The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/15134 |
Resumo: | Recently, there is strong evidence for the beneficial role of antioxidants in the treatment of periodontal diseases. A drug that is gaining more and more focus in new research is N-acetylcysteine, an antioxidant that contributes to the increase in glutathione (GSH), used as a mucolytic agent, however, recent studies have shown its significant role in decreasing levels of reactive oxygen species and in the bone resorption process in experimental periodontitis, therefore, this review sought to elucidate whether N-acetylcysteine is effective in the treatment of periodontitis and also in the involved mechanisms already mentioned in the literature. The present study is a mini-review, in which a search was performed on Google Scholar, PubMed and Web of Science and databases for the collection of studies published in the last 10 years (2009-2020). The mini-review included studies that addressed a direct or indirect link between the effects of N-acetylcysteine on periodontitis, studies published in recent years, and in vitro and in vivo studies (animal and / or human models). Seven articles were selected from the following databases: PubMed (03) and Google Scholar (04) were subsequently analyzed. As for the language and the journal, all were published in international Journals and in English. It was concluded that N-acetylcysteine was effective in bone resorption in experimental periodontitis, but further studies are suggested in order to elucidate all the mechanisms involved in the observed results. |
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The Effect of N-acetylcysteine on Periodontitis: A mini-review of literatureLos efectos de la N-acetilcisteína en la periodontitis: Una mini-revisión de la literaturaEfeitos da N-acetilcisteína sobre a Periodontite: Uma mini-revisão da literaturaBone resorptionN-acetylcysteinePeriodontitisOxygen-reactive species.Reabsorción óseaN-acetilcisteínaPeriodontitisEspecies de oxigenio reactivas.Reabsorção ósseaN-acetilcisteínaPeriodontiteEspécies reativas de oxigênio.Recently, there is strong evidence for the beneficial role of antioxidants in the treatment of periodontal diseases. A drug that is gaining more and more focus in new research is N-acetylcysteine, an antioxidant that contributes to the increase in glutathione (GSH), used as a mucolytic agent, however, recent studies have shown its significant role in decreasing levels of reactive oxygen species and in the bone resorption process in experimental periodontitis, therefore, this review sought to elucidate whether N-acetylcysteine is effective in the treatment of periodontitis and also in the involved mechanisms already mentioned in the literature. The present study is a mini-review, in which a search was performed on Google Scholar, PubMed and Web of Science and databases for the collection of studies published in the last 10 years (2009-2020). The mini-review included studies that addressed a direct or indirect link between the effects of N-acetylcysteine on periodontitis, studies published in recent years, and in vitro and in vivo studies (animal and / or human models). Seven articles were selected from the following databases: PubMed (03) and Google Scholar (04) were subsequently analyzed. As for the language and the journal, all were published in international Journals and in English. It was concluded that N-acetylcysteine was effective in bone resorption in experimental periodontitis, but further studies are suggested in order to elucidate all the mechanisms involved in the observed results.Recientemente, existe una fuerte evidencia del papel beneficioso de los antioxidantes en el tratamiento de las enfermedades periodontales. Un fármaco que está ganando cada vez más atención en las nuevas investigaciones es la N-acetilcisteína, un antioxidante que contribuye al aumento de glutatión (GSH), utilizado como agente mucolítico; sin embargo, estudios recientes han demostrado su importante papel en la disminución de los niveles de reactivos especies de oxígeno y en el proceso de resorción ósea en periodontitis experimental, por lo que esta revisión buscó dilucidar si la N-acetilcisteína es efectiva en el tratamiento de la periodontitis y también en los mecanismos involucrados ya mencionados en la literatura El presente estudio es una mini-revisión, en la que se realizó