Persea americana study in the control of Diabetes mellitus: systematic review
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Publication Date: | 2022 |
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Format: | Article |
Language: | por |
Source: | Research, Society and Development |
Download full: | https://rsdjournal.org/index.php/rsd/article/view/29068 |
Summary: | Background: Diabetes mellitus (DM) is a prevalent disease that represents one of the great challenges for public health. The use of medicinal plants has been used in the control of diabetes such as Persea americana. Thus, this work aims to collect scientific knowledge about the plant species P. americana in the control of DM through a systematic review. Methods: This is a systematic review of in vivo and in vitro studies, according to the recommendations of the PRISMA protocol, in the following steps: 1) elaboration of the guiding question occurred from the acronym PICO (P - Population and/or Problem, I - Intervention, C - Comparison and O - Outcome/outcomes) with definition of descriptors; 2) sampling (selection of articles) following inclusion/exclusion criteria; 3) search for articles in Scopus, PubMed/MEDLINE and VHL (BIREME) databases; 4) sampling (selection of articles); 5) definition of the information to be extracted from the reviewed works; 6) synthesis of knowledge evidenced in the analyzed articles. Results: Of the 12 articles selected, eight were experimental in vivo studies and 4 were experimental in vitro studies. Diabetic animal models such as Goto-Kakizaki rats and models induced with streptozocin and alloxan were used. The studies showed a reduction in glycemia with the use of P. americana extracts through different pathophysiological pathways. Conclusion: P. americana can contribute to the reduction of DM control and may be a precursor of new substances with pharmacological activity and defined as a great potential for transforming a future antidiabetic drug. |
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Persea americana study in the control of Diabetes mellitus: systematic reviewEstudio de Persea americana en el control de la Diabetes mellitus: revisión sistemáticaEstudo da Persea americana no controle do Diabetes mellitus: revisão sistemáticaDiabetes mellitusPerseaHipoglucemia.Diabetes mellitusPerseaHypoglycemia.Diabetes mellitusPersea americanaHipoglicemia.Background: Diabetes mellitus (DM) is a prevalent disease that represents one of the great challenges for public health. The use of medicinal plants has been used in the control of diabetes such as Persea americana. Thus, this work aims to collect scientific knowledge about the plant species P. americana in the control of DM through a systematic review. Methods: This is a systematic review of in vivo and in vitro studies, according to the recommendations of the PRISMA protocol, in the following steps: 1) elaboration of the guiding question occurred from the acronym PICO (P - Population and/or Problem, I - Intervention, C - Comparison and O - Outcome/outcomes) with definition of descriptors; 2) sampling (selection of articles) following inclusion/exclusion criteria; 3) search for articles in Scopus, PubMed/MEDLINE and VHL (BIREME) databases; 4) sampling (selection of articles); 5) definition of the information to be extracted from the reviewed works; 6) synthesis of knowledge evidenced in the analyzed articles. Results: Of the 12 articles selected, eight were experimental in vivo studies and 4 were experimental in vitro studies. Diabetic animal models such as Goto-Kakizaki rats and models induced with streptozocin and alloxan were used. The studies showed a reduction in glycemia with the use of P. americana extracts through different pathophysiological pathways. Conclusion: P. americana can contribute to the reduction of DM control and may be a precursor of new substances with pharmacological activity and defined as a great potential for transforming a future antidiabetic drug.Introducción: La diabetes mellitus (DM) es una enfermedad prevalente que representa uno de los grandes desafíos para la salud pública. En el control de la diabetes se ha utilizado el uso de plantas medicinales como la Persea americana. Así, este trabajo tiene como objetivo recopilar el conocimiento científico sobre la especie