Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/34344 |
Resumo: | The study by objective describes the results of the quality studies. The leaves were dried and pulverized, and the powders were selected for pharmacognostic tests for pH, foam index, moisture determination and density. From maceration of maceration with ethanol, the extract of the leaves obtained (E) and through the fractions of maceration, dichlorom of half hexanol, followed by prospection phytoethanolic by half-ethane and chemical reflux methane by reflux. For in silico studies, Luteolin 7-[βglucopyranosyl]-(1→2)-βramnosyl-(1→6)β-glucopyranoside, Luteolin-7-O Rutinoside, β-Sitosterol, Campesterol, Friedelinol , lupeol, justiflorinol and apigenin the programs Marvin JS, PreADMETox and OSIRIS were used to evaluate the toxicological aspects of the species associated with the in vitro test against Artemia Salina L. of humidity within the parameters recommendations, with low density and neutral pH. In phytochemical analysis, flavonoids, coumarins, terpenes and steroids, tannins and depsones were detected. Among the non-genic genetics, β -S-Campesterol, Friedelinolforam, apigenin and luteolin7-O-carcinoside are not carcinogens. The EEF and the fractions showed levels of toxicity against the Artemia salina test. |
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Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahlPharmacognostic Study, Phytochemical and Toxicity Assessment of Justicia secunda vahlEstudo Farmacognóstico, Fitoquímio e Avaliação de Toxicidade de Justicia secunda vahlSanguínariaTóxicoEstudo in sílico.OptimistaTóxicoEstudio in silico. SanguineToxicIn silico study.The study by objective describes the results of the quality studies. The leaves were dried and pulverized, and the powders were selected for pharmacognostic tests for pH, foam index, moisture determination and density. From maceration of maceration with ethanol, the extract of the leaves obtained (E) and through the fractions of maceration, dichlorom of half hexanol, followed by prospection phytoethanolic by half-ethane and chemical reflux methane by reflux. For in silico studies, Luteolin 7-[βglucopyranosyl]-(1→2)-βramnosyl-(1→6)β-glucopyranoside, Luteolin-7-O Rutinoside, β-Sitosterol, Campesterol, Friedelinol , lupeol, justiflorinol and apigenin the programs Marvin JS, PreADMETox and OSIRIS were used to evaluate the toxicological aspects of the species associated with the in vitro test against Artemia Salina L. of humidity within the parameters recommendations, with low density and neutral pH. In phytochemical analysis, flavonoids, coumarins, terpenes and steroids, tannins and depsones were detected. Among the non-genic genetics, β -S-Campesterol, Friedelinolforam, apigenin and luteolin7-O-carcinoside are not carcinogens. The EEF and the fractions showed levels of toxicity against the Artemia salina test.El estudio por objetivo describe los resultados de los estudios de calidad. Las hojas se secaron y pulverizaron, y los polvos se seleccionaron para pruebas farmaconósticas de pH, índice de espuma, determinación de humedad y densidad. A partir de maceración de maceración con etanol, se obtuvo el extracto de las hojas (E) ya través de las fracciones de maceración, diclorom de mitad hexanol, seguido de prospección fitoetanólica por mitad de etano y metano de reflujo químico por reflujo. Para los estudios in silico, 7-[β-glucopiranosil]-(1→2)-βramnosil-(1→6)β-glucopiranósido, Luteolin-7-O Rutinoside, β-Sitosterol, Campesterol, Friedelinol, lupeol, justiflorinol y Se utilizaron los programas apigenin Marvin JS, PreADMETox y OSIRIS para evaluar los aspectos toxicológicos de las especies asociadas al ensayo in vitro contra Artemia Salina L. de humedad dentro de los parámetros recomendados, con baja densidad y pH neutro. En el análisis fitoquímico se detectaron flavonoides, cumarinas, terpenos y esteroides, taninos y depsonas. Entre las genéticas no génicas, el β-S-campesterol, el Friedelinolforam, la apigenina y la luteolina-7-O-carcinósido no son cancerígenos. El EEF y las fracciones mostraron niveles de toxicidad frente a la prueba de Artemia salina.O estudo tem por objetivo descrever os resultados obtidos dos parâmetros de qualidade farmacognóstico, prospecção fitoquímica, toxicidade por estudos in silico e in vitro das folhas da Justicia secunda vahl. As folhas foram secas e pulverizadas, e os pós foram submetidos a testes farmacognóstico de pH, índice de espuma, determinação de umidade e densidade. Por meio de maceração com etanol obteve-se o extrato das folhas (EEF) e através de fracionamento por refluxo obteve-se as frações de hexano, diclorometano e metanol, seguido de prospecção fitoquímica do extrato etanólico por meio de precipitação. Para os estudos in silico selecionou-se as moléculas Luteolina 7-O- [β-glucopiranosil-(1→2)-β-ramnosil-(1→6)]β-glucopiranosídeo , Luteolina-7-O Rutinoside, β -Sitosterol, Campesterol, Friedelinol, lupeol, justiflorinol e apigenina onde utilizou-se os programas Marvin JS, PreADMETox e OSIRIS, para avaliação dos aspectos toxicológicos da espécie associado ao teste