Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/35270 |
Resumo: | Thyroid function is closely associated with neuropsychological functions, including mental status and cognitive functions. Subclinical hypothyroidism (HSC) is defined as a condition with elevated levels of thyroid stimulating hormone (TSH) and normal levels of free thyroxine (T4). Although the role played by thyroid hormones in the pathophysiology of mental disorders is unclear, it has been suggested that small changes in thyroid hormone levels, even within the normal range, may be related to altered brain function in depression. Currently, there are 2 explanatory hypotheses: serotonin deficit and noradrenaline deficit in the central nervous system caused by hormonal disorders. It is important to emphasize that the thyroid-psychic pathway is bidirectional, therefore, both thyroid alterations can cause depressive symptoms or exacerbate a previous psychiatric pathology, and depression can promote thyroid disorders, the latter being less frequent. Thus, the role of thyroid function in depressive illness is unclear. Although there is some evidence that mild thyroid alterations predispose to cases of depression, the specific abnormalities involving the thyroid and depressive conditions remain poorly understood. However, there is a causal link. |
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Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature reviewRelación entre la función tiroidea y el Trastorno Depresivo Mayor (MDD): una revisión integrativa de la literaturaRelação entre a função tireoidiana e o Transtorno Depressivo Maior (TDM): uma revisão integrativa de literatura HipotireoidismoHipófiseTiroxinaSerotonina.HypothyroidismHypophysisThyroxineSerotonin.HipófisisTiroxinaHipotiroidismoSerotonina.Thyroid function is closely associated with neuropsychological functions, including mental status and cognitive functions. Subclinical hypothyroidism (HSC) is defined as a condition with elevated levels of thyroid stimulating hormone (TSH) and normal levels of free thyroxine (T4). Although the role played by thyroid hormones in the pathophysiology of mental disorders is unclear, it has been suggested that small changes in thyroid hormone levels, even within the normal range, may be related to altered brain function in depression. Currently, there are 2 explanatory hypotheses: serotonin deficit and noradrenaline deficit in the central nervous system caused by hormonal disorders. It is important to emphasize that the thyroid-psychic pathway is bidirectional, therefore, both thyroid alterations can cause depressive symptoms or exacerbate a previous psychiatric pathology, and depression can promote thyroid disorders, the latter being less frequent. Thus, the role of thyroid function in depressive illness is unclear. Although there is some evidence that mild thyroid alterations predispose to cases of depression, the specific abnormalities involving the thyroid and depressive conditions remain poorly understood. However, there is a causal link.La función tiroidea está estrechamente relacionada con las funciones neuropsicológicas, incluido el estado mental y las funciones cognitivas. El hipotiroidismo subclínico (HSC) se define como una condición con niveles elevados de hormona estimulante de la tiroides (TSH) y niveles normales de tiroxina libre (T4). Aunque el papel que juegan las hormonas tiroideas en la fisiopatología de los trastornos mentales no está claro, se ha sugerido que pequeños cambios en los niveles de hormonas tiroideas, incluso dentro del rango normal, pueden estar relacionados con la función cerebral alterada en la depresión. Actualmente, existen 2 hipótesis explicativas: el déficit de serotonina y el déficit de noradrenalina en el sistema nervioso central causados por trastornos hormonales. Es importante recalcar que la vía psíquica-tiroidea es bidireccional, por tanto, tanto las alteraciones tiroideas pueden provocar síntomas depresivos o exacerbar una patología psiquiátrica previa, como la depresión puede promover trastornos tiroideos, siendo estos últimos menos frecuentes. Por lo tanto, el papel de la función tiroidea en la enfermedad depresiva no está claro. Aunque existe alguna evidencia de que las alteraciones leves de la tiroides predisponen a los casos de depresión, las anomalías específicas que involucran la tiroides y las condiciones depresivas siguen sin comprenderse bien. Sin embargo, existe un nexo de causalidad.A função tireoidiana está intimamente associada às funções neuropsicológicas, incluindo o estado mental e as funções cognitivas. O hipotireoidismo subclínico (HSC) é definido como uma condição com níveis elevados de hormônio estimulador da tireoide (TSH) e níveis normais de tiroxina livre (T4). Ainda que não seja claro o papel desempenhado pelos hormônios tireoidianos na fisiopatologia dos transtornos mentais, tem sido sugerido que pequenas mudanças nos níveis de hormônio da tireoide, mesmo dentro da faixa normal, podem estar relacionadas à alteração da função cerebral na depressão. Atualmente, existem 2 hipóteses explicativas: o déficit de serotonina e o déficit de noradrenalina no sistema nervoso central provocados pelos distúrbios hormonais. É importante ressaltar que a via tireoidiana-psíquica é bidirecional, portanto, tanto alterações tireoidianas podem provocar sintomas depressivos ou exacerbar uma patologia psiquiátrica prévia, quanto a depressão pode promover distúrbios tireoidianos, sendo este segundo caso menos frequente. Assim, o papel da função tireoidiana nas doenças depressivas é pouco