LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT

Detalhes bibliográficos
Autor(a) principal: Freitas, Camila Fabiano de
Data de Publicação: 2020
Outros Autores: Batistela, Vagner Roberto, Caetano, Wilker, Hioka, Noboru
Tipo de documento: Artigo
Idioma: por
Título da fonte: UNINGÁ Review
Texto Completo: https://revista.uninga.br/uningareviews/article/view/3400
Resumo: In recent years, nanotechnology has been a strong ally to Medicinal Chemistry. Liposomes stand out, being cell membrane models and excellent biocompatible drug delivery systems. However, liposomes have limitations due to their low stability in solutions and rapid elimination from the blood stream. These factors prevent the accumulation of these structures in tumor tissues, as well as the effects of permeability and retention (EPR effect). Given this scenario, several strategies have been developed aiming to increase the stability and the circulation of liposome in the blood stream. Recent research has shown that surface-modified liposomes with polyethylene glycol (PEG), triblock ABA-like copolymers or site-specific ligands are able to overcome these issues. With that in mind, this article brings a review of the main scientific contributions in the development, optimization and improvement of liposomes as long circulation systems aiming at new strategies for drug formulation in cancer treatment.
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spelling LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENTLIPOSSOMAS DE LONGA-CIRCULAÇÃO COMO ESTRATÉGIA PROMISSORA PARA O TRANSPORTE E BIODISPONIBILIZAÇÃO DE FÁRMACOS NO TRATAMENTO DO CÂNCERCopolímeros TriblocoFormulação de medicamentosLipossomasLipossomas de Longa-circulaçãoTratamento do câncerTransporte e Entrega de fármaosLipossomosLipossomos convencionaisLipossomos ModificadosLipossomos de longa circulaçãoLipossomos furtivosCopolímeros triblocoCancer TreatmentDrug FormulationLiposomesLong Circulating LiposomesTriblock CopolymersIn recent years, nanotechnology has been a strong ally to Medicinal Chemistry. Liposomes stand out, being cell membrane models and excellent biocompatible drug delivery systems. However, liposomes have limitations due to their low stability in solutions and rapid elimination from the blood stream. These factors prevent the accumulation of these structures in tumor tissues, as well as the effects of permeability and retention (EPR effect). Given this scenario, several strategies have been developed aiming to increase the stability and the circulation of liposome in the blood stream. Recent research has shown that surface-modified liposomes with polyethylene glycol (PEG), triblock ABA-like copolymers or site-specific ligands are able to overcome these issues. With that in mind, this article brings a review of the main scientific contributions in the development, optimization and improvement of liposomes as long circulation systems aiming at new strategies for drug formulation in cancer treatment.Nos últimos anos a nanotecnologia revelou-se uma forte aliada no desenvolvimento da Química Medicinal. Nessa vertente, destacam-se os lipossomas que além de serem modelos de membrana celular também são excelentes sistemas biocompatíveis de formulação, carreamento e liberação de fármacos. Entretanto, os lipossomas apresentam limitações relacionadas à sua baixa estabilidade em solução e rápida eliminação da circulação sanguínea. Esses fatores acabam impedindo o acúmulo dessas estruturas em tecidos tumorais, inclusive pelo efeito de permeabilidade e retenção (efeito EPR). Diante deste quadro, diversas estratégias vêm sendo desenvolvidas com o objetivo de aumentar a estabilidade e principalmente o tempo de circulação sanguínea dos lipossomas. Pesquisas recentes têm mostrado a obtenção de lipossomas modicados superficialmente com polietilenoglicol (PEG), com copolímeros tribloco do tipo ABA ou ainda com ligantes sítios específicos. Nesse sentido, o presente artigo traz uma revisão sobre as principais contribuições científicas no desenvolvimento, otimização e aprimoramento de lipossomas como sistemas de longa circulação visando novas estratégias de formulação de medicamentos para o tratamento do câncer.Editora Uningá2020-07-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontextpapplication/pdfhttps://revista.uninga.br/uningareviews/article/view/3400Uningá Review ; Vol. 35 (2020); eRUR3400Uningá Review ; v. 35 (2020); eRUR34002178-2571reponame:UNINGÁ Reviewinstname:Centro Universitário Uningáinstacron:UNINGAporhttps://revista.uninga.br/uningareviews/article/view/3400/2209Copyright (c) 2020 REVISTA UNINGÁ REVIEWhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFreitas, Camila Fabiano de Batistela, Vagner RobertoCaetano, WilkerHioka, Noboru2023-10-17T15:05:53Zoai:ojs.revista.uninga.br:article/3400Revistahttps://revista.uninga.br/uningareviews/indexPUBhttps://revista.uninga.br/uningareviews/oairevistauningareview@uninga.edu.br || sec.revistas@uninga.edu.br2178-25712178-2571opendoar:2023-10-17T15:05:53UNINGÁ Review - Centro Universitário Uningáfalse
