Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/28478 |
Resumo: | Cancer is one of the most important causes of death in the world. Mitochondrial dysfunctions – related to mutation or not –, oxidative stress and activation of immune cells are related to the pathophysiology of cancer, due to the induction of oncogenic factors by multiple pathways. Heretofore, the production and development of antitumor drugs for the treatment of cancer is still a barrier, until the formulation is available in safe conditions to patients. In this sense, the approach with plants of reported traditional use, such as Ayapana triplinervis, started to draw attention owing to the great observed potential of its secondary metabolites and the widespread use. Phytosterols and flavonoids are widely consumed as nutraceuticals and have reported antioxidant and anti-inflammatory actions. Thus, the present integrative review aimed to gather the mechanisms by which compounds previously identified in A. triplinervis perform antitumor activity, in addition, we sought to present toxicological aspects attributed to these molecules. Based on a critical analysis of the selected literature, the present review gathers data, which show that the metabolites β-sitosterol, stigmasterol and kaempferol play a significant antitumor role through mitochondrial dysfunction, oxidative pathways and modulation of genes. Regarding the toxicological aspects of these molecules, the present study emphasizes the importance of experimental designs in in vivo models, given the need to perform assertive calculations of effective doses – for antitumor activity – and toxic of these compounds. |
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Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanismsCompuestos bioactivos identificados en Ayapana triplinervis: Una revisión de los mecanismos antitumoralesCompostos bioativos identificados em Ayapana triplinervis: Uma revisão sobre mecanismos antitumoraisCompostos bioativosTumorigêneseEstresse oxidativoGenotoxicidadeAyapana triplinveris.Metabolitos secundáriosTumorigénesisEstrés OxidativoGenotoxicidadAyapana triplinveris.Secondary metabolitesTumorigenesisOxidative stressGenotoxicityAyapana triplinveris.Cancer is one of the most important causes of death in the world. Mitochondrial dysfunctions – related to mutation or not –, oxidative stress and activation of immune cells are related to the pathophysiology of cancer, due to the induction of oncogenic factors by multiple pathways. Heretofore, the production and development of antitumor drugs for the treatment of cancer is still a barrier, until the formulation is available in safe conditions to patients. In this sense, the approach with plants of reported traditional use, such as Ayapana triplinervis, started to draw attention owing to the great observed potential of its secondary metabolites and the widespread use. Phytosterols and flavonoids are widely consumed as nutraceuticals and have reported antioxidant and anti-inflammatory actions. Thus, the present integrative review aimed to gather the mechanisms by which compounds previously identified in A. triplinervis perform antitumor activity, in addition, we sought to present toxicological aspects attributed to these molecules. Based on a critical analysis of the selected literature, the present review gathers data, which show that the metabolites β-sitosterol, stigmasterol and kaempferol play a significant antitumor role through mitochondrial dysfunction, oxidative pathways and modulation of genes. Regarding the toxicological aspects of these molecules, the present study emphasizes the importance of experimental designs in in vivo models, given the need to perform assertive calculations of effective doses – for antitumor activity – and toxic of these compounds.El cáncer es una de las causas más importantes de muerte en el mundo. Las disfunciones mitocondriales -relacionadas con mutaciones o no-, el estrés oxidativo y la activación de las células inmunitarias están relacionadas con la fisiopatología del cáncer, debido a la inducción de factores oncogénicos por múltiples vías. Hasta ahora, la producción y desarrollo de fármacos antitumorales para el tratamiento del cáncer sigue siendo una barrera, hasta que la formulación esté disponible en condiciones seguras para los pacientes. En este sentido, el abordaje con plantas de uso tradicional reportado, como Ayapana triplinervis, empezó a llamar la atención por el gran potencial observado de sus metabolitos secundarios y el uso generalizado. Los fitoesteroles y los flavonoides se consumen ampliamente como nutracéuticos y se han informado acciones antioxidantes y antiinflamatorias. Así, la presente revisión integradora tuvo como objetivo recopilar los mecanismos por los cuales compuestos previamente identificados en A. triplinervis realizan actividad antitumoral, además, buscamos presentar aspectos toxicológicos atribuidos a estas moléculas. Con base en un análisis crítico de la literatura seleccionada, la presente revisión recopila datos que muestran que los metabolitos β-sitosterol, estigmasterol y kaempferol desempeñan un papel antitumoral significativo a través de la disfunción mitocondrial, las vías oxidativas y la modulación génica. En cuanto a los aspectos toxicológicos de estas moléculas, el presente estudio enfatiza la importancia de los diseños experimentales en modelos in vivo, dada la necesidad de realizar cálculos asertivos de dosis efectivas -para la actividad antitumoral- y tóxicas de estos compuestos.O câncer está entre as principais causas de morte no mundo. Disfunções mitocondriais – relacionadas a mutação ou não –, estresse oxidativo e ativação de células imunes se relacionam à fisiopatologia do câncer, em função da indução por múltiplas vias de fatores oncogênicos. Até o momento, a produção e o desenvolvimento de drogas antitumorais para o tratamento do câncer ainda se configura como uma barreira, até que a formulação esteja disponível em condições seguras aos pacientes. Nesse contexto, a abordagem com plantas de uso tradicional relatado, como