Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/32454 |
Resumo: | Azadirachta indica A. Juss (Neen) has great ethnomedicinal importance, being known for its insecticidal power and for various therapeutic purposes as a folk medicine. Studies show that endophytes isolated from medicinal plants have potential as an alternative source of secondary metabolites. More than 400 compounds have been isolated from different parts of Neen, including important bioactive secondary metabolites such as azadirachtin, nimbidin, nimbin, nimbolide, gedunin, however, the metabolites of fungi already isolated and characterized showed that more than half of the molecules have antibacterial activity, antifungal and antitumor. Penicillin, cephalosporin, ergotrate and statins are fungal secondary metabolites. The present work aimed to carry out a review of the literature on bioactive products from endophytic fungi of Azadirachta indica and their applications. Activities from extracts of plant parts (leaves, stems, roots) or from cultivation and selection of endophytes other than the kingdom Fungi were excluded. 11 articles were found in the databases that present 12 different endophytic fungi, isolated from Azadirachta indica, with the production of different secondary metabolites and varied applications. Antimicrobial, antifungal, insecticidal and nematicidal activities and improvement in plant adaptation mechanisms. Thirty-four metabolites were identified and tested in different techniques and applications. |
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Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their ApplicationsDerivados Bioactivos de Hongos Endofíticos Aislados de Azadirachta Indica (Neem) y sus AplicacionesBioativos Derivados de Fungos Endofíticos Isolados da Azadirachta Indica (Neem) e suas aplicações BioprospecciónMetabolitos secundariosMicroorganismosPlantas medicinales.BioprospectingSecondary metabolitesMicro-organismsMedicinal plants.BioprospecçãoMetabólitos secundáriosMicrorganismos endofíticosPlantas medicinais.Azadirachta indica A. Juss (Neen) has great ethnomedicinal importance, being known for its insecticidal power and for various therapeutic purposes as a folk medicine. Studies show that endophytes isolated from medicinal plants have potential as an alternative source of secondary metabolites. More than 400 compounds have been isolated from different parts of Neen, including important bioactive secondary metabolites such as azadirachtin, nimbidin, nimbin, nimbolide, gedunin, however, the metabolites of fungi already isolated and characterized showed that more than half of the molecules have antibacterial activity, antifungal and antitumor. Penicillin, cephalosporin, ergotrate and statins are fungal secondary metabolites. The present work aimed to carry out a review of the literature on bioactive products from endophytic fungi of Azadirachta indica and their applications. Activities from extracts of plant parts (leaves, stems, roots) or from cultivation and selection of endophytes other than the kingdom Fungi were excluded. 11 articles were found in the databases that present 12 different endophytic fungi, isolated from Azadirachta indica, with the production of different secondary metabolites and varied applications. Antimicrobial, antifungal, insecticidal and nematicidal activities and improvement in plant adaptation mechanisms. Thirty-four metabolites were identified and tested in different techniques and applications.Azadirachta indica A. Juss (Neen) tiene gran importancia etnomedicinal, siendo conocida por su poder insecticida y por diversos fines terapéuticos como medicina popular. Los estudios muestran que los endófitos aislados de plantas medicinales tienen potencial como fuente alternativa de metabolitos secundários. Se han aislado más de 400 compuestos de diferentes partes de Neen, incluidos importantes metabolitos secundarios bioactivos como azadirachtin, nimbidin, nimbin, nimbolide, gedunin, sin embargo, los metabolitos de hongos ya aislados y caracterizados mostraron que más de la mitad de las moléculas tienen propiedades antibacterianas. actividad antifúngica y antitumoral. La penicilina, la cefalosporina, el ergotrato y las estatinas son metabolitos secundarios fúngicos. El presente trabajo tuvo como objetivo realizar una revisión de la literatura sobre productos bioactivos a partir de hongos endófitos de Azadirachta indica y sus aplicaciones. Se excluyeron las actividades de extractos de partes de plantas (hojas, tallos, raíces) o del cultivo y selección de endófitos distintos del reino Fungi. Se encontraron 11 artículos en las bases de datos que presentan 12 hongos endófitos diferentes, aislados de Azadirachta indica, con producción de diferentes metabolitos secundarios y variadas aplicaciones. Actividades antimicrobianas, antifúngicas, insecticidas y nematicidas y mejora en los mecanismos de adaptación de las plantas. Treinta y cuatro metabolitos fueron identificados y probados en diferentes técnicas y aplicaciones.A Azadirachta indica A. Juss (Neen) tem grande importância etnomedicinal, sendo conhecida por seu poder inseticida e para diversos fins terapêuticos como medicamento popular. Estudos demonstram que endófitos isolados de plantas medicinais têm potencial como fonte alternativa de metabólitos secundários. Mais de 400 compostos foram isolados de diferentes partes do Neen, incluindo metabólitos secundários bioativos importantes, como azadiractina, nimbidin, nimbin, nimbolide, gedunin, contudo, os metabólitos de fungos já isolados e caracterizados mostraram que mais da metade das moléculas apresentam atividade antibacteriana, antifúngica e antitumoral. Penicilina, cefalosporina, ergotrato e as estatinas são metabólitos secundários fúngicos. No presente trabalho objetivou - se realizar uma revisão da literatura