Analysis of the redox state of patients acetilsalicylic acid users
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/27817 |
Resumo: | One of the major global health problems is chronic non-transmissible diseases such as heart and coronary diseases, diabetes, hypertension, among others, leading to a high number of premature deaths and physiological changes related to oxidative metabolism, causing excessive increases in the production of oxigen reactive species. The objective of this study was to analyze the redox status of patients with acetylsalicylic acid (AAS) users with healthy and volunteer subjects in the same pathological conditions, but not users of the medication, through the antioxidant analyzes of the levels of GSH, TBARS and total serum antioxidant capacity (TEAC). The study included volunteers aged 19-96 and AAS users for more than one year. Analyzes of GSH levels showed a significant decrease in volunteers with coronary disorders. In the analysis of TBARS and TEAC levels, there was an increase in the lipid peroxidation activity and a decrease in the TEAC in the non-users of the medication. The observations made regarding the embrittlement of the antioxidant system can not be directly related to the use of the drug in question, since biological and environmental factors must be taken into account, for such studies under controlled conditions should be carried out to determine the direct relation between drug use and oxidant activity. |
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Analysis of the redox state of patients acetilsalicylic acid usersAnálisis del estado redox de pacientes que utilizan ácido acetilsalicílicoAnálise do status redox de pacientes usuários de ácido acetilsalicílico Redox statusAcetylsalicylic acidNSAIDsAntioxidant.Estado redoxÁcido acetilsalicílicoAINEAntioxidante.Status redoxÁcido acetilsalicílicoAINESAntioxidante.One of the major global health problems is chronic non-transmissible diseases such as heart and coronary diseases, diabetes, hypertension, among others, leading to a high number of premature deaths and physiological changes related to oxidative metabolism, causing excessive increases in the production of oxigen reactive species. The objective of this study was to analyze the redox status of patients with acetylsalicylic acid (AAS) users with healthy and volunteer subjects in the same pathological conditions, but not users of the medication, through the antioxidant analyzes of the levels of GSH, TBARS and total serum antioxidant capacity (TEAC). The study included volunteers aged 19-96 and AAS users for more than one year. Analyzes of GSH levels showed a significant decrease in volunteers with coronary disorders. In the analysis of TBARS and TEAC levels, there was an increase in the lipid peroxidation activity and a decrease in the TEAC in the non-users of the medication. The observations made regarding the embrittlement of the antioxidant system can not be directly related to the use of the drug in question, since biological and environmental factors must be taken into account, for such studies under controlled conditions should be carried out to determine the direct relation between drug use and oxidant activity.Uno de los mayores problemas de salud a nivel mundial lo constituyen las enfermedades crónicas no transmisibles como son las enfermedades cardíacas y coronarias, diabetes, hipertensión, entre otras, generando un alto número de muertes prematuras y alteraciones fisiológicas relacionadas con el metabolismo oxidativo, generando aumentos desmesurados en la producción. de especies reactivas al oxígeno. El objetivo de este estudio fue analizar el estado redox de pacientes con patologías cardíacas que utilizan ácido acetilsalicílico (AAS) frente a grupos de individuos sanos y voluntarios en las mismas condiciones patológicas, pero no usuarios del medicamento, mediante el análisis de los niveles antioxidantes. de GSH, TBARS y capacidad antioxidante total en suero de voluntarios (TEAC). El estudio contó con voluntarios de entre 19 y 96 años y usuarios de AAS durante más de un año. Los análisis de los niveles de GSH mostraron una disminución significativa en los voluntarios con trastornos coronarios. En el análisis de los niveles de TBARS y TEAC, se observó un aumento de la actividad de peroxidación lipídica lipídica y una disminución de TEAC en el grupo con cardiopatía que no usó el medicamento. Las observaciones realizadas sobre el debilitamiento del sistema antioxidante no pueden relacionarse directamente con el uso del fármaco en cuestión, ya que se deben tener en cuenta factores biológicos y ambientales. Por lo tanto, se deben realizar estudios bajo condiciones controladas para determinar la relación directa entre el uso de drogas y la actividad oxidante.Um dos maiores problemas globais de saúde é constituído pelas doenças crônicas não transmissíveis ao exemplo das doenças cardíacas e coronarianas, diabetes, hipertensão, dentre outras, gerando um elevado número de mortes prematuras e ainda alterações fisiológicas relacionadas ao metabolismo oxidativo gerando aumentos excessivos na produção de espécies reativas de oxigênio. Objetivou-se neste trabalho analisar o status redox de pacientes com patologias cardíacas usuários de ácido acetilsalicílico (AAS) frente a grupos de indivíduos