Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/29001 |
Resumo: | Objective: The objective of the present review was to relate the scientific production presented in the last 5 years on the effect of photodynamic therapy using the methylene blue photosensitizer on the microorganisms present in the oral biofilm. Methods: systematic review looking for research in English of primary studies such as randomized clinical trials and without randomization, individual case-control, and qualitative descriptive studies, using the PubMed/MEDLINE and Scopus databases as references, from 2017 to 2021. Results: 15 articles were analyzed, being 67% national publications and 33% international studies. Considering the samples described in the studies, 73% were in vitro, 7% were in vivo and 20% were clinical samples. As for the light source, 66% used laser, 20% used LED and 14% the association of laser and LED devices. The power density used ranged from 0.0026 W/cm2 to 1415 W/cm2. The energy density ranged from 3 J/cm2 to 640 J/cm2. The power ranged from 10 mW to 110 mW. The irradiation time ranged from 24 to 294 seconds. In most publications, 87% used the wavelength of 660 nm. As for the photosensitizer, the most used concentration, in 33% of the studies, was 0.01%, with the pre-irradiation time most used being 300 seconds in 40% of the studies. Conclusion: Photodynamic Methylene Blue Therapy is being accepted as effective in therapies of various oral curative conditions and has been shown to be a useful and effective therapy, as well as a complementary approach to control the development/growth of oral biofilm in clinical situations. |
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Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic ReviewTerapia fotodinámica mediada por azul de metileno en el tratamiento de la microbiota oral. Una Revisión SistemáticaA terapia fotodinâmica mediada pelo azul de metileno no tratamento da microbiota bucal. Uma Revisão SistemáticaFotoquimioterapiaFotossensibilizadorBocaBiofilmes.FotoquimioterapiaFotosensibilizanteOralBiopelículas.PhotochemotherapyPhotosensitizerMouthBiofilms.Objective: The objective of the present review was to relate the scientific production presented in the last 5 years on the effect of photodynamic therapy using the methylene blue photosensitizer on the microorganisms present in the oral biofilm. Methods: systematic review looking for research in English of primary studies such as randomized clinical trials and without randomization, individual case-control, and qualitative descriptive studies, using the PubMed/MEDLINE and Scopus databases as references, from 2017 to 2021. Results: 15 articles were analyzed, being 67% national publications and 33% international studies. Considering the samples described in the studies, 73% were in vitro, 7% were in vivo and 20% were clinical samples. As for the light source, 66% used laser, 20% used LED and 14% the association of laser and LED devices. The power density used ranged from 0.0026 W/cm2 to 1415 W/cm2. The energy density ranged from 3 J/cm2 to 640 J/cm2. The power ranged from 10 mW to 110 mW. The irradiation time ranged from 24 to 294 seconds. In most publications, 87% used the wavelength of 660 nm. As for the photosensitizer, the most used concentration, in 33% of the studies, was 0.01%, with the pre-irradiation time most used being 300 seconds in 40% of the studies. Conclusion: Photodynamic Methylene Blue Therapy is being accepted as effective in therapies of various oral curative conditions and has been shown to be a useful and effective therapy, as well as a complementary approach to control the development/growth of oral biofilm in clinical situations.Objetivo: El objetivo de la presente revisión fue relacionar la producción científica presentada en los últimos 5 años sobre el efecto de la terapia fotodinámica utilizando el fotosensibilizador azul de metileno sobre los microorganismos presentes en el biofilm oral. Métodos: revisión sistemática buscando investigaciones en inglés de estudios primarios como ensayos clínicos aleatorizados y sin aleatorización, estudios descriptivos individuales de casos y controles, utilizando como referencias las bases de datos PubMed/MEDLINE y Scopus, de 2017 a 2021. Resultados: 15 artículos fueron analizados, siendo un 67% publicacciones nacionales y un 33% estudios internacionales. Considerando las muestras descritas en los estudios, el 73% fueron in vitro, el 7% fueron in vivo y el 20% fueron muestras clínicas. En cuanto a la fuente de luz, el 66% utilizó láser, el 20% LED y el 14% la asociación de dispositivos láser y LED. La densidad de potencia utilizada osciló entre 0,0026 W/cm2 y 1415 W/cm2. La densidad de energía osciló entre 3 J/cm2 y 640 J/cm2. La potencia osciló entre 10 mW y 110 mW. El tiempo de irradiación osciló entre 24 y 294 segundos. En la mayoría de las publicaciones, el 87% utilizó la longitud de onda de 660 nm. En cuanto al fotosensibilizante, la concentración más utilizada, en el 33% de los estudios, fue del 0,01%, siendo el tiempo de preirradiación más utilizado de 300 segundos en el 40% de los estudios. Conclusión: La terapia fotodinámica con azul de metileno está siendo aceptada como efectiva en terapias de varias condiciones curativas orales y ha demostrado ser una terapia útil y efectiva, así como un enfoque complementario para controlar el desarrollo/crecimiento de biopelícula oral en situaciones clínicas.Objetivo: O objetivo da presente revisão foi relacionar a produção científica apresentada nos últimos 5 anos sobre o efeito da terapia fotodinâmica utilizando o fotossensibilizador azul de metileno sobre os microrganismos presentes no biofilme oral. Métodos: Revisão sistemática buscando pesquisas em inglês de estudos primários como ensaios clínicos randomizados e sem randomização, caso-controle individual e estudos descritivos qualitativos, tendo como referências as bases de dados PubMed/MEDLINE e Scopus, no período de 2017 a 2021. Resultados: Foram identificados 