Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/21498 |
Resumo: | The Hypertrophic Cardiomyopathy (HCM) is a cardiac disease from genetic bases and most common hereditary transmission, has been identified numerous mutations in the genes of the cardiac sarcomere. The major characteristic of the disease is left ventricular hypertrophy (LVH) of diferente morphologies, without other causes that explain the condition. Its clinical manifestations vary according to the mutations of each individual and/or family; the patient may present in the asymptomatic form, or evolve with outcomes such as arrhythmias, subvalvular aortic stenosis, heart failure and even sudden death. Thus, the objective of this work is to approach the main clinical manifestations of HCM. An Integrative Literature Review was carried out, searching the Scielo, LILACS, UpToDate and MEDLINE databases. Articles published from 2015 to 2021, in full and available electronically in English, Spanish or Portuguese, were included. Articles that were repeated themselves, made available only in summary or unrelated to the purpose of the study, were excluded. Has been found 17.796 publications summing all platforms, after using the inclusion and exclusion criteria and using the descriptors 3187 articles remained; then, after reading the titles and/or abstracts, 25 articles were selected and analyzed. Therefore, it was understood that HCM is a silent disease in many cases, making screening essential to detect the disease early and allow precocious medical intervention, improving the prognosis and quality of life of patients; in addition, there is great difficulty in determining the risk of developing clinical manifestations, such as sudden cardiac death (SCD). |
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Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative reviewMiocardiopatía hipertrófica, una causa importante de muerte súbita en jóvenes: revisión integradoraCardiomiopatia hipertrófica, uma importante causa de morte súbita em jovens: revisão integrativaHypertrophic cardiomyopathySudden deathClinical manifestations.Miocardiopatía hipertróficaMuerte súbitaManifestaciones clínicas.Cardiomiopatia hipertróficaMorte súbitaManifestações clínicas.The Hypertrophic Cardiomyopathy (HCM) is a cardiac disease from genetic bases and most common hereditary transmission, has been identified numerous mutations in the genes of the cardiac sarcomere. The major characteristic of the disease is left ventricular hypertrophy (LVH) of diferente morphologies, without other causes that explain the condition. Its clinical manifestations vary according to the mutations of each individual and/or family; the patient may present in the asymptomatic form, or evolve with outcomes such as arrhythmias, subvalvular aortic stenosis, heart failure and even sudden death. Thus, the objective of this work is to approach the main clinical manifestations of HCM. An Integrative Literature Review was carried out, searching the Scielo, LILACS, UpToDate and MEDLINE databases. Articles published from 2015 to 2021, in full and available electronically in English, Spanish or Portuguese, were included. Articles that were repeated themselves, made available only in summary or unrelated to the purpose of the study, were excluded. Has been found 17.796 publications summing all platforms, after using the inclusion and exclusion criteria and using the descriptors 3187 articles remained; then, after reading the titles and/or abstracts, 25 articles were selected and analyzed. Therefore, it was understood that HCM is a silent disease in many cases, making screening essential to detect the disease early and allow precocious medical intervention, improving the prognosis and quality of life of patients; in addition, there is great difficulty in determining the risk of developing clinical manifestations, such as sudden cardiac death (SCD).La miocardiopatía hipertrófica (MCH) es la enfermedad cardíaca de base genética y la transmisión hereditaria más común, y se han identificado numerosas mutaciones en los genes del sarcómero cardíaco. La principal característica de la enfermedad es la hipertrofia ventricular izquierda (HVI) de diferentes morfologías, sin otras causas que expliquen la condición. Sus manifestaciones clínicas varían según las mutaciones de cada individuo y / o familia; el paciente puede presentarse de forma asintomática o evolucionar con resultados como arritmias, estenosis aórtica subvalvular, insuficiencia cardíaca e incluso muerte súbita. Así, el objetivo de este trabajo es abordar las principales manifestaciones clínicas de la MCH. Se realizó una Revisión Integrativa de Literatura, buscando en las bases de datos Scielo, LILACS, UpToDate y MEDLINE. Se incluyeron artículos publicados de 2015 a 2021, en su totalidad y disponibles electrónicamente en inglés, español o portugués. Se excluyeron los artículos que se repitieron, que se pusieron a disposición solo en forma resumida o que no estaban relacionados con el propósito del estudio. Encontramos 17796 publicaciones sumando todas las plataformas, luego de usar los criterios de inclusión y exclusión y usar los descriptores, quedaron 3187 artículos; luego, luego de la lectura de los títulos y / o resúmenes, se seleccionaron y analizaron 25 artículos. Por tanto, se entiende que la MCH es una enfermedad silenciosa en muchos casos, por lo que el cribado es fundamental para detectar precozmente la enfermedad y permitir una intervención médica precoz, mejorando el pronóstico y la calidad de vida de los pacientes; Además, existe una gran dificultad para determinar el riesgo de desarrollar manifestaciones clínicas, como la muerte súbita cardíaca (MSC).A Cardiomiopatia Hipertrófica (CMH) é a doença cardíaca de base genética e transmissão hereditária mais comum, tendo sido identificados inúmeras mutações nos genes do sarcômero cardíaco. A principal característica da doença é a hipertrofia ventricular esquerda (HVE) de morfologias diversas, sem outras causas que expliquem a condição. Suas manifestações clínicas são variadas de acordo com as mutações de cada indivíduo e/ou família; o paciente pode apresentar-se na forma assintomática, ou evoluir com desfechos