Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/19607 |
Resumo: | The expansion of 2,4-D consumption raises concerns about the environment and especially human health, as exposure to this chemical agent can cause harmful effects to the body. The aim of this research was to histopathologically evaluate the nasal epithelium and the hematological profile of rats submitted to chronic inhaled spraying of the 2,4-D herbicide. Forty adult male Wistar rats were used, divided into 4 groups, namely: Control Group (GC), Low Concentration Group (GBC), Medium Concentration Group (GMC) and High Concentration Group (GAC). The exposure protocol was carried out using 2 boxes connected to 2 ultrasonic nebulizers, which sprayed the herbicide daily for 15 minutes for 6 months. After the exposure period, a blood sample was collected to prepare the blood count and collection and analysis of the nasal epithelium to quantify the mast cells and inflammatory infiltrate. There was a statistically significant difference in relation to the Mean Corpuscular Hemoglobin Concentration (CHCM) values of the GBC when compared to the CG, but the CG had high values and the GBC had values whin the normal range. Regarding the other hematological parameters evaluated, mast cells and inflammatory infiltrate were not observed statistically significant differences in the groups exposed to the 2,4-D herbicide when compared to the CG. Thus, the 2,4-D herbicide showed no toxicity to hematological parameters and nasal epithelium of Wistar rats after chronic inhalation exposure for a period of 6 months when compared to the control group. |
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Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D)Análisis histopatológico de ratos expuestas crónicamente por inhalación al herbicida ácido 2,4-diclorofenoxiacético (2,4-D)Análise histopatológica de ratos cronicamente expostos por inalação ao herbicida ácido 2,4-Diclorofenoxiacético (2,4-D)Recuento de células sanguíneasMucosa nasalRatonesMucosa respiratoriaSistema respiratorioToxicidad.Blood Cell CountNasal MucosaRespiratory MucosaRespiratory SystemRatsToxicity.Contagem de Células SanguíneasMucosa NasalMucosa RespiratóriaSistema respiratórioRatosToxicidade.The expansion of 2,4-D consumption raises concerns about the environment and especially human health, as exposure to this chemical agent can cause harmful effects to the body. The aim of this research was to histopathologically evaluate the nasal epithelium and the hematological profile of rats submitted to chronic inhaled spraying of the 2,4-D herbicide. Forty adult male Wistar rats were used, divided into 4 groups, namely: Control Group (GC), Low Concentration Group (GBC), Medium Concentration Group (GMC) and High Concentration Group (GAC). The exposure protocol was carried out using 2 boxes connected to 2 ultrasonic nebulizers, which sprayed the herbicide daily for 15 minutes for 6 months. After the exposure period, a blood sample was collected to prepare the blood count and collection and analysis of the nasal epithelium to quantify the mast cells and inflammatory infiltrate. There was a statistically significant difference in relation to the Mean Corpuscular Hemoglobin Concentration (CHCM) values of the GBC when compared to the CG, but the CG had high values and the GBC had values whin the normal range. Regarding the other hematological parameters evaluated, mast cells and inflammatory infiltrate were not observed statistically significant differences in the groups exposed to the 2,4-D herbicide when compared to the CG. Thus, the 2,4-D herbicide showed no toxicity to hematological parameters and nasal epithelium of Wistar rats after chronic inhalation exposure for a period of 6 months when compared to the control group.La expansión del consumo de 2,4-D genera preocupaciones sobre el medio ambiente y especialmente la salud humana, ya que la exposición a este agente químico puede causar efectos nocivos para el cuerpo. El objetivo de esta investigación fue evaluar histopatológicamente el epitelio nasal y el perfil hematológico de ratones sometidos a aspersión crónica inhalada del herbicida 2,4-D. Se utilizaron cuarenta ratones Wistar macho adultos, divididos en 4 grupos, a saber: Grupo de control (GC), Grupo de