Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid

Detalhes bibliográficos
Autor(a) principal: Galdino, Taynah Pereira
Data de Publicação: 2022
Outros Autores: Oliveira, Lucas Cordeiro de, Lima, Eunice Paloma Nascimento, Farias, Raid Ícaro Rached, Jesus, Raquel Albino de, Queiroz, Suelyn Fabiana Aciole Morais de, Santos, Antonio Carlos de Queiroz, Fook, Marcus Vinicius Lia
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/27634
Resumo: Hyaluronic acid (HA) has been an important component in several fields, such as dermal filling, tissue engineering, treatment of the vascular and cartilaginous region, and its application is limited because its excessive use can promote a reduction in cell adhesion, due to its presence of negative charges, characteristic of this material. To solve this limitation, a cationic and anionic material can be used, such as O-Carboxymethylchitosan (O-CMQ), which has a similar chemical structure and similar properties to HA. Therefore, this work aimed to determine the conditions for the synthesis and characterization of O-Carboxymethylchitosan (O-CMQ), and to evaluate its application as an alternative to hyaluronic acid. From the chitosan produced and characterized, the synthesis of O-CMQ was carried out in the proportions 1:1, 1:2 and 1.5:2 (m/v), followed by the characterizations through Visual Analysis, Optical Microscopy (OM), Fourier Transform Infrared Spectroscopy (FTIR), Hydrogen Potential (pH) and Conductivity, Thermogravimetry Analysis (TGA) and Differential Scanning Calorimetry (DSC). It was concluded that the synthesis methodology was efficient for the production of O-Carboxymethylchitosan with different properties. The comparison with hyaluronic acid confirmed the chemical, physical and biological similarities between the samples, being promising for application as a substitute for this material.
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spelling Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic AcidSíntesis y caracterización de O-Carboximetilquitosano como alternativa al uso de Ácido HialurónicoSíntese e caracterização da O-Carboximetilquitosana como alternativa ao uso do Ácido HialurônicoO-CarboximetilquitosanaÁcido HialurônicoBiomaterial.O-carboximetilquitosanoÁcido hialurónicoBiomaterial.O-Carboxymethyl ChitosanHyaluronic acidBiomaterial.Hyaluronic acid (HA) has been an important component in several fields, such as dermal filling, tissue engineering, treatment of the vascular and cartilaginous region, and its application is limited because its excessive use can promote a reduction in cell adhesion, due to its presence of negative charges, characteristic of this material. To solve this limitation, a cationic and anionic material can be used, such as O-Carboxymethylchitosan (O-CMQ), which has a similar chemical structure and similar properties to HA. Therefore, this work aimed to determine the conditions for the synthesis and characterization of O-Carboxymethylchitosan (O-CMQ), and to evaluate its application as an alternative to hyaluronic acid. From the chitosan produced and characterized, the synthesis of O-CMQ was carried out in the proportions 1:1, 1:2 and 1.5:2 (m/v), followed by the characterizations through Visual Analysis, Optical Microscopy (OM), Fourier Transform Infrared Spectroscopy (FTIR), Hydrogen Potential (pH) and Conductivity, Thermogravimetry Analysis (TGA) and Differential Scanning Calorimetry (DSC). It was concluded that the synthesis methodology was efficient for the production of O-Carboxymethylchitosan with different properties. The comparison with hyaluronic acid confirmed the chemical, physical and biological similarities between the samples, being promising for application as a substitute for this material.El ácido hialurónico (HA) ha sido un componente importante en varios campos, como el relleno dérmico, la ingeniería de tejidos, el tratamiento de la región vascular y cartilaginosa, y su aplicación es limitada porque el uso excesivo puede promover la reducción de la adhesión celular, debido a la presencia de cargas negativas, propias de este material. Para solucionar esta limitación, se puede utilizar un material catiónico y aniónico, como el O-Carboximetilquitosano (O-CMQ), que tiene una estructura química similar y propiedades similares al HA. Por tanto, este trabajo tuvo como objetivo determinar las condiciones de síntesis y caracterización del O-Carboximetilquitosano (O-CMQ), y evaluar su aplicación como alternativa al ácido hialurónico. A partir del quitosano producido y caracterizado, se realizó la síntesis de O-CMQ en las proporciones 1:1, 1:2 y 1.5:2 (m/v), seguido de las caracterizaciones por Análisis Visual, Microscopía Óptica (OM), Espectroscopia Infrarroja por Transformada de Fourier (FTIR), Potencial de Hidrógeno (pH) y Conductivimetría, Análisis Termogravimétrico (TGA) y Calorimetría Exploratoria Diferencial (DSC). Se concluyó que la metodología de síntesis fue eficiente para la producción de O-Carboximetilquitosano con diferentes propiedades. La comparación con el ácido hialurónico confirmó las similitudes químicas, físicas y biológicas entre las muestras, siendo prometedora su aplicación como sustituto de este material.O ácido Hialurônico (AH) tem sido um componente importante em diversos campos, como preenchimento dérmico, engenharia de tecidos, tratamento da região vascular e cartilaginosa, tendo sua aplicação limitada pois o uso em excesso pode promover a redução da adesão celular, devido à presença de cargas negativas, característico deste material. Para solucionar esta limitação, pode ser empregado um material catiônico e aniônico, tal como a O-Carboximetilquitosana (O-CMQ), que possui uma estrutura química similar e propriedades análogas ao AH. Portanto, esse trabalho teve como objetivo a determinação das condições de síntese e caracterização da O-Carboximetilquitosana (O-CMQ), e avaliação da aplicação como alternativa ao ácido hialurônico. A partir da quitosana produzida e caracterizada foi realizada a síntese da O-CMQ nas proporções 1:1, 1:2 e 1,5:2 (m/v), seguindo das caracterizações através de Análise Visual, Microscopia Óptica (MO), Espectroscopia no Infravermelho por Transformada de Fourier (FTIR), Potencial Hidrogeniônico (pH) e Condutivimetria, Análise Termogravimétrica (TGA) e Calorimetria Diferencial Exploratória (DSC). Concluiu-se que a metodologia de síntese foi eficiente para a produção da O-Carboximetilquitosana com diferentes propriedades. A comparação com o ácido hialurônico confirmou as semelhanças químicas, físicas e biológicas, entre as amostras, sendo promissoras para a aplicação como substituto a esse material.Research, Society and Development2022-03-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2763410.33448/rsd-v11i5.27634Research, Society and Development; Vol. 11 No. 5; e5011527634Research, Society and Development; Vol. 11 Núm. 5; e5011527634Research, Society and Development; v. 11 n. 5; e50115276342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/27634/24316Copyright (c) 2022 Taynah Pereira Galdino; Lucas Cordeiro de Oliveira; Eunice Paloma Nascimento Lima; Raid Ícaro Rached Farias; Raquel Albino de Jesus; Suelyn Fabiana Aciole Morais de Queiroz; Antonio Carlos de Queiroz Santos; Marcus Vinicius Lia Fookhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGaldino, Taynah PereiraOliveira, Lucas Cordeiro deLima, Eunice Paloma NascimentoFarias, Raid Ícaro RachedJesus, Raquel Albino deQueiroz, Suelyn Fabiana Aciole Morais de Santos, Antonio Carlos de Queiroz Fook, Marcus Vinicius Lia 2022-04-17T18:18:56Zoai:ojs.pkp.sfu.ca:article/27634Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:45:17.755399Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
Síntesis y caracterización de O-Carboximetilquitosano como alternativa al uso de Ácido Hialurónico
Síntese e caracterização da O-Carboximetilquitosana como alternativa ao uso do Ácido Hialurônico
title Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
spellingShingle Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
Galdino, Taynah Pereira
O-Carboximetilquitosana
Ácido Hialurônico
Biomaterial.
O-carboximetilquitosano
Ácido hialurónico
Biomaterial.
O-Carboxymethyl Chitosan
Hyaluronic acid
Biomaterial.
title_short Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
title_full Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
title_fullStr Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
title_full_unstemmed Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
title_sort Synthesis and characterization of O-Carboxymethylchitosan as an alternative to the use of Hyaluronic Acid
author Galdino, Taynah Pereira
author_facet Galdino, Taynah Pereira
Oliveira, Lucas Cordeiro de
Lima, Eunice Paloma Nascimento
Farias, Raid Ícaro Rached
Jesus, Raquel Albino de
Queiroz, Suelyn Fabiana Aciole Morais de
Santos, Antonio Carlos de Queiroz
Fook, Marcus Vinicius Lia
author_role author
author2 Oliveira, Lucas Cordeiro de
Lima, Eunice Paloma Nascimento
Farias, Raid Ícaro Rached
Jesus, Raquel Albino de
Queiroz, Suelyn Fabiana Aciole Morais de
Santos, Antonio Carlos de Queiroz
Fook, Marcus Vinicius Lia
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Galdino, Taynah Pereira
Oliveira, Lucas Cordeiro de
Lima, Eunice Paloma Nascimento
Farias, Raid Ícaro Rached
Jesus, Raquel Albino de
Queiroz, Suelyn Fabiana Aciole Morais de
Santos, Antonio Carlos de Queiroz
Fook, Marcus Vinicius Lia
dc.subject.por.fl_str_mv O-Carboximetilquitosana
Ácido Hialurônico
Biomaterial.
O-carboximetilquitosano
Ácido hialurónico
Biomaterial.
O-Carboxymethyl Chitosan
Hyaluronic acid
Biomaterial.
topic O-Carboximetilquitosana
Ácido Hialurônico
Biomaterial.
O-carboximetilquitosano
Ácido hialurónico
Biomaterial.
O-Carboxymethyl Chitosan
Hyaluronic acid
Biomaterial.
description Hyaluronic acid (HA) has been an important component in several fields, such as dermal filling, tissue engineering, treatment of the vascular and cartilaginous region, and its application is limited because its excessive use can promote a reduction in cell adhesion, due to its presence of negative charges, characteristic of this material. To solve this limitation, a cationic and anionic material can be used, such as O-Carboxymethylchitosan (O-CMQ), which has a similar chemical structure and similar properties to HA. Therefore, this work aimed to determine the conditions for the synthesis and characterization of O-Carboxymethylchitosan (O-CMQ), and to evaluate its application as an alternative to hyaluronic acid. From the chitosan produced and characterized, the synthesis of O-CMQ was carried out in the proportions 1:1, 1:2 and 1.5:2 (m/v), followed by the characterizations through Visual Analysis, Optical Microscopy (OM), Fourier Transform Infrared Spectroscopy (FTIR), Hydrogen Potential (pH) and Conductivity, Thermogravimetry Analysis (TGA) and Differential Scanning Calorimetry (DSC). It was concluded that the synthesis methodology was efficient for the production of O-Carboxymethylchitosan with different properties. The comparison with hyaluronic acid confirmed the chemical, physical and biological similarities between the samples, being promising for application as a substitute for this material.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/27634
10.33448/rsd-v11i5.27634
url https://rsdjournal.org/index.php/rsd/article/view/27634
identifier_str_mv 10.33448/rsd-v11i5.27634
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/27634/24316
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 5; e5011527634
Research, Society and Development; Vol. 11 Núm. 5; e5011527634
Research, Society and Development; v. 11 n. 5; e5011527634
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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