Resumo: | Tricyclic antidepressants (TCAs) are a class of psychotropic medications primarily used in the treatment of major depressive disorders, although their indications extend to a variety of psychiatric and neurological conditions. This class of medications was one of the first to be developed for the treatment of depression, marking a revolution in the management of this condition in the mid-20th century. The aim of this study is to present a narrative review in the form of an update on the pharmacokinetic properties, pharmacodynamics, indications, and side effects of tricyclic antidepressants. For this purpose, a narrative review in the format of an update was carried out, which analyzed 42 manuscripts. TCAs have various pharmacological and therapeutic properties, low cost, but their major limitation is their side effects. Since the clinical trials for this class were conducted well before the launch of new antidepressants, new research is needed to allow comparison of these groups within the same methodology and with more up-to-date statistics. |
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Tricyclic antidepressants: An updateAntidepresivos tricíclicos: Una actualizaciónAntidepressivos tricíclicos: Uma atualizaçãoAntidepresivos tricíclicosTranstornos mentalesPsicotrópicosUsos terapéuticosEfectos colaterales y reacciones adversas relacionados con medicamentos.Tricyclic antidepressive agentsMental disordersPsychotropic drugsTherapeutic usesDrug-related side effects and adverse reactions.Antidepressivos tricíclicosTranstornos mentaisPsicotrópicosUsos terapêuticosEfeitos colaterais e reações adversas relacionados a medicamentos.Tricyclic antidepressants (TCAs) are a class of psychotropic medications primarily used in the treatment of major depressive disorders, although their indications extend to a variety of psychiatric and neurological conditions. This class of medications was one of the first to be developed for the treatment of depression, marking a revolution in the management of this condition in the mid-20th century. The aim of this study is to present a narrative review in the form of an update on the pharmacokinetic properties, pharmacodynamics, indications, and side effects of tricyclic antidepressants. For this purpose, a narrative review in the format of an update was carried out, which analyzed 42 manuscripts. TCAs have various pharmacological and therapeutic properties, low cost, but their major limitation is their side effects. Since the clinical trials for this class were conducted well before the launch of new antidepressants, new research is needed to allow comparison of these groups within the same methodology and with more up-to-date statistics.Los antidepresivos tricíclicos (ATC) son una clase de medicamentos psicotrópicos utilizados principalmente para el tratamiento de trastornos depresivos mayores, aunque sus indicaciones se extienden a una variedad de condiciones psiquiátricas y neurológicas. Esta clase de medicamentos fue una de las primeras en ser desarrollada para el tratamiento de la depresión, marcando una revolución en el manejo de esta condición en la mitad del siglo XX. El objetivo de este estudio es presentar una revisión narrativa en forma de actualización sobre las propiedades farmacocinéticas, farmacodinámicas, indicaciones y efectos secundarios de los antidepresivos tricíclicos. Para ello se realizó una revisión narrativa en formato de actualización que analizó 42 manuscitos. Los ATC presentan diversas propiedades farmacológicas y terapéuticas, bajo costo, sin embargo, su mayor limitación son sus efectos secundarios. Como los ensayos clínicos de esta clase fueron realizados en un período mucho anterior al lanzamiento de los nuevos antidepresivos, son necesarias nuevas investigaciones que permitan la comparación de estos grupos dentro de la misma metodología y con estadísticas más actualizadas.Os antidepressivos tricíclicos (ADTs) são uma classe de medicamentos psicotrópicos utilizados principalmente no tratamento de transtornos depressivos maiores, embora suas indicações se estendam a uma variedade de condições psiquiátricas e neurológicas. Esta classe de medicamentos foi uma das primeiras a ser desenvolvida para o tratamento da depressão, marcando uma revolução no manejo desta condição na metade do século XX. O objetivo deste estudo é apresentar uma revisão narrativa na forma de atualização sobre as propriedades farmacocinéticas, farmacodinâmicas, indicações e efeitos colaterais dos antidepressivos tricíclicos. Para tal foi realizada uma revisão narrativa no formato de atualização que analisou 42 manuscritos. Os ADTs apresentam diversas propriedades farmacológicas e terapêuticas, custo baixo, porém sua maior limitação são seus efeitos colaterais. Como os ensaios clínicos dessa classe foram realizadas em período bem anterior ao lançamento dos novos antidepressivos são necessárias novas pesquisas que permitam a comparação desses grupos