Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos

Detalhes bibliográficos
Autor(a) principal: Maciejewski, Narco Afonso Ravazzoli
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações do UNIOESTE
Texto Completo: http://tede.unioeste.br/handle/tede/3993
Resumo: Information derived from the analysis of the mechanical behavior of biological tissues increases the efficiency of diagnosis, as well as of clinical and surgical treatments. The importance of this resides in the fact that, in many organs such as the colon, the rupture of tissues is associated with high rates of morbidity and mortality. In this context, several mechanical tests are used to evaluate the mechanical resistance of biological tissues. However, most of the existing tests are susceptible to criticism, since these materials have microstructures with heterogeneous and anisotropic characteristics. In this way, based on the knowledge that the majority of biological tissues present a non-linear viscoelastic mechanical behavior, a new method was proposed in this work for the analysis and identification of the properties of these materials. The proposed method aims to analyze curves generated by means of mechanical traction tests of biological tissues under constant speed. Its originality is based on the mathematical modeling of these tissues behavior and the discretization of the function in three regions, which are characterized by elastic, elastoplastic and leakage periods. This methodological process enabled to detect constants of proportionality in the elastic and elastoplastic regions, denominated as tissue elasticity (KT ) and tissue stiffness (KR). The proposed method was applied to a case study using data derived from descending colon segments of 20 rats, obtained through the Total Energy of Rupture (ETR) biomechanical test. Initially, the mathematical modeling was performed with the Boltzmann sigmoidal model for all curves. Then, with these adjustments, the coefficients of determination of each function were calculated, along with its average and respective standard deviation (R2 = 0, 9975 +/- 0; 0021). After these procedures,the curve, in its integrality, was discretized by first and second order numerical derivation for each point of the curve. Then the elastic regions were determined, and the mean relative to the remainder of the curve was calculated (6; 9120 +/- 1; 2577%), as well as the mean of the constant KT (34; 5437 +/- 3; 7547gf=cm). The same procedure was performed for the elastoplastic regions (mean = 89; 3334 +/- 5; 3974% and the KR = 87; 8945 +/- 8; 1226gf=cm). After these procedures, it was possible to construct a standard curve, with lower and upper limits, to describe the mechanical behavior of the intestinal rings of rats with the average Boltzmann model parameters for each curve. According to the criteria evaluated, the proposed method for the analysis and identification of non-linear viscoelastic materials properties showed to be accurate and reliable, as the mechanical properties of these materials were fully analyzed employing the method proposed in this work.
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spelling Lee, Huei Dianahttp://lattes.cnpq.br/2999453247853080Chung, Wu Fenghttp://lattes.cnpq.br/9411757525231574Lotero, Roberto Cayetanohttp://lattes.cnpq.br/2866486851342810Nihei, Oscar Kenjihttp://lattes.cnpq.br/8679080014455133http://lattes.cnpq.br/9214991739582650Maciejewski, Narco Afonso Ravazzoli2018-10-30T19:51:43Z2018-03-06MACIEJEWSKI, Narco Afonso Ravazzoli. Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos. 2018. 117p. Dissertação (Mestrado em Engenharia Elétrica e Computação) - Universidade Estadual do Oeste do Paraná, Foz do Iguaçu, 2018.http://tede.unioeste.br/handle/tede/3993Information derived from the analysis of the mechanical behavior of biological tissues increases the efficiency of diagnosis, as well as of clinical and surgical treatments. The importance of this resides in the fact that, in many organs such as the colon, the rupture of tissues is associated with high rates of morbidity and mortality. In this context, several mechanical tests are used to evaluate the mechanical resistance of biological tissues. However, most of the existing tests are susceptible to criticism, since these materials have microstructures with heterogeneous and anisotropic characteristics. In this way, based on the knowledge that the majority of biological tissues present a non-linear viscoelastic mechanical behavior, a new method was proposed in this work for the analysis and identification of the properties of these materials. The proposed method aims to analyze curves generated by means of mechanical traction tests of biological tissues under constant speed. Its originality is based on the mathematical modeling of these tissues behavior and the discretization of the function in three regions, which are characterized by elastic, elastoplastic and leakage periods. This methodological process enabled to detect constants of proportionality in the elastic and elastoplastic regions, denominated as tissue elasticity (KT ) and tissue stiffness (KR). The proposed method was applied to a case study using data derived from descending colon segments of 20 rats, obtained through the Total Energy of Rupture (ETR) biomechanical test. Initially, the mathematical modeling was performed with the Boltzmann sigmoidal model for all curves. Then, with these adjustments, the coefficients of determination of each function were calculated, along with its average and respective