Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/32423 |
Resumo: | Botulinum toxin type A (BTX-A) has been used as one of the treatment options to control sialorrhea, however its systemic effects after chronic treatment are not yet known. Therefore, the objective was to evaluate histopathological alterations of the hepatic and renal parenchyma of rats chronically treated with botulinum toxin type A injection in the submandibular-sublingual complex. Twenty-one adult Wistar rats were divided into three groups with 7 animals each: control; groups BTX-12 and BTX-35, which received 3 intercalated applications of BTX-A. The BTX-12 and BTX-35 groups were analyzed at 12 and 35 days after treatment, respectively. Histopathological and histomorphometric analyzes of the liver and kidney of all animals in the groups were performed. In the liver, histopathological changes were observed characterized by hypertrophy of hepatocytes, pyknosis, centrilobular degeneration and lymphohistiocytic, neutrophilic infiltrate and in the kidneys, decreased capsular space, glomerulopathies and degenerations in nephrons and convoluted tubules were observed. Histomorphometry revealed a reduction in the size of the hepatocyte nuclei and also of the renal glomerulus. Therefore, it can be suggested that botulinum toxin type A administered to rats for the treatment of sialorrhea has hepatotoxic and nephrotoxic potential. |
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Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary glandEvaluación hepática y renal en ratas sometidas a la administración crónica de toxina botulínica tipo A en la glándula saliva submandibularAvaliação hepática e renal em ratas submetidas à administração crônica de toxina botulínica tipo A na glândula salivar submandibularNeurotoxinLiverKidneyToxicityHistopathology.NeurotoxinaHígadoRiñónToxicidadHistopatología.NeurotoxinaFígadoRimToxicidadeHistopatologia.Botulinum toxin type A (BTX-A) has been used as one of the treatment options to control sialorrhea, however its systemic effects after chronic treatment are not yet known. Therefore, the objective was to evaluate histopathological alterations of the hepatic and renal parenchyma of rats chronically treated with botulinum toxin type A injection in the submandibular-sublingual complex. Twenty-one adult Wistar rats were divided into three groups with 7 animals each: control; groups BTX-12 and BTX-35, which received 3 intercalated applications of BTX-A. The BTX-12 and BTX-35 groups were analyzed at 12 and 35 days after treatment, respectively. Histopathological and histomorphometric analyzes of the liver and kidney of all animals in the groups were performed. In the liver, histopathological changes were observed characterized by hypertrophy of hepatocytes, pyknosis, centrilobular degeneration and lymphohistiocytic, neutrophilic infiltrate and in the kidneys, decreased capsular space, glomerulopathies and degenerations in nephrons and convoluted tubules were observed. Histomorphometry revealed a reduction in the size of the hepatocyte nuclei and also of the renal glomerulus. Therefore, it can be suggested that botulinum toxin type A administered to rats for the treatment of sialorrhea has hepatotoxic and nephrotoxic potential.La toxina botulínica tipo A (BTX-A) se ha utilizado como una de las opciones de tratamiento para controlar la sialorrea, sin embargo, aún no se conocen sus efectos sistémicos después del tratamiento crónico. Por tanto, el objetivo fue evaluar las alteraciones histopatológicas del parénquima hepático y renal de ratas tratadas crónicamente con inyección de toxina botulínica tipo A en el complejo submandibular-sublingual. Veintiún ratas Wistar adultas se dividieron en tres grupos de 7 animales cada uno: control; grupos BTX-12 y BTX-35, que recibieron 3 aplicaciones intercaladas de BTX-A. Los grupos BTX-12 y BTX-35 se analizaron a los 12 y 35 días después del tratamiento, respectivamente. Se realizaron análisis histopatológicos e histomorfométricos del hígado y riñón de todos los animales de los grupos. En hígado se observaron cambios histopatológicos caracterizados por hipertrofia de hepatocitos, picnosis, degeneración centrolobulillar e infiltrado linfohistiocitario, neutrofílico y en riñones se observó disminución del espacio capsular, glomerulopatías y degeneraciones en nefronas y túbulos contorneados. La histomorfometría reveló una reducción del tamaño de los núcleos de los hepatocitos y también del glomérulo renal. Por lo tanto, se puede sugerir que la toxina botulínica tipo A administrada a ratas para el tratamiento de la sialorrea tiene potencial hepatotóxico y nefrotóxico.A toxina botulínica tipo A (BTX-A) tem sido utilizada como uma das opções de tratamento para controlar a sialorreia, entretanto ainda não se conhece seus efeitos sistêmicos após tratamento crônico. Sendo assim, objetivou-se avaliar alterações histopatológicas do parênquima hepático e renal de ratas tratadas cronicamente com injeção de toxina botulínica tipo A no complexo submandibular-sublingual. Foram utilizadas 21 ratas Wistar adultas, distribuídas em três grupos com 7 animais cada: controle; grupos BTX-12 e BTX-35, que receberam 3 aplicações intercaladas de BTX-A. O grupo BTX-12 e BTX-35 foram analisados aos 12 e 35 dias após o tratamento, respectivamente. Foram realizadas as análises histopatológicas e histomorfométricas do fígado e do rim de todos os animais dos grupos. No fígado foi observado alterações histopatológicas caracterizadas por hipertrofia de hepatócitos, picnose, degeneração centrolobular e infiltrado linfo-histiocitário, neutrofílico e nos rins foi observado diminuição do espaço capsular, glomerulopatias e degenerações nos néfrons e túbulos contorcidos. A histomorfometria