Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/30510 |
Resumo: | The aim of this study was to evaluate the effect of X radiation in single and fractionated doses in tibias of rats by micro-computer tomography (µCT) analysis. The sample was consisted by 20 male rats, divided into 3 groups: Control, Single dose and Fractionated dose. The rats were submitted to a radiation X exposure on lower limbs. The single dose group was exposed to single radiation of 15 gray (Gy), while the fractionated group was submitted to three irradiation sessions of 5 Gy each, totaling 15 Gy. After 24 hours and 25 days, the rats were euthanized; the tibias were removed and scanned using a µCT unit, SkyScan 1174 Compact Micro-CT (Kontich, Bélgica). The parameters total bone area (Tt.Ar) , cortical bone area (Ct.Ar) , total cross-sectional bone area ratio (Ct.Ar / Tt.Ar) e cortical thickness (Ct.Th) for cortical bone, e bone volume ratio (BV / TV), trabecular number (Tb.N), trabecular thickness (Tb.Th) e trabecular separation (Tb.Sp), for trabecular bone analysis were evaluated. Data were submitted to one-way ANOVA and Tukey’s test (α = 0.05). The µCT evaluation showed significant differences on Tt.Ar and Tb.Sp parameters (p<0,05). It was observed a lower Tt.Ar in the fractionated group compared to control, and higher Tb.Sp in the group receiving a single dose when compared to the control and fractionated groups. It is concluded, in relation to bone microarchitecture, that the radiation X in fractionated doses presents more deleterious effects on the cortical bone and when in singe doses, more damage on trabecular spaces, leading to a higher porosity. |
id |
UNIFEI_ce9bd8acdcfe4520c09322ae56e4718d |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/30510 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibiasEvaluación por Micro CT del efecto de dosis de radiación X fraccionadas y únicas en tibias de ratasAvaliação microtomográfica do efeito de doses únicas e fracionadas de radiação X em tibias de ratosMicrotomografía de Rayos XTerapia de Rayos XFraccionamiento de dosisDosis de radiaciónRadiación Ionizante.Microtomografia de Raios-XTerapia de Raios-XFracionamento de doseDosagem de radiaçãoRadiação Ionizante. X-Ray MicrotomographyX-Ray TherapyDose FractionationRadiation DosageRadiation, Ionizing.The aim of this study was to evaluate the effect of X radiation in single and fractionated doses in tibias of rats by micro-computer tomography (µCT) analysis. The sample was consisted by 20 male rats, divided into 3 groups: Control, Single dose and Fractionated dose. The rats were submitted to a radiation X exposure on lower limbs. The single dose group was exposed to single radiation of 15 gray (Gy), while the fractionated group was submitted to three irradiation sessions of 5 Gy each, totaling 15 Gy. After 24 hours and 25 days, the rats were euthanized; the tibias were removed and scanned using a µCT unit, SkyScan 1174 Compact Micro-CT (Kontich, Bélgica). The parameters total bone area (Tt.Ar) , cortical bone area (Ct.Ar) , total cross-sectional bone area ratio (Ct.Ar / Tt.Ar) e cortical thickness (Ct.Th) for cortical bone, e bone volume ratio (BV / TV), trabecular number (Tb.N), trabecular thickness (Tb.Th) e trabecular separation (Tb.Sp), for trabecular bone analysis were evaluated. Data were submitted to one-way ANOVA and Tukey’s test (α = 0.05). The µCT evaluation showed significant differences on Tt.Ar and Tb.Sp parameters (p<0,05). It was observed a lower Tt.Ar in the fractionated group compared to control, and higher Tb.Sp in the group receiving a single dose when compared to the control and fractionated groups. It is concluded, in relation to bone microarchitecture, that the radiation X in fractionated doses presents more deleterious effects on the cortical bone and when in singe doses, more damage on trabecular spaces, leading to a higher porosity.El objetivo de este estudio fue evaluar el efecto de la radiación X en dosis únicas y fraccionadas en tibias de ratas mediante análisis microtomografía computarizada (µCT). La muestra estuvo constituida por 20 ratas macho, divididas en 3 grupos: Control, Dosis Única y Dosis Fraccionada. Las ratas fueron sometidas a una exposición a radiación X en las extremidades inferiores. El grupo