una búsqueda en Google Scholar, PubMed y Web of Science y bases de datos para la colección de estudios publicados en los últimos 10 años (2009-2020). La mini revisión incluyó estudios que abordaron un vínculo directo o indirecto entre los efectos de la N-acetilcisteína en la periodontitis, estudios publicados en los últimos años y estudios in vitro e in vivo (modelos animales y / o humanos) posteriormente se analizaron. Se seleccionaron siete artículos de las siguientes bases de datos: PubMed (03) y Google Scholar (04). En cuanto al idioma y la revista, todos fueron publicados en periódicos internacionales y en inglés. Se concluyó que la N-acetilcisteína fue eficaz en la resorción ósea en la periodontitis experimental, pero se sugieren más estudios para dilucidar todos los mecanismos involucrados en los resultados observados.Recentemente, há fortes evidências do papel benéfico dos antioxidantes no tratamento de doenças periodontais. Uma droga que está ganhando cada vez mais foco em novas pesquisas é a N-acetilcisteína, um fármaco antioxidante que contribui para o aumento de glutationa (GSH), usada como agente mucolítico, no entanto, estudos recentes demonstraram seu papel significativo na diminuição dos níveis de espécies reativas de oxigênio e no processo de reabsorção óssea na periodontite experimental, portanto, esta revisão procurou elucidar se a N-acetilcisteína é eficaz no tratamento da periodontite e também nos mecanismos envolvidos já mencionados na literatura. O presente estudo trata-se de uma mini-revisão, em que uma busca foi realizada no Google Acadêmico, PubMed e Web of Science e bancos de dados para a coleta de estudos publicados nos últimos 10 anos (2009-2020). A mini-revisão incluiu estudos que abordaram uma ligação direta ou indireta entre os efeitos da N-acetilcisteína na periodontite, estudos publicados nos últimos anos e estudos in vitro e in vivo (modelos animais e / ou humanos). Sete artigos foram selecionados nas seguintes bases de dados: PubMed (03) e Google Acadêmico (04) posteriormente foram analisados. Quanto ao idioma e ao periódico, todos foram publicados em jornais internacionais e em idioma inglês. Concluiu-se que a N-acetilcisteína foi eficaz na reabsorção óssea na periodontite experimental, mas sugerem-se novos estudos a fim de elucidar todos os mecanismos envolvidos nos resultados observados.Research, Society and Development2021-05-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1513410.33448/rsd-v10i5.15134Research, Society and Development; Vol. 10 No. 5; e42610515134Research, Society and Development; Vol. 10 Núm. 5; e42610515134Research, Society and Development; v. 10 n. 5; e426105151342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/15134/13560Copyright (c) 2021 André dos Santos Carvalho; Even Herlany Pereira Alves; Mateus Cardoso do Amaral; Hélio Mateus Silva Nascimento; Ayane Araújo Rodrigues; Vinicius da Silva Caetano; Ana Clara Silva Sales; Thais Amanda de Lima Nunes; Wesley Rodrigues da Silva; John Arlley Sousa Pinho de Lira; Paulo Roberto Carneiro Gomes; Francisco Alex da Rocha Coelho; João Paulo Araujo de Sousa; Jacks Renan Neves Fernandes; Daniel Fernando Pereira Vasconceloshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarvalho, André dos Santos Alves, Even Herlany Pereira Amaral, Mateus Cardoso do Nascimento, Hélio Mateus Silva Rodrigues, Ayane Araújo Caetano, Vinicius da Silva Sales, Ana Clara Silva Nunes, Thais Amanda de Lima Silva, Wesley Rodrigues da Lira, John Arlley Sousa Pinho de Gomes, Paulo Roberto Carneiro Coelho, Francisco Alex da Rocha Sousa, João Paulo Araujo de Fernandes, Jacks Renan Neves Vasconcelos, Daniel Fernando Pereira 2021-05-17T18:20:49Zoai:ojs.pkp.sfu.ca:article/15134Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:02.101307Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature Los efectos de la N-acetilcisteína en la periodontitis: Una mini-revisión de la literatura Efeitos da N-acetilcisteína sobre a Periodontite: Uma mini-revisão da literatura |
title |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature |
spellingShingle |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature Carvalho, André dos Santos Bone resorption N-acetylcysteine Periodontitis Oxygen-reactive species. Reabsorción ósea N-acetilcisteína Periodontitis Especies de oxigenio reactivas. Reabsorção óssea N-acetilcisteína Periodontite Espécies reativas de oxigênio. |