dentro da mesma metodologia e com estatística mais atualizada.Research, Society and Development2024-04-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4553910.33448/rsd-v13i4.45539Research, Society and Development; Vol. 13 No. 4; e4413445539Research, Society and Development; Vol. 13 Núm. 4; e4413445539Research, Society and Development; v. 13 n. 4; e44134455392525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/45539/36262Copyright (c) 2024 Leonardo Baldaçara; Railson Freitas; Raquel Prudente de Carvalho Baldaçarahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBaldaçara, LeonardoFreitas, RailsonBaldaçara, Raquel Prudente de Carvalho 2024-04-04T18:36:37Zoai:ojs.pkp.sfu.ca:article/45539Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-04-04T18:36:37Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Tricyclic antidepressants: An update Antidepresivos tricíclicos: Una actualización Antidepressivos tricíclicos: Uma atualização |
title |
Tricyclic antidepressants: An update |
spellingShingle |
Tricyclic antidepressants: An update Baldaçara, Leonardo Antidepresivos tricíclicos Transtornos mentales Psicotrópicos Usos terapéuticos Efectos colaterales y reacciones adversas relacionados con medicamentos. Tricyclic antidepressive agents Mental disorders Psychotropic drugs Therapeutic uses Drug-related side effects and adverse reactions. Antidepressivos tricíclicos Transtornos mentais Psicotrópicos Usos terapêuticos Efeitos colaterais e reações adversas relacionados a medicamentos. |
title_short |
Tricyclic antidepressants: An update |
title_full |
Tricyclic antidepressants: An update |
title_fullStr |
Tricyclic antidepressants: An update |
title_full_unstemmed |
Tricyclic antidepressants: An update |
title_sort |
Tricyclic antidepressants: An update |
author |
Baldaçara, Leonardo |
author_facet |
Baldaçara, Leonardo Freitas, Railson Baldaçara, Raquel Prudente de Carvalho |
author_role |
author |
author2 |
Freitas, Railson Baldaçara, Raquel Prudente de Carvalho |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Baldaçara, Leonardo Freitas, Railson Baldaçara, Raquel Prudente de Carvalho |
dc.subject.por.fl_str_mv |
Antidepresivos tricíclicos Transtornos mentales Psicotrópicos Usos terapéuticos Efectos colaterales y reacciones adversas relacionados con medicamentos. Tricyclic antidepressive agents Mental disorders Psychotropic drugs Therapeutic uses Drug-related side effects and adverse reactions. Antidepressivos tricíclicos Transtornos mentais Psicotrópicos Usos terapêuticos Efeitos colaterais e reações adversas relacionados a medicamentos. |
topic |
Antidepresivos tricíclicos Transtornos mentales Psicotrópicos Usos terapéuticos Efectos colaterales y reacciones adversas relacionados con medicamentos. Tricyclic antidepressive agents Mental disorders Psychotropic drugs Therapeutic uses Drug-related side effects and adverse reactions. Antidepressivos tricíclicos Transtornos mentais Psicotrópicos Usos terapêuticos Efeitos colaterais e reações adversas relacionados a medicamentos. |
description |
Tricyclic antidepressants (TCAs) are a class of psychotropic medications primarily used in the treatment of major depressive disorders, although their indications extend to a variety of psychiatric and neurological conditions. This class of medications was one of the first to be developed for the treatment of depression, marking a revolution in the management of this condition in the mid-20th century. The aim of this study is to present a narrative review in the form of an update on the pharmacokinetic properties, pharmacodynamics, indications, and side effects of tricyclic antidepressants. For this purpose, a narrative review in the format of an update was carried out, which analyzed 42 manuscripts. TCAs have various pharmacological and therapeutic properties, low cost, but their major limitation is their side effects. Since the clinical trials for this class were conducted well before the launch of new antidepressants, new research is needed to allow comparison of these groups within the same methodology and with more up-to-date statistics. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-04-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/45539 10.33448/rsd-v13i4.45539 |
url |
https://rsdjournal.org/index.php/rsd/article/view/45539 |
identifier_str_mv |
10.33448/rsd-v13i4.45539 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/45539/36262 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2024 Leonardo Baldaçara; Railson Freitas; Raquel Prudente de Carvalho Baldaçara https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2024 Leonardo Baldaçara; Railson Freitas; Raquel Prudente de Carvalho Baldaçara https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 13 No. 4; e4413445539 Research, Society and Development; Vol. 13 Núm. 4; e4413445539 Research, Society and Development; v. 13 n. 4; e4413445539 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052639864684544 |