Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS
Autor(a) principal: | |
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Data de Publicação: | 2015 |
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Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Saúde e Desenvolvimento Humano |
Texto Completo: | https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/view/2317-8582.15.4 |
Resumo: | This study aims to verify and analyze the occurrence of liver damage in HIV-patients under antiretroviral therapy, scrutinizing which treatment regimens have higher degree of toxicity. Nine patients who were already under antiretroviral therapy were selected, considering as inclusion criteria to be over 18 years old and be under treatment for more than six months. Exclusion criteria were unwillingness to participate in the study, people who were under treatment with antituberculosis drugs and HCV-positive persons. For data assessment, it was conducted a questionnaire covering demographic and behavioral females issues; furthermore to the accomplishment of a laboratory profile, which include the aspartate aminotransferase (AST) and alanine aminotransferase (ALDT) levels. Among the results, it was found that prevailed first in females with 66.6% and mean age of 38.7 years; followed by 44.5% that reported heterosexual intercourse as mode of infection. Evaluating the therapy extent, 44.4% reported that were using it for 5 to 8 years, 55.5% were using a triple therapy, among this therapy evaluation, 66.6% reported to have side effects. The laboratorial analysis showed values within the benchmark ranges. Thus, by analyzing the results were possible to understand the effectiveness of highly active antiretroviral therapy (HAART), the treatment regimens with the most effective antiretroviral and less liver damage, which showed no increase in transaminases of the patients studied. |
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Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RSAvaliação do dano hepático em pacientes HIV positivo sob terapia antirretroviral no município de Carazinho/RSAntiretroviral theraphy; Liver damage; AST/ALDTBioquímica; HIVTerapia Antiretroviral; Altamente Ativa; Síndrome da Imunodeficiência Humana; HepatotoxicidadeThis study aims to verify and analyze the occurrence of liver damage in HIV-patients under antiretroviral therapy, scrutinizing which treatment regimens have higher degree of toxicity. Nine patients who were already under antiretroviral therapy were selected, considering as inclusion criteria to be over 18 years old and be under treatment for more than six months. Exclusion criteria were unwillingness to participate in the study, people who were under treatment with antituberculosis drugs and HCV-positive persons. For data assessment, it was conducted a questionnaire covering demographic and behavioral females issues; furthermore to the accomplishment of a laboratory profile, which include the aspartate aminotransferase (AST) and alanine aminotransferase (ALDT) levels. Among the results, it was found that prevailed first in females with 66.6% and mean age of 38.7 years; followed by 44.5% that reported heterosexual intercourse as mode of infection. Evaluating the therapy extent, 44.4% reported that were using it for 5 to 8 years, 55.5% were using a triple therapy, among this therapy evaluation, 66.6% reported to have side effects. The laboratorial analysis showed values within the benchmark ranges. Thus, by analyzing the results were possible to understand the effectiveness of highly active antiretroviral therapy (HAART), the treatment regimens with the most effective antiretroviral and less liver damage, which showed no increase in transaminases of the patients studied.O presente trabalho teve como objetivo verificar e analisar a existência do dano hepático em pacientes sob tratamento antiretroviral, analisando quais esquemas terapêuticos apresentam maior grau de toxicidade. Foram selecionados nove pacientes que estavam fazendo terapia antiretroviral, tendo como inclusão idade superior a 18 anos e sob tratamento há mais de seis meses. Foi realizado um questionário, além da realização do perfil laboratorial, com dosagens de AST e ALT. Dentre os resultados, verificou-se que prevaleceu o sexo feminino com 66,6%, idade média de 38,7 anos, 44,5% relataram modo de infecção por relação heterossexual. Avaliando-se a terapia, 44,4% faziam uso da terapia de 5 a 8 anos, 55,5% faziam uso de terapia tríplice, e 66,6% apresentaram efeitos colaterais. Os valores laboratoriais encontravam-se dentro da faixa dos valores de referência. Desta forma, através da análise dos resultados foi possível compreender a eficiência da terapia antiretroviral altamente ativa, os esquemas terapêuticos com os antiretrovirais mais efetivos e com menos dano hepático, os quais não apresentaram aumento das transaminase nos pacientes em estudo.Universidade LaSalle - Unilasalle CanoasAraújo, Patricia DiasEhrhardt, Alexandre2015-11-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/view/2317-8582.15.410.18316/2317-8582.15.4Saúde e Desenvolvimento Humano; v. 3, n. 2 (2015); p. 45-54Saúde e Desenvolvimento Humano; v. 3, n. 2 (2015); p. 45-542317-8582reponame:Saúde e Desenvolvimento Humanoinstname:Universidade La Salle (UNILASALLE)instacron:UNILASALLEporhttps://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/view/2317-8582.15.4/1472https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/downloadSuppFile/2317-8582.15.4/409https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/downloadSuppFile/2317-8582.15.4/410https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/downloadSuppFile/2317-8582.15.4/415info:eu-repo/semantics/openAccess2022-04-11T13:38:20Zoai:ojs.revistas.unilasalle.edu.br:article/2468Revistahttp://www.revistas.unilasalle.edu.br/index.php/saude_desenvolvimentohttps://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/oaisdh@unilasalle.edu.br2317-85822317-8582opendoar:2022-04-11T13:38:20Saúde e Desenvolvimento Humano - Universidade La Salle (UNILASALLE)false |
