Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review

Detalhes bibliográficos
Autor(a) principal: Salles Filho, Anderson Silva
Data de Publicação: 2022
Outros Autores: Campos, Helton Oliveira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/26914
Resumo: Acute Promyelocytic Leukemia (APL) is a type of cancer that mainly attacks blood cells and requires intensive treatments that damage and directly affect health. The treatments used to control APL associated with drugs affect the individual, manifesting side effects. This systematic review aimed to analyze the side effects associated with the treatments used for APL. For this, a systematic review was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The literature search was carried out in the following databases: PubMed and Web of Science using combinations of the following keywords in English and Portuguese: acute myeloid leukemia, promyelocytic leukemia, M3, treatment, side effects and drugs. Studies that met the following criteria were included in the systematic review: (I) the participants were diagnosed with APL, (II) the patients underwent a treatment protocol for the pathology, (III) the side effects associated with the treatment were described. A total of 31 articles were selected for inclusion in the systematic review. The most frequent side effects associated with the treatment of APL found were: skin reactions, gastrointestinal discomfort, nausea, vomiting and migraine. Based on the results found in this systematic review, it was observed that some side effects frequently appear in patients with APL, regardless of the type of treatment used, namely: nausea, vomiting, skin reactions, migraine and gastrointestinal discomfort.
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spelling Side effects associated with treatment of Acute Promielocytic Leukemia: systematic reviewEfectos secundarios asociados al tratamiento de la Leucemia Promielocítica Aguda: una revisión sistemáticaEfeitos colaterais associados ao tratamento da Leucemia Promielocítica Aguda: revisão sistemáticaTerapêuticaFármacos hematológicosLeucemia mieloide aguda.TherapeuticsHematologic agentsAcute myeloid leukemia.TerapéuticaFármacos hematológicosLeucemia mieloide aguda.Acute Promyelocytic Leukemia (APL) is a type of cancer that mainly attacks blood cells and requires intensive treatments that damage and directly affect health. The treatments used to control APL associated with drugs affect the individual, manifesting side effects. This systematic review aimed to analyze the side effects associated with the treatments used for APL. For this, a systematic review was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The literature search was carried out in the following databases: PubMed and Web of Science using combinations of the following keywords in English and Portuguese: acute myeloid leukemia, promyelocytic leukemia, M3, treatment, side effects and drugs. Studies that met the following criteria were included in the systematic review: (I) the participants were diagnosed with APL, (II) the patients underwent a treatment protocol for the pathology, (III) the side effects associated with the treatment were described. A total of 31 articles were selected for inclusion in the systematic review. The most frequent side effects associated with the treatment of APL found were: skin reactions, gastrointestinal discomfort, nausea, vomiting and migraine. Based on the results found in this systematic review, it was observed that some side effects frequently appear in patients with APL, regardless of the type of treatment used, namely: nausea, vomiting, skin reactions, migraine and gastrointestinal discomfort.La leucemia promielocítica aguda (LPA) es un tipo de cáncer que ataca principalmente a las células sanguíneas y requiere tratamientos intensivos que atacan y afectan directamente a la salud. Los tratamientos utilizados para el control de la ALI asociados a fármacos afectan al individuo, manifestando efectos secundarios. Esta revisión sistemática tuvo como objetivo analizar los efectos secundarios asociados con los tratamientos utilizados para ALI. Para ello, se realizó una revisión sistemática de acuerdo con las guías PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). La búsqueda bibliográfica se realizó en las siguientes bases de datos: PubMed y Web of Science utilizando combinaciones de las siguientes palabras clave en inglés y portugués: leucemia mieloide aguda, leucemia promielocítica, M3, tratamiento, efectos secundarios y fármacos. Se incluyeron en la revisión sistemática los estudios que cumplieron con los siguientes criterios: (I) los participantes tenían un diagnóstico de LPA, (II) los pacientes se sometieron a un protocolo de tratamiento para la patología, (III) se describieron los efectos secundarios asociados al tratamiento. Se seleccionaron un total de 31 artículos para su inclusión en la revisión sistemática. Los efectos secundarios más frecuentes asociados al tratamiento de la APL encontrados fueron: reacciones cutáneas, molestias gastrointestinales, náuseas, vómitos y migraña. Con base en los resultados encontrados en esta revisión sistemática, se observó que algunos efectos secundarios aparecen con frecuencia en pacientes con LPA, independientemente del tipo de tratamiento utilizado, a saber: náuseas, vómitos, reacciones cutáneas, migraña y molestias gastrointestinales.A Leucemia Promielocítica Aguda (LPA) é um tipo de câncer que ataca principalmente as células sanguíneas e necessita de tratamentos intensivos que agridem e afetam de forma direta a saúde. Os tratamentos utilizados para controlar a LPA associados aos fármacos, afetam o indivíduo, manifestando efeitos colaterais. Esta revisão sistemática teve por objetivo analisar os efeitos