title_short |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature |
title_full |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature |
title_fullStr |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature |
title_full_unstemmed |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature |
title_sort |
The Effect of N-acetylcysteine on Periodontitis: A mini-review of literature |
author |
Carvalho, André dos Santos |
author_facet |
Carvalho, André dos Santos Alves, Even Herlany Pereira Amaral, Mateus Cardoso do Nascimento, Hélio Mateus Silva Rodrigues, Ayane Araújo Caetano, Vinicius da Silva Sales, Ana Clara Silva Nunes, Thais Amanda de Lima Silva, Wesley Rodrigues da Lira, John Arlley Sousa Pinho de Gomes, Paulo Roberto Carneiro Coelho, Francisco Alex da Rocha Sousa, João Paulo Araujo de Fernandes, Jacks Renan Neves Vasconcelos, Daniel Fernando Pereira |
author_role |
author |
author2 |
Alves, Even Herlany Pereira Amaral, Mateus Cardoso do Nascimento, Hélio Mateus Silva Rodrigues, Ayane Araújo Caetano, Vinicius da Silva Sales, Ana Clara Silva Nunes, Thais Amanda de Lima Silva, Wesley Rodrigues da Lira, John Arlley Sousa Pinho de Gomes, Paulo Roberto Carneiro Coelho, Francisco Alex da Rocha Sousa, João Paulo Araujo de Fernandes, Jacks Renan Neves Vasconcelos, Daniel Fernando Pereira |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, André dos Santos Alves, Even Herlany Pereira Amaral, Mateus Cardoso do Nascimento, Hélio Mateus Silva Rodrigues, Ayane Araújo Caetano, Vinicius da Silva Sales, Ana Clara Silva Nunes, Thais Amanda de Lima Silva, Wesley Rodrigues da Lira, John Arlley Sousa Pinho de Gomes, Paulo Roberto Carneiro Coelho, Francisco Alex da Rocha Sousa, João Paulo Araujo de Fernandes, Jacks Renan Neves Vasconcelos, Daniel Fernando Pereira |
dc.subject.por.fl_str_mv |
Bone resorption N-acetylcysteine Periodontitis Oxygen-reactive species. Reabsorción ósea N-acetilcisteína Periodontitis Especies de oxigenio reactivas. Reabsorção óssea N-acetilcisteína Periodontite Espécies reativas de oxigênio. |
topic |
Bone resorption N-acetylcysteine Periodontitis Oxygen-reactive species. Reabsorción ósea N-acetilcisteína Periodontitis Especies de oxigenio reactivas. Reabsorção óssea N-acetilcisteína Periodontite Espécies reativas de oxigênio. |
description |
Recently, there is strong evidence for the beneficial role of antioxidants in the treatment of periodontal diseases. A drug that is gaining more and more focus in new research is N-acetylcysteine, an antioxidant that contributes to the increase in glutathione (GSH), used as a mucolytic agent, however, recent studies have shown its significant role in decreasing levels of reactive oxygen species and in the bone resorption process in experimental periodontitis, therefore, this review sought to elucidate whether N-acetylcysteine is effective in the treatment of periodontitis and also in the involved mechanisms already mentioned in the literature. The present study is a mini-review, in which a search was performed on Google Scholar, PubMed and Web of Science and databases for the collection of studies published in the last 10 years (2009-2020). The mini-review included studies that addressed a direct or indirect link between the effects of N-acetylcysteine on periodontitis, studies published in recent years, and in vitro and in vivo studies (animal and / or human models). Seven articles were selected from the following databases: PubMed (03) and Google Scholar (04) were subsequently analyzed. As for the language and the journal, all were published in international Journals and in English. It was concluded that N-acetylcysteine was effective in bone resorption in experimental periodontitis, but further studies are suggested in order to elucidate all the mechanisms involved in the observed results. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-12 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/15134 10.33448/rsd-v10i5.15134 |
url |
https://rsdjournal.org/index.php/rsd/article/view/15134 |
identifier_str_mv |
10.33448/rsd-v10i5.15134 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/15134/13560 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 5; e42610515134 Research, Society and Development; Vol. 10 Núm. 5; e42610515134 Research, Society and Development; v. 10 n. 5; e42610515134 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052748821168128 |