Biological properties of Oncocalyxone A: a review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/14343 |
Resumo: | Quinones are a classic example of molecules isolated from natural products. These compounds are secondary metabolites produced by plants, fungi, bacteria, and insects and correspond to an interesting chemical class ubiquitously found in nature. The [rel-8α-Hydroxy-5-hydroxymethyl-2-methoxy-8α, β-methyl-7, 8, 8a, 9-tetahydro-1, 4-anthracenedione] [oncocalyxone A, onco-A] is a benzoquinone of dark red color isolated from the ethanolic extract of the species Cordia oncocalyx (Auxemma oncocalyx Allem). In this review, we aimed to investigate the main biological activities described for oncocalyxone A, as well as its isolation and characterization processes. For this review, the following descriptors were employed in multiple databases: medicinal plants, quinones, Auxemma oncocalyx, Cordia oncocalyx, biological activity. Besides, experimental papers published in international journals and with full text available were used as inclusion criteria. The biological activity profiles found for onco-A according to the literature were: antiproliferative/cytotoxic effects against SW1573 (alveolar cell carcinoma) and CCD922 (normal skin fibroblasts) cell lines; anti-inflammatory and analgesic potential; inhibitory effect on cell growth and DNA reactivity; antiplatelet activity; antitumor potential; anti-glycation agent; beneficial and/or toxic potential in goats and neuroinhibitory effect; antibacterial and antibiofilm activity. The substance has a broad spectrum of pharmacological applications, most of which are associated with its cytotoxic activity. The work also intends to compile the activities described in the literature, to understand how the molecule acts on the various targets, but, in some cases, more in-depth research is needed to elucidate the mechanisms of action. |
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Biological properties of Oncocalyxone A: a reviewPropiedades biológicas de la Oncocalyxona A: una revisiónPropriedades biológicas da Oncocalixona A: uma revisãoQuinonesChemical propertiesIsolated substanceActivity profileNatural productsMetabolites secondary.QuinonasPropriedades químicasSubstância isoladaPerfil de atividadeProdutos naturaisMetabólitos secundários.QuinonasPropiedades químicasSustancia aisladaPerfil de actividadProductos naturalesMetabolitos secundarios.Quinones are a classic example of molecules isolated from natural products. These compounds are secondary metabolites produced by plants, fungi, bacteria, and insects and correspond to an interesting chemical class ubiquitously found in nature. The [rel-8α-Hydroxy-5-hydroxymethyl-2-methoxy-8α, β-methyl-7, 8, 8a, 9-tetahydro-1, 4-anthracenedione] [oncocalyxone A, onco-A] is a benzoquinone of dark red color isolated from the ethanolic extract of the species Cordia oncocalyx (Auxemma oncocalyx Allem). In this review, we aimed to investigate the main biological activities described for oncocalyxone A, as well as its isolation and characterization processes. For this review, the following descriptors were employed in multiple databases: medicinal plants, quinones, Auxemma oncocalyx, Cordia oncocalyx, biological activity. Besides, experimental papers published in international journals and with full text available were used as inclusion criteria. The biological activity profiles found for onco-A according to the literature were: antiproliferative/cytotoxic effects against SW1573 (alveolar cell carcinoma) and CCD922 (normal skin fibroblasts) cell lines; anti-inflammatory and analgesic potential; inhibitory effect on cell growth and DNA reactivity; antiplatelet activity; antitumor potential; anti-glycation agent; beneficial and/or toxic potential in goats and neuroinhibitory effect; antibacterial and antibiofilm activity. The substance has a broad spectrum of pharmacological applications, most of which are associated with its cytotoxic activity. The work also intends to compile the activities described in the literature, to understand how the molecule acts on the various targets, but, in some cases, more in-depth research is needed to elucidate the mechanisms of action.Las quinonas son un ejemplo clásico de moléculas aisladas de productos naturales. Estos son metabolitos secundarios de plantas, hongos, bacterias e insectos, y corresponden a una clase química interesante que se encuentra ubicuamente en la naturaleza. La [rel-8α-hidroxi-5-hidroximetil-2-metoxi-8α, β-metil-7, 8, 8a, 