dc.title.none.fl_str_mv |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS Avaliação do dano hepático em pacientes HIV positivo sob terapia antirretroviral no município de Carazinho/RS |
title |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS |
spellingShingle |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS Araújo, Patricia Dias Antiretroviral theraphy; Liver damage; AST/ALDT Bioquímica; HIV Terapia Antiretroviral; Altamente Ativa; Síndrome da Imunodeficiência Humana; Hepatotoxicidade |
title_short |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS |
title_full |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS |
title_fullStr |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS |
title_full_unstemmed |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS |
title_sort |
Liver damage assessment in HIV-positive patients in antiretroviral therapy in the municipality of Carazinho/RS |
author |
Araújo, Patricia Dias |
author_facet |
Araújo, Patricia Dias Ehrhardt, Alexandre |
author_role |
author |
author2 |
Ehrhardt, Alexandre |
author2_role |
author |
dc.contributor.none.fl_str_mv |
|
dc.contributor.author.fl_str_mv |
Araújo, Patricia Dias Ehrhardt, Alexandre |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
Antiretroviral theraphy; Liver damage; AST/ALDT Bioquímica; HIV Terapia Antiretroviral; Altamente Ativa; Síndrome da Imunodeficiência Humana; Hepatotoxicidade |
topic |
Antiretroviral theraphy; Liver damage; AST/ALDT Bioquímica; HIV Terapia Antiretroviral; Altamente Ativa; Síndrome da Imunodeficiência Humana; Hepatotoxicidade |
description |
This study aims to verify and analyze the occurrence of liver damage in HIV-patients under antiretroviral therapy, scrutinizing which treatment regimens have higher degree of toxicity. Nine patients who were already under antiretroviral therapy were selected, considering as inclusion criteria to be over 18 years old and be under treatment for more than six months. Exclusion criteria were unwillingness to participate in the study, people who were under treatment with antituberculosis drugs and HCV-positive persons. For data assessment, it was conducted a questionnaire covering demographic and behavioral females issues; furthermore to the accomplishment of a laboratory profile, which include the aspartate aminotransferase (AST) and alanine aminotransferase (ALDT) levels. Among the results, it was found that prevailed first in females with 66.6% and mean age of 38.7 years; followed by 44.5% that reported heterosexual intercourse as mode of infection. Evaluating the therapy extent, 44.4% reported that were using it for 5 to 8 years, 55.5% were using a triple therapy, among this therapy evaluation, 66.6% reported to have side effects. The laboratorial analysis showed values within the benchmark ranges. Thus, by analyzing the results were possible to understand the effectiveness of highly active antiretroviral therapy (HAART), the treatment regimens with the most effective antiretroviral and less liver damage, which showed no increase in transaminases of the patients studied. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-11-27 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/view/2317-8582.15.4 10.18316/2317-8582.15.4 |
url |
https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/view/2317-8582.15.4 |
identifier_str_mv |
10.18316/2317-8582.15.4 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/view/2317-8582.15.4/1472 https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/downloadSuppFile/2317-8582.15.4/409 https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/downloadSuppFile/2317-8582.15.4/410 https://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento/article/downloadSuppFile/2317-8582.15.4/415 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade LaSalle - Unilasalle Canoas |
publisher.none.fl_str_mv |
Universidade LaSalle - Unilasalle Canoas |
dc.source.none.fl_str_mv |
Saúde e Desenvolvimento Humano; v. 3, n. 2 (2015); p. 45-54 Saúde e Desenvolvimento Humano; v. 3, n. 2 (2015); p. 45-54 2317-8582 reponame:Saúde e Desenvolvimento Humano instname:Universidade La Salle (UNILASALLE) instacron:UNILASALLE |
instname_str |
Universidade La Salle (UNILASALLE) |
instacron_str |
UNILASALLE |
institution |
UNILASALLE |
reponame_str |
Saúde e Desenvolvimento Humano |
collection |
Saúde e Desenvolvimento Humano |
repository.name.fl_str_mv |
Saúde e Desenvolvimento Humano - Universidade La Salle (UNILASALLE) |
repository.mail.fl_str_mv |
sdh@unilasalle.edu.br |
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1749120544531283968 |