Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/26545 |
Resumo: | Several studies have been conducted aiming to detect the variety of genetic markers associated with malaria resistance. This work aimed to describe the relationship of glucose-6-phosphate dehydrogenase deficiency in host resistance to Plasmodium spp. To this end, a systematic review with meta-analysis was performed, following PRISMA guidelines. The search strategy was done in Medline via Pubmed, Science Direct, Lilacs, Scopus and Google academic. Risk of bias was used to evaluate each selected article using the Joanna Briggs Institute Critical Appraisal Checklist. Subsequently, together, the papers were evaluated using Egger's Test. In total, 638 articles were found. Of these, 26 participated in the qualitative synthesis and 15 in the quantitative. Of the 26 studies, 18 reported a relationship between enzyme deficit and malaria resistance. As for the results of the meta-analysis, it was found that G6PD deficiency may be associated with an individual's resistance to develop malaria, especially in Asians and Africans. Therefore, the results of this article may help in the development of new therapeutic strategies for this disease, benefiting public health worldwide. |
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Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysisDeficiencia de glucosa-6-fosfato deshidrogenasa en la resistencia genética a la malaria: una revisión sistemática e metanálisisDeficiência de glicose-6-fosfato desidrogenase na resistência genética à malária: uma revisão sistemática e metanálisePlasmodiumGenetic polymorphismDisease resistancePublic health.PlasmodiumPolimorfismo genéticoRésitance a la enfermedadSalud pública.PlasmodiumPolimorfismo GenéticoResistência a doençaSaúde pública. Several studies have been conducted aiming to detect the variety of genetic markers associated with malaria resistance. This work aimed to describe the relationship of glucose-6-phosphate dehydrogenase deficiency in host resistance to Plasmodium spp. To this end, a systematic review with meta-analysis was performed, following PRISMA guidelines. The search strategy was done in Medline via Pubmed, Science Direct, Lilacs, Scopus and Google academic. Risk of bias was used to evaluate each selected article using the Joanna Briggs Institute Critical Appraisal Checklist. Subsequently, together, the papers were evaluated using Egger's Test. In total, 638 articles were found. Of these, 26 participated in the qualitative synthesis and 15 in the quantitative. Of the 26 studies, 18 reported a relationship between enzyme deficit and malaria resistance. As for the results of the meta-analysis, it was found that G6PD deficiency may be associated with an individual's resistance to develop malaria, especially in Asians and Africans. Therefore, the results of this article may help in the development of new therapeutic strategies for this disease, benefiting public health worldwide.Se han realizado varios estudios para detectar la variedad de marcadores genéticos asociados a la resistencia a la malaria. Este estudio tuvo como objetivo describir la relación de la deficiencia de glucosa-6-fosfato deshidrogenasa en la resistencia del huésped a Plasmodium spp. Para ello, se realizó una revisión sistemática con meta-análisis, siguiendo las directrices PRISMA. La estrategia de búsqueda se realizó en Medline a través de Pubmed, Science Direct, Lilacs, Scopus y Google academic. El riesgo de sesgo se utilizó para evaluar cada artículo seleccionado mediante la lista de comprobación de la evaluación crítica del Instituto Joanna Briggs. Posteriormente, los trabajos se evaluaron conjuntamente mediante la prueba de Egger. Se encontró un total de 638 artículos. De ellos, 26 participaron en la síntesis cualitativa y 15 en la cuantitativa. De los 26 estudios, 18 informaron de una relación entre el déficit enzimático y la resistencia a la malaria. En cuanto a los resultados del meta-análisis, se encontró que la deficiencia de G6PD puede estar asociada con la resistencia de un individuo a desarrollar malaria, especialmente en asiáticos y africanos. Por lo tanto, los resultados de este artículo pueden ayudar al desarrollo de nuevas estrategias terapéuticas para esta enfermedad, beneficiando a la salud pública en todo el mundo.Vários estudos têm sido conduzidos almejando detectar a variedade de marcadores genéticos associados à resistência malárica. Este trabalho teve como objetivo descrever a relação da deficiência de glicose-6-fosfato desidrogenase na resistência do hospedeiro ao Plasmodium spp. Para isso, realizou-se uma revisão sistemática com metanálise, seguindo as orientações PRISMA. A estratégia de busca foi feita no Medline via Pubmed, Science Direct, Lilacs, Scopus e Google acadêmico. O risco de viés foi utilizado para avaliar cada artigo selecionado através da lista de verificação de avaliação crítica do Instituto Joanna Briggs. Posteriormente, em conjunto, os trabalhos foram avaliados através de Teste de Egger. No total, encontrou-se 638 artigos. Destes, 26 participaram da síntese qualitativa e 15 na quantitativa. Dos 26 estudos, 18 relataram haver relação entre o déficit enzimático e a resistência malária. Quanto aos resultados