sobre os produtos bioativos provenientes de fungos endofíticos da Azadirachta indica e a suas aplicações. Atividades provenientes de extratos de partes da planta (folhas, caules, raízes) ou do cultivo e seleção de outros endófitos, que não do reino Fungi, foram excluídos. Foram encontrados nas bases de dados 11 artigos que apresentam 12 diferentes fungos endofíticos, isolados da Azadirachta indica, com a produção de diferentes metabólitos secundários e aplicações variadas. Ações antimicrobianas, antifúngicas, atividades inseticidas, nematicidas e melhoria nos mecanismos de adaptação da planta. Trinta e quatro metabólitos foram identificados e testados em diferentes técnicas e aplicações.Research, Society and Development2022-07-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3245410.33448/rsd-v11i9.32454Research, Society and Development; Vol. 11 No. 9; e13911932454Research, Society and Development; Vol. 11 Núm. 9; e13911932454Research, Society and Development; v. 11 n. 9; e139119324542525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32454/27470Copyright (c) 2022 Ana Patrícia Ricci; José Celso Rocha Martins Júnior; Vanessa Pinto Oleques Pradebon; Laís Rezende Maia; Alfred Werner Medina Loosli ; Antonia Railda Roel; Tiago Tognolli de Almeidahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRicci, Ana PatríciaMartins Júnior, José Celso RochaPradebon, Vanessa Pinto OlequesMaia, Laís RezendeLoosli , Alfred Werner Medina Roel, Antonia RaildaAlmeida, Tiago Tognolli de2022-07-21T12:36:16Zoai:ojs.pkp.sfu.ca:article/32454Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:27.896501Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications Derivados Bioactivos de Hongos Endofíticos Aislados de Azadirachta Indica (Neem) y sus Aplicaciones Bioativos Derivados de Fungos Endofíticos Isolados da Azadirachta Indica (Neem) e suas aplicações |
title |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications |
spellingShingle |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications Ricci, Ana Patrícia Bioprospección Metabolitos secundarios Microorganismos Plantas medicinales. Bioprospecting Secondary metabolites Micro-organisms Medicinal plants. Bioprospecção Metabólitos secundários Microrganismos endofíticos Plantas medicinais. |
title_short |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications |
title_full |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications |
title_fullStr |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications |
title_full_unstemmed |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications |
title_sort |
Bioactives Derived from Endophytic Fungi Isolated from Azadirachta Indica (Neem) and their Applications |
author |
Ricci, Ana Patrícia |
author_facet |
Ricci, Ana Patrícia Martins Júnior, José Celso Rocha Pradebon, Vanessa Pinto Oleques Maia, Laís Rezende Loosli , Alfred Werner Medina Roel, Antonia Railda Almeida, Tiago Tognolli de |
author_role |
author |
author2 |
Martins Júnior, José Celso Rocha Pradebon, Vanessa Pinto Oleques Maia, Laís Rezende Loosli , Alfred Werner Medina Roel, Antonia Railda Almeida, Tiago Tognolli de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ricci, Ana Patrícia Martins Júnior, José Celso Rocha Pradebon, Vanessa Pinto Oleques Maia, Laís Rezende Loosli , Alfred Werner Medina Roel, Antonia Railda Almeida, Tiago Tognolli de |
dc.subject.por.fl_str_mv |
Bioprospección Metabolitos secundarios Microorganismos Plantas medicinales. Bioprospecting Secondary metabolites Micro-organisms Medicinal plants. Bioprospecção Metabólitos secundários Microrganismos endofíticos Plantas medicinais. |
topic |
Bioprospección Metabolitos secundarios Microorganismos Plantas medicinales. Bioprospecting Secondary metabolites Micro-organisms Medicinal plants. Bioprospecção Metabólitos secundários Microrganismos endofíticos Plantas medicinais. |
description |
Azadirachta indica A. Juss (Neen) has great ethnomedicinal importance, being known for its insecticidal power and for various therapeutic purposes as a folk medicine. Studies show that endophytes isolated from medicinal plants have potential as an alternative source of secondary metabolites. More than 400 compounds have been isolated from different parts of Neen, including important bioactive secondary metabolites such as azadirachtin, nimbidin, nimbin, nimbolide, gedunin, however, the metabolites of fungi already isolated and characterized showed that more than half of the molecules have antibacterial activity, antifungal and antitumor. Penicillin, cephalosporin, ergotrate and statins are fungal secondary metabolites. The present work aimed to carry out a review of the literature on bioactive products from endophytic fungi of Azadirachta indica and their applications. Activities from extracts of plant parts (leaves, stems, roots) or from cultivation and selection of endophytes other than the kingdom Fungi were excluded. 11 articles were found in the databases that present 12 different endophytic fungi, isolated from Azadirachta indica, with the production of different secondary metabolites and varied applications. Antimicrobial, antifungal, insecticidal and nematicidal activities and improvement in plant adaptation mechanisms. Thirty-four metabolites were identified and tested in different techniques and applications. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32454 10.33448/rsd-v11i9.32454 |
url |
https://rsdjournal.org/index.php/rsd/article/view/32454 |
identifier_str_mv |
10.33448/rsd-v11i9.32454 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/32454/27470 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 9; e13911932454 Research, Society and Development; Vol. 11 Núm. 9; e13911932454 Research, Society and Development; v. 11 n. 9; e13911932454 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052718415609856 |