Vitamin D in COVID-19 patients: current overview

• Autor(a) principal: Albuquerque, Ana Beatriz Bessa de
• Data de Publicação: 2021
• Outros Autores: Fernandes, Alan Lins, Reis, Bruna Zavarize
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/21167
• topic: 25OHD; Cholecalciferol; Ergocalciferol; SARS-CoV-2; Coronaviruses; COVID-19.; 25OHD; Colecalciferol; Ergocalciferol; SARS-CoV-2; Coronavirus; COVID-19.; 25OHD; Colecalciferol; Ergocalciferol; SARS-CoV-2; Coronavírus; COVID-19.

The search for therapeutic resources that add to the vaccine and are able to prevent and/or treat COVID-19 suggests vitamin D. Vitamin D is known to play several extra-skeletal roles in the body, particularly in the immune system. This review aims to address the current attributions and perspectives for the use of vitamin D in patients with COVID-19. The search was performed using the Medline (PubMed) database, between May and July 2021, regarding the physiological and immunological roles of vitamin D in respiratory infections, as well as its mechanisms of action, concerning COVID- 19. The results suggest a possible association between serum 25(OH)D concentrations and the clinical setting of COVID-19 (mortality, systemic inflammation, illness severity, mechanical ventilation requirement or admission to the ICU), although the studies found differ in the design, sample size and outcomes, mitigating an accurate between-trial comparison. Therefore, further studies with a well-defined design evaluating the role of vitamin D in the prevention and/or treatment of COVID-19 is still necessary.