da metanálise, verificou-se que a deficiência de G6PD pode estar associado à resistência do indivíduo desenvolver a malária, principalmente em asiáticos e africanos. Portanto, os resultados deste artigo poderão auxiliar no desenvolvimento de novas estratégias terapêuticas para esta enfermidade, beneficiando a saúde pública mundial.Research, Society and Development2022-02-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2654510.33448/rsd-v11i3.26545Research, Society and Development; Vol. 11 No. 3; e35111326545Research, Society and Development; Vol. 11 Núm. 3; e35111326545Research, Society and Development; v. 11 n. 3; e351113265452525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/26545/23325Copyright (c) 2022 Marcelo Cerilo Santos-Filho; Maria Tairla Viana Gonçalves; Karolayne Silva Souza; Myrela Conceição Santos de Jesus; Luciane Moreno Storti-Melo; Erika dos Santos Nunes; Katia Cilene da Silva Felixhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos-Filho, Marcelo CeriloGonçalves, Maria Tairla VianaSouza, Karolayne SilvaJesus, Myrela Conceição Santos de Storti-Melo, Luciane Moreno Nunes, Erika dos SantosFelix, Katia Cilene da Silva2022-03-09T13:44:38Zoai:ojs.pkp.sfu.ca:article/26545Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:33.570163Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis Deficiencia de glucosa-6-fosfato deshidrogenasa en la resistencia genética a la malaria: una revisión sistemática e metanálisis Deficiência de glicose-6-fosfato desidrogenase na resistência genética à malária: uma revisão sistemática e metanálise |
title |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis |
spellingShingle |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis Santos-Filho, Marcelo Cerilo Plasmodium Genetic polymorphism Disease resistance Public health. Plasmodium Polimorfismo genético Résitance a la enfermedad Salud pública. Plasmodium Polimorfismo Genético Resistência a doença Saúde pública. |
title_short |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis |
title_full |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis |
title_fullStr |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis |
title_full_unstemmed |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis |
title_sort |
Glucose-6-phosphate dehydrogenase deficiency in genetic resistance to malaria: a systematic review and meta-analysis |
author |
Santos-Filho, Marcelo Cerilo |
author_facet |
Santos-Filho, Marcelo Cerilo Gonçalves, Maria Tairla Viana Souza, Karolayne Silva Jesus, Myrela Conceição Santos de Storti-Melo, Luciane Moreno Nunes, Erika dos Santos Felix, Katia Cilene da Silva |
author_role |
author |
author2 |
Gonçalves, Maria Tairla Viana Souza, Karolayne Silva Jesus, Myrela Conceição Santos de Storti-Melo, Luciane Moreno Nunes, Erika dos Santos Felix, Katia Cilene da Silva |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos-Filho, Marcelo Cerilo Gonçalves, Maria Tairla Viana Souza, Karolayne Silva Jesus, Myrela Conceição Santos de Storti-Melo, Luciane Moreno Nunes, Erika dos Santos Felix, Katia Cilene da Silva |
dc.subject.por.fl_str_mv |
Plasmodium Genetic polymorphism Disease resistance Public health. Plasmodium Polimorfismo genético Résitance a la enfermedad Salud pública. Plasmodium Polimorfismo Genético Resistência a doença Saúde pública. |
topic |
Plasmodium Genetic polymorphism Disease resistance Public health. Plasmodium Polimorfismo genético Résitance a la enfermedad Salud pública. Plasmodium Polimorfismo Genético Resistência a doença Saúde pública. |
description |
Several studies have been conducted aiming to detect the variety of genetic markers associated with malaria resistance. This work aimed to describe the relationship of glucose-6-phosphate dehydrogenase deficiency in host resistance to Plasmodium spp. To this end, a systematic review with meta-analysis was performed, following PRISMA guidelines. The search strategy was done in Medline via Pubmed, Science Direct, Lilacs, Scopus and Google academic. Risk of bias was used to evaluate each selected article using the Joanna Briggs Institute Critical Appraisal Checklist. Subsequently, together, the papers were evaluated using Egger's Test. In total, 638 articles were found. Of these, 26 participated in the qualitative synthesis and 15 in the quantitative. Of the 26 studies, 18 reported a relationship between enzyme deficit and malaria resistance. As for the results of the meta-analysis, it was found that G6PD deficiency may be associated with an individual's resistance to develop malaria, especially in Asians and Africans. Therefore, the results of this article may help in the development of new therapeutic strategies for this disease, benefiting public health worldwide. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26545 10.33448/rsd-v11i3.26545 |
url |
https://rsdjournal.org/index.php/rsd/article/view/26545 |
identifier_str_mv |
10.33448/rsd-v11i3.26545 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26545/23325 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 3; e35111326545 Research, Society and Development; Vol. 11 Núm. 3; e35111326545 Research, Society and Development; v. 11 n. 3; e35111326545 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052762897252352 |