in vitro frente Artemia Salina L. Os pós foram classificados como moderadamente grossos, com teor de umidade dentro dos parâmetros recomendados, com presença de saponinas, pH neutro e baixa densidade. Na prospecção fitoquímica foram detectados flavonoides, cumarinas, terpenos e esteroides, taninos e depsideos e depsonas. Dentre as moléculas avaliadas β -Sitosterol, Campesterol, Friedelinol não foram mutagênicas, apigenina e luteolina-7-O-rutinosideo não são carcinogênicas. O EEF e as frações apresentaram baixos níveis de toxicidade frente ao teste de Artemia salina.Research, Society and Development2022-09-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3434410.33448/rsd-v11i12.34344Research, Society and Development; Vol. 11 No. 12; e240111234344Research, Society and Development; Vol. 11 Núm. 12; e240111234344Research, Society and Development; v. 11 n. 12; e2401112343442525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/34344/29030Copyright (c) 2022 Camilla Eduarda Lima Rolim; Ana Carolina Sousa Quaresma Quaresma; Cristian Kallahan Silva Chagas; José Otávio Carréra Silva Júnior; Paulo Ricardo de Souza Melo; Maria Fâni Dolabelahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRolim, Camilla Eduarda Lima Quaresma, Ana Carolina Sousa QuaresmaChagas, Cristian Kallahan Silva Carréra Silva Júnior, José Otávio Melo, Paulo Ricardo de SouzaDolabela, Maria Fâni2022-09-26T11:56:08Zoai:ojs.pkp.sfu.ca:article/34344Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:49:41.099783Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl Pharmacognostic Study, Phytochemical and Toxicity Assessment of Justicia secunda vahl Estudo Farmacognóstico, Fitoquímio e Avaliação de Toxicidade de Justicia secunda vahl |
title |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl |
spellingShingle |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl Rolim, Camilla Eduarda Lima Sanguínaria Tóxico Estudo in sílico. Optimista Tóxico Estudio in silico. Sanguine Toxic In silico study. |
title_short |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl |
title_full |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl |
title_fullStr |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl |
title_full_unstemmed |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl |
title_sort |
Estudio Farmacognostico, Evaluación Fitoquímica y Toxicidad de Justicia secunda vahl |
author |
Rolim, Camilla Eduarda Lima |
author_facet |
Rolim, Camilla Eduarda Lima Quaresma, Ana Carolina Sousa Quaresma Chagas, Cristian Kallahan Silva Carréra Silva Júnior, José Otávio Melo, Paulo Ricardo de Souza Dolabela, Maria Fâni |
author_role |
author |
author2 |
Quaresma, Ana Carolina Sousa Quaresma Chagas, Cristian Kallahan Silva Carréra Silva Júnior, José Otávio Melo, Paulo Ricardo de Souza Dolabela, Maria Fâni |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rolim, Camilla Eduarda Lima Quaresma, Ana Carolina Sousa Quaresma Chagas, Cristian Kallahan Silva Carréra Silva Júnior, José Otávio Melo, Paulo Ricardo de Souza Dolabela, Maria Fâni |
dc.subject.por.fl_str_mv |
Sanguínaria Tóxico Estudo in sílico. Optimista Tóxico Estudio in silico. Sanguine Toxic In silico study. |
topic |
Sanguínaria Tóxico Estudo in sílico. Optimista Tóxico Estudio in silico. Sanguine Toxic In silico study. |
description |
The study by objective describes the results of the quality studies. The leaves were dried and pulverized, and the powders were selected for pharmacognostic tests for pH, foam index, moisture determination and density. From maceration of maceration with ethanol, the extract of the leaves obtained (E) and through the fractions of maceration, dichlorom of half hexanol, followed by prospection phytoethanolic by half-ethane and chemical reflux methane by reflux. For in silico studies, Luteolin 7-[βglucopyranosyl]-(1→2)-βramnosyl-(1→6)β-glucopyranoside, Luteolin-7-O Rutinoside, β-Sitosterol, Campesterol, Friedelinol , lupeol, justiflorinol and apigenin the programs Marvin JS, PreADMETox and OSIRIS were used to evaluate the toxicological aspects of the species associated with the in vitro test against Artemia Salina L. of humidity within the parameters recommendations, with low density and neutral pH. In phytochemical analysis, flavonoids, coumarins, terpenes and steroids, tannins and depsones were detected. Among the non-genic genetics, β -S-Campesterol, Friedelinolforam, apigenin and luteolin7-O-carcinoside are not carcinogens. The EEF and the fractions showed levels of toxicity against the Artemia salina test. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-12 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/34344 10.33448/rsd-v11i12.34344 |
url |
https://rsdjournal.org/index.php/rsd/article/view/34344 |
identifier_str_mv |
10.33448/rsd-v11i12.34344 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/34344/29030 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 12; e240111234344 Research, Society and Development; Vol. 11 Núm. 12; e240111234344 Research, Society and Development; v. 11 n. 12; e240111234344 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052771432660992 |