vegetal P. americana en el control de la DM a través de una revisión sistemática. Métodos: Se trata de una revisión sistemática de estudios in vivo e in vitro, de acuerdo con las recomendaciones del protocolo PRISMA, en los siguientes pasos: 1) elaboración de la pregunta guía ocurrida a partir de las siglas PICO (P - Población y/o Problema, I - Intervención, C - Comparación y O - Resultado/resultados) con definición de descriptores; 2) muestreo (selección de artículos) siguiendo criterios de inclusión/exclusión; 3) búsqueda de artículos en las bases de datos Scopus, PubMed/MEDLINE y BVS (BIREME); 4) muestreo (selección de artículos); 5) definición de la información a extraer de los trabajos revisados; 6) síntesis de conocimientos evidenciados en los artículos analizados. Resultados: De los 12 artículos seleccionados, ocho eran estudios experimentales in vivo y 4 eran estudios experimentales in vitro. Se utilizaron modelos animales diabéticos como ratas Goto-Kakizaki y modelos inducidos con estreptozocina y aloxano, los estudios mostraron una reducción de la glucemia con el uso de extractos de P. americana a través de diferentes vías fisiopatológicas. Conclusión: P. americana puede contribuir a la reducción del control de la DM y puede ser precursora de nuevas sustancias con actividad farmacológica y definida como un gran potencial para transformarse en un futuro fármaco antidiabético.Introdução: Diabetes mellitus (DM) é uma doença prevalente que representa um dos grandes desafios para saúde pública. O uso de plantas medicinais vem sendo usada no controle do diabetes como a Persea americana. Desse modo, este trabalho tem como objetivo fazer a coletânea do conhecimento científico sobre a espécie vegetal P. americana no controle do DM por meio de uma revisão sistemática. Métodos: Trata-se de uma revisão sistemática de estudos in vivo e em vitro, segundo recomendações do protocolo PRISMA, nas seguintes etapas: 1) elaboração da pergunta norteadora ocorreu partir do acrônimo PICO (P – População e/ou Problema, I - Intervenção, C - Comparação e O – Outcome /desfechos) com definição dos descritores; 2) amostragem (seleção dos artigos) obedecendo critérios para inclusão/exclusão; 3) busca dos artigos nas bases de dados Scopus, PubMed/MEDLINE e BVS (BIREME); 4) amostragem (seleção dos artigos); 5) definição das informações a serem extraídas dos trabalhos revisados; 6) síntese do conhecimento evidenciado nos artigos analisados. Resultados: Dos 12 artigos selecionados, oito eram estudos experimentais in vivo e 4 estudos experimentais in vitro. Foram usados modelos de animais diabéticos como ratos Goto-Kakizaki e os modelos induzidos com estreptozocina e aloxana. Os estudos mostraram uma redução da glicemia com o uso de extratos de P. americana por diferentes vias fisiopatológicas. Conclusão: A P. americana pode contribuir para a redução do controle do DM podendo ser precursora de novas substâncias com atividade farmacológica e definida como grande potencialidade de transformação de uma futura droga antidiabética.Research, Society and Development2022-04-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2906810.33448/rsd-v11i6.29068Research, Society and Development; Vol. 11 No. 6; e24811629068Research, Society and Development; Vol. 11 Núm. 6; e24811629068Research, Society and Development; v. 11 n. 6; e248116290682525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/29068/25177Copyright (c) 2022 Vivian Brito Silva; Clariano Pires de Oliveira Neto; Maylla Luanna Barbosa Martins Bragança; Suzanne Silva Barros Lima; Darci Ramos Fernandes; Mara Alessandra Pereira Moreira; Shirley Martins; Maria do Socorro de Sousa Cartágenes; Manuel dos Santos Faria; Fernanda Ferreira Lopeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Vivian Brito Oliveira Neto, Clariano Pires de Bragança, Maylla Luanna Barbosa Martins Lima, Suzanne Silva Barros Fernandes, Darci Ramos Moreira, Mara Alessandra Pereira Martins, ShirleyCartágenes, Maria do Socorro de Sousa Faria, Manuel dos Santos Lopes, Fernanda Ferreira 2022-05-13T18:04:10Zoai:ojs.pkp.sfu.ca:article/29068Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:14.842631Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Persea americana study in the control of Diabetes mellitus: systematic review Estudio de Persea americana en el control de la Diabetes mellitus: revisión sistemática Estudo da Persea americana no controle do Diabetes mellitus: revisão sistemática |