revelou redução no tamanho dos núcleos dos hepatócitos e também do glomérulo renal. Sendo assim, pode-se sugerir que a toxina botulínica tipo A administrada em ratas para o tratamento da sialorreia tem potencial hepatotóxico e nefrotóxico.Research, Society and Development2022-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3242310.33448/rsd-v11i10.32423Research, Society and Development; Vol. 11 No. 10; e148111032423Research, Society and Development; Vol. 11 Núm. 10; e148111032423Research, Society and Development; v. 11 n. 10; e1481110324232525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32423/27635Copyright (c) 2022 Janayze Suéllen de Lima Mendes Silva; Francisco de Assis Leite Souza; Maria Edna Gomes de Barros ; Augusto César Leal da Silva Leonel ; Liriane Baratella Evêncio; Luciana Silva Regueira ; Joaquim Evêncio Neto ; Jaciel Benedito de Oliveira; Juliana Pinto de Medeiroshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Janayze Suéllen de Lima Mendes Souza, Francisco de Assis Leite Barros , Maria Edna Gomes deLeonel , Augusto César Leal da Silva Evêncio, Liriane Baratella Regueira , Luciana Silva Evêncio Neto , Joaquim Oliveira, Jaciel Benedito de Medeiros, Juliana Pinto de 2022-08-12T22:23:03Zoai:ojs.pkp.sfu.ca:article/32423Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:26.512103Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland Evaluación hepática y renal en ratas sometidas a la administración crónica de toxina botulínica tipo A en la glándula saliva submandibular Avaliação hepática e renal em ratas submetidas à administração crônica de toxina botulínica tipo A na glândula salivar submandibular |
| title |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland |
| spellingShingle |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland Silva, Janayze Suéllen de Lima Mendes Neurotoxin Liver Kidney Toxicity Histopathology. Neurotoxina Hígado Riñón Toxicidad Histopatología. Neurotoxina Fígado Rim Toxicidade Histopatologia. |
| title_short |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland |
| title_full |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland |
| title_fullStr |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland |
| title_full_unstemmed |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland |
| title_sort |
Hepatic and renal evaluation in rats submitted to chronic administration of botulinum toxin tip A in the submandibular salivary gland |
| author |
Silva, Janayze Suéllen de Lima Mendes |
| author_facet |
Silva, Janayze Suéllen de Lima Mendes Souza, Francisco de Assis Leite Barros , Maria Edna Gomes de Leonel , Augusto César Leal da Silva Evêncio, Liriane Baratella Regueira , Luciana Silva Evêncio Neto , Joaquim Oliveira, Jaciel Benedito de Medeiros, Juliana Pinto de |
| author_role |
author |
| author2 |
Souza, Francisco de Assis Leite Barros , Maria Edna Gomes de Leonel , Augusto César Leal da Silva Evêncio, Liriane Baratella Regueira , Luciana Silva Evêncio Neto , Joaquim Oliveira, Jaciel Benedito de Medeiros, Juliana Pinto de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Janayze Suéllen de Lima Mendes Souza, Francisco de Assis Leite Barros , Maria Edna Gomes de Leonel , Augusto César Leal da Silva Evêncio, Liriane Baratella Regueira , Luciana Silva Evêncio Neto , Joaquim Oliveira, Jaciel Benedito de Medeiros, Juliana Pinto de |
| dc.subject.por.fl_str_mv |
Neurotoxin Liver Kidney Toxicity Histopathology. Neurotoxina Hígado Riñón Toxicidad Histopatología. Neurotoxina Fígado Rim Toxicidade Histopatologia. |
| topic |
Neurotoxin Liver Kidney Toxicity Histopathology. Neurotoxina Hígado Riñón Toxicidad Histopatología. Neurotoxina Fígado Rim Toxicidade Histopatologia. |
| description |
Botulinum toxin type A (BTX-A) has been used as one of the treatment options to control sialorrhea, however its systemic effects after chronic treatment are not yet known. Therefore, the objective was to evaluate histopathological alterations of the hepatic and renal parenchyma of rats chronically treated with botulinum toxin type A injection in the submandibular-sublingual complex. Twenty-one adult Wistar rats were divided into three groups with 7 animals each: control; groups BTX-12 and BTX-35, which received 3 intercalated applications of BTX-A. The BTX-12 and BTX-35 groups were analyzed at 12 and 35 days after treatment, respectively. Histopathological and histomorphometric analyzes of the liver and kidney of all animals in the groups were performed. In the liver, histopathological changes were observed characterized by hypertrophy of hepatocytes, pyknosis, centrilobular degeneration and lymphohistiocytic, neutrophilic infiltrate and in the kidneys, decreased capsular space, glomerulopathies and degenerations in nephrons and convoluted tubules were observed. Histomorphometry revealed a reduction in the size of the hepatocyte nuclei and also of the renal glomerulus. Therefore, it can be suggested that botulinum toxin type A administered to rats for the treatment of sialorrhea has hepatotoxic and nephrotoxic potential. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-07-26 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/32423 10.33448/rsd-v11i10.32423 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/32423 |
| identifier_str_mv |
10.33448/rsd-v11i10.32423 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
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https://rsdjournal.org/index.php/rsd/article/view/32423/27635 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 11 No. 10; e148111032423 Research, Society and Development; Vol. 11 Núm. 10; e148111032423 Research, Society and Development; v. 11 n. 10; e148111032423 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052813073711104 |