colaterais associados aos tratamentos utilizados para a LPA. Para isto, uma revisão sistemática foi conduzida de acordo com as diretrizes do PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). A pesquisa bibliográfica foi realizada nas seguintes bases de dados: PubMed e Web of Science utilizando combinações das seguintes palavras-chave em inglês e português: acute myeloid leukemia, promyelocytic leukemia, M3, treatment, side effects and drugs. Foram incluídos na revisão sistemática estudos que atenderam aos seguintes critérios: (I) os participantes apresentavam diagnóstico de LPA, (II) os pacientes foram submetidos a um protocolo de tratamento para a patologia, (III) os efeitos colaterais associados ao tratamento foram descritos. Um total de 31 artigos foram selecionados para inclusão na revisão sistemática. Os efeitos colaterais mais frequentes associados ao tratamento da LPA encontrados foram: reações cutâneas, desconfortos gastrointestinais, náuseas, vômitos e enxaqueca. A partir dos resultados encontrados nesta revisão sistemática, observou- se que alguns efeitos colaterais aparecem frequentemente nos pacientes com LPA, independentemente do tipo de tratamento utilizado, sendo eles: náuseas, vômitos, reações cutâneas, enxaqueca e desconfortos gastrointestinais.Research, Society and Development2022-03-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2691410.33448/rsd-v11i3.26914Research, Society and Development; Vol. 11 No. 3; e45711326914Research, Society and Development; Vol. 11 Núm. 3; e45711326914Research, Society and Development; v. 11 n. 3; e457113269142525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/26914/23439Copyright (c) 2022 Anderson Silva Salles Filho; Helton Oliveira Camposhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSalles Filho, Anderson SilvaCampos, Helton Oliveira2022-03-09T13:44:38Zoai:ojs.pkp.sfu.ca:article/26914Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:49.356491Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
Efectos secundarios asociados al tratamiento de la Leucemia Promielocítica Aguda: una revisión sistemática
Efeitos colaterais associados ao tratamento da Leucemia Promielocítica Aguda: revisão sistemática
title Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
spellingShingle Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
Salles Filho, Anderson Silva
Terapêutica
Fármacos hematológicos
Leucemia mieloide aguda.
Therapeutics
Hematologic agents
Acute myeloid leukemia.
Terapéutica
Fármacos hematológicos
Leucemia mieloide aguda.
title_short Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
title_full Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
title_fullStr Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
title_full_unstemmed Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
title_sort Side effects associated with treatment of Acute Promielocytic Leukemia: systematic review
author Salles Filho, Anderson Silva
author_facet Salles Filho, Anderson Silva
Campos, Helton Oliveira
author_role author
author2 Campos, Helton Oliveira
author2_role author
dc.contributor.author.fl_str_mv Salles Filho, Anderson Silva
Campos, Helton Oliveira
dc.subject.por.fl_str_mv Terapêutica
Fármacos hematológicos
Leucemia mieloide aguda.
Therapeutics
Hematologic agents
Acute myeloid leukemia.
Terapéutica
Fármacos hematológicos
Leucemia mieloide aguda.
topic Terapêutica
Fármacos hematológicos
Leucemia mieloide aguda.
Therapeutics
Hematologic agents
Acute myeloid leukemia.
Terapéutica
Fármacos hematológicos
Leucemia mieloide aguda.
description Acute Promyelocytic Leukemia (APL) is a type of cancer that mainly attacks blood cells and requires intensive treatments that damage and directly affect health. The treatments used to control APL associated with drugs affect the individual, manifesting side effects. This systematic review aimed to analyze the side effects associated with the treatments used for APL. For this, a systematic review was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The literature search was carried out in the following databases: PubMed and Web of Science using combinations of the following keywords in English and Portuguese: acute myeloid leukemia, promyelocytic leukemia, M3, treatment, side effects and drugs. Studies that met the following criteria were included in the systematic review: (I) the participants were diagnosed with APL, (II) the patients underwent a treatment protocol for the pathology, (III) the side effects associated with the treatment were described. A total of 31 articles were selected for inclusion in the systematic review. The most frequent side effects associated with the treatment of APL found were: skin reactions, gastrointestinal discomfort, nausea, vomiting and migraine. Based on the results found in this systematic review, it was observed that some side effects frequently appear in patients with APL, regardless of the type of treatment used, namely: nausea, vomiting, skin reactions, migraine and gastrointestinal discomfort.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26914
10.33448/rsd-v11i3.26914
url https://rsdjournal.org/index.php/rsd/article/view/26914
identifier_str_mv 10.33448/rsd-v11i3.26914
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26914/23439
dc.rights.driver.fl_str_mv Copyright (c) 2022 Anderson Silva Salles Filho; Helton Oliveira Campos
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Anderson Silva Salles Filho; Helton Oliveira Campos
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 3; e45711326914
Research, Society and Development; Vol. 11 Núm. 3; e45711326914
Research, Society and Development; v. 11 n. 3; e45711326914
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052811104485376

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