Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer

Detalhes bibliográficos
Autor(a) principal: Nascimento, Daniela Macedo
Data de Publicação: 2022
Outros Autores: Macedo, Jeane Pereira, Nascimento, Ademir Macedo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/34985
Resumo: Pluronic F98 and F127 have a higher hydrophilic percentage (70 wt%), in the case of Pluronic F127 and 80% in the case of F98. The article consists of a comparison of the LBL parameter and its influence on the formation of Gold Nanoparticles. These nanoparticles are chosen because they have low toxicity, as well as being effective in medicinal application. Stomach cancer has a high incidence. There is the formation of compounds with a hydrophobic core of polypropylene oxide (PPO) and a hydrophilic crown of polyethylene oxide (PEO). The Pluronic-Nanoparticle system will be gradually released in the patient's body, for less toxicity and greater treatment efficacy. The methodologies used in this first phase are the bibliographic sources and their survey and the use of the main databases for this purpose.
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spelling Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancerInfluencia del parámetro de Equilibrio Hidrofílico- Hidrofóbico (HLB) de los polímeros F98 y F127 en la efectividad de la formación de nanopartículas de oro y encapsulación del fármaco capecitabina para el tratamiento del cáncer de estómagoInfluência do Parâmetro de Equilíbrio Hidrofílico- Hidrofóbico (HLB) dos Polímeros F98 e F127 na eficácia da formação de nanopartículas de ouro e encapsulamento do fármaco capecitabina para tratamento de câncer de estomâgoNanopartícula de OuroPluronic F127Pluronic F98Câncer de estômago.Golden NanoparticlePluronic F127Pluronic F98Stomach cancer.Pluronic F127Pluronic F98Nanopartícula de OroCáncer de estómago.Pluronic F98 and F127 have a higher hydrophilic percentage (70 wt%), in the case of Pluronic F127 and 80% in the case of F98. The article consists of a comparison of the LBL parameter and its influence on the formation of Gold Nanoparticles. These nanoparticles are chosen because they have low toxicity, as well as being effective in medicinal application. Stomach cancer has a high incidence. There is the formation of compounds with a hydrophobic core of polypropylene oxide (PPO) and a hydrophilic crown of polyethylene oxide (PEO). The Pluronic-Nanoparticle system will be gradually released in the patient's body, for less toxicity and greater treatment efficacy. The methodologies used in this first phase are the bibliographic sources and their survey and the use of the main databases for this purpose.Pluronic F98 y F127 óxido de polietileno (PEO), teniendo un mayor porcentaje hidrofílico (70% en peso), en el caso de Pluironic F127 y 80% en el caso de F98. El artículo consiste en comparar el parámetro HLB y su influencia en la formación de Nanopartículas de Oro, se escogen estas nanopartículas por presentar baja toxicidad, además de ser efectivas en aplicación medicinal. El cáncer de estómago es uno de los cánceres más comunes. La formación de compuestos por un núcleo hidrofóbico de óxido de polipropileno (PPO) y una corona hidrofílica de óxido de polietileno (PEO). El sistema Pluronic-Nanopartículas se liberará gradualmente en el cuerpo del paciente, para una menor toxicidad y una mayor eficacia del tratamiento. para una menor toxicidad y una mayor eficacia del tratamiento. Las metodologías utilizadas en esta primera fase son las fuentes bibliográficas y su levantamiento y el uso de las principales bases de datos para tal fin.O Pluronic F98 e F127 possui maior porcentagem hidrofílica (70 wt%), no caso do Pluronic F127 e 80% no caso do F98. O artigo consiste na comparação do parâmetro HLB e da sua influência na formação das Nanopartículas de Ouro. São escolhidas essas nanopartículas, por apresentarem baixa toxicidade, como também ser eficaz em aplicação medicinal. O câncer de estômago exibe alta incidência. Há a formação dos compostos com um núcleo hidrofóbico de polióxido de propileno (PPO) e uma coroa hidrofílica de polióxido de etileno (PEO). O objetivo do trabalho é sintetizar um sistema Pluronic-Nanopartícula que irá liberar gradualmente a Capecitabina no organismo dos pacientes, para menor toxicidade e maior eficácia do tratamento. As metodologias empregadas nesta primeira fase são as fontes bibliográficas e levantamento das mesmas e utilização das principais bases de dados para esta