dc.title.none.fl_str_mv LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
LIPOSSOMAS DE LONGA-CIRCULAÇÃO COMO ESTRATÉGIA PROMISSORA PARA O TRANSPORTE E BIODISPONIBILIZAÇÃO DE FÁRMACOS NO TRATAMENTO DO CÂNCER
title LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
spellingShingle LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
Freitas, Camila Fabiano de
Copolímeros Tribloco
Formulação de medicamentos
Lipossomas
Lipossomas de Longa-circulação
Tratamento do câncer
Transporte e Entrega de fármaos
Lipossomos
Lipossomos convencionais
Lipossomos Modificados
Lipossomos de longa circulação
Lipossomos furtivos
Copolímeros tribloco
Cancer Treatment
Drug Formulation
Liposomes
Long Circulating Liposomes
Triblock Copolymers
title_short LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
title_full LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
title_fullStr LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
title_full_unstemmed LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
title_sort LONG-CIRCULATING LIPOSOMES AS A PROMISING STRATEGY FOR THE TRANSPORT AND BIOAVAILABILITY OF DRUGS IN CANCER TREATMENT
author Freitas, Camila Fabiano de
author_facet Freitas, Camila Fabiano de
Batistela, Vagner Roberto
Caetano, Wilker
Hioka, Noboru
author_role author
author2 Batistela, Vagner Roberto
Caetano, Wilker
Hioka, Noboru
author2_role author
author
author
dc.contributor.author.fl_str_mv Freitas, Camila Fabiano de
Batistela, Vagner Roberto
Caetano, Wilker
Hioka, Noboru
dc.subject.por.fl_str_mv Copolímeros Tribloco
Formulação de medicamentos
Lipossomas
Lipossomas de Longa-circulação
Tratamento do câncer
Transporte e Entrega de fármaos
Lipossomos
Lipossomos convencionais
Lipossomos Modificados
Lipossomos de longa circulação
Lipossomos furtivos
Copolímeros tribloco
Cancer Treatment
Drug Formulation
Liposomes
Long Circulating Liposomes
Triblock Copolymers
topic Copolímeros Tribloco
Formulação de medicamentos
Lipossomas
Lipossomas de Longa-circulação
Tratamento do câncer
Transporte e Entrega de fármaos
Lipossomos
Lipossomos convencionais
Lipossomos Modificados
Lipossomos de longa circulação
Lipossomos furtivos
Copolímeros tribloco
Cancer Treatment
Drug Formulation
Liposomes
Long Circulating Liposomes
Triblock Copolymers
description In recent years, nanotechnology has been a strong ally to Medicinal Chemistry. Liposomes stand out, being cell membrane models and excellent biocompatible drug delivery systems. However, liposomes have limitations due to their low stability in solutions and rapid elimination from the blood stream. These factors prevent the accumulation of these structures in tumor tissues, as well as the effects of permeability and retention (EPR effect). Given this scenario, several strategies have been developed aiming to increase the stability and the circulation of liposome in the blood stream. Recent research has shown that surface-modified liposomes with polyethylene glycol (PEG), triblock ABA-like copolymers or site-specific ligands are able to overcome these issues. With that in mind, this article brings a review of the main scientific contributions in the development, optimization and improvement of liposomes as long circulation systems aiming at new strategies for drug formulation in cancer treatment.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
textp
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.uninga.br/uningareviews/article/view/3400
url https://revista.uninga.br/uningareviews/article/view/3400
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.uninga.br/uningareviews/article/view/3400/2209
dc.rights.driver.fl_str_mv Copyright (c) 2020 REVISTA UNINGÁ REVIEW
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 REVISTA UNINGÁ REVIEW
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora Uningá
publisher.none.fl_str_mv Editora Uningá
dc.source.none.fl_str_mv Uningá Review ; Vol. 35 (2020); eRUR3400
Uningá Review ; v. 35 (2020); eRUR3400
2178-2571
reponame:UNINGÁ Review
instname:Centro Universitário Uningá
instacron:UNINGA
instname_str Centro Universitário Uningá
instacron_str UNINGA
institution UNINGA
reponame_str UNINGÁ Review
collection UNINGÁ Review
repository.name.fl_str_mv UNINGÁ Review - Centro Universitário Uningá
repository.mail.fl_str_mv revistauningareview@uninga.edu.br || sec.revistas@uninga.edu.br
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