baja concentración (GBC), Grupo de concentración media (GMC) y Grupo de alta concentración (GAC). El protocolo de exposición se llevó a cabo utilizando 2 cajas conectadas a 2 nebulizadores ultrasónicos, que rociaron el herbicida diariamente durante 15 minutos durante 6 meses. Después del período de exposición, se tomó una muestra de sangre para preparar el recuento sanguíneo y la recolección y análisis del epitelio nasal para cuantificar los mastocitos y el infiltrado inflamatorio. Hubo una diferencia estadísticamente significativa en relación a los valores de Concentración de Hemoglobina Corpuscular Media (CHCM) del GBC en comparación con el GC, pero el GC tuvo valores altos y el GBC tuvo valores dentro del rango normal. En cuanto al resto de parámetros hematológicos evaluados, los mastocitos y el infiltrado inflamatorio no se observaron diferencias estadísticamente significativas en los grupos expuestos al herbicida 2,4-D en comparación con el GC. Por lo tanto, el herbicida 2,4-D no mostró toxicidad para los parámetros hematológicos y el epitelio nasal de las ratones Wistar después de la exposición crónica por inhalación durante un período de 6 meses en comparación con el grupo de control.A expansão do consumo do 2,4-D traz preocupações em relação ao meio ambiente e principalmente a saúde humana, pois a exposição a esse agente químico poderá gerar efeitos nocivos ao organismo. O objetivo da presente pesquisa foi avaliar histopatologicamente o epitélio nasal e o perfil hematológico de ratos submetidos à pulverização crônica por via inalatória do herbicida 2,4-D. Foram utilizados 40 ratos Wistar adultos machos, divididos em 4 grupos, sendo eles: Grupo Controle (GC), Grupo Baixa Concentração (GBC), Grupo Média Concentração (GMC) e Grupo Alta concentração (GAC). O Protocolo de exposição foi realizado através de 2 caixas ligadas a 2 dois nebulizadores ultrassônicos, que realizaram a pulverização diária do herbicida por 15 minutos, durante 6 meses. Após o período de exposição, foi feita a coleta de amostra de sangue para confecção do hemograma e coleta e análise do epitélio nasal para quantificação dos mastócitos e infiltrado inflamatório. Houve diferença estatisticamente significativa em relação aos valores de Concentração de Hemoglobina Corpuscular Média (CHCM) do GBC quando comparado ao GC, porém o GC estava com valores elevados e o GBC estava com valores dentro dos padrões de normalidade. Em relação aos outros parâmetros hematológicos avaliados, os mastócitos e o infiltrado inflamatório não foram observados diferença estatisticamente significativa dos grupos expostos ao herbicida 2,4-D quando comparados ao GC. Sendo assim, o herbicida 2,4-D não demonstrou toxicidade aos parâmetros hematológicos e epitélio nasal de ratos Wistar após exposição crônica inalatória no período de 6 meses quando comparados ao grupo controle.Research, Society and Development2021-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1960710.33448/rsd-v10i11.19607Research, Society and Development; Vol. 10 No. 11; e282101119607Research, Society and Development; Vol. 10 Núm. 11; e282101119607Research, Society and Development; v. 10 n. 11; e2821011196072525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/19607/17527Copyright (c) 2021 Gabriela Vidotto Cavallieri; Geovana Letícia Fernandes de Oliveira; Gisele Alborghetti Nai; Edson Assunção Mareco; Matheus Ribeiro Bizuti; Debora Tavares de Resende e Silva; Ana Karina Marques Salge; Renata Calciolari Rossihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCavallieri, Gabriela VidottoOliveira, Geovana Letícia Fernandes de Nai, Gisele Alborghetti Mareco, Edson Assunção Bizuti, Matheus Ribeiro Silva, Debora Tavares de Resende e Salge, Ana Karina Marques Rossi, Renata Calciolari 2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/19607Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:28.617209Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) Análisis histopatológico de ratos expuestas crónicamente por inhalación al herbicida ácido 2,4-diclorofenoxiacético (2,4-D) Análise histopatológica de ratos cronicamente expostos por inalação ao herbicida ácido 2,4-Diclorofenoxiacético (2,4-D) |
title |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) |