standard deviation (R2 = 0, 9975 +/- 0; 0021). After these procedures,the curve, in its integrality, was discretized by first and second order numerical derivation for each point of the curve. Then the elastic regions were determined, and the mean relative to the remainder of the curve was calculated (6; 9120 +/- 1; 2577%), as well as the mean of the constant KT (34; 5437 +/- 3; 7547gf=cm). The same procedure was performed for the elastoplastic regions (mean = 89; 3334 +/- 5; 3974% and the KR = 87; 8945 +/- 8; 1226gf=cm). After these procedures, it was possible to construct a standard curve, with lower and upper limits, to describe the mechanical behavior of the intestinal rings of rats with the average Boltzmann model parameters for each curve. According to the criteria evaluated, the proposed method for the analysis and identification of non-linear viscoelastic materials properties showed to be accurate and reliable, as the mechanical properties of these materials were fully analyzed employing the method proposed in this work.Informações provenientes da análise do comportamento mecânico de tecidos biológicos proporcionam o aumento da eficiência de diagnósticos e de tratamentos clínicos e cirúrgicos. A importância disso está no fato de que em muitos órgãos, como o cólon, a ruptura de seus tecidos está associada a altos índices de morbidade e mortalidade. Nesse contexto, diversos ensaios mecânicos são utilizados para avaliar a resistência mecânica de tecidos biológicos. No entanto, grande parte dos testes existentes são passíveis de críticas, pois esses materiais possuem microestruturas com características heterogêneas e anisotrópicas. Desse modo, com o conhecimento de que a maioria dos tecidos biológicos apresentam comportamento mecânico viscoelástico não linear, foi proposto um novo método para a análise e a identificação das propriedades desses materiais. O método proposto tem como objetivo analisar as curvas geradas por meio de ensaios mecânicos de tração sob velocidade constante de tecidos biológicos e a originalidade está fundamentada na modelagem matemática e na discretização da função em três regiões, caracterizadas pelos períodos elástico, elastoplástico e de escoamento do comportamento desses tecidos. Assim, foi possível detectar nas regiões elástica e elastoplástica constantes de proporcionalidade, sendo estas denominadas elasticidade tecidual (KT ) e rigidez tecidual (KR), respectivamente. Um estudo de caso foi realizado com dados provenientes de segmentos de cólon descendente de 20 ratos, obtidos por meio do ensaio biomecânico Energia Total de Ruptura (ETR). Inicialmente, a modelagem matemática foi realizada com o modelo sigmoidal de Boltzmann para todas as curvas, e, com esses ajustes, foram então calculados os coeficientes de determinação de cada função e a sua média com o respectivo desvio padrão (R2 = 0, 9975+/-0; 0021). Posteriormente, a curva, na sua integralidade, foi discretizada por meio da derivação numérica de primeira e de segunda ordem para cada ponto da mesma, e, assim, as regiões elásticas foram determinadas e a média calculada (6, 9120+/-1; 2577%) em relação ao restante da curva, assim como a média da constante KT (34, 5437 +/- 3; 7547gf=cm). O mesmo procedimento foi aplicado para as regiões elastoplásticas alcançando a média de 89, 3334 +/- 5; 3974% e o KR = 87, 8945 +/- 8; 1226gf=cm. Após, foi possível a construção de uma curva padrão, com os limites inferior e superior, para descrever o comportamento mecânico de alças intestinais de ratos com a média dos parâmetros do modelo de Boltzmann para cada curva. Sendo assim, de acordo com os critérios avaliados, o método proposto para a análise e identificação das propriedades de materiais viscoelásticos não lineares se mostrou preciso e confiável, pois as propriedades mecânicas desses materiais foram integralmente analisadas por meio do método proposto nesse trabalho.Submitted by Wagner Junior (wagner.junior@unioeste.br) on 2018-10-30T19:51:43Z No. of bitstreams: 2 referencia.pdf: 27563 bytes, checksum: 74f45da034fcc5757becd278cfad8b50 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2018-10-30T19:51:43Z (GMT). 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dc.title.por.fl_str_mv Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
dc.title.alternative.eng.fl_str_mv Development of a method for analyzing and identifying the properties of biological materials
title Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
spellingShingle Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
Maciejewski, Narco Afonso Ravazzoli
Coloproctologia
Cicatrização
Elasticidade Tecidual
Reologia
Coloproctology
Healing
Tissue Elasticity
Rheology
CIRURGIA::CIRURGIA PROCTOLOGICA
title_short Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
title_full Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
title_fullStr Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
title_full_unstemmed Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
title_sort Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos
author Maciejewski, Narco Afonso Ravazzoli
author_facet Maciejewski, Narco Afonso Ravazzoli
author_role author
dc.contributor.advisor1.fl_str_mv Lee, Huei Diana
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2999453247853080
dc.contributor.advisor-co1.fl_str_mv Chung, Wu Feng
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/9411757525231574
dc.contributor.referee1.fl_str_mv Lotero, Roberto Cayetano
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/2866486851342810
dc.contributor.referee2.fl_str_mv Nihei, Oscar Kenji
