Substances administered for the induction of Alzheimer's disease in rats

Detalhes bibliográficos
Autor(a) principal: Cordeiro, Raquel Barbosa
Data de Publicação: 2019
Outros Autores: Ticli, Fábio Kiss, Cavallet, Mikael
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/974
Resumo: Estimates of the progressive expansion of Alzheimer's disease (AD) worldwide indicate the need for constant studies on this pathology, still without cure. Studies have investigated AD in non-human animal models using substances that induced AD. The present study aimed to review the literature on the substances and procedures used in laboratory to reproduce AD in rats. We selected 44 of 111 studies analyzed, keeping only papers that induced AD by chemical substances. The identified substances were aluminum, beta-amyloid, colchicine, d-galactose, scopolamine, streptozocin and homocysteine. It was verified that of the 44 articles, the most used substance was beta-amyloid, the main biomarker of AD. Although different studies have replicated results that simulate the occurrence of AD in rats and the treatments performed with rats in the laboratory appear promising, no cure has yet been found.
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spelling Substances administered for the induction of Alzheimer's disease in ratsSustancias administradas para la inducción de la enfermedad de Alzheimer en ratasSubstâncias administradas para a indução da Doença de Alzheimer em ratosAlzheimer's diseaseinductionchemical substancesratsbeta-amyloid.Doença de Alzheimerinduçãosubstâncias químicasratosbeta-amiloide.Enfermedad de Alzheimerinducciónsustancias químicasratasbeta-amiloide.Estimates of the progressive expansion of Alzheimer's disease (AD) worldwide indicate the need for constant studies on this pathology, still without cure. Studies have investigated AD in non-human animal models using substances that induced AD. The present study aimed to review the literature on the substances and procedures used in laboratory to reproduce AD in rats. We selected 44 of 111 studies analyzed, keeping only papers that induced AD by chemical substances. The identified substances were aluminum, beta-amyloid, colchicine, d-galactose, scopolamine, streptozocin and homocysteine. It was verified that of the 44 articles, the most used substance was beta-amyloid, the main biomarker of AD. Although different studies have replicated results that simulate the occurrence of AD in rats and the treatments performed with rats in the laboratory appear promising, no cure has yet been found.Las estimaciones sobre la expansión de los casos de la enfermedad de Alzheimer (EA) en el mundo indican la necesidad de constantes estudios sobre esta patología aún sin cura. Los estudios han investigado la EA en modelos animales no humanos utilizando sustancias químicas que inducen a la EA. El presente estudio tuvo como objetivo realizar una revisión de la literatura sobre las sustancias usadas en laboratorio para reproducir la EA en ratas. Se seleccionaron 44 de 111 estudios analizados, manteniendo sólo los artículos que indujeron a EA por sustancias químicas. Las sustancias identificadas fueron el aluminio, la beta-amiloide, la colchicina, la d-galactosa, la escopolamina, la estreptozocina y la homocisteína. Se comprobó que de los 44 artículos, la sustancia más utilizada fue la beta-amiloide, principal biomarcador de la EA. Aunque diferentes estudios han replicado resultados que simulan la ocurrencia de EA en ratas y los tratamientos realizados con ratas en laboratorio parecen prometedores, no se ha encontrado ninguna cura.As estimativas sobre a expansão dos casos da Doença de Alzheimer (DA) no mundo indicam a necessidade de constantes estudos sobre essa patologia ainda sem cura. Os estudos têm investigado a DA em modelos animais não-humanos utilizando substâncias químicas que induzem à DA. O presente estudo teve por objetivo realizar uma revisão da literatura sobre as substâncias usadas em laboratório para reproduzir a DA em ratos. Foram selecionados 44 de 111 estudos analisados, mantendo apenas os artigos que induziram a DA por substâncias químicas. As substâncias identificadas foram o alumínio, a beta-amiloide, a colchicina, a d-galactose, a escopolamina, a estreptozocina e a homocisteína. Verificou-se que dos 44 artigos, a substância mais