title |
Persea americana study in the control of Diabetes mellitus: systematic review |
spellingShingle |
Persea americana study in the control of Diabetes mellitus: systematic review Silva, Vivian Brito Diabetes mellitus Persea Hipoglucemia. Diabetes mellitus Persea Hypoglycemia. Diabetes mellitus Persea americana Hipoglicemia. |
title_short |
Persea americana study in the control of Diabetes mellitus: systematic review |
title_full |
Persea americana study in the control of Diabetes mellitus: systematic review |
title_fullStr |
Persea americana study in the control of Diabetes mellitus: systematic review |
title_full_unstemmed |
Persea americana study in the control of Diabetes mellitus: systematic review |
title_sort |
Persea americana study in the control of Diabetes mellitus: systematic review |
author |
Silva, Vivian Brito |
author_facet |
Silva, Vivian Brito Oliveira Neto, Clariano Pires de Bragança, Maylla Luanna Barbosa Martins Lima, Suzanne Silva Barros Fernandes, Darci Ramos Moreira, Mara Alessandra Pereira Martins, Shirley Cartágenes, Maria do Socorro de Sousa Faria, Manuel dos Santos Lopes, Fernanda Ferreira |
author_role |
author |
author2 |
Oliveira Neto, Clariano Pires de Bragança, Maylla Luanna Barbosa Martins Lima, Suzanne Silva Barros Fernandes, Darci Ramos Moreira, Mara Alessandra Pereira Martins, Shirley Cartágenes, Maria do Socorro de Sousa Faria, Manuel dos Santos Lopes, Fernanda Ferreira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Vivian Brito Oliveira Neto, Clariano Pires de Bragança, Maylla Luanna Barbosa Martins Lima, Suzanne Silva Barros Fernandes, Darci Ramos Moreira, Mara Alessandra Pereira Martins, Shirley Cartágenes, Maria do Socorro de Sousa Faria, Manuel dos Santos Lopes, Fernanda Ferreira |
dc.subject.por.fl_str_mv |
Diabetes mellitus Persea Hipoglucemia. Diabetes mellitus Persea Hypoglycemia. Diabetes mellitus Persea americana Hipoglicemia. |
topic |
Diabetes mellitus Persea Hipoglucemia. Diabetes mellitus Persea Hypoglycemia. Diabetes mellitus Persea americana Hipoglicemia. |
description |
Background: Diabetes mellitus (DM) is a prevalent disease that represents one of the great challenges for public health. The use of medicinal plants has been used in the control of diabetes such as Persea americana. Thus, this work aims to collect scientific knowledge about the plant species P. americana in the control of DM through a systematic review. Methods: This is a systematic review of in vivo and in vitro studies, according to the recommendations of the PRISMA protocol, in the following steps: 1) elaboration of the guiding question occurred from the acronym PICO (P - Population and/or Problem, I - Intervention, C - Comparison and O - Outcome/outcomes) with definition of descriptors; 2) sampling (selection of articles) following inclusion/exclusion criteria; 3) search for articles in Scopus, PubMed/MEDLINE and VHL (BIREME) databases; 4) sampling (selection of articles); 5) definition of the information to be extracted from the reviewed works; 6) synthesis of knowledge evidenced in the analyzed articles. Results: Of the 12 articles selected, eight were experimental in vivo studies and 4 were experimental in vitro studies. Diabetic animal models such as Goto-Kakizaki rats and models induced with streptozocin and alloxan were used. The studies showed a reduction in glycemia with the use of P. americana extracts through different pathophysiological pathways. Conclusion: P. americana can contribute to the reduction of DM control and may be a precursor of new substances with pharmacological activity and defined as a great potential for transforming a future antidiabetic drug. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29068 10.33448/rsd-v11i6.29068 |
url |
https://rsdjournal.org/index.php/rsd/article/view/29068 |
identifier_str_mv |
10.33448/rsd-v11i6.29068 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29068/25177 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 6; e24811629068 Research, Society and Development; Vol. 11 Núm. 6; e24811629068 Research, Society and Development; v. 11 n. 6; e24811629068 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052765766156288 |