hígidos e voluntários nas mesmas condições patológicas, porém, não usuários da medicação, através das análises antioxidantes dos níveis de GSH, TBARS e capacidade antioxidante total no soro dos voluntários (TEAC). O estudo contou com voluntários entre 19 e 96 anos e usuários de AAS a mais de um ano. As análises dos níveis de GSH evidenciaram uma diminuição significativa em voluntários com desordens coronarianas. Na análise dos níveis de TBARS e TEAC observou-se um aumento da atividade da lipoperoxidação lipídica e diminuição da TEAC no grupo cardiopata não usuário da medicação. As observações realizadas frente à fragilização do sistema antioxidante não podem ser diretamente relacionadas ao uso do fármaco em questão, uma vez que fatores de ordens biológicas e ambientais devem ser levados em consideração. Sendo assim, estudos em condições controladas deverão ser realizados para determinar a relação direta entre uso do fármaco e atividade oxidante.Research, Society and Development2022-03-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2781710.33448/rsd-v11i5.27817Research, Society and Development; Vol. 11 No. 5; e8911527817Research, Society and Development; Vol. 11 Núm. 5; e8911527817Research, Society and Development; v. 11 n. 5; e89115278172525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/27817/24355Copyright (c) 2022 Suély Bastos da Silva; Jessica Camile Favarin; Vilmair Zancanaro; Emyr Hiago Bellaverhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Suély Bastos da Favarin, Jessica CamileZancanaro, VilmairBellaver, Emyr Hiago2022-04-17T18:18:56Zoai:ojs.pkp.sfu.ca:article/27817Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:45:25.730067Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Analysis of the redox state of patients acetilsalicylic acid users Análisis del estado redox de pacientes que utilizan ácido acetilsalicílico Análise do status redox de pacientes usuários de ácido acetilsalicílico |
title |
Analysis of the redox state of patients acetilsalicylic acid users |
spellingShingle |
Analysis of the redox state of patients acetilsalicylic acid users Silva, Suély Bastos da Redox status Acetylsalicylic acid NSAIDs Antioxidant. Estado redox Ácido acetilsalicílico AINE Antioxidante. Status redox Ácido acetilsalicílico AINES Antioxidante. |
title_short |
Analysis of the redox state of patients acetilsalicylic acid users |
title_full |
Analysis of the redox state of patients acetilsalicylic acid users |
title_fullStr |
Analysis of the redox state of patients acetilsalicylic acid users |
title_full_unstemmed |
Analysis of the redox state of patients acetilsalicylic acid users |
title_sort |
Analysis of the redox state of patients acetilsalicylic acid users |
author |
Silva, Suély Bastos da |
author_facet |
Silva, Suély Bastos da Favarin, Jessica Camile Zancanaro, Vilmair Bellaver, Emyr Hiago |
author_role |
author |
author2 |
Favarin, Jessica Camile Zancanaro, Vilmair Bellaver, Emyr Hiago |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Suély Bastos da Favarin, Jessica Camile Zancanaro, Vilmair Bellaver, Emyr Hiago |
dc.subject.por.fl_str_mv |
Redox status Acetylsalicylic acid NSAIDs Antioxidant. Estado redox Ácido acetilsalicílico AINE Antioxidante. Status redox Ácido acetilsalicílico AINES Antioxidante. |
topic |
Redox status Acetylsalicylic acid NSAIDs Antioxidant. Estado redox Ácido acetilsalicílico AINE Antioxidante. Status redox Ácido acetilsalicílico AINES Antioxidante. |
description |
One of the major global health problems is chronic non-transmissible diseases such as heart and coronary diseases, diabetes, hypertension, among others, leading to a high number of premature deaths and physiological changes related to oxidative metabolism, causing excessive increases in the production of oxigen reactive species. The objective of this study was to analyze the redox status of patients with acetylsalicylic acid (AAS) users with healthy and volunteer subjects in the same pathological conditions, but not users of the medication, through the antioxidant analyzes of the levels of GSH, TBARS and total serum antioxidant capacity (TEAC). The study included volunteers aged 19-96 and AAS users for more than one year. Analyzes of GSH levels showed a significant decrease in volunteers with coronary disorders. In the analysis of TBARS and TEAC levels, there was an increase in the lipid peroxidation activity and a decrease in the TEAC in the non-users of the medication. The observations made regarding the embrittlement of the antioxidant system can not be directly related to the use of the drug in question, since biological and environmental factors must be taken into account, for such studies under controlled conditions should be carried out to determine the direct relation between drug use and oxidant activity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/27817 10.33448/rsd-v11i5.27817 |
url |
https://rsdjournal.org/index.php/rsd/article/view/27817 |
identifier_str_mv |
10.33448/rsd-v11i5.27817 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/27817/24355 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 5; e8911527817 Research, Society and Development; Vol. 11 Núm. 5; e8911527817 Research, Society and Development; v. 11 n. 5; e8911527817 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052835347562496 |