de dosis única fue expuesto a sola radiación de 15 gray (Gy), mientras que el grupo fraccionado fue sometido a tres sesiones de irradiación de 5 Gy cada una, totalizando 15 Gy. Después de 24 horas y 25 días, las ratas fueron sacrificadas; las tibias se extrajeron y escanearon usando una unidad µCT, SkyScan 1174 Compact Micro-CT (Kontich, Bélgica). Se evaluaron los parámetros área total de la sección transversal (Tt.Ar) , área del hueso cortical (Ct.Ar) , relación total del área ósea de la sección transversal (Ct.Ar / Tt.Ar) y grosor cortical (Ct.Th) para hueso cortical, e relación de volumen óseo (BV / TV), número trabecular (Tb.N), espesor trabecular (Tb.Th) y distancia trabecular (Tb.Sp), para análisis de hueso trabecular. Los datos se sometieron a ANOVA unidireccional y prueba de Tukey (α = 0,05). La evaluación µCT mostró diferencias significativas en los parámetros Tt.Ar y Tb.Sp (p<0,05). Se observó una menor Tt.Ar en el grupo fraccionado en comparación con el control, y una mayor (Tb.Sp) en el grupo que recibió una dosis única en comparación con los grupos control y fraccionado. Se concluye, en relación a la microarquitectura ósea, que la radiación X en dosis fraccionadas presenta más efectos deletéreos sobre el hueso cortical y cuando en dosis únicas, más daño sobre los espacios trabeculares, lo que conduce a una mayor porosidad.O objetivo deste estudo foi avaliar o efeito da radiação X em doses únicas e fracionadas em tíbias de ratos por análise de microtomografia computadorizada (µCT). A amostra foi composta por 20 ratos machos, divididos em 3 grupos: Controle, Dose Única e Dose Fracionada. Os ratos foram submetidos à exposição da radiação X nos membros inferiores. O grupo dose única foi exposto a radiação única de 15 gray(Gy), enquanto o grupo fracionado foi submetido a três sessões de irradiação de 5 Gy cada, totalizando 15 Gy. Após 24 horas e 25 dias, os ratos foram eutanasiados; as tíbias foram removidas e digitalizadas usando uma unidade µCT, SkyScan 1174 Compact Micro-CT (Kontich, Bélgica). Foram avaliados os parâmetros área transversal total (Tt.Ar) , área do osso cortical (Ct.Ar) , razão total da área óssea transversal (Ct.Ar / Tt.Ar) e espessura cortical (Ct.Th) para osso cortical, e proporção de volume ósseo (BV/TV), número trabecular (Tb.N), espessura trabecular (Tb.Th) e distância trabecular (Tb.Sp), para análise de osso trabecular. Os dados foram submetidos a ANOVA one-way e teste de Tukey (α = 0,05). A avaliação do µCT mostrou diferenças significativas nos parâmetros Tt.Ar e Tb.Sp (p<0,05). Observou-se menor Tt.Ar no grupo fracionado em relação ao controle, e maior Tb.Sp no grupo que recebeu dose única quando comparado aos grupos controle e fracionado. Conclui-se, em relação à microarquitetura óssea, que a radiação X em doses fracionadas apresenta mais efeitos deletérios na cortical óssea e quando em doses únicas, mais danos nos espaços trabeculares, levando a uma maior porosidade.Research, Society and Development2022-06-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3051010.33448/rsd-v11i7.30510Research, Society and Development; Vol. 11 No. 7; e53911730510Research, Society and Development; Vol. 11 Núm. 7; e53911730510Research, Society and Development; v. 11 n. 7; e539117305102525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/30510/26136Copyright (c) 2022 Stefanya Dias de Oliveira; Luciana Neves Machado Rezende; Rafael Antônio Velôso Caixeta; Carolina Cintra Gomes; Priscilla Barbosa Ferreira Soares; Solange Maria de Almeida; Gabriella Lopes de Rezende Barbosahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Stefanya Dias deRezende, Luciana Neves MachadoCaixeta, Rafael Antônio VelôsoGomes, Carolina CintraSoares, Priscilla Barbosa FerreiraAlmeida, Solange Maria deBarbosa, Gabriella Lopes de Rezende2022-06-06T15:12:05Zoai:ojs.pkp.sfu.ca:article/30510Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:47:14.233849Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias Evaluación por Micro CT del efecto de dosis de radiación X fraccionadas y únicas en tibias de ratas Avaliação microtomográfica do efeito de doses únicas e fracionadas de radiação X em tibias de ratos |
title |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias |
spellingShingle |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias Oliveira, Stefanya Dias de Microtomografía de Rayos X Terapia de Rayos X Fraccionamiento de dosis Dosis de radiación Radiación Ionizante. Microtomografia de Raios-X Terapia de Raios-X Fracionamento de dose Dosagem de radiação Radiação Ionizante. X-Ray Microtomography X-Ray Therapy Dose Fractionation Radiation Dosage Radiation, Ionizing. |
title_short |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias |
title_full |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias |
title_fullStr |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias |
title_full_unstemmed |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias |
title_sort |
Micro CT assessment of the effect of single and fractionated X radiation doses in rats tibias |
author |
Oliveira, Stefanya Dias de |
author_facet |
Oliveira, Stefanya Dias de Rezende, Luciana Neves Machado Caixeta, Rafael Antônio Velôso Gomes, Carolina Cintra Soares, Priscilla Barbosa Ferreira Almeida, Solange Maria de Barbosa, Gabriella Lopes de Rezende |
author_role |
author |
author2 |
Rezende, Luciana Neves Machado Caixeta, Rafael Antônio Velôso Gomes, Carolina Cintra Soares, Priscilla Barbosa Ferreira Almeida, Solange Maria de Barbosa, Gabriella Lopes de Rezende |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Stefanya Dias de Rezende, Luciana Neves Machado Caixeta, Rafael Antônio Velôso Gomes, Carolina Cintra Soares, Priscilla Barbosa Ferreira Almeida, Solange Maria de Barbosa, Gabriella Lopes de Rezende |
dc.subject.por.fl_str_mv |
Microtomografía de Rayos X Terapia de Rayos X Fraccionamiento de dosis Dosis de radiación Radiación Ionizante. Microtomografia de Raios-X Terapia de Raios-X Fracionamento de dose Dosagem de radiação Radiação Ionizante. X-Ray Microtomography X-Ray Therapy Dose Fractionation Radiation Dosage Radiation, Ionizing. |
topic |
Microtomografía de Rayos X Terapia de Rayos X Fraccionamiento de dosis Dosis de radiación Radiación Ionizante. Microtomografia de Raios-X Terapia de Raios-X Fracionamento de dose Dosagem de radiação Radiação Ionizante. X-Ray Microtomography X-Ray Therapy Dose Fractionation Radiation Dosage Radiation, Ionizing. |
description |
The aim of this study was to evaluate the effect of X radiation in single and fractionated doses in tibias of rats by micro-computer tomography (µCT) analysis. The sample was consisted by 20 male rats, divided into 3 groups: Control, Single dose and Fractionated dose. The rats were submitted to a radiation X exposure on lower limbs. The single dose group was exposed to single radiation of 15 gray (Gy), while the fractionated group was submitted to three irradiation sessions of 5 Gy each, totaling 15 Gy. After 24 hours and 25 days, the rats were euthanized; the tibias were removed and scanned using a µCT unit, SkyScan 1174 Compact Micro-CT (Kontich, Bélgica). The parameters total bone area (Tt.Ar) , cortical bone area (Ct.Ar) , total cross-sectional bone area ratio (Ct.Ar / Tt.Ar) e cortical thickness (Ct.Th) for cortical bone, e bone volume ratio (BV / TV), trabecular number (Tb.N), trabecular thickness (Tb.Th) e trabecular separation (Tb.Sp), for trabecular bone analysis were evaluated. Data were submitted to one-way ANOVA and Tukey’s test (α = 0.05). The µCT evaluation showed significant differences on Tt.Ar and Tb.Sp parameters (p<0,05). It was observed a lower Tt.Ar in the fractionated group compared to control, and higher Tb.Sp in the group receiving a single dose when compared to the control and fractionated groups. It is concluded, in relation to bone microarchitecture, that the radiation X in fractionated doses presents more deleterious effects on the cortical bone and when in singe doses, more damage on trabecular spaces, leading to a higher porosity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/30510 10.33448/rsd-v11i7.30510 |
url |
https://rsdjournal.org/index.php/rsd/article/view/30510 |
identifier_str_mv |
10.33448/rsd-v11i7.30510 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/30510/26136 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 7; e53911730510 Research, Society and Development; Vol. 11 Núm. 7; e53911730510 Research, Society and Development; v. 11 n. 7; e53911730510 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052767265619968 |