Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review

Detalhes bibliográficos
Autor(a) principal: Cunha, Ítalo Íris Boiba Rodrigues da
Data de Publicação: 2022
Outros Autores: Lopes, Ana Carolina Reinaldo de Sá, Silva, Ana Flávia de Oliveira Domingos, Araújo, Francisco Mickael dos Santos, Mendes, Gabriel Antunes Ribeiro, Roehrs, Dieison Danrlei, Alencar, Itiel Elanã Soares, Cunha, Lara Lima Pereira da, Silva, Roberta Maria Amaral, Gomes, Symonne Araújo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/35270
Resumo: Thyroid function is closely associated with neuropsychological functions, including mental status and cognitive functions. Subclinical hypothyroidism (HSC) is defined as a condition with elevated levels of thyroid stimulating hormone (TSH) and normal levels of free thyroxine (T4). Although the role played by thyroid hormones in the pathophysiology of mental disorders is unclear, it has been suggested that small changes in thyroid hormone levels, even within the normal range, may be related to altered brain function in depression. Currently, there are 2 explanatory hypotheses: serotonin deficit and noradrenaline deficit in the central nervous system caused by hormonal disorders. It is important to emphasize that the thyroid-psychic pathway is bidirectional, therefore, both thyroid alterations can cause depressive symptoms or exacerbate a previous psychiatric pathology, and depression can promote thyroid disorders, the latter being less frequent. Thus, the role of thyroid function in depressive illness is unclear. Although there is some evidence that mild thyroid alterations predispose to cases of depression, the specific abnormalities involving the thyroid and depressive conditions remain poorly understood. However, there is a causal link.
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spelling Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature reviewRelación entre la función tiroidea y el Trastorno Depresivo Mayor (MDD): una revisión integrativa de la literaturaRelação entre a função tireoidiana e o Transtorno Depressivo Maior (TDM): uma revisão integrativa de literatura HipotireoidismoHipófiseTiroxinaSerotonina.HypothyroidismHypophysisThyroxineSerotonin.HipófisisTiroxinaHipotiroidismoSerotonina.Thyroid function is closely associated with neuropsychological functions, including mental status and cognitive functions. Subclinical hypothyroidism (HSC) is defined as a condition with elevated levels of thyroid stimulating hormone (TSH) and normal levels of free thyroxine (T4). Although the role played by thyroid hormones in the pathophysiology of mental disorders is unclear, it has been suggested that small changes in thyroid hormone levels, even within the normal range, may be related to altered brain function in depression. Currently, there are 2 explanatory hypotheses: serotonin deficit and noradrenaline deficit in the central nervous system caused by hormonal disorders. It is important to emphasize that the thyroid-psychic pathway is bidirectional, therefore, both thyroid alterations can cause depressive symptoms or exacerbate a previous psychiatric pathology, and depression can promote thyroid disorders, the latter being less frequent. Thus, the role of thyroid function in depressive illness is unclear. Although there is some evidence that mild thyroid alterations predispose to cases of depression, the specific abnormalities involving the thyroid and depressive conditions remain poorly understood. However, there is a causal link.La función tiroidea está estrechamente relacionada con las funciones neuropsicológicas, incluido el estado mental y las funciones cognitivas. El hipotiroidismo subclínico (HSC) se define como una condición con niveles elevados de hormona estimulante de la tiroides (TSH) y niveles normales de tiroxina libre (T4). Aunque el papel que juegan las hormonas tiroideas en la fisiopatología de los trastornos mentales no está claro, se ha sugerido que pequeños cambios en los niveles de hormonas tiroideas, incluso dentro del rango normal, pueden estar relacionados con la función cerebral alterada en la depresión. Actualmente, existen 2 hipótesis explicativas: el déficit de serotonina y el déficit de noradrenalina en el sistema nervioso central causados ​​por trastornos hormonales. Es importante recalcar que la vía psíquica-tiroidea es bidireccional, por tanto, tanto las alteraciones tiroideas pueden provocar síntomas depresivos o exacerbar una patología psiquiátrica previa, como la depresión puede promover trastornos tiroideos, siendo estos últimos menos frecuentes. Por lo tanto, el papel de la función tiroidea en la enfermedad depresiva no está claro. Aunque existe alguna evidencia de que las alteraciones leves de la tiroides predisponen a los casos de depresión, las anomalías específicas que involucran la tiroides y las condiciones depresivas siguen sin comprenderse bien. Sin embargo, existe un nexo de causalidad.A função tireoidiana está intimamente associada às funções neuropsicológicas, incluindo o estado mental e as funções cognitivas. O hipotireoidismo subclínico (HSC) é definido como uma condição com níveis elevados de hormônio estimulador da tireoide (TSH) e níveis normais de tiroxina livre (T4). Ainda que não seja claro o papel desempenhado pelos hormônios tireoidianos na fisiopatologia dos transtornos mentais, tem sido sugerido que pequenas mudanças nos níveis de hormônio da tireoide, mesmo dentro da faixa normal, podem estar relacionadas à alteração da função cerebral na depressão. Atualmente, existem 2 hipóteses explicativas: o déficit de serotonina e o déficit de noradrenalina no sistema nervoso central provocados pelos distúrbios hormonais. É importante ressaltar que a via tireoidiana-psíquica é bidirecional, portanto, tanto alterações tireoidianas podem