utilizada foi a beta-amiloide, principal biomarcador da DA. Embora diferentes estudos tenham replicado resultados que simulam a ocorrência de DA em ratos e os tratamentos realizados com ratos em laboratório pareçam promissores, nenhuma cura foi encontrada ainda.Research, Society and Development2019-03-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/97410.33448/rsd-v8i6.974Research, Society and Development; Vol. 8 No. 6; e486974Research, Society and Development; Vol. 8 Núm. 6; e486974Research, Society and Development; v. 8 n. 6; e4869742525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/974/857Copyright (c) 2019 Mikael Cavalletinfo:eu-repo/semantics/openAccessCordeiro, Raquel BarbosaTicli, Fábio KissCavallet, Mikael2020-03-25T16:06:59Zoai:ojs.pkp.sfu.ca:article/974Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:26:12.541180Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Substances administered for the induction of Alzheimer's disease in rats
Sustancias administradas para la inducción de la enfermedad de Alzheimer en ratas
Substâncias administradas para a indução da Doença de Alzheimer em ratos
title Substances administered for the induction of Alzheimer's disease in rats
spellingShingle Substances administered for the induction of Alzheimer's disease in rats
Cordeiro, Raquel Barbosa
Alzheimer's disease
induction
chemical substances
rats
beta-amyloid.
Doença de Alzheimer
indução
substâncias químicas
ratos
beta-amiloide.
Enfermedad de Alzheimer
inducción
sustancias químicas
ratas
beta-amiloide.
title_short Substances administered for the induction of Alzheimer's disease in rats
title_full Substances administered for the induction of Alzheimer's disease in rats
title_fullStr Substances administered for the induction of Alzheimer's disease in rats
title_full_unstemmed Substances administered for the induction of Alzheimer's disease in rats
title_sort Substances administered for the induction of Alzheimer's disease in rats
author Cordeiro, Raquel Barbosa
author_facet Cordeiro, Raquel Barbosa
Ticli, Fábio Kiss
Cavallet, Mikael
author_role author
author2 Ticli, Fábio Kiss
Cavallet, Mikael
author2_role author
author
dc.contributor.author.fl_str_mv Cordeiro, Raquel Barbosa
Ticli, Fábio Kiss
Cavallet, Mikael
dc.subject.por.fl_str_mv Alzheimer's disease
induction
chemical substances
rats
beta-amyloid.
Doença de Alzheimer
indução
substâncias químicas
ratos
beta-amiloide.
Enfermedad de Alzheimer
inducción
sustancias químicas
ratas
beta-amiloide.
topic Alzheimer's disease
induction
chemical substances
rats
beta-amyloid.
Doença de Alzheimer
indução
substâncias químicas
ratos
beta-amiloide.
Enfermedad de Alzheimer
inducción
sustancias químicas
ratas
beta-amiloide.
description Estimates of the progressive expansion of Alzheimer's disease (AD) worldwide indicate the need for constant studies on this pathology, still without cure. Studies have investigated AD in non-human animal models using substances that induced AD. The present study aimed to review the literature on the substances and procedures used in laboratory to reproduce AD in rats. We selected 44 of 111 studies analyzed, keeping only papers that induced AD by chemical substances. The identified substances were aluminum, beta-amyloid, colchicine, d-galactose, scopolamine, streptozocin and homocysteine. It was verified that of the 44 articles, the most used substance was beta-amyloid, the main biomarker of AD. Although different studies have replicated results that simulate the occurrence of AD in rats and the treatments performed with rats in the laboratory appear promising, no cure has yet been found.
publishDate 2019
dc.date.none.fl_str_mv 2019-03-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/974
10.33448/rsd-v8i6.974
url https://rsdjournal.org/index.php/rsd/article/view/974
identifier_str_mv 10.33448/rsd-v8i6.974
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/974/857
dc.rights.driver.fl_str_mv Copyright (c) 2019 Mikael Cavallet
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Mikael Cavallet
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 8 No. 6; e486974
Research, Society and Development; Vol. 8 Núm. 6; e486974
Research, Society and Development; v. 8 n. 6; e486974
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052733019127808

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