9-tetahidro-1, 4-antracenodiona] [oncocalyxona A, onco-A] una benzoquinona de color oscuro color rojo aislado del extracto etanólico de la especie Cordia oncocalyx (Auxemma oncocalyx Allem). En esta revisión, proponemos investigar las principales actividades biológicas descritas para la oncocalyxona A, desde su aislamiento hasta el proceso de caracterización. Métodos. Para esta revisión, se emplearon los siguientes descriptores en múltiples bases de datos: plantas medicinales, quinonas, Auxemma oncocalyx, Cordia oncocalyx, actividad biológica. Además, se utilizaron como criterios de inclusión artículos experimentales publicados en revistas internacionales y con texto completo disponible. Resultados y discusión. Los perfiles de actividad biológica encontrados para onco-A según la literatura fueron: antiproliferativo/citotóxico en leucemia, tumor de pulmón [SW1573] y fibroblastos de piel normal [CCD922]; antiinflamatorio y analgésico; efecto inhibidor sobre el crecimiento celular y la reactividad del ADN; actividad antiplaquetaria; potencial antitumoral; agente anti-glicación; potencial beneficioso y / o tóxico en cabras y efecto neuroinhibidor; actividad antibacteriana y antibiofilm. La sustancia tiene un amplio espectro de aplicaciones farmacológicas, la mayoría de las cuales están interconectadas con la actividad citotóxica. El trabajo busca, además de recopilar las actividades descritas en la literatura, comprender cómo actúa la molécula sobre las distintas dianas, pero, en algunos casos, se necesita una investigación más profunda para dilucidar los mecanismos de acción de la misma.As quinonas são um exemplo clássico de moléculas isoladas de produtos naturais. Estes são metabólitos secundários de plantas, fungos, bactérias e insetos, e correspondem a uma classe química interessante encontrada ubiquamente na natureza. O [rel-8α-hidroxi-5-hidroximetil-2-metoxi-8α, β-metil-7, 8, 8a, 9-tetahidro-1, 4-antracenediona] [oncocalixona A, onco-A] uma benzoquinona escura cor vermelha isolada do extrato etanólico da espécie Cordia oncocalyx (Auxemma oncocalyx Allem). Nesta revisão, propomos investigar as principais atividades biológicas descritas para a oncocalixona A, desde o seu isolamento até o processo de caracterização. Para esta revisão, os seguintes descritores foram empregados em múltiplas bases de dados: medicinal plants, quinones, Auxemma oncocalyx, Cordia oncocalyx, atividade biológica. Além disso, artigos experimentais publicados em periódicos internacionais e com texto completo disponível foram utilizados como critérios de inclusão. Os perfis de atividade biológica encontrados para o onco-A de acordo com a literatura foram: efeito antiproliferativo/citotóxico nas linhagens celulares SW1573 (carcinoma de células alveolares) e CCD922 (fibroblastos normais de pele); antiinflamatório e analgésico; efeito inibitório sobre o crescimento celular e reatividade do DNA; atividade antiplaquetária; potencial antitumoral; agente anti-glicação; potencial benéfico e / ou tóxico em caprinos e efeito neuroinibitório; atividade antibacteriana e antibiofilme. A substância possui um amplo espectro de aplicações farmacológicas, muitas das quais interligadas à atividade citotóxica. O trabalho busca, além de compilar as atividades descritas na literatura, entender como a molécula atua nos diversos alvos, mas, em alguns casos, pesquisas mais aprofundadas são necessárias para elucidar seus mecanismos de ação.Research, Society and Development2021-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1434310.33448/rsd-v10i4.14343Research, Society and Development; Vol. 10 No. 4; e57810414343Research, Society and Development; Vol. 10 Núm. 4; e57810414343Research, Society and Development; v. 10 n. 4; e578104143432525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/14343/12991Copyright (c) 2021 Raí Emanuel da Silva; Fábio de Oliveira Silva Ribeiro ; Gisele Santos de Araújo; Bruno Iles; Otília Deusdênia Loiola Pessoa; Alyne Rodrigues de Araújo; Maria José dos Santos Soareshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Raí Emanuel da Ribeiro , Fábio de Oliveira Silva Araújo, Gisele Santos de Iles, BrunoPessoa, Otília Deusdênia Loiola Araújo, Alyne Rodrigues de Soares, Maria José dos Santos 2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/14343Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:30.202512Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Biological properties of Oncocalyxone A: a review Propiedades biológicas de la Oncocalyxona A: una revisión Propriedades biológicas da Oncocalixona A: uma revisão |