provocar sintomas depressivos ou exacerbar uma patologia psiquiátrica prévia, quanto a depressão pode promover distúrbios tireoidianos, sendo este segundo caso menos frequente. Assim, o papel da função tireoidiana nas doenças depressivas é pouco claro. Embora existam algumas evidências de que discretas alterações tireoidianas predisponham a casos de depressão, as anormalidades específicas envolvendo a tireoide e os quadros depressivos permanecem pouco conhecidas. No entanto, existe um vínculo de causalidade.Research, Society and Development2022-09-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3527010.33448/rsd-v11i12.35270Research, Society and Development; Vol. 11 No. 12; e599111235270Research, Society and Development; Vol. 11 Núm. 12; e599111235270Research, Society and Development; v. 11 n. 12; e5991112352702525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/35270/29272Copyright (c) 2022 Ítalo Íris Boiba Rodrigues da Cunha; Ana Carolina Reinaldo de Sá Lopes; Ana Flávia de Oliveira Domingos Silva; Francisco Mickael dos Santos Araújo; Gabriel Antunes Ribeiro Mendes; Dieison Danrlei Roehrs; Itiel Elanã Soares Alencar; Lara Lima Pereira da Cunha; Roberta Maria Amaral Silva; Symonne Araújo Gomeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCunha, Ítalo Íris Boiba Rodrigues da Lopes, Ana Carolina Reinaldo de SáSilva, Ana Flávia de Oliveira DomingosAraújo, Francisco Mickael dos SantosMendes, Gabriel Antunes RibeiroRoehrs, Dieison DanrleiAlencar, Itiel Elanã SoaresCunha, Lara Lima Pereira da Silva, Roberta Maria AmaralGomes, Symonne Araújo2022-09-26T11:56:08Zoai:ojs.pkp.sfu.ca:article/35270Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:50:14.276633Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
Relación entre la función tiroidea y el Trastorno Depresivo Mayor (MDD): una revisión integrativa de la literatura
Relação entre a função tireoidiana e o Transtorno Depressivo Maior (TDM): uma revisão integrativa de literatura
title Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
spellingShingle Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
Cunha, Ítalo Íris Boiba Rodrigues da
Hipotireoidismo
Hipófise
Tiroxina
Serotonina.
Hypothyroidism
Hypophysis
Thyroxine
Serotonin.
Hipófisis
Tiroxina
Hipotiroidismo
Serotonina.
title_short Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
title_full Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
title_fullStr Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
title_full_unstemmed Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
title_sort Relationship between thyroid function and Major Depressive Disorder (MDD): an integrative literature review
author Cunha, Ítalo Íris Boiba Rodrigues da
author_facet Cunha, Ítalo Íris Boiba Rodrigues da
Lopes, Ana Carolina Reinaldo de Sá
Silva, Ana Flávia de Oliveira Domingos
Araújo, Francisco Mickael dos Santos
Mendes, Gabriel Antunes Ribeiro
Roehrs, Dieison Danrlei
Alencar, Itiel Elanã Soares
Cunha, Lara Lima Pereira da
Silva, Roberta Maria Amaral
Gomes, Symonne Araújo
author_role author
author2 Lopes, Ana Carolina Reinaldo de Sá
Silva, Ana Flávia de Oliveira Domingos
Araújo, Francisco Mickael dos Santos
Mendes, Gabriel Antunes Ribeiro
Roehrs, Dieison Danrlei
Alencar, Itiel Elanã Soares
Cunha, Lara Lima Pereira da
Silva, Roberta Maria Amaral
Gomes, Symonne Araújo
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, Ítalo Íris Boiba Rodrigues da
Lopes, Ana Carolina Reinaldo de Sá
Silva, Ana Flávia de Oliveira Domingos
Araújo, Francisco Mickael dos Santos
Mendes, Gabriel Antunes Ribeiro
Roehrs, Dieison Danrlei
Alencar, Itiel Elanã Soares
Cunha, Lara Lima Pereira da
Silva, Roberta Maria Amaral
Gomes, Symonne Araújo
dc.subject.por.fl_str_mv Hipotireoidismo
Hipófise
Tiroxina
Serotonina.
Hypothyroidism
Hypophysis
Thyroxine
Serotonin.
Hipófisis
Tiroxina
Hipotiroidismo
Serotonina.
topic Hipotireoidismo
Hipófise
Tiroxina
Serotonina.
Hypothyroidism
Hypophysis
Thyroxine
Serotonin.
Hipófisis
Tiroxina
Hipotiroidismo
Serotonina.
description Thyroid function is closely associated with neuropsychological functions, including mental status and cognitive functions. Subclinical hypothyroidism (HSC) is defined as a condition with elevated levels of thyroid stimulating hormone (TSH) and normal levels of free thyroxine (T4). Although the role played by thyroid hormones in the pathophysiology of mental disorders is unclear, it has been suggested that small changes in thyroid hormone levels, even within the normal range, may be related to altered brain function in depression. Currently, there are 2 explanatory hypotheses: serotonin deficit and noradrenaline deficit in the central nervous system caused by hormonal disorders. It is important to emphasize that the thyroid-psychic pathway is bidirectional, therefore, both thyroid alterations can cause depressive symptoms or exacerbate a previous psychiatric pathology, and depression can promote thyroid disorders, the latter being less frequent. Thus, the role of thyroid function in depressive illness is unclear. Although there is some evidence that mild thyroid alterations predispose to cases of depression, the specific abnormalities involving the thyroid and depressive conditions remain poorly understood. However, there is a causal link.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/35270
10.33448/rsd-v11i12.35270
url https://rsdjournal.org/index.php/rsd/article/view/35270
identifier_str_mv 10.33448/rsd-v11i12.35270
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/35270/29272
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 12; e599111235270
Research, Society and Development; Vol. 11 Núm. 12; e599111235270
Research, Society and Development; v. 11 n. 12; e599111235270
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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