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/8679080014455133
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9214991739582650
dc.contributor.author.fl_str_mv Maciejewski, Narco Afonso Ravazzoli
contributor_str_mv Lee, Huei Diana
Chung, Wu Feng
Lotero, Roberto Cayetano
Nihei, Oscar Kenji
dc.subject.por.fl_str_mv Coloproctologia
Cicatrização
Elasticidade Tecidual
Reologia
topic Coloproctologia
Cicatrização
Elasticidade Tecidual
Reologia
Coloproctology
Healing
Tissue Elasticity
Rheology
CIRURGIA::CIRURGIA PROCTOLOGICA
dc.subject.eng.fl_str_mv Coloproctology
Healing
Tissue Elasticity
Rheology
dc.subject.cnpq.fl_str_mv CIRURGIA::CIRURGIA PROCTOLOGICA
description Information derived from the analysis of the mechanical behavior of biological tissues increases the efficiency of diagnosis, as well as of clinical and surgical treatments. The importance of this resides in the fact that, in many organs such as the colon, the rupture of tissues is associated with high rates of morbidity and mortality. In this context, several mechanical tests are used to evaluate the mechanical resistance of biological tissues. However, most of the existing tests are susceptible to criticism, since these materials have microstructures with heterogeneous and anisotropic characteristics. In this way, based on the knowledge that the majority of biological tissues present a non-linear viscoelastic mechanical behavior, a new method was proposed in this work for the analysis and identification of the properties of these materials. The proposed method aims to analyze curves generated by means of mechanical traction tests of biological tissues under constant speed. Its originality is based on the mathematical modeling of these tissues behavior and the discretization of the function in three regions, which are characterized by elastic, elastoplastic and leakage periods. This methodological process enabled to detect constants of proportionality in the elastic and elastoplastic regions, denominated as tissue elasticity (KT ) and tissue stiffness (KR). The proposed method was applied to a case study using data derived from descending colon segments of 20 rats, obtained through the Total Energy of Rupture (ETR) biomechanical test. Initially, the mathematical modeling was performed with the Boltzmann sigmoidal model for all curves. Then, with these adjustments, the coefficients of determination of each function were calculated, along with its average and respective standard deviation (R2 = 0, 9975 +/- 0; 0021). After these procedures,the curve, in its integrality, was discretized by first and second order numerical derivation for each point of the curve. Then the elastic regions were determined, and the mean relative to the remainder of the curve was calculated (6; 9120 +/- 1; 2577%), as well as the mean of the constant KT (34; 5437 +/- 3; 7547gf=cm). The same procedure was performed for the elastoplastic regions (mean = 89; 3334 +/- 5; 3974% and the KR = 87; 8945 +/- 8; 1226gf=cm). After these procedures, it was possible to construct a standard curve, with lower and upper limits, to describe the mechanical behavior of the intestinal rings of rats with the average Boltzmann model parameters for each curve. According to the criteria evaluated, the proposed method for the analysis and identification of non-linear viscoelastic materials properties showed to be accurate and reliable, as the mechanical properties of these materials were fully analyzed employing the method proposed in this work.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-30T19:51:43Z
dc.date.issued.fl_str_mv 2018-03-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACIEJEWSKI, Narco Afonso Ravazzoli. Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos. 2018. 117p. Dissertação (Mestrado em Engenharia Elétrica e Computação) - Universidade Estadual do Oeste do Paraná, Foz do Iguaçu, 2018.
dc.identifier.uri.fl_str_mv http://tede.unioeste.br/handle/tede/3993
identifier_str_mv MACIEJEWSKI, Narco Afonso Ravazzoli. Desenvolvimento de método para análise e identificação das propriedades de materiais biológicos. 2018. 117p. Dissertação (Mestrado em Engenharia Elétrica e Computação) - Universidade Estadual do Oeste do Paraná, Foz do Iguaçu, 2018.
url http://tede.unioeste.br/handle/tede/3993
dc.language.iso.fl_str_mv por
language por
dc.relation.por.fl_str_mv Embargado pelo autor/orientador em 13/07/2018 e autorizado o povoamento pelo autor/orientador em 07/03/2019.
dc.relation.program.fl_str_mv -1040084669565072649
dc.relation.confidence.fl_str_mv 600
600
600
dc.relation.department.fl_str_mv -7734402124082146922
dc.relation.cnpq.fl_str_mv 7079017099023736753
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual do Oeste do Paraná
Foz do Iguaçu
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Engenharia Elétrica e Computação
dc.publisher.initials.fl_str_mv UNIOESTE
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Centro de Engenharias e Ciências Exatas
publisher.none.fl_str_mv Universidade Estadual do Oeste do Paraná
Foz do Iguaçu
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTE
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instname_str Universidade Estadual do Oeste do Paraná (UNIOESTE)
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institution UNIOESTE
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repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações do UNIOESTE - Universidade Estadual do Oeste do Paraná (UNIOESTE)
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