Kartagener syndrome: limiting aspects to sperm motility and the applicability of assisted fertilization

• Autor(a) principal: Medeiros, Arissa Stéphane Alves de
• Data de Publicação: 2020
• Outros Autores: Silva, Pedro Ivo Raimundo da, Padilha, Rodrigo Tenório, Padilha, Deborah de Melo Magalhães
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/7323
• topic: Dineína; Inviabilidad ciliar; Ciliopatia; Infertilidad masculine; Reproducción asistida.; Dineína; Inviabilidade ciliar; Ciliopatia; Infertilidade masculina; Reprodução assistida.; Dinein; Ciliary unfeasibility; Ciliopathy; Male infertility; Assisted reproduction.

In view of the relevance of Kartagener Syndrome (KS) for male health and the few information about this syndrome, the current paper review aims to clarify how KS is related with male infertility, and show alternatives in assisted reproduction that help infertile individuals. Thus, in this article an integrative review was carried out, and a total of 56 scientific articles were used as a reference, in English, Spanish and Portuguese. The KS is an autosomal recessive genetic condition characterized by problems at the cellular level, whereby the microtubules of the flagellum cytoskeleton and hair cell exhibit anomalies that result in the immotility of these organelles. The consequence of these anomalies is the presence of respiratory infections, since childhood, and male infertility with the presence of asthenozoospermia. To overcome this problem, assisted reproduction techniques have been shown to be very effective in contributing to the fertility of the individuals affected with KS. In view of the existing reproductive biotechnologies, Intracytoplasmic Sperm Injection (ICSI) is today the best alternative for men with severe asthenozoospermia factors due to KS. However, in most cases, the origins of infertility in men with KS are not systematically investigated by health professionals. In conclusion, a greater theoretical background and genetic studies of KS are needed in order to increase the chances of an early diagnosis of infertility in men.