finalidade.Research, Society and Development2022-09-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3498510.33448/rsd-v11i13.34985Research, Society and Development; Vol. 11 No. 13; e43111334985Research, Society and Development; Vol. 11 Núm. 13; e43111334985Research, Society and Development; v. 11 n. 13; e431113349852525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/34985/29457Copyright (c) 2022 Daniela Macedo Nascimento; Jeane Pereira Macedo; Ademir Macedo Nascimentohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNascimento, Daniela Macedo Macedo, Jeane Pereira Nascimento, Ademir Macedo 2022-10-17T13:43:46Zoai:ojs.pkp.sfu.ca:article/34985Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:50:04.090560Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
Influencia del parámetro de Equilibrio Hidrofílico- Hidrofóbico (HLB) de los polímeros F98 y F127 en la efectividad de la formación de nanopartículas de oro y encapsulación del fármaco capecitabina para el tratamiento del cáncer de estómago
Influência do Parâmetro de Equilíbrio Hidrofílico- Hidrofóbico (HLB) dos Polímeros F98 e F127 na eficácia da formação de nanopartículas de ouro e encapsulamento do fármaco capecitabina para tratamento de câncer de estomâgo
title Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
spellingShingle Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
Nascimento, Daniela Macedo
Nanopartícula de Ouro
Pluronic F127
Pluronic F98
Câncer de estômago.
Golden Nanoparticle
Pluronic F127
Pluronic F98
Stomach cancer.
Pluronic F127
Pluronic F98
Nanopartícula de Oro
Cáncer de estómago.
title_short Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
title_full Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
title_fullStr Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
title_full_unstemmed Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
title_sort Influence of Hydrophilic-Lipophilic Balance (HLB) parameter of F98 and F127 polymers on the effectiveness of the formation of gold nanoparticles and encapsulation of the drug capecitabine for the treatment of stomach cancer
author Nascimento, Daniela Macedo
author_facet Nascimento, Daniela Macedo
Macedo, Jeane Pereira
Nascimento, Ademir Macedo
author_role author
author2 Macedo, Jeane Pereira
Nascimento, Ademir Macedo
author2_role author
author
dc.contributor.author.fl_str_mv Nascimento, Daniela Macedo
Macedo, Jeane Pereira
Nascimento, Ademir Macedo
dc.subject.por.fl_str_mv Nanopartícula de Ouro
Pluronic F127
Pluronic F98
Câncer de estômago.
Golden Nanoparticle
Pluronic F127
Pluronic F98
Stomach cancer.
Pluronic F127
Pluronic F98
Nanopartícula de Oro
Cáncer de estómago.
topic Nanopartícula de Ouro
Pluronic F127
Pluronic F98
Câncer de estômago.
Golden Nanoparticle
Pluronic F127
Pluronic F98
Stomach cancer.
Pluronic F127
Pluronic F98
Nanopartícula de Oro
Cáncer de estómago.
description Pluronic F98 and F127 have a higher hydrophilic percentage (70 wt%), in the case of Pluronic F127 and 80% in the case of F98. The article consists of a comparison of the LBL parameter and its influence on the formation of Gold Nanoparticles. These nanoparticles are chosen because they have low toxicity, as well as being effective in medicinal application. Stomach cancer has a high incidence. There is the formation of compounds with a hydrophobic core of polypropylene oxide (PPO) and a hydrophilic crown of polyethylene oxide (PEO). The Pluronic-Nanoparticle system will be gradually released in the patient's body, for less toxicity and greater treatment efficacy. The methodologies used in this first phase are the bibliographic sources and their survey and the use of the main databases for this purpose.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/34985
10.33448/rsd-v11i13.34985
url https://rsdjournal.org/index.php/rsd/article/view/34985
identifier_str_mv 10.33448/rsd-v11i13.34985
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/34985/29457
dc.rights.driver.fl_str_mv Copyright (c) 2022 Daniela Macedo Nascimento; Jeane Pereira Macedo; Ademir Macedo Nascimento
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Daniela Macedo Nascimento; Jeane Pereira Macedo; Ademir Macedo Nascimento
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 13; e43111334985
Research, Society and Development; Vol. 11 Núm. 13; e43111334985
Research, Society and Development; v. 11 n. 13; e43111334985
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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