Molecular changes in the development of prostate cancer

Detalhes bibliográficos
Autor(a) principal: Borges, Açucena de Oliveira
Data de Publicação: 2021
Outros Autores: Souza, Juliana Paniago, Pereira, Letícia Góes, Gomes, Eriston Vieira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/23969
Resumo: Introduction: Prostate cancer (PC) is the second most diagnosed in the male population in the world. Clinically, PC is subdivided into primary cancer, castration-resistant metastatic prostate cancer, and neuroendocrine prostate cancer. Objective: to describe the main molecular changes necessary for the development of primary prostate cancer (PCa). Methodology: this is a descriptive literature review. The databases PUBMED, SCIELO, Science Direct and Academic Google and National Cancer Institute (INCA) were used. The inclusion/exclusion criteria were articles from 2015 to 2021, available in Portuguese, English and Spanish. Results and discussion: the molecular bases of PC present several genomic alterations such as mutations, alterations in the number of copies of DNA, rearrangements and gene fusions. For primary cancer, the most prevalent genetic alterations are alterations in the ETS family genes such as ERG gene fusions (which occur in 50% of cases and mutations mainly in the CHD1, SPOP and BRCA1 or BRCA2 genes). In castration-resistant metastatic prostate cancer, the most prevalent genetic alteration alters androgen receptors and oncosuppressors (e.g. PTEN and TP53). Conclusion: alterations in genetic and epigenetic levels in specific genes regulated by androgen hormones are closely related to the pathogenesis of PC. These data are of paramount importance for understanding the pathophysiological mechanism of this condition, as well as providing the basis for a more specific treatment.
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spelling Molecular changes in the development of prostate cancerAlteraciones moleculares en el desarrollo del cáncer de próstataAlterações moleculares no desenvolvimento do câncer de próstataCáncer de próstataAlteraciones molecularesGenes ETS.Câncer de próstataAlterações molecularesETS.Prostate cancerMolecular alterationsGenes ETS.Introduction: Prostate cancer (PC) is the second most diagnosed in the male population in the world. Clinically, PC is subdivided into primary cancer, castration-resistant metastatic prostate cancer, and neuroendocrine prostate cancer. Objective: to describe the main molecular changes necessary for the development of primary prostate cancer (PCa). Methodology: this is a descriptive literature review. The databases PUBMED, SCIELO, Science Direct and Academic Google and National Cancer Institute (INCA) were used. The inclusion/exclusion criteria were articles from 2015 to 2021, available in Portuguese, English and Spanish. Results and discussion: the molecular bases of PC present several genomic alterations such as mutations, alterations in the number of copies of DNA, rearrangements and gene fusions. For primary cancer, the most prevalent genetic alterations are alterations in the ETS family genes such as ERG gene fusions (which occur in 50% of cases and mutations mainly in the CHD1, SPOP and BRCA1 or BRCA2 genes). In castration-resistant metastatic prostate cancer, the most prevalent genetic alteration alters androgen receptors and oncosuppressors (e.g. PTEN and TP53). Conclusion: alterations in genetic and epigenetic levels in specific genes regulated by androgen hormones are closely related to the pathogenesis of PC. These data are of paramount importance for understanding the pathophysiological mechanism of this condition, as well as providing the basis for a more specific treatment.Introducción: El cáncer de próstata (CP) es el segundo más diagnosticado en la población masculina del mundo. Clínicamente, el CP se subdivide en cáncer primario, cáncer de próstata metastásico resistente a la castración y cáncer de próstata neuroendocrino. Objetivo: describir los principales cambios moleculares necesarios para el desarrollo del cáncer de próstata primario (CaP). Metodología: se trata de una revisión descriptiva de la literatura. Se utilizaron las bases de datos PUBMED, SCIELO, Science Direct y Google Academic y National Cancer Institute (INCA). Los criterios de inclusión / exclusión fueron artículos de 2015 a 2021, disponibles en portugués, inglés y español. Resultados y discusión: las bases moleculares del PC presentan diversas alteraciones genómicas como mutaciones, alteraciones en el número de copias de ADN, reordenamientos y fusiones de genes. En el caso del cáncer primario, las alteraciones genéticas más prevalentes son las alteraciones en los genes de la familia ETS como las fusiones del gen ERG (que ocurren en el 50% de los casos y mutaciones principalmente en los genes CHD1, SPOP y BRCA1 o BRCA2). En el cáncer de próstata metastásico resistente a la castración, la alteración genética más prevalente altera los receptores de andrógenos y los oncosupresores (e.g. PTEN y TP53). Conclusión: las alteraciones en los niveles genéticos y epigenéticos en genes específicos regulados por hormonas andrógenas están estrechamente relacionadas con la patogenia del CP. Estos datos son de suma importancia para comprender el mecanismo fisiopatológico de esta afección, además de proporcionar la base para un tratamiento más específico.Introdução: O câncer de próstata (CP) é o segundo mais diagnosticado na população masculina do mundo. Clinicamente, o CP é subdividido em câncer primário, câncer de próstata metastático resistente à castração e o câncer de próstata neuroendócrino. Objetivo: descrever as principais alterações moleculares necessárias para o desenvolvimento do câncer de próstata primário (CPa). Metodologia: trata-se de uma revisão descritiva da literatura. Foram utilizadas as bases de dados PUBMED, SCIELO, Science Direct e Google Acadêmico e Instituto Nacional de Câncer (INCA). Como critério de inclusão/exclusão, foram artigos compreendidos entre 2015 a 2021, disponíveis em português, inglês e espanhol.  