15 artigos, sendo 67% publicações nacionais e 33% internacionais. Considerando as amostras descritas nos estudos, 73% eram in vitro, 7% eram in vivo e 20% eram amostras clínicas. Quanto à fonte de luz, 66% utilizaram laser, 20% utilizaram LED e 14% a associação de laser e LED. A densidade de potência utilizada variou de 0,0026 W/cm2 a 1415 W/cm2. A densidade de energia variou de 3 J/cm2 a 640 J/cm2. A potência variou de 10 mW a 110 mW. O tempo de irradiação variou de 24 a 294 segundos. Na maioria das publicações, 87% empregaram-se o comprimento de ondas de 660 nm. Quanto ao fotossensibilizador, a concentração mais utilizada, em 33% dos estudos, foi de 0,01%, sendo o tempo pré-irradiação mais utilizado de 300 segundos em 40% dos estudos. Conclusão: A Terapia Fotodinâmica com azul de metileno está sendo aceita como eficaz em terapias de diversas condições curativas orais e tem se mostrado uma terapia útil e eficaz, bem como uma abordagem complementar para controlar o desenvolvimento/crescimento do biofilme oral em situações clínicas.Research, Society and Development2022-05-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2900110.33448/rsd-v11i6.29001Research, Society and Development; Vol. 11 No. 6; e53411629001Research, Society and Development; Vol. 11 Núm. 6; e53411629001Research, Society and Development; v. 11 n. 6; e534116290012525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/29001/25478Copyright (c) 2022 Lucieni Cristina Trovati Moreti; Lívia Assis Garcia; Karina Gonzalez Camara Fernandes; Dora Inés Kozusny-Andreani; José Antonio Santos Souza; Carla Roberta Tim https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMoreti, Lucieni Cristina Trovati Garcia, Lívia Assis Fernandes, Karina Gonzalez Camara Kozusny-Andreani, Dora Inés Souza, José Antonio Santos Tim , Carla Roberta 2022-05-13T18:04:10Zoai:ojs.pkp.sfu.ca:article/29001Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:12.424888Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review Terapia fotodinámica mediada por azul de metileno en el tratamiento de la microbiota oral. Una Revisión Sistemática A terapia fotodinâmica mediada pelo azul de metileno no tratamento da microbiota bucal. Uma Revisão Sistemática |
title |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review |
spellingShingle |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review Moreti, Lucieni Cristina Trovati Fotoquimioterapia Fotossensibilizador Boca Biofilmes. Fotoquimioterapia Fotosensibilizante Oral Biopelículas. Photochemotherapy Photosensitizer Mouth Biofilms. |
title_short |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review |
title_full |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review |
title_fullStr |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review |
title_full_unstemmed |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review |
title_sort |
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review |
author |
Moreti, Lucieni Cristina Trovati |
author_facet |
Moreti, Lucieni Cristina Trovati Garcia, Lívia Assis Fernandes, Karina Gonzalez Camara Kozusny-Andreani, Dora Inés Souza, José Antonio Santos Tim , Carla Roberta |
author_role |
author |
author2 |
Garcia, Lívia Assis Fernandes, Karina Gonzalez Camara Kozusny-Andreani, Dora Inés Souza, José Antonio Santos Tim , Carla Roberta |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Moreti, Lucieni Cristina Trovati Garcia, Lívia Assis Fernandes, Karina Gonzalez Camara Kozusny-Andreani, Dora Inés Souza, José Antonio Santos Tim , Carla Roberta |
dc.subject.por.fl_str_mv |
Fotoquimioterapia Fotossensibilizador Boca Biofilmes. Fotoquimioterapia Fotosensibilizante Oral Biopelículas. Photochemotherapy Photosensitizer Mouth Biofilms. |
topic |
Fotoquimioterapia Fotossensibilizador Boca Biofilmes. Fotoquimioterapia Fotosensibilizante Oral Biopelículas. Photochemotherapy Photosensitizer Mouth Biofilms. |
description |
Objective: The objective of the present review was to relate the scientific production presented in the last 5 years on the effect of photodynamic therapy using the methylene blue photosensitizer on the microorganisms present in the oral biofilm. Methods: systematic review looking for research in English of primary studies such as randomized clinical trials and without randomization, individual case-control, and qualitative descriptive studies, using the PubMed/MEDLINE and Scopus databases as references, from 2017 to 2021. Results: 15 articles were analyzed, being 67% national publications and 33% international studies. Considering the samples described in the studies, 73% were in vitro, 7% were in vivo and 20% were clinical samples. As for the light source, 66% used laser, 20% used LED and 14% the association of laser and LED devices. The power density used ranged from 0.0026 W/cm2 to 1415 W/cm2. The energy density ranged from 3 J/cm2 to 640 J/cm2. The power ranged from 10 mW to 110 mW. The irradiation time ranged from 24 to 294 seconds. In most publications, 87% used the wavelength of 660 nm. As for the photosensitizer, the most used concentration, in 33% of the studies, was 0.01%, with the pre-irradiation time most used being 300 seconds in 40% of the studies. Conclusion: Photodynamic Methylene Blue Therapy is being accepted as effective in therapies of various oral curative conditions and has been shown to be a useful and effective therapy, as well as a complementary approach to control the development/growth of oral biofilm in clinical situations. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29001 10.33448/rsd-v11i6.29001 |
url |
https://rsdjournal.org/index.php/rsd/article/view/29001 |
identifier_str_mv |
10.33448/rsd-v11i6.29001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29001/25478 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 6; e53411629001 Research, Society and Development; Vol. 11 Núm. 6; e53411629001 Research, Society and Development; v. 11 n. 6; e53411629001 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052765731553280 |