Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Moda, Tiago Fávero
Data de Publicação: 2022
Outros Autores: Lima, Carlos José de, Carvalho, Henrique Cunha, Salgado, Miguel Angel Castillo, Fernandes, Adriana Barrinha, Zângaro, Renato Amaro, Moreira, Lívia Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/29886
Resumo: Visceral leishmaniasis (VL) is a zoonosis and chronic disease caused by the protozoan Leishmania spp. which is of great concern to public health. Currently, the drugs used to treat the disease are costly and present undesirable side effects. The use of ozone to treat chronic diseases in both humans and dogs has shown satisfactory results. The aim of this study was to evaluate the ozone therapy in dogs with VL (n=6), administered by intra-abdominal application (IAA), to evaluate hematological and serum biochemical parameters. The protocol involves one gas dose per week for four consecutive weeks. The immunomodulatory action of ozone was determined in the laboratory analyses, confirmed by the increase trend in the white series and maintenance of the renal and hepatic function. Ozone therapy was found to be well tolerated and no adverse effects were observed. Further studies are required to elucidate the mechanisms of action on the infected host.
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spelling Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasisEfectos de la ozonoterapia sobre parámetros hematológicos y bioquímicos séricos en perros afectados por leishmaniosis visceralEfeitos da ozonioterapia sobre os parâmetros hematológicos e bioquímico sérico de cães acometidos por leishmaniose visceralDogLeishmaniasisOzoneHaematologicalSerum biochemistry.PerroLeishmaniosisOzonoHematológicoBioquímico sérico.CãoLeishmanioseOzônioHematológicoBioquímico sérico.Visceral leishmaniasis (VL) is a zoonosis and chronic disease caused by the protozoan Leishmania spp. which is of great concern to public health. Currently, the drugs used to treat the disease are costly and present undesirable side effects. The use of ozone to treat chronic diseases in both humans and dogs has shown satisfactory results. The aim of this study was to evaluate the ozone therapy in dogs with VL (n=6), administered by intra-abdominal application (IAA), to evaluate hematological and serum biochemical parameters. The protocol involves one gas dose per week for four consecutive weeks. The immunomodulatory action of ozone was determined in the laboratory analyses, confirmed by the increase trend in the white series and maintenance of the renal and hepatic function. Ozone therapy was found to be well tolerated and no adverse effects were observed. Further studies are required to elucidate the mechanisms of action on the infected host.La Leishmaniosis Visceral (LV) es una zoonosis y enfermedad crónica causada por el protozoo Leishmania spp. lo cual es de gran preocupación para la salud pública. Actualmente, los medicamentos utilizados para tratar la enfermedad son costosos y presentan efectos secundarios indeseables. El uso de ozono para el tratamiento de enfermedades crónicas tanto en humanos como en perros ha mostrado resultados satisfactorios. El objetivo de este estudio fue evaluar la ozonoterapia en perros con LV (n=6), administrada por aplicación intraabdominal (IAA), para evaluar parámetros hematológicos y bioquímicos séricos. En los análisis de laboratorio se determinó la acción inmunomoduladora del ozono, confirmada por la tendencia al aumento de la serie blanca y el mantenimiento de la función renal y hepática. Ozonoterapia fue bien tolerada y no se observaron efectos adversos. Se requieren más estudios futuros para dilucidar los mecanismos de acción sobre el huésped infectado.A Leishmaniose Visceral (LV) é uma zoonose e doença crônica causada pelo protozoário Leishmania spp. que apresenta grande importância em saúde pública. Atualmente, os fármacos utilizados em seu tratamento estão associados ao alto custo e a efeitos colaterais indesejáveis. A utilização do ozônio no tratamento de doenças crônicas tanto em humanos quanto em cães têm mostrado resultados satisfatórios. O objetivo deste estudo foi de avaliar o uso da ozonioterapia em cães com LV (n=6), através da aplicação por via intra-abdominal (IAA), para avaliação dos parâmetros hematológicos e bioquímico sérico. O protocolo consistia de uma aplicação por semana durante quatro semanas. Nas análises laboratoriais foi identificada uma ação imunomoduladora pelo ozônio, verificada pela tendência de aumento da série branca e manutenção da função renal e hepática. A ozonioterapia