claro. Embora existam algumas evidências de que discretas alterações tireoidianas predisponham a casos de depressão, as anormalidades específicas envolvendo a tireoide e os quadros depressivos permanecem pouco conhecidas. No entanto, existe um vínculo de causalidade.Research, Society and Development2022-09-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3527010.33448/rsd-v11i12.35270Research, Society and Development; Vol. 11 No. 12; e599111235270Research, Society and Development; Vol. 11 Núm. 12; e599111235270Research, Society and Development; v. 11 n. 12; e5991112352702525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/35270/29272Copyright (c) 2022 Ítalo Íris Boiba Rodrigues da Cunha; Ana Carolina Reinaldo de Sá Lopes; Ana Flávia de Oliveira Domingos Silva; Francisco Mickael dos Santos Araújo; Gabriel Antunes Ribeiro Mendes; Dieison Danrlei Roehrs; Itiel Elanã Soares Alencar; Lara Lima Pereira da Cunha; Roberta Maria Amaral Silva; Symonne Araújo Gomeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCunha, Ítalo Íris Boiba Rodrigues da Lopes, Ana Carolina Reinaldo de SáSilva, Ana Flávia de Oliveira DomingosAraújo, Francisco Mickael dos SantosMendes, Gabriel Antunes RibeiroRoehrs, Dieison DanrleiAlencar, Itiel Elanã SoaresCunha, Lara Lima Pereira da Silva, Roberta Maria AmaralGomes, Symonne Araújo2022-09-26T11:56:08Zoai:ojs.pkp.sfu.ca:article/35270Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:50:14.276633Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review Relación entre la función tiroidea y el Trastorno Depresivo Mayor (MDD): una revisión integrativa de la literatura Relação entre a função tireoidiana e o Transtorno Depressivo Maior (TDM): uma revisão integrativa de literatura |
title |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review |
spellingShingle |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review Cunha, Ítalo Íris Boiba Rodrigues da Hipotireoidismo Hipófise Tiroxina Serotonina. Hypothyroidism Hypophysis Thyroxine Serotonin. Hipófisis Tiroxina Hipotiroidismo Serotonina. |
title_short |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review |
title_full |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review |
title_fullStr |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review |
title_full_unstemmed |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review |
title_sort |
Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review |
author |
Cunha, Ítalo Íris Boiba Rodrigues da |
author_facet |
Cunha, Ítalo Íris Boiba Rodrigues da Lopes, Ana Carolina Reinaldo de Sá Silva, Ana Flávia de Oliveira Domingos Araújo, Francisco Mickael dos Santos Mendes, Gabriel Antunes Ribeiro Roehrs, Dieison Danrlei Alencar, Itiel Elanã Soares Cunha, Lara Lima Pereira da Silva, Roberta Maria Amaral Gomes, Symonne Araújo |
author_role |
author |
author2 |
Lopes, Ana Carolina Reinaldo de Sá Silva, Ana Flávia de Oliveira Domingos Araújo, Francisco Mickael dos Santos Mendes, Gabriel Antunes Ribeiro Roehrs, Dieison Danrlei Alencar, Itiel Elanã Soares Cunha, Lara Lima Pereira da Silva, Roberta Maria Amaral Gomes, Symonne Araújo |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cunha, Ítalo Íris Boiba Rodrigues da Lopes, Ana Carolina Reinaldo de Sá Silva, Ana Flávia de Oliveira Domingos Araújo, Francisco Mickael dos Santos Mendes, Gabriel Antunes Ribeiro Roehrs, Dieison Danrlei Alencar, Itiel Elanã Soares Cunha, Lara Lima Pereira da Silva, Roberta Maria Amaral Gomes, Symonne Araújo |
dc.subject.por.fl_str_mv |
Hipotireoidismo Hipófise Tiroxina Serotonina. Hypothyroidism Hypophysis Thyroxine Serotonin. Hipófisis Tiroxina Hipotiroidismo Serotonina. |
topic |
Hipotireoidismo Hipófise Tiroxina Serotonina. Hypothyroidism Hypophysis Thyroxine Serotonin. Hipófisis Tiroxina Hipotiroidismo Serotonina. |
description |
Thyroid function is closely associated with neuropsychological functions, including mental status and cognitive functions. Subclinical hypothyroidism (HSC) is defined as a condition with elevated levels of thyroid stimulating hormone (TSH) and normal levels of free thyroxine (T4). Although the role played by thyroid hormones in the pathophysiology of mental disorders is unclear, it has been suggested that small changes in thyroid hormone levels, even within the normal range, may be related to altered brain function in depression. Currently, there are 2 explanatory hypotheses: serotonin deficit and noradrenaline deficit in the central nervous system caused by hormonal disorders. It is important to emphasize that the thyroid-psychic pathway is bidirectional, therefore, both thyroid alterations can cause depressive symptoms or exacerbate a previous psychiatric pathology, and depression can promote thyroid disorders, the latter being less frequent. Thus, the role of thyroid function in depressive illness is unclear. Although there is some evidence that mild thyroid alterations predispose to cases of depression, the specific abnormalities involving the thyroid and depressive conditions remain poorly understood. However, there is a causal link. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/35270 10.33448/rsd-v11i12.35270 |
url |
https://rsdjournal.org/index.php/rsd/article/view/35270 |
identifier_str_mv |
10.33448/rsd-v11i12.35270 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/35270/29272 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 12; e599111235270 Research, Society and Development; Vol. 11 Núm. 12; e599111235270 Research, Society and Development; v. 11 n. 12; e599111235270 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052772271521792 |