a Ayapana triplinervis passou a chamar a atenção tendo a vista o grande potencial observado de seus metabólitos secundários e o uso amplamente difundido. Fitosteróis e flavonóides são amplamente consumidos como nutracêuticos e possuem ações antioxidantes e anti-inflamatórias relatadas. Assim, a presente revisão integrativa objetivou reunir os mecanismos pelos quais compostos anteriormente identificados em A. triplinervis desempenham atividade antitumoral, além disso, buscou-se apresentar aspectos toxicológicos atribuídos a essas moléculas. A partir da análise crítica da literatura selecionada, a presente revisão reúne dados que evidenciam que os metabólitos β-sitosterol, estigmasterol e kaempferol desempenham significativo papel antitumoral por meio de disfunção mitocondrial, rotas oxidativas e modulação gênica. Quanto aos aspectos toxicológicos dessas moléculas, o presente estudo chama atenção para a necessidade de delineamentos experimentais em modelos in vivo, haja vista a necessidade da realização de cálculos assertivos de doses efetivas – para atividade antitumoral – e tóxicas desses compostos.Research, Society and Development2022-04-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2847810.33448/rsd-v11i6.28478Research, Society and Development; Vol. 11 No. 6; e0811628478Research, Society and Development; Vol. 11 Núm. 6; e0811628478Research, Society and Development; v. 11 n. 6; e08116284782525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/28478/24909Copyright (c) 2022 Camila Fernanda Rodrigues Romeiro; Lucas Villar Pedrosa da Silva Pantoja; Marcieni Ataíde de Andradehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Romeiro, Camila Fernanda RodriguesPantoja, Lucas Villar Pedrosa da SilvaAndrade, Marcieni Ataíde de2022-05-13T18:04:10Zoai:ojs.pkp.sfu.ca:article/28478Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:45:51.920491Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms Compuestos bioactivos identificados en Ayapana triplinervis: Una revisión de los mecanismos antitumorales Compostos bioativos identificados em Ayapana triplinervis: Uma revisão sobre mecanismos antitumorais |
title |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms |
spellingShingle |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms Romeiro, Camila Fernanda Rodrigues Compostos bioativos Tumorigênese Estresse oxidativo Genotoxicidade Ayapana triplinveris. Metabolitos secundários Tumorigénesis Estrés Oxidativo Genotoxicidad Ayapana triplinveris. Secondary metabolites Tumorigenesis Oxidative stress Genotoxicity Ayapana triplinveris. |
title_short |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms |
title_full |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms |
title_fullStr |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms |
title_full_unstemmed |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms |
title_sort |
Bioactive compounds identified in Ayapana triplinervis: A review of antitumor mechanisms |
author |
Romeiro, Camila Fernanda Rodrigues |
author_facet |
Romeiro, Camila Fernanda Rodrigues Pantoja, Lucas Villar Pedrosa da Silva Andrade, Marcieni Ataíde de |
author_role |
author |
author2 |
Pantoja, Lucas Villar Pedrosa da Silva Andrade, Marcieni Ataíde de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Romeiro, Camila Fernanda Rodrigues Pantoja, Lucas Villar Pedrosa da Silva Andrade, Marcieni Ataíde de |
dc.subject.por.fl_str_mv |
Compostos bioativos Tumorigênese Estresse oxidativo Genotoxicidade Ayapana triplinveris. Metabolitos secundários Tumorigénesis Estrés Oxidativo Genotoxicidad Ayapana triplinveris. Secondary metabolites Tumorigenesis Oxidative stress Genotoxicity Ayapana triplinveris. |
topic |
Compostos bioativos Tumorigênese Estresse oxidativo Genotoxicidade Ayapana triplinveris. Metabolitos secundários Tumorigénesis Estrés Oxidativo Genotoxicidad Ayapana triplinveris. Secondary metabolites Tumorigenesis Oxidative stress Genotoxicity Ayapana triplinveris. |
description |
Cancer is one of the most important causes of death in the world. Mitochondrial dysfunctions – related to mutation or not –, oxidative stress and activation of immune cells are related to the pathophysiology of cancer, due to the induction of oncogenic factors by multiple pathways. Heretofore, the production and development of antitumor drugs for the treatment of cancer is still a barrier, until the formulation is available in safe conditions to patients. In this sense, the approach with plants of reported traditional use, such as Ayapana triplinervis, started to draw attention owing to the great observed potential of its secondary metabolites and the widespread use. Phytosterols and flavonoids are widely consumed as nutraceuticals and have reported antioxidant and anti-inflammatory actions. Thus, the present integrative review aimed to gather the mechanisms by which compounds previously identified in A. triplinervis perform antitumor activity, in addition, we sought to present toxicological aspects attributed to these molecules. Based on a critical analysis of the selected literature, the present review gathers data, which show that the metabolites β-sitosterol, stigmasterol and kaempferol play a significant antitumor role through mitochondrial dysfunction, oxidative pathways and modulation of genes. Regarding the toxicological aspects of these molecules, the present study emphasizes the importance of experimental designs in in vivo models, given the need to perform assertive calculations of effective doses – for antitumor activity – and toxic of these compounds. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/28478 10.33448/rsd-v11i6.28478 |
url |
https://rsdjournal.org/index.php/rsd/article/view/28478 |
identifier_str_mv |
10.33448/rsd-v11i6.28478 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/28478/24909 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 6; e0811628478 Research, Society and Development; Vol. 11 Núm. 6; e0811628478 Research, Society and Development; v. 11 n. 6; e0811628478 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052765080387584 |