também se mostrou bem tolerável e não foram observados efeitos colaterais, futuros estudos serão necessários para elucidar os mecanismos de ação sobre o hospedeiro infectado.Research, Society and Development2022-05-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2988610.33448/rsd-v11i7.29886Research, Society and Development; Vol. 11 No. 7; e16711729886Research, Society and Development; Vol. 11 Núm. 7; e16711729886Research, Society and Development; v. 11 n. 7; e167117298862525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/29886/25741Copyright (c) 2022 Tiago Fávero Moda; Carlos José de Lima; Henrique Cunha Carvalho; Miguel Angel Castillo Salgado; Adriana Barrinha Fernandes; Renato Amaro Zângaro; Lívia Helena Moreirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessModa, Tiago FáveroLima, Carlos José deCarvalho, Henrique CunhaSalgado, Miguel Angel CastilloFernandes, Adriana BarrinhaZângaro, Renato AmaroMoreira, Lívia Helena2022-06-06T15:12:05Zoai:ojs.pkp.sfu.ca:article/29886Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:50.279163Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
Efectos de la ozonoterapia sobre parámetros hematológicos y bioquímicos séricos en perros afectados por leishmaniosis visceral
Efeitos da ozonioterapia sobre os parâmetros hematológicos e bioquímico sérico de cães acometidos por leishmaniose visceral
title Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
spellingShingle Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
Moda, Tiago Fávero
Dog
Leishmaniasis
Ozone
Haematological
Serum biochemistry.
Perro
Leishmaniosis
Ozono
Hematológico
Bioquímico sérico.
Cão
Leishmaniose
Ozônio
Hematológico
Bioquímico sérico.
title_short Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
title_full Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
title_fullStr Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
title_full_unstemmed Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
title_sort Effects of ozone therapy on hematological and serum biochemical parameters in dogs affected by visceral leishmaniasis
author Moda, Tiago Fávero
author_facet Moda, Tiago Fávero
Lima, Carlos José de
Carvalho, Henrique Cunha
Salgado, Miguel Angel Castillo
Fernandes, Adriana Barrinha
Zângaro, Renato Amaro
Moreira, Lívia Helena
author_role author
author2 Lima, Carlos José de
Carvalho, Henrique Cunha
Salgado, Miguel Angel Castillo
Fernandes, Adriana Barrinha
Zângaro, Renato Amaro
Moreira, Lívia Helena
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moda, Tiago Fávero
Lima, Carlos José de
Carvalho, Henrique Cunha
Salgado, Miguel Angel Castillo
Fernandes, Adriana Barrinha
Zângaro, Renato Amaro
Moreira, Lívia Helena
dc.subject.por.fl_str_mv Dog
Leishmaniasis
Ozone
Haematological
Serum biochemistry.
Perro
Leishmaniosis
Ozono
Hematológico
Bioquímico sérico.
Cão
Leishmaniose
Ozônio
Hematológico
Bioquímico sérico.
topic Dog
Leishmaniasis
Ozone
Haematological
Serum biochemistry.
Perro
Leishmaniosis
Ozono
Hematológico
Bioquímico sérico.
Cão
Leishmaniose
Ozônio
Hematológico
Bioquímico sérico.
description Visceral leishmaniasis (VL) is a zoonosis and chronic disease caused by the protozoan Leishmania spp. which is of great concern to public health. Currently, the drugs used to treat the disease are costly and present undesirable side effects. The use of ozone to treat chronic diseases in both humans and dogs has shown satisfactory results. The aim of this study was to evaluate the ozone therapy in dogs with VL (n=6), administered by intra-abdominal application (IAA), to evaluate hematological and serum biochemical parameters. The protocol involves one gas dose per week for four consecutive weeks. The immunomodulatory action of ozone was determined in the laboratory analyses, confirmed by the increase trend in the white series and maintenance of the renal and hepatic function. Ozone therapy was found to be well tolerated and no adverse effects were observed. Further studies are required to elucidate the mechanisms of action on the infected host.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29886
10.33448/rsd-v11i7.29886
url https://rsdjournal.org/index.php/rsd/article/view/29886
identifier_str_mv 10.33448/rsd-v11i7.29886
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29886/25741
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 7; e16711729886
Research, Society and Development; Vol. 11 Núm. 7; e16711729886
Research, Society and Development; v. 11 n. 7; e16711729886
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052712849768448

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