como arritmias, estenose aórtica subvalvar, insuficiência cardíaca (IC) e, até mesmo, morte súbita. Assim, o objetivo deste trabalho é abordar as principais manifestações clínicas da CMH. Foi realizada uma Revisão Integrativa da Literatura, com busca nas bases de dados Scielo, LILACS, UpToDate e MEDLINE. Foram incluídos os artigos publicados de 2015 a 2021, na íntegra e disponíveis eletronicamente em Inglês, espanhol ou Português. Foram excluídos os artigos que se repetiam, disponibilizados apenas em resumo ou sem relação com o objetivo do estudo. Encontrou-se 17796 publicações somando todas as plataformas, após empregar os critérios de inclusão e exclusão e utilizar os descritores restaram 3187 artigos; em seguida, a partir da leitura dos títulos e/ou resumos foram selecionados e analisados 25 artigos. Portanto, entende-se que a CMH é uma patologia de manifestação silenciosa em muitos casos, tornando a triagem essencial para detectar a doença precocemente e permitir intervenção médica antecipada, melhorando o prognóstico e a qualidade de vida dos pacientes; além disso, tem-se uma grande dificuldade de determinar o risco de desenvolver as manifestações clínicas, como a morte súbita cardíaca.Research, Society and Development2021-10-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2149810.33448/rsd-v10i13.21498Research, Society and Development; Vol. 10 No. 13; e336101321498Research, Society and Development; Vol. 10 Núm. 13; e336101321498Research, Society and Development; v. 10 n. 13; e3361013214982525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/21498/18977Copyright (c) 2021 Thiago do Nascimento Sousa; Higor César Parrião Lustosa; Hian Costa Távora; Marcos André de Sousa Godinho; Marcelo Augustus de Senahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSousa, Thiago do Nascimento Lustosa, Higor César Parrião Távora, Hian Costa Godinho, Marcos André de Sousa Sena, Marcelo Augustus de 2021-11-21T18:26:28Zoai:ojs.pkp.sfu.ca:article/21498Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:40:53.888333Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review Miocardiopatía hipertrófica, una causa importante de muerte súbita en jóvenes: revisión integradora Cardiomiopatia hipertrófica, uma importante causa de morte súbita em jovens: revisão integrativa |
title |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review |
spellingShingle |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review Sousa, Thiago do Nascimento Hypertrophic cardiomyopathy Sudden death Clinical manifestations. Miocardiopatía hipertrófica Muerte súbita Manifestaciones clínicas. Cardiomiopatia hipertrófica Morte súbita Manifestações clínicas. |
title_short |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review |
title_full |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review |
title_fullStr |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review |
title_full_unstemmed |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review |
title_sort |
Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review |
author |
Sousa, Thiago do Nascimento |
author_facet |
Sousa, Thiago do Nascimento Lustosa, Higor César Parrião Távora, Hian Costa Godinho, Marcos André de Sousa Sena, Marcelo Augustus de |
author_role |
author |
author2 |
Lustosa, Higor César Parrião Távora, Hian Costa Godinho, Marcos André de Sousa Sena, Marcelo Augustus de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Thiago do Nascimento Lustosa, Higor César Parrião Távora, Hian Costa Godinho, Marcos André de Sousa Sena, Marcelo Augustus de |
dc.subject.por.fl_str_mv |
Hypertrophic cardiomyopathy Sudden death Clinical manifestations. Miocardiopatía hipertrófica Muerte súbita Manifestaciones clínicas. Cardiomiopatia hipertrófica Morte súbita Manifestações clínicas. |
topic |
Hypertrophic cardiomyopathy Sudden death Clinical manifestations. Miocardiopatía hipertrófica Muerte súbita Manifestaciones clínicas. Cardiomiopatia hipertrófica Morte súbita Manifestações clínicas. |
description |
The Hypertrophic Cardiomyopathy (HCM) is a cardiac disease from genetic bases and most common hereditary transmission, has been identified numerous mutations in the genes of the cardiac sarcomere. The major characteristic of the disease is left ventricular hypertrophy (LVH) of diferente morphologies, without other causes that explain the condition. Its clinical manifestations vary according to the mutations of each individual and/or family; the patient may present in the asymptomatic form, or evolve with outcomes such as arrhythmias, subvalvular aortic stenosis, heart failure and even sudden death. Thus, the objective of this work is to approach the main clinical manifestations of HCM. An Integrative Literature Review was carried out, searching the Scielo, LILACS, UpToDate and MEDLINE databases. Articles published from 2015 to 2021, in full and available electronically in English, Spanish or Portuguese, were included. Articles that were repeated themselves, made available only in summary or unrelated to the purpose of the study, were excluded. Has been found 17.796 publications summing all platforms, after using the inclusion and exclusion criteria and using the descriptors 3187 articles remained; then, after reading the titles and/or abstracts, 25 articles were selected and analyzed. Therefore, it was understood that HCM is a silent disease in many cases, making screening essential to detect the disease early and allow precocious medical intervention, improving the prognosis and quality of life of patients; in addition, there is great difficulty in determining the risk of developing clinical manifestations, such as sudden cardiac death (SCD). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/21498 10.33448/rsd-v10i13.21498 |
url |
https://rsdjournal.org/index.php/rsd/article/view/21498 |
identifier_str_mv |
10.33448/rsd-v10i13.21498 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/21498/18977 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 13; e336101321498 Research, Society and Development; Vol. 10 Núm. 13; e336101321498 Research, Society and Development; v. 10 n. 13; e336101321498 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052757258010624 |