title |
Biological properties of Oncocalyxone A: a review |
spellingShingle |
Biological properties of Oncocalyxone A: a review Silva, Raí Emanuel da Quinones Chemical properties Isolated substance Activity profile Natural products Metabolites secondary. Quinonas Propriedades químicas Substância isolada Perfil de atividade Produtos naturais Metabólitos secundários. Quinonas Propiedades químicas Sustancia aislada Perfil de actividad Productos naturales Metabolitos secundarios. |
title_short |
Biological properties of Oncocalyxone A: a review |
title_full |
Biological properties of Oncocalyxone A: a review |
title_fullStr |
Biological properties of Oncocalyxone A: a review |
title_full_unstemmed |
Biological properties of Oncocalyxone A: a review |
title_sort |
Biological properties of Oncocalyxone A: a review |
author |
Silva, Raí Emanuel da |
author_facet |
Silva, Raí Emanuel da Ribeiro , Fábio de Oliveira Silva Araújo, Gisele Santos de Iles, Bruno Pessoa, Otília Deusdênia Loiola Araújo, Alyne Rodrigues de Soares, Maria José dos Santos |
author_role |
author |
author2 |
Ribeiro , Fábio de Oliveira Silva Araújo, Gisele Santos de Iles, Bruno Pessoa, Otília Deusdênia Loiola Araújo, Alyne Rodrigues de Soares, Maria José dos Santos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Raí Emanuel da Ribeiro , Fábio de Oliveira Silva Araújo, Gisele Santos de Iles, Bruno Pessoa, Otília Deusdênia Loiola Araújo, Alyne Rodrigues de Soares, Maria José dos Santos |
dc.subject.por.fl_str_mv |
Quinones Chemical properties Isolated substance Activity profile Natural products Metabolites secondary. Quinonas Propriedades químicas Substância isolada Perfil de atividade Produtos naturais Metabólitos secundários. Quinonas Propiedades químicas Sustancia aislada Perfil de actividad Productos naturales Metabolitos secundarios. |
topic |
Quinones Chemical properties Isolated substance Activity profile Natural products Metabolites secondary. Quinonas Propriedades químicas Substância isolada Perfil de atividade Produtos naturais Metabólitos secundários. Quinonas Propiedades químicas Sustancia aislada Perfil de actividad Productos naturales Metabolitos secundarios. |
description |
Quinones are a classic example of molecules isolated from natural products. These compounds are secondary metabolites produced by plants, fungi, bacteria, and insects and correspond to an interesting chemical class ubiquitously found in nature. The [rel-8α-Hydroxy-5-hydroxymethyl-2-methoxy-8α, β-methyl-7, 8, 8a, 9-tetahydro-1, 4-anthracenedione] [oncocalyxone A, onco-A] is a benzoquinone of dark red color isolated from the ethanolic extract of the species Cordia oncocalyx (Auxemma oncocalyx Allem). In this review, we aimed to investigate the main biological activities described for oncocalyxone A, as well as its isolation and characterization processes. For this review, the following descriptors were employed in multiple databases: medicinal plants, quinones, Auxemma oncocalyx, Cordia oncocalyx, biological activity. Besides, experimental papers published in international journals and with full text available were used as inclusion criteria. The biological activity profiles found for onco-A according to the literature were: antiproliferative/cytotoxic effects against SW1573 (alveolar cell carcinoma) and CCD922 (normal skin fibroblasts) cell lines; anti-inflammatory and analgesic potential; inhibitory effect on cell growth and DNA reactivity; antiplatelet activity; antitumor potential; anti-glycation agent; beneficial and/or toxic potential in goats and neuroinhibitory effect; antibacterial and antibiofilm activity. The substance has a broad spectrum of pharmacological applications, most of which are associated with its cytotoxic activity. The work also intends to compile the activities described in the literature, to understand how the molecule acts on the various targets, but, in some cases, more in-depth research is needed to elucidate the mechanisms of action. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/14343 10.33448/rsd-v10i4.14343 |
url |
https://rsdjournal.org/index.php/rsd/article/view/14343 |
identifier_str_mv |
10.33448/rsd-v10i4.14343 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/14343/12991 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 4; e57810414343 Research, Society and Development; Vol. 10 Núm. 4; e57810414343 Research, Society and Development; v. 10 n. 4; e57810414343 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052824724439040 |