Resultados e discussão: as bases moleculares do CP apresentam várias alterações genômicas como mutações, alterações de número de cópias de DNA, rearranjos e fusões de genes. Para o câncer primário, as alterações genéticas mais prevalentes são alterações dos genes da família ETS tais como, fusões dos genes ERG (os quais ocorrem em 50% dos casos e mutações principalmente nos genes CHD1, SPOP e BRCA1 ou BRCA2). Já o câncer de próstata metastático resistente à castração, a alteração genética mais prevalente altera receptores de andrógeno e oncossupressores (e.g. PTEN e TP53). Conclusão: alterações em níveis genético e epigenético em genes específicos regulados por hormônios andrógenos, estão intimamente relacionados à patogênese do CP. Esses dados são de suma importância para a compreensão do mecanismo fisiopatológico desta condição, bem como oferecem a base para um tratamento mais específico.Research, Society and Development2021-12-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2396910.33448/rsd-v10i16.23969Research, Society and Development; Vol. 10 No. 16; e539101623969Research, Society and Development; Vol. 10 Núm. 16; e539101623969Research, Society and Development; v. 10 n. 16; e5391016239692525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23969/21189Copyright (c) 2021 Açucena de Oliveira Borges; Juliana Paniago Souza; Letícia Góes Pereira; Eriston Vieira Gomeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBorges, Açucena de Oliveira Souza, Juliana Paniago Pereira, Letícia Góes Gomes, Eriston Vieira 2021-12-20T11:03:07Zoai:ojs.pkp.sfu.ca:article/23969Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:40.546581Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Molecular changes in the development of prostate cancer
Alteraciones moleculares en el desarrollo del cáncer de próstata
Alterações moleculares no desenvolvimento do câncer de próstata
title Molecular changes in the development of prostate cancer
spellingShingle Molecular changes in the development of prostate cancer
Borges, Açucena de Oliveira
Cáncer de próstata
Alteraciones moleculares
Genes ETS.
Câncer de próstata
Alterações moleculares
ETS.
Prostate cancer
Molecular alterations
Genes ETS.
title_short Molecular changes in the development of prostate cancer
title_full Molecular changes in the development of prostate cancer
title_fullStr Molecular changes in the development of prostate cancer
title_full_unstemmed Molecular changes in the development of prostate cancer
title_sort Molecular changes in the development of prostate cancer
author Borges, Açucena de Oliveira
author_facet Borges, Açucena de Oliveira
Souza, Juliana Paniago
Pereira, Letícia Góes
Gomes, Eriston Vieira
author_role author
author2 Souza, Juliana Paniago
Pereira, Letícia Góes
Gomes, Eriston Vieira
author2_role author
author
author
dc.contributor.author.fl_str_mv Borges, Açucena de Oliveira
Souza, Juliana Paniago
Pereira, Letícia Góes
Gomes, Eriston Vieira
dc.subject.por.fl_str_mv Cáncer de próstata
Alteraciones moleculares
Genes ETS.
Câncer de próstata
Alterações moleculares
ETS.
Prostate cancer
Molecular alterations
Genes ETS.
topic Cáncer de próstata
Alteraciones moleculares
Genes ETS.
Câncer de próstata
Alterações moleculares
ETS.
Prostate cancer
Molecular alterations
Genes ETS.
description Introduction: Prostate cancer (PC) is the second most diagnosed in the male population in the world. Clinically, PC is subdivided into primary cancer, castration-resistant metastatic prostate cancer, and neuroendocrine prostate cancer. Objective: to describe the main molecular changes necessary for the development of primary prostate cancer (PCa). Methodology: this is a descriptive literature review. The databases PUBMED, SCIELO, Science Direct and Academic Google and National Cancer Institute (INCA) were used. The inclusion/exclusion criteria were articles from 2015 to 2021, available in Portuguese, English and Spanish. Results and discussion: the molecular bases of PC present several genomic alterations such as mutations, alterations in the number of copies of DNA, rearrangements and gene fusions. For primary cancer, the most prevalent genetic alterations are alterations in the ETS family genes such as ERG gene fusions (which occur in 50% of cases and mutations mainly in the CHD1, SPOP and BRCA1 or BRCA2 genes). In castration-resistant metastatic prostate cancer, the most prevalent genetic alteration alters androgen receptors and oncosuppressors (e.g. PTEN and TP53). Conclusion: alterations in genetic and epigenetic levels in specific genes regulated by androgen hormones are closely related to the pathogenesis of PC. These data are of paramount importance for understanding the pathophysiological mechanism of this condition, as well as providing the basis for a more specific treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-18
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dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23969
10.33448/rsd-v10i16.23969
url https://rsdjournal.org/index.php/rsd/article/view/23969
identifier_str_mv 10.33448/rsd-v10i16.23969
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23969/21189
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
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rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 16; e539101623969
Research, Society and Development; Vol. 10 Núm. 16; e539101623969
Research, Society and Development; v. 10 n. 16; e539101623969
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
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instname_str Universidade Federal de Itajubá (UNIFEI)
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reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
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