spellingShingle |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) Cavallieri, Gabriela Vidotto Recuento de células sanguíneas Mucosa nasal Ratones Mucosa respiratoria Sistema respiratorio Toxicidad. Blood Cell Count Nasal Mucosa Respiratory Mucosa Respiratory System Rats Toxicity. Contagem de Células Sanguíneas Mucosa Nasal Mucosa Respiratória Sistema respiratório Ratos Toxicidade. |
title_short |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) |
title_full |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) |
title_fullStr |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) |
title_full_unstemmed |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) |
title_sort |
Histopathological analysis of rats chronically exposed by inhalation to the herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) |
author |
Cavallieri, Gabriela Vidotto |
author_facet |
Cavallieri, Gabriela Vidotto Oliveira, Geovana Letícia Fernandes de Nai, Gisele Alborghetti Mareco, Edson Assunção Bizuti, Matheus Ribeiro Silva, Debora Tavares de Resende e Salge, Ana Karina Marques Rossi, Renata Calciolari |
author_role |
author |
author2 |
Oliveira, Geovana Letícia Fernandes de Nai, Gisele Alborghetti Mareco, Edson Assunção Bizuti, Matheus Ribeiro Silva, Debora Tavares de Resende e Salge, Ana Karina Marques Rossi, Renata Calciolari |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Cavallieri, Gabriela Vidotto Oliveira, Geovana Letícia Fernandes de Nai, Gisele Alborghetti Mareco, Edson Assunção Bizuti, Matheus Ribeiro Silva, Debora Tavares de Resende e Salge, Ana Karina Marques Rossi, Renata Calciolari |
dc.subject.por.fl_str_mv |
Recuento de células sanguíneas Mucosa nasal Ratones Mucosa respiratoria Sistema respiratorio Toxicidad. Blood Cell Count Nasal Mucosa Respiratory Mucosa Respiratory System Rats Toxicity. Contagem de Células Sanguíneas Mucosa Nasal Mucosa Respiratória Sistema respiratório Ratos Toxicidade. |
topic |
Recuento de células sanguíneas Mucosa nasal Ratones Mucosa respiratoria Sistema respiratorio Toxicidad. Blood Cell Count Nasal Mucosa Respiratory Mucosa Respiratory System Rats Toxicity. Contagem de Células Sanguíneas Mucosa Nasal Mucosa Respiratória Sistema respiratório Ratos Toxicidade. |
description |
The expansion of 2,4-D consumption raises concerns about the environment and especially human health, as exposure to this chemical agent can cause harmful effects to the body. The aim of this research was to histopathologically evaluate the nasal epithelium and the hematological profile of rats submitted to chronic inhaled spraying of the 2,4-D herbicide. Forty adult male Wistar rats were used, divided into 4 groups, namely: Control Group (GC), Low Concentration Group (GBC), Medium Concentration Group (GMC) and High Concentration Group (GAC). The exposure protocol was carried out using 2 boxes connected to 2 ultrasonic nebulizers, which sprayed the herbicide daily for 15 minutes for 6 months. After the exposure period, a blood sample was collected to prepare the blood count and collection and analysis of the nasal epithelium to quantify the mast cells and inflammatory infiltrate. There was a statistically significant difference in relation to the Mean Corpuscular Hemoglobin Concentration (CHCM) values of the GBC when compared to the CG, but the CG had high values and the GBC had values whin the normal range. Regarding the other hematological parameters evaluated, mast cells and inflammatory infiltrate were not observed statistically significant differences in the groups exposed to the 2,4-D herbicide when compared to the CG. Thus, the 2,4-D herbicide showed no toxicity to hematological parameters and nasal epithelium of Wistar rats after chronic inhalation exposure for a period of 6 months when compared to the control group. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19607 10.33448/rsd-v10i11.19607 |
url |
https://rsdjournal.org/index.php/rsd/article/view/19607 |
identifier_str_mv |
10.33448/rsd-v10i11.19607 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19607/17527 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 11; e282101119607 Research, Society and Development; Vol. 10 Núm. 11; e282101119607 Research, Society and Development; v. 10 n. 11; e282101119607 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052825409159168 |